Heterogeneity in Pancreatitis: Recognizing Heterogeneity and Its Role in the Management of Pancreatitis

Event Details

Purpose

The heterogeneity of pancreatitis confounds the ability to provide optimum care to patients.

Multiple etiologies—including congenital variations in pancreatis anatomy, multiple courses of disease, various complications, and the absence of clear treatment algorithms—all contribute to the complexity of pancreatitis.

Should the treatment of acute, recurrent acute, or chronic pancreatitis be determined by the etiology, morphology, or stage of disease?

To address these issues, NIDDK will hold a one-day workshop to unravel the contributions of etiology and stage of disease, understand the heterogeneity of pancreatitis symptoms, and create strategies to develop well-designed treatment trials.

Meeting Objectives

1. Understand the heterogeneity of pancreatitis:
   • Understand the pathophysiology of subtypes of pancreatitis.
   • Understand the heterogeneity of pain.
   • Understand how deep learning and artificial intelligence can predict outcomes and responses to treatment for subtypes of pancreatitis.
2. Understand how the pathophysiology of subtypes of pancreatitis can uncover therapeutic targets and treatment strategies:
   • Review the current drug trials and their therapeutic targets.
   • Understand the enrollment criteria and outcome measures.
   • Establish uniform protocols and a clinical trial network to facilitate treatment trials in pancreatitis.

Organizing Committee

* Workshop Co-chairs

Registration Deadline

June 27, 2024

Agenda

7:30 a.m. – 8:00 a.m.

Registration

8:00 a.m. – 8:10 a.m.

Welcome, Introductions, and Housekeeping Issues
Melena Bellin, M.D., Pediatric Endocrinologist; Professor, Department of Pediatrics, Division of Pediatric Endocrinology, and Department of Surgery, University of Minnesota

Dhiraj Yadav, M.D., M.P.H., Professor of Medicine; Associate Chief, Clinical Research and Academic Development; Co-director, EMERGE; Vice Chair for Clinical Research, Department of Medicine, University of Pittsburgh Medical Center

8:10 a.m. – 8:40 a.m.

Keynote Addresses

Hereditary Pancreatitis Total Pancreatectomy with Islet Auto-Transplantation
Amy Jensen
Patient

Recurrent Severe Acute Pancreatitis Secondary to Hypertriglyceridemia
Dianna Born, M.S.
Patient

Session I—The Role of Heterogeneity of Pancreatitis in the Management of the Disease and Its Complications

Moderators:

Melena Bellin, M.D., Pediatric Endocrinologist; Professor, Department of Pediatrics, Division of Pediatric Endocrinology, and Department of Surgery, University of Minnesota

Dhiraj Yadav, M.D., M.P.H., Professor of Medicine; Associate Chief, Clinical Research and Academic Development; Co-director, EMERGE; Vice Chair for Clinical Research, Department of Medicine, University of Pittsburg Medical Center

8:40 a.m. – 9:00 a.m.

How and When Does Etiology Drive the Treatment of Pancreatitis?
David C. Whitcomb, M.D., Ph.D., Editor-in-Chief, Clinical and Translational Gastroenterology, University of Pittsburgh Medical Center

9:00 a.m. – 9:20 a.m.

How and When Does Stage of Disease Drive the Treatment of Pancreatitis?
Vikesh Singh, M.D., M.Sc., Director of Pancreatology, Professor of Medicine, Johns Hopkins Medicine

9:20 a.m. – 9:40 a.m.

How Different Laboratory Models of Pancreatitis Inform Possible Treatment
Miklos Sahin-Toth, Ph.D., Professor, Division of General Surgery, Department of Surgery, David Geffen School of Medicine, University of California, Los Angeles

9:40 a.m. – 10:00 a.m.

How Might the Heterogeneity of Pancreatogenic Diabetes Inform Treatment?
Frederico Toledo, M.D., Director, Endocrinology Clinical Research Core, Translational Research Center, University of Pittsburgh Medical Center

10:00 a.m. – 10:20 a.m.

Break

Session II—Heterogeneity of Pain, the Principal Symptom of Pancreatitis

Moderators:

Jeff Easler, M.D., Associate Professor of Medicine, Indiana University School of Medicine

Venkata Akshintala, M.B.B.S., Program Director, Medical Pancreatology Fellowship, Professor of Medicine, Johns Hopkins Medicine

10:20 a.m. – 10:40 a.m.

