Synthetic Bioactive Molecules Section

Using synthetic organic chemistry to create new molecules with unique biological activities.

Select Publications

Inhibition of HIV Maturation via Selective Unfolding and Cross-Linking of Gag Polyprotein by a Mercaptobenzamide Acetylator.
Miller Jenkins LM, Paine EL, Deshmukh L, Nikolayevskiy H, Lyons GC, Scerba MT, George Rosenker K, Luecke HF, Louis JM, Chertova E, Gorelick RJ, Ott DE, Clore GM, Appella DH.
J Am Chem Soc (2019 May 22) 141:8327-8338. Abstract/Full Text
Reaction Kinetics Direct a Rational Synthesis of an HIV-1 Inactivator of Nucleocapsid Protein 7 and Provide Mechanistic Insight into Cellular Metabolism and Antiviral Activity.
Nikolayevskiy H, Scerba MT, Deschamps JR, Appella DH.
Chemistry (2018 Jul 5) 24:9485-9489. Abstract/Full Text
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