The information provided on niddk.nih.gov is not being updated. Please refer to nih.gov.

U.S. flag

An official website of the United States government

NIH: National Institute of Diabetes and Digestive and Kidney Diseases NIH: National Institute of Diabetes and Digestive and Kidney Diseases
  1. Home
  2. About NIDDK
  3. Advisory & Coordinating Committees
  4. National Diabetes & Digestive & Kidney Diseases Advisory Council
  5. Concept Clearances
  6. Continuation of the Cardiovascular Repository for-Type 1 Diabetes (CARE-T1D) Consortium Research Teams (Open Competition)
Return to Concept Clearances

Continuation of the Cardiovascular Repository for-Type 1 Diabetes (CARE-T1D) Consortium Research Teams (Open Competition)

September 2025 Council

Lead Division/Office

DEM

Point(s) of Contact

Nishadi Rajapakse, Ph.D., M.H.S.

Executive Summary

Cardiovascular complications remain the leading cause of death among individuals with type 1 diabetes (T1D) and significantly reduce life expectancy. The underlying mechanisms driving atherosclerosis, cardiomyopathy, endothelial dysfunction, and cardiac autonomic neuropathy in type 1 diabetes (T1D) remain poorly understood.

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), in collaboration with the National Heart, Lung, and Blood Institute (NHLBI), aims to solicit applications for discovery and mechanistic research to advance the understanding of cardiovascular disease in T1D, through a continuation of the CARE-T1D consortium. The CARE-T1D biorepository was established in 2020 through RFA-DK-21-010 and has successfully collected, stored, and analyzed cardiovascular tissue (hearts, aortas, carotid arteries, and kidneys) from organ donors with T1D, type 2 diabetes (T2D), and those without diabetes. A consortium of six research teams was formed in 2024 through RFA-DK-23-021 to conduct hypothesis-driven research on the pathogenesis of cardiac disease in T1D using multi-omics and molecular approaches, leveraging the CARE-T1D resources. The primary objective of this Notice of Funding Opportunity (NOFO) is to expand and recruit investigative research teams with complementary expertise who will leverage these unique resources—both individually and collaboratively—to advance the understanding of CVD pathogenesis in T1D.