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Continuation of the NIDDK Consortium to Investigate Gastrointestinal Disorders of Interoception in Children and Adults

September 2025 Council

Lead Division/Office

DDN

Point(s) of Contact

Katrina Loh, M.D.; Terez Shea-Donohue, Ph.D; Diana Cummings, Ph.D.

Executive Summary

A major accomplishment of the Gastroparesis Clinical Research Consortium (GpCRC) was the creation of a large database with information on patients with symptoms of either delayed or normal gastric emptying. The GpCRC had the foresight to include pediatric patients with gastroparesis forming the first comprehensive registry of children and adolescents with gastroparesis in the US. The GpCRC conducted 4 clinical trials providing clarity and insight in our understanding of gastroparesis, but the symptoms of greatest concern to patients continue to have inadequate treatments. Gastroparesis, irritable bowel syndrome, and functional dyspepsia are among the gastrointestinal (GI) motility disorders associated with shared symptoms including nausea, vomiting, and altered bowel habits. These symptoms have poor specificity, little correlation with functional changes, and overlap with other GI conditions. Recent NIDDK-sponsored workshops identified altered GI interoceptive awareness and processing as characteristic of these motility disorders. This continuation initiative will realign research priorities to concentrate on the mechanisms underlying patient symptoms and new interdisciplinary research opportunities to focus on GI disorders associated with impaired interoception in adults and children. The collaborative effort will lead to the discovery of cellular and molecular mechanisms of interoceptive signaling in the gut and accelerate progress towards more effective therapies.