Synthetic Bioactive Molecules Section

Daniel Appella, Ph.D.

Section Chief

Using synthetic organic chemistry to create new molecules with unique biological activities.

Select Publications

Thyclotides, tetrahydrofuran-modified peptide nucleic acids that efficiently penetrate cells and inhibit microRNA-21.: Clausse V, Zheng H, Amarasekara H, Kruhlak M, Appella DH.; Nucleic Acids Res (2022 Oct 28) 50:10839-10856. Abstract/Full Text
Alkyl-substituted N-methylaryl-N'-aryl-4-aminobenzamides: A new series of small molecule inhibitors for Wip1 phosphatase.: Robello M, Zheng H, Saha M, George Rosenker KM, Debnath S, Kumar JP, Tagad HD, Mazur SJ, Appella E, Appella DH.; Eur J Med Chem (2022 Dec 5) 243:114763. Abstract/Full Text