Adriaan Bax, Ph.D., NIH Distinguished Investigator

Photo of Dr. Adriaan Bax
Scientific Focus Areas: Biomedical Engineering and Biophysics, Chemical Biology, Molecular Biology and Biochemistry, Structural Biology


A selection of recent and significant publications can be viewed below.

Select Publications

pH-triggered, activated-state conformations of the influenza hemagglutinin fusion peptide revealed by NMR.
Lorieau JL, Louis JM, Schwieters CD, Bax A.
Proc Natl Acad Sci U S A (2012 Dec 4) 109:19994-9. Abstract/Full Text
Study of protein folding under native conditions by rapidly switching the hydrostatic pressure inside an NMR sample cell.
Charlier C, Alderson TR, Courtney JM, Ying J, Anfinrud P, Bax A.
Proc Natl Acad Sci U S A (2018 May 1) 115:E4169-E4178. Abstract/Full Text
Weak alignment offers new NMR opportunities to study protein structure and dynamics.
Bax A.
Protein Sci (2003 Jan) 12:1-16. Abstract/Full Text
Monitoring Hydrogen Exchange During Protein Folding by Fast Pressure Jump NMR Spectroscopy.
Alderson TR, Charlier C, Torchia DA, Anfinrud P, Bax A.
J Am Chem Soc (2017 Aug 16) 139:11036-11039. Abstract/Full Text
Tilted, Uninterrupted, Monomeric HIV-1 gp41 Transmembrane Helix from Residual Dipolar Couplings.
Chiliveri SC, Louis JM, Ghirlando R, Baber JL, Bax A.
J Am Chem Soc (2018 Jan 10) 140:34-37. Abstract/Full Text

Additional Publications

The Role of Molecular Flexibility in Antigen Presentation and T Cell Receptor-Mediated Signaling.
Natarajan K, Jiang J, May NA, Mage MG, Boyd LF, McShan AC, Sgourakis NG, Bax A, Margulies DH.
Front Immunol (2018) 9:1657. Abstract/Full Text
Monitoring 15N Chemical Shifts During Protein Folding by Pressure-Jump NMR.
Charlier C, Courtney JM, Alderson TR, Anfinrud P, Bax A.
J Am Chem Soc (2018 Jul 5) 140:8096-8099. Abstract/Full Text
Accurate Measurement of Residual Dipolar Couplings in Large RNAs by Variable Flip Angle NMR.
Marchant J, Bax A, Summers MF.
J Am Chem Soc (2018 Jun 6) 140:6978-6983. Abstract/Full Text
Isoindole Linkages Provide a Pathway for DOPAL-Mediated Cross-Linking of α-Synuclein.
Werner-Allen JW, Monti S, DuMond JF, Levine RL, Bax A.
Biochemistry (2018 Mar 6) 57:1462-1474. Abstract/Full Text
Propensity for cis-Proline Formation in Unfolded Proteins.
Alderson TR, Lee JH, Charlier C, Ying J, Bax A.
Chembiochem (2018 Jan 4) 19:37-42. Abstract/Full Text
Prediction of nearest neighbor effects on backbone torsion angles and NMR scalar coupling constants in disordered proteins.
Shen Y, Roche J, Grishaev A, Bax A.
Protein Sci (2018 Jan) 27:146-158. Abstract/Full Text
Sparse multidimensional iterative lineshape-enhanced (SMILE) reconstruction of both non-uniformly sampled and conventional NMR data.
Ying J, Delaglio F, Torchia DA, Bax A.
J Biomol NMR (2017 Jun) 68:101-118. Abstract/Full Text
Superoxide is the critical driver of DOPAL autoxidation, lysyl adduct formation, and crosslinking of α-synuclein.
Werner-Allen JW, Levine RL, Bax A.
Biochem Biophys Res Commun (2017 May 27) 487:281-286. Abstract/Full Text
An allosteric site in the T-cell receptor Cβ domain plays a critical signalling role.
