Synthetic Bioactive Molecules Section
Using synthetic organic chemistry to create new molecules with unique biological activities.
Select Publications
- Inhibition of HIV Maturation via Selective Unfolding and Cross-Linking of Gag Polyprotein by a Mercaptobenzamide Acetylator.
- Miller Jenkins LM, Paine EL, Deshmukh L, Nikolayevskiy H, Lyons GC, Scerba MT, George Rosenker K, Luecke HF, Louis JM, Chertova E, Gorelick RJ, Ott DE, Clore GM, Appella DH.
- J Am Chem Soc (2019 May 22) 141:8327-8338. Abstract/Full Text
- Reaction Kinetics Direct a Rational Synthesis of an HIV-1 Inactivator of Nucleocapsid Protein 7 and Provide Mechanistic Insight into Cellular Metabolism and Antiviral Activity.
- Nikolayevskiy H, Scerba MT, Deschamps JR, Appella DH.
- Chemistry (2018 Jul 5) 24:9485-9489. Abstract/Full Text