Cystic Fibrosis-Related Diabetes Scientific Workshop

Event Details

Cystic fibrosis (CF) results from the dysfunction of the cystic fibrosis transmembrane conductance regulatory (CFTR) protein, which affects both bicarbonate and chloride transport. Although most commonly associated with lung disease, CF also is associated with diabetes. Cystic fibrosis–related diabetes (CFRD) now affects up to 50 percent of adult patients and is associated with significant increased mortality. The mechanisms by which CFTR dysfunction contributes to diabetes remain poorly defined.

The CFRD Scientific Workshop, sponsored by the CF Foundation and NIDDK, is an online webinar to be held June 23–25, 2021. Multiple aspects of CFRD will be discussed, such as the mechanisms of disease, including the sites of CFTR function and the interaction between the exocrine and endocrine pancreas. In addition, prevention and treatment of CFRD and the effect of CFTR modulator therapy on glucose and insulin will be discussed.

The workshop goals are to share basic and clinical research data that highlight our understanding of CFRD disease mechanisms and treatment and to identify key research questions and knowledge gaps that will inform research priorities and potentially help NIDDK and/or the CF Foundation frame future funding opportunities.

Registration Deadline

June 25, 2021

Agenda

June 23, 2021

10:00 a.m. – 10:10 a.m.

Welcome
Tom Eggerman
J. P. Clancy
Katherine Tuggle

MECHANISMS OF DISEASE

Moderators: Andi Kelly, Michael Rickels

10:10 a.m. – 10:30 a.m.

Incretins, Exocrine Pancreas
David D’Alessio

10:30 a.m. – 10:50 a.m.

Enteroinsular Axis in Cystic Fibrosis (CF)
Michael Rickels

10:50 a.m. – 11:10 a.m.

Exocrine Pancreas Disease and Diabetes
Aliye Uc

11:10 a.m. – 11:30 a.m.

Islet Vascularization and Inflammation in CF
Rebecca Hull-Meichle

11:30 a.m. – 11:45 a.m.

Break

11:45 a.m. – 12:05 p.m.

Innervation of the CF Pancreas
Andy Norris

12:05 p.m. – 12:25 p.m.

Cystic Fibrosis–Related Diabetes (CFRD) Genetics
Scott Blackman

12:25 p.m. – 12:45 p.m.

Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), Islets, and Insulin Secretion
Al Powers

12:45 p.m. – 1:05 p.m.

Role of Insulin Resistance (CF Post-CFTR Modulators)
Remi Rabasa-Lhoret

1:05 p.m. – 1:35 p.m.

General Discussion with Summary Knowledge Gaps

1:35 p.m. – 2:15 p.m.

CFRD from a Parent’s/Patient’s Perspective
Meagan Helmick and Sharon Cray

June 24, 2021

PREVENTION AND TREATMENT, PART 1

Moderator: Melissa Putman and George Gittes

10:00 a.m. – 10:20 a.m.

Glycemic Abnormalities in Young Children
Katie Larson Ode

10:20 a.m. – 10:40 a.m.

Pancreatic Progenitors and Disease Remodeling
Lori Sussel

10:40 a.m. – 11:00 a.m.

Developmental Aspects of CFRD: How Early Are CFTR Modulators Needed?
John Engelhardt

11:00 a.m. – 11:20 a.m.

CFTR Modulators and the Exocrine Pancreas and Bile Acids
Virginia Stallings

11:20 a.m. – 11:35 a.m.

Break

11:35 a.m. – 11:55 a.m.

CFTR Modulators: Impact upon Glucose and Insulin Secretion
Andi Kelly

11:55 a.m. – 12:15 p.m.

Nutritional Impact upon Glycemia and Insulin Secretion
Jessica Alvarez

12:15 p.m. – 12:35 p.m.

Anabolic Effects of Insulin, Needed before Diabetes?
Antoinette Moran

12:35 p.m. – 12:55 p.m.

Defining Glycemic Targets in CFRD Management
Christine Chan

12:55 p.m. – 1:15 p.m.

Artificial Pancreas Technology for CFRD
Melissa Putman

1:15 p.m. – 2:00 p.m.

General Discussion with Summary of Knowledge Gaps

June 25, 2021

PREVENTION AND TREATMENT, PART 2

Moderator: Tanicia Daley Andy Norris

9:00 a.m. – 9:20 a.m.

Preventing CFRD: The Role of Redox Imbalance
Arlene Stecenko

9:20 a.m. – 9:40 a.m.

Microvascular Complications in Type 1 Diabetes: How Do These Apply to CF?
Dana Dabelea

9:40 a.m. – 10:00 a.m.

Clinical Future of CFRD: 10-Year View
Andi Kelly
Andy Norris
Melissa Putman

WRAP UP

10:00 a.m. – 10:50 a.m.

Panel Discussion of Knowledge Gaps

10:50 a.m. – 11:00 a.m.

Closing Remarks

11:00 a.m.

Adjournment