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Gut Microbiota and Kidney Disease

May 28 - 29, 2024 Contacts

Registration Closed

Registration ended May 29, 2024

Event Details Agenda Abstracts

Meeting Resources

Executive Summary (PDF, 97.98 KB)

Purpose

The gut microbiome is a dynamic ecosystem that reflects body’s response to various systemic pathologies, including kidney diseases. However, its value as a determinant of kidney diseases has rarely been investigated. This workshop will address the overall impact of microbiome/microbiota on kidney diseases with specific focus on their role as markers, mediators or amplifiers of kidney function or dysfunction. In addition, the workshop will explore biological/mechanistic interplay between the kidney (in disease) and the gut microbiome. The workshop will also discuss a roadmap for future studies, which will help define novel associations between gut microbiota and kidney diseases, identify mechanisms linking gut microbiota and kidney diseases, and assessing the clinical value of gut microbiota in diagnosing and treating kidney diseases.

Meeting Objectives

Through this collaborative workshop, we intend to advance the understanding of the gut microbiota and kidney disease nexus that could lead to answering the central question of whether changes in the gut microbiota and/or microbiome can be an early measure of kidney dysfunction.
The workshop will bring together relevant disciplines to address the state of the science, identify gaps in knowledge relevant to establishing the diagnostic role of gut microbiota in kidney diseases, and encourage collaborative efforts in the field.
The workshop will also discuss best approaches to study microbiota in kidney diseases, the spectrum of kidney diseases to be studied.

Abstract Submission Deadline

April 15, 2024

Registration Deadline

May 29, 2024

May 28, 2024

10:00 a.m. – 10:25 a.m.: Opening Remarks
Robert Star, M.D., Director, Division of Kidney, Urologic, & Hematologic Diseases (KUH), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Deepak Nihalani, Ph.D., Program Director, KUH, NIDDK; Patient Talks
10:25 a.m. – 12:20 p.m.
Session 1: Microbial Dysbiosis—A Cause or Consequence of Kidney Disease
10:25 a.m. – 10:35 a.m.: The Gut Microbiome in Chronic Kidney Disease: Cause, Consequence, or Both
Annabel Biruete, Ph.D., R.D., FNKF, FASN, Assistant Professor, Department of Nutrition Science, Purdue University
10:35 a.m. – 10:45 a.m.: Dietary Metabolism, the Gut Microbiome, and Cardio-Renal Diseases
W. H. Wilson Tang, M.D., Department of Cardiovascular & Metabolic Sciences and the Genomic Medicine Institute, Cleveland Clinic Lerner Research Institute
10:45 a.m. – 10:55 a.m.: Challenges and Prospects for Microbiome-based Interventions
Alan W. Walker, P.H.D., School of Medicine, Medical Sciences and Nutrition, University of Aberdeen
10:55 a.m. – 11:00 a.m.: Lightning Talks (selected from submitted abstracts)
Jose Agudelo, M.D.
Mangesh Suryavanshi, Ph.D
11:00 a.m. – 11:15 a.m.: Audience Questions
11:15 a.m. – 11:20 a.m.: Break
11:20 a.m. – 11:30 a.m.: High-throughput Discovery of Microbial Biochemical Mechanisms
Curtis Huttenhower, Ph.D., Professor of Biostatistics and Computational Biology, Harvard T.H. Chan School of Public Health
11:30 a.m. – 11:40 a.m.: The Intestinal Microbiota and the CKD - CVD Relationship
Nicola Wilck, M.D., Medical Department, Division of Nephrology and Internal Intensive Care Medicine, Charité – Universitätsmedizin Berlin
11:40 a.m. – 11:50 a.m.: Metabolite-based Host-Microbe Interactions in the Intestinal Tract
Sebastian Winter, Ph.D., Associate Professor, Center for Immunology and Infectious Disease, School of Medicine, University of California, Davis
11:50 a.m. – 12:00 p.m.: Metabolic and Migratory Links between the Gut Microbiota and Kidney Disease
Aaron Miller, Ph.D., Head, Urology Translational Research Laboratory and Faculty, Microbiome Center for Human Health, Cleveland Clinic, Lerner Research Institute
12:00 p.m. – 12:20 p.m.: Audience Questions
12:20 p.m. – 12:45 p.m.: Lunch
12:45 p.m. – 1:55 p.m.
Session 2: Gut Microbiome-Drug Interactions—A Two-way Street
12:45 p.m. – 12:55 p.m.: Targeted Inhibition of the Gut Microbial TMAO Pathway for the Treatment of Chronic Kidney Disease
Stan Hazen, MD., PhD., Department Chair, The Jan Bleeksma Chair in Vascular Cell Biology and Atherosclerosis, Director, Center for Cardiovascular Diagnostics & Prevention, Director, Center for Microbiome & Human Health, Cleveland Clinic, Lerner Research Institute.
12:55 p.m. – 1:05 p.m.: Metabolic Organ Communication by SGLT2 Inhibition
Markus M. Rinschen, M.D., Associate Professor, Department of Biomedicine, Aarhus University
1:05 p.m. – 1:15 p.m.: Small Molecules from the Human Microbiota
Michael Fischbach, Ph.D., Professor of Bioengineering, Stanford University
1:15 p.m. – 1:25 p.m.: Towards a Pharma[e]cological View of Precision Medicine
Peter Turnbaugh, Ph.D., Professor, Department of Microbiology and Immunology, University of California, San Fransico
1:25 p.m. – 1:35 p.m.: Gut Microbial Enzymes in Kidney Disease and Transplantation
Matthew Redinbo, Ph.D., Professor of Biochemistry and Biophysics, Professor of Microbiology and Immunology, Director of Structural Biology, The University of North Carolina at Chapel Hill
1:35 p.m. – 1:40 p.m.: Lightning Talks (selected from submitted abstracts)
1:40 p.m. – 1:55 p.m.: Audience Questions
1:55 p.m. – 2:00 p.m.: Break
2:00 p.m. – 3:30 p.m.: Breakout Sessions
There will be two separate breakout groups discussing questions related to the relevant sessions. Each audience member will be preassigned to a breakout group.
3:30 p.m. – 4:00 p.m.: Summary of Breakout Group Findings
The group findings will be presented to the full audience by each moderator.
4:00 p.m.: Day 1 Adjournment

