Event Details
Agenda
Event Details
Background
Pain is the most common symptom in patients with benign or malignant diseases of the pancreas, and frequently the most challenging for physicians to treat. Severe pain is often refractory to treatment and chronic pain is frequently disabling for adults and children with pancreatitis. Although a common manifestation of pancreatic disease, pain is an unreliable indicator of the extent of pancreatic damage and is difficult to fully understand or assess.
Purpose
The purpose of this workshop is to explore recent developments in understanding the origin and mechanisms of pain in pancreatic disease, the relationship of visceral neural pathways and central pain centers, the role of behavioral factors and disorders on the perception of pain, and differences in pain perception and processes in children compared to adults. In addition the role of genetic risk factors for pain, and the mechanisms and role of placebos in pain treatment will be discussed. Methods of pain assessment including quantitative sensory testing will be examined, as well the process of central sensitization of pain. Finally, newer approaches to pain management including cognitive behavioral therapy, nerve stimulation, experimental (non-opioid) drugs, and cannabinoid compounds will be covered.
Registration Deadline
July 20, 2021
Agenda
July 21, 2021
- 10:00 a.m. – 10:10 a.m.
- Welcome
Aliye Uc, M.D. and Dhiraj Yadav, M.D., M.P.H.
- 10:10 a.m. – 10:30 a.m.
- Overview Lecture: The Clinical Problem of Pancreatic Pain
Vikesh Singh, M.D., M.Sc., Johns Hopkins University
Session One: The Pathophysiology of Pain
Moderators: Aliye Uc, M.D. and Dhiraj Yadav, M.D., M.P.H.
- 10:30 a.m. – 10:55 a.m.
- Peripheral Processes in the Pathophysiology of Pancreatic Pain
Jay Pasricha, M.D., Johns Hopkins University
- 10:55 a.m. – 11:20 a.m.
- Central Pain Processes: CNS Pathways and Mediators
Vania Apkarian, Ph.D., Northwestern University, Feinberg School of Medicine
- 11:20 a.m. – 11:30 a.m.
- Discussion and Q&A
- 11:30 a.m. – 11:40 a.m.
- Break
Session Two: Biomarkers, Mediators, and Pharmacology of Pain
Moderators: Jami Saloman, Ph.D. and Melena Bellin, M.D.
- 11:40 a.m. – 12:00 p.m.
- Genetic Biomarkers of Pancreatic Pain
Ellyn Dunbar, M.S., University of Pittsburgh
- 12:00 p.m. – 12:20 p.m.
- Chronic Pain in Children
Sarah Jane Schwarzenberg, M.D., University of Minnesota
- 12:20 p.m. – 12:40 p.m. a.m.
- Depression and Anxiety as Mediators of Pain
Glenn Treisman, M.D., Ph.D., Johns Hopkins University School of Medicine
- 12:40 p.m. – 1:00 p.m.
- Placebo Effects in the Response to Pain Treatment
Luana Colloca, M.D., Ph.D., M.S., University of Maryland School of Medicine and School of Nursing
- 1:00 p.m. -1:10 p.m.
- Discussion and Q&A
- 1:10 p.m. – 1:45 p.m.
- Lunch
- 1:45 p.m. – 2:05 p.m.
- The NIH HEAL Initiative
Gwendolyn Sowa, M.D., Ph.D. University of Pittsburgh School of Medicine
Session Three: Pain Assessment
Moderators: Asbjørn Drewes, Ph.D., D.Sc. and Christopher Forsmark, M.D.
- 2:05 p.m. – 2:25 p.m.
- Systems and Tools of Pancreatic Pain Assessment
John Windsor, M.D., The University of Auckland
- 2:25 p.m. – 2:45 p.m.
- Central Sensitization and Hypersensitization to Pain Due to Chronic Opioid Use
George Koob, Ph.D., National Institute on Alcohol Abuse and Alcoholism
- 2:45 p.m. – 3:05 p.m.
- Quantitative Sensory Testing
Anna Evans Phillips, M.D., University of Pittsburgh School of Medicine
- 3:05 p.m. – 3:15 p.m.
- Discussion and Q&A
- 3:15 p.m. – 3:30 p.m.
- Break
Session Four: Pain Treatment—Challenges and Opportunities
Moderators: Marc Goodman, Ph.D., M.P.H. and Stephen Pandol, M.D.
- 3:30 p.m. – 3:50 p.m.
- Neurolysis and Nerve Stimulation as Treatments of Pain
Leo Kapural, M.D., Ph.D. Carolinas Pain Institute
- 3:50 p.m. – 4:10 p.m.
- Ketamine and Other Experimental Drugs as Treatment of Pain
Thomas Strouse, M.D. University of California, Los Angeles
- 4:10 p.m. – 4:30 p.m.
- Cognitive Behavioral Therapy of Pancreatic Pain in Children and Adults
Tonya Palermo, Ph.D., University of Washington and Seattle Children’s Research Institute
- 4:30 p.m. – 4:50 p.m.
- Endocannabinoid Signaling and Cannabinoid Treatment of Pain
Daniele Piomelli, Ph.D., University of California, Irvine
- 4:50 p.m. – 5:00 p.m.
- Discussion and Q&A
- 5:00 p.m. – 5:30 p.m.
- Panel Discussion: Setting the Research Priorities
Patients, Speakers TBD
- 5:30 p.m.
- Adjournment