Natarajan K, McShan AC, Jiang J, Kumirov VK, Wang R, Zhao H, Schuck P, Tilahun ME, Boyd LF, Ying J, Bax A, Margulies DH, Sgourakis NG.
Nat Commun (2017 May 16) 8:15260. Abstract/Full Text
A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity.
Perni M, Galvagnion C, Maltsev A, Meisl G, Müller MB, Challa PK, Kirkegaard JB, Flagmeier P, Cohen SI, Cascella R, Chen SW, Limbocker R, Sormanni P, Heller GT, Aprile FA, Cremades N, Cecchi C, Chiti F, Nollen EA, Knowles TP, Vendruscolo M, Bax A, Zasloff M, Dobson CM.
Proc Natl Acad Sci U S A (2017 Feb 7) 114:E1009-E1017. Abstract/Full Text
A Role for Neuronal Alpha-Synuclein in Gastrointestinal Immunity.
Stolzenberg E, Berry D, Yang, Lee EY, Kroemer A, Kaufman S, Wong GCL, Oppenheim JJ, Sen S, Fishbein T, Bax A, Harris B, Barbut D, Zasloff MA.
J Innate Immun (2017) 9:456-463. Abstract/Full Text
Nuclear Magnetic Resonance Observation of α-Synuclein Membrane Interaction by Monitoring the Acetylation Reactivity of Its Lysine Side Chains.
Lee JH, Ying J, Bax A.
Biochemistry (2016 Sep 6) 55:4949-59. Abstract/Full Text
Insights into the Conformation of the Membrane Proximal Regions Critical to the Trimerization of the HIV-1 gp41 Ectodomain Bound to Dodecyl Phosphocholine Micelles.
Louis JM, Baber JL, Ghirlando R, Aniana A, Bax A, Roche J.
PLoS One (2016) 11:e0160597. Abstract/Full Text
ARTSY-J: Convenient and precise measurement of (3)JHNHα couplings in medium-size proteins from TROSY-HSQC spectra.
Roche J, Ying J, Shen Y, Torchia DA, Bax A.
J Magn Reson (2016 Jul) 268:73-81. Abstract/Full Text
Toxic Dopamine Metabolite DOPAL Forms an Unexpected Dicatechol Pyrrole Adduct with Lysines of α-Synuclein.
Werner-Allen JW, DuMond JF, Levine RL, Bax A.
Angew Chem Int Ed Engl (2016 Jun 20) 55:7374-8. Abstract/Full Text
Global Dynamics and Exchange Kinetics of a Protein on the Surface of Nanoparticles Revealed by Relaxation-Based Solution NMR Spectroscopy.
Ceccon A, Tugarinov V, Bax A, Clore GM.
J Am Chem Soc (2016 May 11) 138:5789-92. Abstract/Full Text
Quantitative evaluation of positive ϕ angle propensity in flexible regions of proteins from three-bond J couplings.
Lee JH, Ying J, Bax A.
Phys Chem Chem Phys (2016 Feb 17) 18:5759-70. Abstract/Full Text
Observation of α-Helical Hydrogen-Bond Cooperativity in an Intact Protein.
Li J, Wang Y, Chen J, Liu Z, Bax A, Yao L.
J Am Chem Soc (2016 Feb 17) 138:1824-7. Abstract/Full Text
Monomeric Aβ(1-40) and Aβ(1-42) Peptides in Solution Adopt Very Similar Ramachandran Map Distributions That Closely Resemble Random Coil.
Roche J, Shen Y, Lee JH, Ying J, Bax A.
Biochemistry (2016 Feb 9) 55:762-75. Abstract/Full Text
Parkinson's disease: Disorder in the court.
Alderson TR, Bax A.
Nature (2016 Feb 4) 530:38-9. Abstract/Full Text
Accurate measurement of (3)J(HNHα) couplings in small or disordered proteins from WATERGATE-optimized TROSY spectra.
Roche J, Ying J, Bax A.
