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  5. Triazole Derivatives of 4,7-disubstituted 2 naphthoic acid (PPTN) as P2Y14 Receptor Antagonists

Triazole Derivatives of 4,7-disubstituted 2 naphthoic acid (PPTN) as P2Y14 Receptor Antagonists

Disclosed are novel small molecules that serve as potent and selective antagonist ligands of the P2Y14 receptor for UDP-glucose, which is a G protein-coupled receptor (GPCR). Blocking this receptor has been shown to be useful in models of asthma, diabetes, acute kidney injury and other conditions.

Resource Details

https://www.techtransfer.nih.gov/tech/tab-3040

tao@niddk.nih.gov

Jacobson, Kenneth

E-213-2015-0

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Last Reviewed February 2024