Hematopoietic Response to Stress
With the advent of single cell analyses, the classical hierarchical model of hematopoiesis is being challenged. Recent models predict that Hematopoietic Stem Cells (HSCs) are heterogeneous and that a subset is selectively favored to respond to environmental stress conditions by rapid proliferation. The purpose of the workshop is to explore data for the identity of such a “stress-response” cell and to examine how these cells invoke different pathways from normal hematopoiesis. The molecular bases of these responses are emerging as variations on themes such as the maintenance of the integrity of the genome, post-transcriptional regulation of gene expression, changes in epitranscriptomics, alterations in subcellular organelles, and management of reactive oxygen species. This workshop aims to review the most recent progress in the field and to promote discussion of the gaps in our knowledge of these biological processes and pathways. We also expect to gain a specific understanding of the current scientific and technologic barriers to the hematology research community in the pursuit of knowledge in this area.
This conference supports the mission to disseminate science-based information on hematologic diseases by inviting leaders investigating the impact of stress on hematopoiesis to share their latest research findings with the research community. This conference supports the goal to maintain a vigorous investigator-initiated research portfolio by allowing the opportunity for investigators to articulate specific research needs and by providing an opportunity for commentary by the community.
April 5, 2019