J Biomol NMR (2016 Jan) 64:1-7. Abstract/Full Text
A Novel MHC-I Surface Targeted for Binding by the MCMV m06 Immunoevasin Revealed by Solution NMR.
Sgourakis NG, May NA, Boyd LF, Ying J, Bax A, Margulies DH.
J Biol Chem (2015 Nov 27) 290:28857-68. Abstract/Full Text
Side Chain Conformational Distributions of a Small Protein Derived from Model-Free Analysis of a Large Set of Residual Dipolar Couplings.
Li F, Grishaev A, Ying J, Bax A.
J Am Chem Soc (2015 Nov 25) 137:14798-811. Abstract/Full Text
MERA: a webserver for evaluating backbone torsion angle distributions in dynamic and disordered proteins from NMR data.
Mantsyzov AB, Shen Y, Lee JH, Hummer G, Bax A.
J Biomol NMR (2015 Sep) 63:85-95. Abstract/Full Text
Homology modeling of larger proteins guided by chemical shifts.
Shen Y, Bax A.
Nat Methods (2015 Aug) 12:747-50. Abstract/Full Text
Complete dissociation of the HIV-1 gp41 ectodomain and membrane proximal regions upon phospholipid binding.
Roche J, Louis JM, Aniana A, Ghirlando R, Bax A.
J Biomol NMR (2015 Apr) 61:235-48. Abstract/Full Text
Quantitative residue-specific protein backbone torsion angle dynamics from concerted measurement of 3J couplings.
Lee JH, Li F, Grishaev A, Bax A.
J Am Chem Soc (2015 Feb 4) 137:1432-5. Abstract/Full Text
Conformation of inhibitor-free HIV-1 protease derived from NMR spectroscopy in a weakly oriented solution.
Roche J, Louis JM, Bax A.
Chembiochem (2015 Jan 19) 16:214-8. Abstract/Full Text
Protein structural information derived from NMR chemical shift with the neural network program TALOS-N.
Shen Y, Bax A.
Methods Mol Biol (2015) 1260:17-32. Abstract/Full Text
The structure of mouse cytomegalovirus m04 protein obtained from sparse NMR data reveals a conserved fold of the m02-m06 viral immune modulator family.
Sgourakis NG, Natarajan K, Ying J, Vogeli B, Boyd LF, Margulies DH, Bax A.
Structure (2014 Sep 2) 22:1263-1273. Abstract/Full Text
A maximum entropy approach to the study of residue-specific backbone angle distributions in α-synuclein, an intrinsically disordered protein.
Mantsyzov AB, Maltsev AS, Ying J, Shen Y, Hummer G, Bax A.
Protein Sci (2014 Sep) 23:1275-90. Abstract/Full Text
Structural basis of hAT transposon end recognition by Hermes, an octameric DNA transposase from Musca domestica.
Hickman AB, Ewis HE, Li X, Knapp JA, Laver T, Doss AL, Tolun G, Steven AC, Grishaev A, Bax A, Atkinson PW, Craig NL, Dyda F.
Cell (2014 Jul 17) 158:353-367. Abstract/Full Text
Homonuclear decoupling for enhancing resolution and sensitivity in NOE and RDC measurements of peptides and proteins.
Ying J, Roche J, Bax A.
J Magn Reson (2014 Apr) 241:97-102. Abstract/Full Text
Improved cross validation of a static ubiquitin structure derived from high precision residual dipolar couplings measured in a drug-based liquid crystalline phase.
Maltsev AS, Grishaev A, Roche J, Zasloff M, Bax A.
J Am Chem Soc (2014 Mar 12) 136:3752-5. Abstract/Full Text
Dissociation of the trimeric gp41 ectodomain at the lipid-water interface suggests an active role in HIV-1 Env-mediated membrane fusion.
Roche J, Louis JM, Grishaev A, Ying J, Bax A.
Proc Natl Acad Sci U S A (2014 Mar 4) 111:3425-30. Abstract/Full Text
Impact of hydrostatic pressure on an intrinsically disordered protein: a high-pressure NMR study of α-synuclein.
