Neural Plasticity in Energy Homeostasis and Obesity

April 13 - 14, 2023 Contacts

Event Details Agenda

Background

Obesity and associated metabolic syndromes are major public health concerns. It is increasingly clear that dynamic neural circuits and pathways play critical roles in appetite regulation and energy metabolism. More effective strategies to prevent and treat these conditions require a greater understanding of how obesogenic environmental and physiological conditions alter the neural networks that control appetite, eating, and energy homeostasis.

Purpose

The purpose of this workshop is to bring together experts in the neural plasticity of central and peripheral circuits that control food intake, energy homeostasis, and metabolism in healthy and unhealthy states, such as obesity, to review the science, identify knowledge gaps regarding the functional plasticity within these circuits, and identify high priority areas of research that may lead to therapeutic advances for obesity and other disorders related to metabolic dysregulation and food intake.

Registration Deadline

April 2, 2023

Day 1: April 13, 2023

9:30 a.m. – 9:40 a.m.: Welcome
Bradley Cooke, Ph.D., Program Director, Division of Diabetes, Endocrinology and Metabolic Diseases (DEM), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Will Cefalu, M.D., Director, DEM, NIDDK

Workshop Chairs: Carrie Ferrario, Ph.D., University of Michigan; Heike Muenzberg-Gruening, Ph.D., Pennington Biomedical Research Center; and Linda Rinaman, Ph.D., Florida State University
9:40 a.m. – 10:20 a.m.: Neural Systems that Control Food Intake and Energy Balance
Alan Watts, Ph.D., University of Southern California
10:40 a.m. – 10:55 a.m.: Neural Plasticity and Reversibility in the Gustatory System
David Hill, Ph.D., University of Virginia
11:00 a.m. – 11:15 a.m.: Dietary Modulation of Taste Plasticity: Causes & Consequences
Monica Dus, Ph.D., University of Michigan
11:20 a.m. – 11:35 a.m.: Olfactory Function Drives Energy Homeostasis
Debra Fadool, Ph.D., Florida State University
11:40 a.m. – 11:55 a.m.: Taste Signaling and Obesity
Kathryn Medler, Ph.D., University at Buffalo
12:00 p.m. – 12:20 p.m.: Moderated Discussion
All speakers
1:05 p.m. – 1:20 p.m.: Plasticity in Peripheral and Central Circuits Mediating Food Cues
Nicholas Betley, Ph.D., University of Pennsylvania
1:25 p.m. – 1:40 p.m.: Diet-Induced Inflammation and Microbiota-Driven Neural Plasticity
Claire de La Serre, Ph.D., University of Georgia
1:45 p.m. – 2:00 p.m.: Vagal and Spinal Gastrointestinal Circuit Plasticity
Ivan De Araujo, Ph.D., Icahn School of Medicine at Mount Sinai
2:05 p.m. – 2:20 p.m.: Neuropod Enteroendocrine Cell Plasticity and Vagal Transmission
Diego Bohorquez, Ph.D., Duke University
2:25 p.m. – 2:45 p.m.: Moderated Discussion
All speakers
3:05 p.m. – 3:20 p.m.: Central and Peripheral GLP1 Signaling
Darleen Sandoval, Ph.D., University of Colorado
3:25 p.m. – 3:40 p.m.: Developmental Modulation of Brainstem Neurocircuits
Kirsteen Browning, Ph.D., Penn State University
3:45 p.m. – 4:00 p.m.: Pancreatic Innervation and Glucose Homeostasis
Sarah Stanley, Ph.D., Cornell University
4:05 p.m. – 4:20 p.m.: Plasticity and Neuropathy in Adipose Innervation
Kristy L. Townsend, Ph.D., The Ohio State University
4:20 p.m. – 4:40 p.m.: Moderated Discussion
All speakers
4:40 p.m.: Wrap-up for Day 1
Diana Cummings, Ph.D., Program Director, Division of Digestive Diseases and Nutrition (DDN), NIDDK

Day 2: April 14, 2023

9:30 a.m. – 9:36 a.m.: Welcome
Padma Maruvada, Ph.D., Program Director, DDN, NIDDK
Stephen James, M.D., Director, DDN, NIDDK
9:40 a.m. – 9:55 a.m.: Integration of Systems Regulating Feeding & Metabolism
Greg Morton, Ph.D., University of Washington
10:00 a.m. – 10:15 a.m.: Role of Hypothalamus in Energy Sensing
Brad Lowell, M.D., Ph.D., Harvard University
10:20 a.m. – 10:35 a.m.: Hypothalamic Plasticity and Obesity
Richard Simerly, Ph.D., Vanderbilt University
10:40 a.m. – 10:55 a.m.: Hypothalamus and Metabolic Adaptation to Exercise
Kevin Williams, Ph.D., The University of Texas Southwestern Medical Center
11:00 a.m. – 11:20 a.m.: Moderated Discussion
All speakers
11:40 a.m. – 11:55 a.m.: Diet-Induced Plasticity in Mesolimbic and Ventral Striatal Pathways
Carrie Ferrario, Ph.D., University of Michigan
12:00 p.m. – 12:15 p.m.: Diet-Induced Plasticity in Frontal Cortex
Stephanie Borgland, Ph.D., University of Calgary
12:20 p.m. – 12:35 p.m.: Hippocampal Pathways: Metabolic State–Dependent Learning
Scott Kanoski, Ph.D., University of Southern California
12:40 p.m. – 12:55 p.m.: Moderated Discussion
All speakers
1:45 p.m. – 2:00 p.m.: Neuro-Glial Interplay in Synaptic Plasticity of Brain Circuits During Metabolic Adaptations
Tamas Horvath, D.V.M., Ph.D., Yale University
2:05 p.m. – 2:20 p.m.: Role of Brain-Derived Neurotrophic Factor in Energy Homeostasis
Maribel Rios, Ph.D., Tufts University
2:25 p.m. – 2:40 p.m.: Glial and Cerebrovascular Cell Contributions to Metabolic Stress
Alexis Stranahan, Ph.D., Augusta University
2:45 p.m. – 3:05 p.m.: Moderated Discussion
All speakers
3:25 p.m. – 4:00 p.m.: Three breakout sessions focusing on CNS, Brain-gut axis, and Visceral organs and enteric nervous system. Attendees may choose which session to attend. The goal will be to develop an answer to the question, “Assuming obesity is a chronic disorder, what is the role of neural plasticity in obesity?
4:00 p.m. – 4:30 p.m.: Break-out summaries, 10 minutes each
4:35 p.m.: Closing Remarks: Chairs; Adjourn: Brad Cooke, Ph.D., DEM, NIDDK

Location

Webinar

Registered participants will receive the link to join the webinar prior to the meeting via email.

Contacts

Program Contact
Cooke, Brad
NIDDK
T: 301-480-9896

Cummings, Diana
NIDDK
T: 301-435-5991

Marudava, Padma
NIDDK
T: 301-594-8884

Meeting Logistics
Rachel Pisarski
The Scientific Consulting Group, Inc.
T: 301-670-4990

Neural Plasticity in Energy Homeostasis and Obesity

Registration

Event Details