Interventions for Pancreatitis: New Approaches, Knowledge Gaps, and Research Opportunities

Event Details

Purpose

This one-day workshop aims to inform investigators of new developments in the field and identify the knowledge gaps and research opportunities that might inform possible future funding initiatives for NIDDK.

Background

Recent NIDDK Workshops have focused on the requirements for designing and conducting clinical trials in pancreatitis.

The breadth and variety of currently planned or underway interventions include behavioral interventions, nutritional studies, studies with pharmacologic and biologic agents, and mechanical studies with endoscopy and surgery.

Organizing Committee

* Workshop Co-chairs

Registration Deadline

June 30, 2023

Agenda

July 26, 2023

7:30 a.m. – 8:00 a.m.

Registration

8:00 a.m. – 8:10 a.m.

Welcome, Housekeeping, and Introductions
Steven Hughes, M.D., University of Florida
Anna Evans Phillips, M.D., M.S., University of Pittsburgh

Keynote Presentations

8:10 a.m. – 8:35 a.m.

Current Interventions for Pancreatitis and Important Gaps in Knowledge
Chris Forsmark, M.D., University of Florida

8:35 a.m. – 8:55 a.m.

Patient Observations and Priorities in Chronic Pancreatitis
Adriana Cowdin, National Pancreas Foundation

Session 1: Behavioral Interventions in Pancreatitis
Moderators: Christie Jeon, D.Sc., M.S., Cedars-Sinai Medical Center/University of California, Los Angeles and Tonya Palermo, Ph.D., Seattle Children’s Hospital/University of Washington

8:55 a.m. – 9:15 a.m.

Whole-person Approach to Chronic Pancreatitis Intervention: Connections across Biological, Behavioral, Social, and Environmental Domains
Tonya Palermo, Ph.D., Seattle Children’s Hospital/University of Washington

9:15 a.m. – 9:35 a.m.

Treatment Strategies for Alcohol Use Disorder Patients with Pancreatitis
Nancy Diazgranados, M.D., M.S., National Institute on Alcohol Abuse and Alcoholism

9:35 a.m. – 9:55 a.m.

Comprehensive Pain Assessment Tool for Chronic Pancreatitis (COMPAT): Development, Validation, and Applications
Dhiraj Yadav, M.D., M.P.H., University of Pittsburgh

9:55 a.m. – 10:00 a.m.

Discussion

10:00 a.m. – 10:20 a.m.

Break

Session 2: Nutritional Interventions in Pancreatitis
Moderators: Phil Hart, M.D., The Ohio State University and Stephen Pandol, M.D., Cedars-Sinai Medical Center/University of California, Los Angeles

10:20 a.m. – 10:45 a.m.

Research Priorities in Nutrition Studies in Chronic Pancreatitis: Rationale and Approach to Study Design
Sinead Duggan, Ph.D., RD, Trinity College Dublin

10:45 a.m. – 11:05 a.m.

Dietary Patterns in Recurrent Acute and Chronic Pancreatitis: Understanding Beneficial Nutritional Components and Constituents of Food to Pursue Appropriate Nutrition-based Interventions
Kristen Roberts, Ph.D., M.S., RD, The Ohio State University

11:05 a.m. – 11:25 a.m.

Nutrition in Pancreatitis: Knowledge Gaps, New Approaches, and Research Opportunity
Martin Rosenthal, M.D., University of Florida

11:25 a.m. – 11:45 a.m.

The Use of Pancreatic Enzyme Supplementation in Recurrent Acute and Chronic Pancreatitis: Knowns and Unknowns, Benefits and Shortfalls
Jay Freeman, M.D., M.Sc., Nationwide Children’s Hospital/The Ohio State University

11:45 a.m. – 12:00 p.m.

Discussion

12:00 p.m. – 1:00 p.m.

Lunch

Session 3: Pharmacological and Biological Approaches for Pancreatitis: Promising, New, or Novel Treatments
Moderators: Vikesh Singh, M.D., M.Sc., Johns Hopkins University and David Whitcomb, M.D., Ph.D., University of Pittsburgh

1:00 p.m. – 1:20 p.m.

Repurposing FDA-approved Anti-fibrosis Agents: Evolution of Pirfenidone From Rodents to Man
Vikas Dudeja, M.D., The University of Alabama at Birmingham

1:20 p.m. – 1:40 p.m.

TLY012 – A Potent Anti-Fibrotic with the Potential to Reduce Pain and Limit Fibrosis in Chronic Pancreatitis
Adam Bell, Ph.D., Theraly Fibrosis

1:40 p.m. – 2:00 p.m.

Lacosamide for the Treatment of Painful Chronic Pancreatitis
Evan Fogel, M.D., M.Sc., Indiana University

2:00 p.m. – 2:20 p.m.

Human Autologous Stem Cells as Potential Therapy in Necrotizing Pancreatitis
Nicholas Zyromski, M.D., Indiana University

2:20 p.m. – 2:30 p.m.

Discussion

2:30 p.m. – 2:50 p.m.

Break

Session 4: Bioengineering, Surgical, and Endoscopic Approaches for Pancreatitis
Moderators: Randall Brand, M.D., University of Pittsburgh and Steven Hughes, M.D., University of Florida

2:50 p.m. – 3:10 p.m

Advances in in Pancreatic Endotherapy
Gregory Coté, M.D., M.S., Oregon Health & Science University

3:10 p.m. – 3:30 p.m.

Chemical Pancreatectomy: A Potential Non-Operative Treatment for Chronic Pancreatitis
George Gittes, M.D., University of Pittsburgh

3:30 p.m. – 3:50 p.m.

Excavation versus Resection for Chronic Pancreatitis
William Nealon, M.D., Northwell Health/Hofstra University

3:50 p.m. – 4:10 p.m.

Timing and Design of Surgical Intervention Trials for Pancreatitis
John Neoptolemos, M.D., Ph.D., University of Heidelberg

4:10 p.m. – 4:30 p.m.

Closing Discussion and Recommendations

4:30 p.m.

Adjournment