Gut Feelings: Interoceptive Contributions to Obesity and Disorders of Gut-Brain Interaction
The purpose of the Gut Feelings: Interoceptive Contributions to Obesity and Disorders of Gut–Brain Interaction workshop is to bring together experts in interoception, obesity, and disorders of gut–brain interaction (DGBIs) to examine the contribution of interoceptive processes to the development or exacerbation of these diseases and identify research gaps and opportunities to advance the field.
- Highlight current knowledge, gaps, and opportunities in interoception research relevant to obesity and DGBIs.
- Explore potential physiological mechanisms that lead to or exacerbate these disorders, such as stress.
- Emphasize technical challenges and opportunities for measuring and modulating gastrointestinal interoception.
- Delve into underlying mechanisms of altered interoceptive processing in obesity and DGBIs that may lead to the development of new therapeutic targets.
Interoception is the process through which the nervous system senses and interprets signals regarding the inner physiological state of the body (e.g., hunger, satiety) that are used to motivate behavior to meet physical needs for homeostasis (e.g., food intake, meal termination). The emerging progress in research on interoception, as emphasized and supported by recent NIH-sponsored workshops and initiatives, reflects the critical importance of body-brain interactions for health and disease. The current workshop focuses on the role of interoceptive processes in obesity and disorders of gut-brain interaction (DGBIs) (e.g., irritable bowel syndrome, functional dyspepsia, etc.). A mechanistic understanding of interoceptive sensations of hunger and satiety is fundamental and transformative for obesity research given the unprecedented success of nutrient-stimulated hormone pharmacotherapies that work by altering these sensations to allow for reduced caloric intake and weight loss. In addition, the contribution of gastrointestinal interoceptive dysfunction in DGBIs is an under-studied area of investigation that would benefit from additional exploration. The overall goal of this workshop is to highlight research needs and opportunities for furthering the understanding of interoceptive processes relevant to obesity and DGBIs.
External Organizing Committee
Lin Chang, M.D.
Vice-Chief, Vatche and Tamar Manoukian Division of Digestive Diseases
David Geffen School of Medicine
University of California, Los Angeles
Zachary Knight, Ph.D.
Department of Physiology
University of California, San Francisco
Investigator, Howard Hughes Medical Institute
Christoph Thaiss, Ph.D.
Department of Microbiology
Perelman School of Medicine
University of Pennsylvania
Bradley Cooke, Ph.D.
Program Director, Division of Diabetes, Endocrinology, & Metabolic Diseases (DEM)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Diana Cummings, Ph.D.
Program Director, Division of Digestive Diseases and Nutrition (DDN), NIDDK
Voula Osganian, M.D., Sc.D., M.P.H.
Program Director, DDN, NIDDK
Terez Shea-Donohue, Ph.D.
Program Director, DDN, NIDDK
April 29, 2024
Abstract Submission Deadline
March 11, 2024
Neuroscience Center Building
6001 Executive Boulevard
North Bethesda, MD 20852
This is a hybrid workshop. Virtual participation is available. For those attending via webinar, the link will be distributed via email prior to the date of the event.
The Scientific Consulting Group, Inc.