Short-term Improvements in Pancreatic Pain Treatment: Lessons Learned from Negative Clinical Trials
Georgios Papachristou, M.D., Ph.D., Chief of the Division of Gastroenterology and Hepatology, Professor of Medicine, The Ohio State University

10:40 a.m. – 11:00 a.m.

Phenotyping Pain in Chronic Pancreatitis: Methods, Classification Systems, and Implications for Treatment
Anna Evans Phillips, M.D., M.S., Assistant Professor of Medicine, University of Pittsburgh Medical Center

11:00 a.m. – 11:20 a.m.

Can Functional Brain Imaging Provide Meaningful Insights into Pain from Chronic Pancreatitis?
Robert Coghill, Ph.D., Neuroscientist, Division of Behavioral Medicine and Clinical Psychology; Director, Pediatric Pain Research Center; Professor, Department of Pediatrics, University of Cincinnati, Cincinnati Children’s Hospital

11:20 a.m. – 11:40 a.m.

What Is the Neurophysiologic Basis of Virtual Reality Therapeutics?
Omer Liran, M.D., Assistant Professor, Psychiatry and Behavioral Neuroscience, Cedars-Sinai Medical Center

11:40 a.m. – 12:00 p.m.

Discussion

12:00 p.m. – 1:00 p.m.

Lunch

Session III—Treatment Trials for Pancreatitis: Current and Future Considerations

Moderators:

Evan Fogel, M.D., Stuart Sherman Professor of Gastroenterology, Indiana University School of Medicine

Jay Freeman, M.D., M.Sc., Medical Director Pancreatic Disease Program at Nationwide Children’s Hospital

1:00 p.m. – 1:20 p.m.

Should Interventional Trials of Endoscopy and/or Surgery Be Limited to Advanced-stage Disease?
Steven Hughes, M.D., Professor, Chief of Surgical Oncology, University of Florida College of Medicine

1:20 p.m. – 1:40 p.m.

Should the Immunologic Heterogeneity of Pancreatitis Inform Treatment Trials?
Walter Park, M.D., Associate Professor of Medicine, Gastroenterology and Hepatology, Stanford Medicine

1:40 p.m. – 2:00 p.m.

What Eligibility Criteria Should Be Considered for Drug Treatment Trials to Halt Progression of Pancreatitis?
Stephen Pandol, M.D., Director, Basic and Translational Pancreas Research Medicine; Program Director, Gastroenterology Fellowship Medicine, Cedars-Sinai Medical Center

2:00 p.m. – 2:20 p.m.

Outcome Measures to Consider for Treatment Trials in Pancreatitis
Tonya Palermo, Ph.D., Interim Director, Center for Child Health, Behavior, and Development, Seattle Children’s Research Institute

2:20 p.m. – 2:30 p.m.

Discussion

2:30 p.m. – 2:50 p.m.

Break

Session IV—A Pancreatitis Clinical Trials Network: Considerations and Recommendations

Moderators:

Sarah Jane Schwarzenberg, M.D., Vice Chair for Clinical Affairs, Department of Pediatrics; Professor, Division Director, Division of Pediatric Gastroenterology Hepatology and Nutrition; Co-Director, Cystic Fibrosis Center, University of Minnesota Medical School

Chris Forsmark, M.D., Chief, Professor of Medicine, Division of Gastroenterology, Hepatology & Nutrition, University of Florida

2:50 p.m. – 3:10 p.m.

Designing a Clinical Trials Network: Lessons from the Cystic Fibrosis Foundation
Jill Van Dalfsen, Seattle Children’s Research Institute

3:10 p.m. – 3:30 p.m.

What Elements Are Needed for a Clinical Trials Network in Pancreatitis?
Bechien Wu, M.D., M.P.H., Physician Director, Division of Clinician Research, Kaiser Permanente Southern California

3:30 p.m. – 3:50 p.m.

Funding Sources and Commercialization Plan for a Pancreatitis Clinical Trials Network
Linda Martin, Chairperson, Misson: Cure

3:50 p.m. – 4:00 p.m.

Questions

4:00 p.m. – 4:30 p.m.

General Discussion

4:30 p.m.

Adjournment