Publications

A selection of recent and significant publications can be viewed below.

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Conformational constraints of cyclopentane peptide nucleic acids facilitate tunable binding to DNA.: Zheng H, Botos I, Clausse V, Nikolayevskiy H, Rastede EE, Fouz MF, Mazur SJ, Appella DH.; Nucleic Acids Res (2021 Jan 25) 49:713-725. Abstract/Full Text
Inhibition of HIV Maturation via Selective Unfolding and Cross-Linking of Gag Polyprotein by a Mercaptobenzamide Acetylator.: Miller Jenkins LM, Paine EL, Deshmukh L, Nikolayevskiy H, Lyons GC, Scerba MT, George Rosenker K, Luecke HF, Louis JM, Chertova E, Gorelick RJ, Ott DE, Clore GM, Appella DH.; J Am Chem Soc (2019 May 22) 141:8327-8338. Abstract/Full Text
Reaction Kinetics Direct a Rational Synthesis of an HIV-1 Inactivator of Nucleocapsid Protein 7 and Provide Mechanistic Insight into Cellular Metabolism and Antiviral Activity.: Nikolayevskiy H, Scerba MT, Deschamps JR, Appella DH.; Chemistry (2018 Jul 5) 24:9485-9489. Abstract/Full Text
Probing Mercaptobenzamides as HIV Inactivators via Nucleocapsid Protein 7.: Saha M, Scerba MT, Shank NI, Hartman TL, Buchholz CA, Buckheit RW Jr, Durell SR, Appella DH.; ChemMedChem (2017 May 22) 12:714-721. Abstract/Full Text
Quantification of plasma HIV RNA using chemically engineered peptide nucleic acids.: Zhao C, Hoppe T, Setty MK, Murray D, Chun TW, Hewlett I, Appella DH.; Nat Commun (2014 Oct 6) 5:5079. Abstract/Full Text

