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Continuation of the Collaborative Islet Transplantation Registry (CITR)

September 2025 Council

Lead Division/Office

DEM

Point(s) of Contact

Guillermo Arreaza-Rubin, M.D.; Tom Eggerman, M.D., Ph.D.

Executive Summary

The CITR began in 2001 after the successful “Edmonton Trial” in 1999. It has pooled data from 47 programs. Through 2025, there were 1517 allograft recipients, 1363 autograft recipients and 3557 islet preparations in its databases. CITR prepares comprehensive periodic reports about every two years on allograft islet transplantation and another on autoislet transplantation after pancreatectomy. The latter had its first report in 2018 and a third is planned for 2025. Additional data are now beginning to be collected on pancreatectomy patients who do not receive islet auto- transplantation to allow a safety and efficacy comparison with islet autografts. The CITR islet transplantation data this cycle will have been presented at 5 international meetings by summer 2025. Two virtual international CITR meetings will have been held, one in 2022, another in 2025. These meetings provide a forum for islet transplantation investigators and coordinators to meet and compare approaches and provide guidance on problems occurring at their sites. Key results from islet efforts are also provided via annual reports and in peer-reviewed publications stemming from specific data analysis of registry information. Licensure of human islets occurred in 2023 and is expected to increase islet transplantation activity in the US. As allograft islet transplantation will no longer be considered an experimental therapy, it is important that CITR monitor results to ensure continued safety and efficacy.