May 29, 2024

10:00 a.m. – 11:00 a.m.
Session 3: Prognostic Value of Gut Microbiota and Metabolites in Kidney Disease
10:00 a.m. – 10:10 a.m.: The Importance of Gut Microbiota and Metabolites in Predicting the Circulating Metabolome and Chronic Kidney Disease Progression
Amanda Hyre Anderson, Ph.D., M.P.H., FASN, Professor of Epidemiology, School of Public Health, The University of Alabama at Birmingham
10:10 a.m. – 10:20 a.m.: Identification of a Commensal as a Potential Biomarker/therapy for Kidney Disease
Bina Joe, Ph.D., FAHA, FAPS, ISHF, Distinguished University Professor and Chair, Physiology and Pharmacology, Frederick-Hiss Endowed Professor, The University of Toledo College of Medicine.
10:20 a.m. – 10:30 a.m.: Progression of diagnostics in the Microbiome Field: From Ecology to Machine Learning to AI
Rob Knight, Ph.D., Professor of Pediatrics, Bioengineering, and Computer Science & Engineering, University of California, San Diego
10:30 a.m. – 10:40 a.m.: Therapeutic Bubble Tea for the Removal of Uremic Toxins Precursors from the Gut
Mari Winkler, Ph.D., John R. Kiely Endowed Professor, Civil & Environmental Engineering, University of Washington
10:40 a.m. – 10:45 a.m.: Lightning Talks (selected from submitted abstracts)
10:45 a.m. – 11:00 a.m.: Audience Questions
11:00 a.m. – 11:10 a.m.: Break
11:10 a.m. – 2:00 p.m.
Session 4: Gut Microbiota—A Novel Gateway to Kidney Disease Therapeutics
11:10 a.m. – 11:20 a.m.: Gut Microbiome and GFR
Jen Pluznick, Ph.D., Associate Professor of Physiology, The Johns Hopkins University School of Medicine
11:20 a.m. – 11:30 a.m.: Gut Microbiome and Acute Kidney Injury
Hamid Rabb, M.D., Medical Director, Johns Hopkins Kidney Transplant Program, Professor of Medicine, John Hopkins School of Medicine
11:30 a.m. – 11:40 a.m.: Gut Microbiome and Kidney Stones
Kristina Penniston, Ph.D., Senior Scientist and Clinical Nutritionist, Department of Urology, University of Wisconsin School of Medicine and Public Health
11:40 a.m. – 11:50 a.m.: The Ecology of the Human Small Intestinal Microbiota
KC Huang, Ph.D., Professor of Bioengineering and of Microbiology & Immunology, James H. Clark Center, Stanford University
11:50 a.m. – 12:00 p.m.: Reducing Multidrug-resistant Organism Colonization and Infection in Renal Transplant Recipients with Microbiota Transplantation
Michael Woodworth, M.D., Assistant Professor, Department of Medicine, Emory University School of Medicine
12:00 p.m. – 12:05 p.m.: Lightning Talks (selected from submitted abstracts)
Jiaojiao Xu, Ph.D.
12:05 p.m. – 12:20 p.m.: Audience Questions and Panel Discussion
12:20 p.m. – 12:50 p.m.: Lunch Break
12:50 p.m. – 1:00 p.m.: Prebiotic and Microbial Co-Metabolism in CKD
Anvesha Srivastava, Ph.D., Postdoctoral fellow (Dr. Dominic Raj lab). The George Washington University School of Medicine
1:00 p.m. – 1:10 p.m.: Targeting a Microbial Pathway for Management of Kidney Disease
Tao Yang, Ph.D., Assistant Professor, Microbiota and Drug Metabolism in Hypertension Research Laboratory, The University of Toledo
1:10 p.m. – 1:20 p.m.: Diet Posttranslationally Modifies the Gut Microbial Proteome to Modulate Renal Function
Wendy Garrett, M.D., Ph.D., Irene Heinz Given Professor of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health; Professor of Medicine, Dana–Farber Cancer Institute and Harvard Medical School
1:20 p.m. – 1:30 p.m.: Oxalobacter Formigenes-Derived Peptides with Therapeutic Potential for Hyperoxalemia, Hyperoxaluria, and Related Kidney Stones
Hatim Hassan, M.D., Ph.D., Associate Professor of Medicine, Division of Nephrology & Hypertension, Department of Internal Medicine, Mayo Clinic
1:30 p.m. – 1:40 p.m.: A Gut Microbial Pathway to Treat Hyperuricemia in CKD
Dylan Dodd, M.D., Assistant Professor of Pathology and of Microbiology and Immunology, Stanford University
1:40 p.m. – 1:45 p.m.: Lightning Talks (selected from submitted abstracts)
Ahmed Babiker, MBBS., MSc.
1:45 p.m. – 2:00 p.m.: Audience Questions and Panel Discussion
2:00 p.m. – 2:05 p.m.: Break
2:05 p.m. – 3:15 p.m.: Breakout Sessions
There will be two separate breakout groups discussing the questions related to the relevant sessions. Each audience member will be preassigned to a breakout group.
3:15 p.m. – 3:45 p.m.: Summary of Breakout Group Findings
The group findings will be presented to the full audience by each moderator.
3:45 p.m. – 3:50 p.m.: Closing Remarks
Speaker: Robert Star, M.D., Director, KUH, NIDDK
3:50 p.m.: Meeting Adjournment

