Alcoholic and Nonalcoholic Steatohepatitis: Pathogens and Mechanisms of Liver Injury
Traditionally, alcoholic and nonalcoholic fatty liver disease have been considered distinct entities, separable on the basis of clinical history of alcohol exposure. Nevertheless, the two diseases resemble each other histologically and may well share underlying pathophysiologic mechanisms. Sharing of ideas and interactions between the research communities that focus on alcoholic and nonalcoholic liver injury might well enrich both fields, by generating new ideas and directions in elucidating the causes and developing therapies for these two important liver diseases.
This research workshop is being jointly sponsored by the NIAAA and NIDDK with the aim of bringing together research investigators in these two fields, and summarizing the current state of the science of various pathophysiological mechanisms that lead to fatty liver injury. A particular focus will be on how the possible pathologic mechanism might be shared or distinct in alcoholic versus nonalcoholic fatty liver disease.
September 10, 2019