The Physiology of the Weight Reduced State

Event Details

Background

Preventing regain of lost weight is the most difficult challenge in the treatment of obesity. Various physiological adaptations occur that make maintaining weight loss difficult by reducing energy expenditure and increasing energy intake.

Objectives

The overarching goal of this workshop is to explore the mechanisms and integrative physiology of adaptations in appetite, energy expenditure, and thermogenesis (metabolic adaptation) that occur in the weight reduced state and may oppose weight loss maintenance.

The workshop will include—

• Clinical experience with weight reduction and weight loss maintenance versus regain across interventions
• Factors opposing weight loss maintenance
• Factors affecting energy intake in the weight reduced state, including neural and endocrine regulation and the integration of homeostatic and hedonic pathways along with microbiome links
• Metabolic adaptation/adaptive thermogenesis and tissue-specific roles and mechanisms
• Strategies for understanding the physiology of the weight reduced state and improving weight loss maintenance
• Factors potentially responsible for physiological variability in weight maintenance versus regain

Meeting Co-chairs

Rudolph L. Leibel, M.D., Columbia University
Kevin D. Hall, Ph.D., NIDDK

Organizing Committee

Mary Evans, Ph.D., NIDDK
Maren Laughlin, Ph.D., NIDDK
Christopher J. Lynch, Ph.D., NIDDK
Stavroula K. Osganian, M.D., Sc.D., M.P.H., NIDDK
Susan Z. Yanovski, M.D., NIDDK

Registration Deadline

May 25, 2019

Agenda

June 3, 2019

7:30 a.m. – 8:30 a.m.

Registration

8:30 a.m. – 8:40 a.m.

Introduction and Workshop Goals
Christopher J. Lynch, Ph.D., National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

8:40 a.m. – 8:50 a.m.

Welcoming Remarks
Griffin P. Rodgers, M.D., M.A.C.P., Director, NIDDK

Session 1 Describing the Weight Reduced State

Moderator: Samuel Klein, M.D., Washington University

8:50 a.m. – 9:20 a.m.

The Physiology of the Weight Reduced State: Factors Opposing Weight Loss Maintenance
Rudolph Leibel, M.D., Columbia University
Kevin Hall, Ph.D., NIDDK

9:20 a.m. – 9:50 a.m.

Weight Loss and Weight Loss Maintenance: Response to Behavioral and Lifestyle Interventions
John Jakicic, Ph.D., University of Pittsburgh

9:50 a.m. – 10:10 a.m.

Break

10:10 a.m. – 10:40 a.m.

Weight Loss Maintenance with Medical and Surgical Treatments
Louis Aronne, M.D., Weill Cornell Medicine

10:40 a.m. – 11:10 a.m.

Biobehavioral Dysregulation, Behavioral Phenotypes, and Weight Loss Maintenance
Michael Lowe, Ph.D., Drexel University

11:10 a.m. – 11:45 a.m.

Panel Discussion

11:45 a.m. – 12:45 p.m.

Lunch

Session 2 Physiology of Energy Intake in the Weight Reduced State

Moderator: Susan Roberts, Ph.D., Tufts University

12:45 p.m. – 1:15 p.m.

Overview: Homeostatic and Hedonic Pathways Regulating Food Intake
Hans-Rudolf Berthoud, Ph.D., Louisiana State University

1:15 p.m. – 1:45 p.m.

Overview: Neural Regulation of Food Intake
Randy Seeley, Ph.D., University of Michigan

1:45 p.m. – 2:15 p.m.

Overview: Gut-Brain Biology in Regulation of Food Intake
Lee Kaplan, M.D., Ph.D., Harvard University

2:15 p.m. – 3:00 p.m.

Panel Discussion

3:00 p.m. – 3:15 p.m.

Break

Session 3 Physiology of Energy Expenditure in the Weight Reduced State

Moderator: Anthony Ferrante, M.D., Ph.D., Columbia University

3:15 p.m. – 3:45 p.m.

Overview: Metabolic Adaptations in the Weight Reduced State
Eric Ravussin, Ph.D., Pennington Biomedical Research

3:45 p.m. – 4:15 p.m.

Overview: Tissue-Specific Mechanisms of Metabolic Adaptation
Steven Smith, M.D., AdventHealth

4:15 p.m. – 4:45 p.m.

Debate: What Is the Role of Exercise in Weight Loss and Weight Loss Maintenance?
Paul MacLean, Ph.D., University of Colorado Denver
Herman Pontzer, Ph.D., Duke University

4:45 p.m. – 5:15 p.m.

Roundtable Discussion

5:15 p.m.

Recess

June 4, 2019

Session 4 Strategies to Understand the Weight Reduced State

Moderator: Charles Burant, M.D., Ph.D., University of Michigan

8:30 a.m. – 9:00 a.m.

Omics Responses to Weight Loss Interventions
Deborah Muoio, Ph.D., Duke University

9:00 a.m. – 9:15 a.m.

Genetics Germane to Weight Loss Maintenance
Ruth Loos, Ph.D., Icahn School of Medicine at Mount Sinai

9:15 a.m. – 9:45 a.m.

Promise and Perils of Human Neuroimaging to Understand the Weight Reduced State
Ellen Schur, M.D., M.S., University of Washington

9:45 a.m. – 10:00 a.m.

Break

Session 4 Strategies to Understand the Weight Reduced State (continued)

10:00 a.m. – 10:45 a.m.

Weight Loss, Weight Loss Maintenance, and Weight Regain—Distinct Physiologic States or Parts of a Continuum?
Michael Rosenbaum, M.D., Columbia University Irving Medical Center
Kevin Hall, Ph.D., NIDDK

10:45 a.m. – 12:00 p.m.

Roundtable Discussion: Strategies for Understanding the Weight Reduced State
Moderators: Rudolph Leibel, M.D., Columbia University
Kevin Hall, Ph.D., NIDDK

12:00 p.m.

Adjournment