Additional Publications

Chemical Features Important for Activity in a Class of Inhibitors Targeting the Wip1 Flap Subdomain.: Tagad HD, Debnath S, Clausse V, Saha M, Mazur SJ, Appella E, Appella DH.; ChemMedChem (2018 May 8) 13:894-901. Abstract/Full Text
Multivalent LKγ-PNA oligomers bind to a human telomere DNA G-rich sequence to form quadruplexes.: Gupta P, Rastede EE, Appella DH.; Bioorg Med Chem Lett (2015 Nov 1) 25:4757-4760. Abstract/Full Text
An Intravaginal Ring for the Simultaneous Delivery of an HIV-1 Maturation Inhibitor and Reverse-Transcriptase Inhibitor for Prophylaxis of HIV Transmission.: Ugaonkar SR, Clark JT, English LB, Johnson TJ, Buckheit KW, Bahde RJ, Appella DH, Buckheit RW Jr, Kiser PF.; J Pharm Sci (2015 Oct) 104:3426-39. Abstract/Full Text
G-quadruplex formation between G-rich PNA and homologous sequences in oligonucleotides and supercoiled plasmid DNA.: Gaynutdinov TI, Englund EA, Appella DH, Onyshchenko MI, Neumann RD, Panyutin IG.; Nucleic Acid Ther (2015 Apr) 25:78-84. Abstract/Full Text
PNA-Based Multivalent Scaffolds Activate the Dopamine D2 Receptor.: Dix AV, Conroy JL, George Rosenker KM, Sibley DR, Appella DH.; ACS Med Chem Lett (2015 Apr 9) 6:425-9. Abstract/Full Text
PPG peptide nucleic acids that promote DNA guanine quadruplexes.: Englund EA, Gupta P, Micklitsch CM, Onyshchenko MI, Remeeva E, Neumann RD, Panyutin IG, Appella DH.; Chembiochem (2014 Sep 5) 15:1887-90. Abstract/Full Text
Recognition of HIV-TAR RNA using neomycin-benzimidazole conjugates.: Ranjan N, Kumar S, Watkins D, Wang D, Appella DH, Arya DP.; Bioorg Med Chem Lett (2013 Oct 15) 23:5689-93. Abstract/Full Text
Novel inhibitors of a Grb2 SH3C domain interaction identified by a virtual screen.: Simister PC, Luccarelli J, Thompson S, Appella DH, Feller SM, Hamilton AD.; Bioorg Med Chem (2013 Jul 15) 21:4027-33. Abstract/Full Text
Cyclopentane-peptide nucleic acids for qualitative, quantitative, and repetitive detection of nucleic acids.: Micklitsch CM, Oquare BY, Zhao C, Appella DH.; Anal Chem (2013 Jan 2) 85:251-7. Abstract/Full Text
Click dimers to target HIV TAR RNA conformation.: Kumar S, Kellish P, Robinson WE Jr, Wang D, Appella DH, Arya DP.; Biochemistry (2012 Mar 20) 51:2331-47. Abstract/Full Text
Programmable multivalent display of receptor ligands using peptide nucleic acid nanoscaffolds.: Englund EA, Wang D, Fujigaki H, Sakai H, Micklitsch CM, Ghirlando R, Martin-Manso G, Pendrak ML, Roberts DD, Durell SR, Appella DH.; Nat Commun (2012 Jan 10) 3:614. Abstract/Full Text
Combinatorial Synthesis, Screening, and Binding Studies of Highly Functionalized Polyamino-amido Oligomers for Binding to Folded RNA.: Pokorski JK, Appella DH.; J Nucleic Acids (2012) 2012:971581. Abstract/Full Text
Quadruplex formation is necessary for stable PNA invasion into duplex DNA of BCL2 promoter region.: Onyshchenko MI, Gaynutdinov TI, Englund EA, Appella DH, Neumann RD, Panyutin IG.; Nucleic Acids Res (2011 Sep 1) 39:7114-23. Abstract/Full Text
A one-pot preparation of N-2-mercaptobenzoyl-amino amides.: Bahde RJ, Appella DH, Trenkle WC.; Tetrahedron Lett (2011 Aug 10) 52:4103-4105. Abstract/Full Text
Optimization of a cyclic peptide inhibitor of Ser/Thr phosphatase PPM1D (Wip1).: Hayashi R, Tanoue K, Durell SR, Chatterjee DK, Jenkins LM, Appella DH, Appella E.; Biochemistry (2011 May 31) 50:4537-49. Abstract/Full Text
Methoxyethylamino-numonafide is an efficacious and minimally toxic amonafide derivative in murine models of human cancer.: Liu Y, Norton JT, Witschi MA, Xu Q, Lou G, Wang C, Appella DH, Chen Z, Huang S.; Neoplasia (2011 May) 13:453-60. Abstract/Full Text
Inhibition of multidrug resistance by SV40 pseudovirion delivery of an antigene peptide nucleic acid (PNA) in cultured cells.: Macadangdang B, Zhang N, Lund PE, Marple AH, Okabe M, Gottesman MM, Appella DH, Kimchi-Sarfaty C.; PLoS One (2011 Mar 22) 6:e17981. Abstract/Full Text
Small-molecule inactivation of HIV-1 NCp7 by repetitive intracellular acyl transfer.: Miller Jenkins LM, Ott DE, Hayashi R, Coren LV, Wang D, Xu Q, Schito ML, Inman JK, Appella DH, Appella E.; Nat Chem Biol (2010 Dec) 6:887-9. Abstract/Full Text
Multivalent binding oligomers inhibit HIV Tat-TAR interaction critical for viral replication.: Wang D, Iera J, Baker H, Hogan P, Ptak R, Yang L, Hartman T, Buckheit RW Jr, Desjardins A, Yang A, Legault P, Yedavalli V, Jeang KT, Appella DH.; Bioorg Med Chem Lett (2009 Dec 15) 19:6893-7. Abstract/Full Text
Stabilization of G-quadruplex in the BCL2 promoter region in double-stranded DNA by invading short PNAs.: Onyshchenko MI, Gaynutdinov TI, Englund EA, Appella DH, Neumann RD, Panyutin IG.; Nucleic Acids Res (2009 Dec) 37:7570-80. Abstract/Full Text
Synthesis and anticancer activities of 6-amino amonafide derivatives.: Norton JT, Witschi MA, Luong L, Kawamura A, Ghosh S, Stack MS, Sim E, Avram MJ, Appella DH, Huang S.; Anticancer Drugs (2008 Jan) 19:23-36. Abstract/Full Text
Colorimetric detection of anthrax DNA with a Peptide nucleic acid sandwich-hybridization assay.: Zhang N, Appella DH.; J Am Chem Soc (2007 Jul 11) 129:8424-5. Abstract/Full Text
Gamma-substituted peptide nucleic acids constructed from L-lysine are a versatile scaffold for multifunctional display.: Englund EA, Appella DH.; Angew Chem Int Ed Engl (2007) 46:1414-8. Abstract/Full Text