Submission Deadline

April 15, 2024

A 1-page abstract (up to 250 words maximum) for the lightning talk is required, along with a cover letter containing a brief explanation of why the submitter thinks the presentation would be helpful for their career development and how their research would contribute to the meeting.

Submitting Abstracts

All abstracts must be submitted via email to Danielle Johnikin at djohnikin@scgcorp.com, of The Scientific Consulting Group, Inc. Abstract submissions should be no longer than 250 words (not including name and affiliation). Download the Abstract Template (DOCX, 24.67 KB).

Formatting Requirements

Please follow the instructions below to format abstracts. (Note: Submissions will not be edited for spelling or grammar and will be accepted “as is.”)

The abstract should be an MS Word document, typed and single-spaced using Times New Roman font. Everything but the title should be in normal, 12-point font.

The abstract’s title should be bold, 16-Point, Title Case font and should clearly represent the nature of the investigation.

On the first line after the title, list the authors’ first and last names, degree, affiliation, city, state, and country.

Separate multiple authors with a semicolon; underline the primary author’s name (one primary author per abstract).

Use one blank line between the title and body of the abstract and between paragraphs.

The abstract file name should follow this format: Last Name of primary author First Word Of Title (e.g., Zucker Effects).

Please ensure that your abstract is the correct length and has 1-inch margins.

Use of standard abbreviations is desirable (e.g., BMI), as well as standard symbols for units of measure (e.g., kg, g, mg, mL, L, and %). Place any special or unusual abbreviations in parentheses after the full word or phrase the first time it appears. Use figures to indicate numbers except to begin sentences, in which case, the number should be spelled out. Do not use subheadings (e.g., Methods, Results).

Simple tables or graphs may be included; however, they must fit within the designated abstract space of one page.

Please identify the author who will be presenting the lightning talk.

Acceptance Notification

Applicants will be notified if their abstract has been accepted for a lightning talk by 04/30/2024.

Registration Closed

Registration ended May 29, 2024

Location

Webinar

The link to join the webinar will be distributed via email prior to the date of the event.

Contacts

Program Contact
Deepak Nihalani, Ph.D.
NIDDK
T: 301-594-6417

Meeting Logistics
Danielle Johnikin, CGMP, DES
The Scientific Consulting Group, Inc.
T: 301-670-4990

Gut Microbiota and Kidney Disease

Registration

Event Details