Synthetic Bioactive Molecules Section

Using synthetic organic chemistry to create new molecules with unique biological activities.

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Thyclotides, tetrahydrofuran-modified peptide nucleic acids that efficiently penetrate cells and inhibit microRNA-21.
Clausse V, Zheng H, Amarasekara H, Kruhlak M, Appella DH.
Nucleic Acids Res (2022 Oct 28) 50:10839-10856. Abstract/Full Text
Alkyl-substituted N-methylaryl-N'-aryl-4-aminobenzamides: A new series of small molecule inhibitors for Wip1 phosphatase.
Robello M, Zheng H, Saha M, George Rosenker KM, Debnath S, Kumar JP, Tagad HD, Mazur SJ, Appella E, Appella DH.
Eur J Med Chem (2022 Dec 5) 243:114763. Abstract/Full Text
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Last Reviewed February 2024