Pancreatic Pain: Knowledge Gaps and Research Opportunities in Children and Adults

July 21, 2021 Contacts

Registration Closed

Registration ended July 20, 2021

Event Details Agenda

Background

Pain is the most common symptom in patients with benign or malignant diseases of the pancreas, and frequently the most challenging for physicians to treat. Severe pain is often refractory to treatment and chronic pain is frequently disabling for adults and children with pancreatitis. Although a common manifestation of pancreatic disease, pain is an unreliable indicator of the extent of pancreatic damage and is difficult to fully understand or assess.

Purpose

The purpose of this workshop is to explore recent developments in understanding the origin and mechanisms of pain in pancreatic disease, the relationship of visceral neural pathways and central pain centers, the role of behavioral factors and disorders on the perception of pain, and differences in pain perception and processes in children compared to adults. In addition the role of genetic risk factors for pain, and the mechanisms and role of placebos in pain treatment will be discussed. Methods of pain assessment including quantitative sensory testing will be examined, as well the process of central sensitization of pain. Finally, newer approaches to pain management including cognitive behavioral therapy, nerve stimulation, experimental (non-opioid) drugs, and cannabinoid compounds will be covered.

Registration Deadline

July 20, 2021

July 21, 2021

10:00 a.m. – 10:10 a.m.: Welcome
Aliye Uc, M.D. and Dhiraj Yadav, M.D., M.P.H.
10:10 a.m. – 10:30 a.m.: Overview Lecture: The Clinical Problem of Pancreatic Pain
Vikesh Singh, M.D., M.Sc., Johns Hopkins University

Session One: The Pathophysiology of Pain

Moderators: Aliye Uc, M.D. and Dhiraj Yadav, M.D., M.P.H.

10:30 a.m. – 10:55 a.m.: Peripheral Processes in the Pathophysiology of Pancreatic Pain
Jay Pasricha, M.D., Johns Hopkins University
10:55 a.m. – 11:20 a.m.: Central Pain Processes: CNS Pathways and Mediators
Vania Apkarian, Ph.D., Northwestern University, Feinberg School of Medicine
11:20 a.m. – 11:30 a.m.: Discussion and Q&A
11:30 a.m. – 11:40 a.m.: Break

Session Two: Biomarkers, Mediators, and Pharmacology of Pain

Moderators: Jami Saloman, Ph.D. and Melena Bellin, M.D.

11:40 a.m. – 12:00 p.m.: Genetic Biomarkers of Pancreatic Pain
Ellyn Dunbar, M.S., University of Pittsburgh
12:00 p.m. – 12:20 p.m.: Chronic Pain in Children
Sarah Jane Schwarzenberg, M.D., University of Minnesota
12:20 p.m. – 12:40 p.m. a.m.: Depression and Anxiety as Mediators of Pain
Glenn Treisman, M.D., Ph.D., Johns Hopkins University School of Medicine
12:40 p.m. – 1:00 p.m.: Placebo Effects in the Response to Pain Treatment
Luana Colloca, M.D., Ph.D., M.S., University of Maryland School of Medicine and School of Nursing
1:00 p.m. -1:10 p.m.: Discussion and Q&A
1:10 p.m. – 1:45 p.m.: Lunch
1:45 p.m. – 2:05 p.m.: The NIH HEAL Initiative
Gwendolyn Sowa, M.D., Ph.D. University of Pittsburgh School of Medicine

Session Three: Pain Assessment

Moderators: Asbjørn Drewes, Ph.D., D.Sc. and Christopher Forsmark, M.D.

2:05 p.m. – 2:25 p.m.: Systems and Tools of Pancreatic Pain Assessment
John Windsor, M.D., The University of Auckland
2:25 p.m. – 2:45 p.m.: Central Sensitization and Hypersensitization to Pain Due to Chronic Opioid Use
George Koob, Ph.D., National Institute on Alcohol Abuse and Alcoholism
2:45 p.m. – 3:05 p.m.: Quantitative Sensory Testing
Anna Evans Phillips, M.D., University of Pittsburgh School of Medicine
3:05 p.m. – 3:15 p.m.: Discussion and Q&A
3:15 p.m. – 3:30 p.m.: Break

Session Four: Pain Treatment—Challenges and Opportunities

Moderators: Marc Goodman, Ph.D., M.P.H. and Stephen Pandol, M.D.

3:30 p.m. – 3:50 p.m.: Neurolysis and Nerve Stimulation as Treatments of Pain
Leo Kapural, M.D., Ph.D. Carolinas Pain Institute
3:50 p.m. – 4:10 p.m.: Ketamine and Other Experimental Drugs as Treatment of Pain
Thomas Strouse, M.D. University of California, Los Angeles
4:10 p.m. – 4:30 p.m.: Cognitive Behavioral Therapy of Pancreatic Pain in Children and Adults
Tonya Palermo, Ph.D., University of Washington and Seattle Children’s Research Institute
4:30 p.m. – 4:50 p.m.: Endocannabinoid Signaling and Cannabinoid Treatment of Pain
Daniele Piomelli, Ph.D., University of California, Irvine
4:50 p.m. – 5:00 p.m.: Discussion and Q&A
5:00 p.m. – 5:30 p.m.: Panel Discussion: Setting the Research Priorities
Patients, Speakers TBD
5:30 p.m.: Adjournment

Registration Closed

Registration ended July 20, 2021

Location

Webinar

Webinar link will be sent via email prior to the event.

Contacts

Program Contact
Dana Andersen
NIDDK

Meeting Logistics
Danielle Johnikin
The Scientific Consulting Group, Inc.

Pancreatic Pain: Knowledge Gaps and Research Opportunities in Children and Adults

Registration

Event Details