Roche J, Ying J, Maltsev AS, Bax A.
Chembiochem (2013 Sep 23) 14:1754-61. Abstract/Full Text
Recommendations of the wwPDB NMR Validation Task Force.
Montelione GT, Nilges M, Bax A, Güntert P, Herrmann T, Richardson JS, Schwieters CD, Vranken WF, Vuister GW, Wishart DS, Berman HM, Kleywegt GJ, Markley JL.
Structure (2013 Sep 3) 21:1563-70. Abstract/Full Text
Protein backbone and sidechain torsion angles predicted from NMR chemical shifts using artificial neural networks.
Shen Y, Bax A.
J Biomol NMR (2013 Jul) 56:227-41. Abstract/Full Text
Internal dynamics of the homotrimeric HIV-1 viral coat protein gp41 on multiple time scales.
Lakomek NA, Kaufman JD, Stahl SJ, Louis JM, Grishaev A, Wingfield PT, Bax A.
Angew Chem Int Ed Engl (2013 Apr 2) 52:3911-5. Abstract/Full Text
Modulating alignment of membrane proteins in liquid-crystalline and oriented gel media by changing the size and charge of phospholipid bicelles.
Lorieau JL, Maltsev AS, Louis JM, Bax A.
J Biomol NMR (2013 Apr) 55:369-77. Abstract/Full Text
The impact of influenza hemagglutinin fusion peptide length and viral subtype on its structure and dynamics.
Lorieau JL, Louis JM, Bax A.
Biopolymers (2013 Mar) 99:189-95. Abstract/Full Text
Site-specific interaction between α-synuclein and membranes probed by NMR-observed methionine oxidation rates.
Maltsev AS, Chen J, Levine RL, Bax A.
J Am Chem Soc (2013 Feb 27) 135:2943-6. Abstract/Full Text
Deuterium isotope shifts for backbone ¹H, ¹⁵N and ¹³C nuclei in intrinsically disordered protein α-synuclein.
Maltsev AS, Ying J, Bax A.
J Biomol NMR (2012 Oct) 54:181-91. Abstract/Full Text
In support of the BMRB.
Markley JL, Akutsu H, Asakura T, Baldus M, Boelens R, Bonvin A, Kaptein R, Bax A, Bezsonova I, Gryk MR, Hoch JC, Korzhnev DM, Maciejewski MW, Case D, Chazin WJ, Cross TA, Dames S, Kessler H, Lange O, Madl T, Reif B, Sattler M, Eliezer D, Fersht A, Forman-Kay J, Kay LE, Fraser J, Gross J, Kortemme T, Sali A, Fujiwara T, Gardner K, Luo X, Rizo-Rey J, Rosen M, Gil RR, Ho C, Rule G, Gronenborn AM, Ishima R, Klein-Seetharaman J, Tang P, van der Wel P, Xu Y, Grzesiek S, Hiller S, Seelig J, Laue ED, Mott H, Nietlispach D, Barsukov I, Lian LY, Middleton D, Blumenschein T, Moore G, Campbell I, Schnell J, Vakonakis IJ, Watts A, Conte MR, Mason J, Pfuhl M, Sanderson MR, Craven J, Williamson M, Dominguez C, Roberts G, Günther U, Overduin M, Werner J, Williamson P, Blindauer C, Crump M, Driscoll P, Frenkiel T, Golovanov A, Matthews S, Parkinson J, Uhrin D, Williams M, Neuhaus D, Oschkinat H, Ramos A, Shaw DE, Steinbeck C, Vendruscolo M, Vuister GW, Walters KJ, Weinstein H, Wüthrich K, Yokoyama S.
Nat Struct Mol Biol (2012 Sep) 19:854-60. Abstract/Full Text
Impact of N-terminal acetylation of α-synuclein on its random coil and lipid binding properties.
Maltsev AS, Ying J, Bax A.
Biochemistry (2012 Jun 26) 51:5004-13. Abstract/Full Text