Rebecca J. Brown, M.D., M.H.Sc., Lasker Tenure Track Investigator

Publications

A selection of recent and significant publications can be viewed below.

Select Publications

Metreleptin-mediated improvements in insulin sensitivity are independent of food intake in humans with lipodystrophy.
Brown RJ, Valencia A, Startzell M, Cochran E, Walter PJ, Garraffo HM, Cai H, Gharib AM, Ouwerkerk R, Courville AB, Bernstein S, Brychta RJ, Chen KY, Walter M, Auh S, Gorden P.
J Clin Invest (2018 Aug 1) 128:3504-3516. Abstract/Full Text
Free fatty acid processing diverges in human pathologic insulin resistance conditions.
Sekizkardes H, Chung ST, Chacko S, Haymond MW, Startzell M, Walter M, Walter PJ, Lightbourne M, Brown RJ.
J Clin Invest (2020 Jul 1) 130:3592-3602. Abstract/Full Text
The Diagnosis and Management of Lipodystrophy Syndromes: A Multi-Society Practice Guideline.
Brown RJ, Araujo-Vilar D, Cheung PT, Dunger D, Garg A, Jack M, Mungai L, Oral EA, Patni N, Rother KI, von Schnurbein J, Sorkina E, Stanley T, Vigouroux C, Wabitsch M, Williams R, Yorifuji T.
J Clin Endocrinol Metab (2016 Dec) 101:4500-4511. Abstract/Full Text
Leptin decreases de novo lipogenesis in patients with lipodystrophy.
Baykal AP, Parks EJ, Shamburek R, Syed-Abdul MM, Chacko S, Cochran E, Startzell M, Gharib AM, Ouwerkerk R, Abd-Elmoniem KZ, Walter PJ, Walter M, Muniyappa R, Chung ST, Brown RJ.
JCI Insight (2020 Jul 23) 5. Abstract/Full Text
Partial and generalized lipodystrophy: comparison of baseline characteristics and response to metreleptin.
Diker-Cohen T, Cochran E, Gorden P, Brown RJ.
J Clin Endocrinol Metab (2015 May) 100:1802-10. Abstract/Full Text

Additional Publications

Effect of Leptin Therapy on Survival in Generalized and Partial Lipodystrophy: A Matched Cohort Analysis.
Cook K, Ali O, Akinci B, Foss de Freitas MC, Montenegro RM, Fernandes VO, Gupta D, Lou KJ, Tuttle E, Oral EA, Brown RJ.
J Clin Endocrinol Metab (2021 Jul 13) 106:e2953-e2967. Abstract/Full Text
Ovarian Hyperandrogenism and Response to Gonadotropin-releasing Hormone Analogues in Primary Severe Insulin Resistance.
Huang-Doran I, Kinzer AB, Jimenez-Linan M, Thackray K, Harris J, Adams CL, de Kerdanet M, Stears A, O'Rahilly S, Savage DB, Gorden P, Brown RJ, Semple RK.
J Clin Endocrinol Metab (2021 Jul 13) 106:2367-2383. Abstract/Full Text
Leptin Attenuates Cardiac Hypertrophy in Patients with Generalized Lipodystrophy.
Nguyen ML, Sachdev V, Burklow TR, Li W, Startzell M, Auh S, Brown RJ.
J Clin Endocrinol Metab (2021 Jul 5) Abstract/Full Text
Complement Factor D (adipsin) Levels Are Elevated in Acquired Partial Lipodystrophy (Barraquer-Simons syndrome).
Corvillo F, González-Sánchez L, López-Lera A, Arjona E, Ceccarini G, Santini F, Araújo-Vilar D, Brown RJ, Villarroya J, Villarroya F, Rodríguez de Córdoba S, Caballero T, Nozal P, López-Trascasa M.
Int J Mol Sci (2021 Jun 21) 22. Abstract/Full Text
Leptin Decreases Energy Expenditure Despite Increased Thyroid Hormone in Patients with Lipodystrophy.
Grover A, Quaye E, Brychta RJ, Christensen J, Startzell MS, Meehan CA, Valencia A, Marshall B, Chen KY, Brown RJ.
J Clin Endocrinol Metab (2021 Apr 23) Abstract/Full Text
Effects of Metreleptin on Patient Outcomes and Quality of Life in Generalized and Partial Lipodystrophy.
Cook K, Adamski K, Gomes A, Tuttle E, Kalden H, Cochran E, Brown RJ.
J Endocr Soc (2021 Apr 1) 5:bvab019. Abstract/Full Text
Apolipoprotein CIII and Angiopoietin-like Protein 8 are Elevated in Lipodystrophy and Decrease after Metreleptin.
Lightbourne M, Wolska A, Abel BS, Rother KI, Walter M, Kushchayeva Y, Auh S, Shamburek RD, Remaley AT, Muniyappa R, Brown RJ.
J Endocr Soc (2021 Feb 1) 5:bvaa191. Abstract/Full Text
Diagnostic Value of Anthropometric Measurements for Familial Partial Lipodystrophy, Dunnigan Variety.
Vasandani C, Li X, Sekizkardes H, Adams-Huet B, Brown RJ, Garg A.
J Clin Endocrinol Metab (2020 Jul 1) 105. Abstract/Full Text
Thyroid Hormone Effects on Glucose Disposal in Patients With Insulin Receptor Mutations.
Kushchayeva YS, Startzell M, Cochran E, Auh S, Sekizkardes H, Soldin SJ, Kushchayev SV, Dieckmann W, Skarulis M, Abdul Sater Z, Brychta RJ, Cypess AM, Lin TC, Lightbourne M, Millo C, Brown RJ.
J Clin Endocrinol Metab (2020 Mar 1) 105. Abstract/Full Text
Metabolomic Analysis of the Effects of Leptin Replacement Therapy in Patients with Lipodystrophy.
Grewal S, Gubbi S, Fosam A, Sedmak C, Sikder S, Talluru H, Brown RJ, Muniyappa R.
J Endocr Soc (2020 Jan 1) 4:bvz022. Abstract/Full Text
Comorbidities and Survival in Patients With Lipodystrophy: An International Chart Review Study.
Akinci B, Oral EA, Neidert A, Rus D, Cheng WY, Thompson-Leduc P, Cheung HC, Bradt P, Foss de Freitas MC, Montenegro RM, Fernandes VO, Cochran E, Brown RJ.
J Clin Endocrinol Metab (2019 Nov 1) 104:5120-5135. Abstract/Full Text
Efficacy of Metreleptin Treatment in Familial Partial Lipodystrophy Due to PPARG vs LMNA Pathogenic Variants.
Sekizkardes H, Cochran E, Malandrino N, Garg A, Brown RJ.
J Clin Endocrinol Metab (2019 Aug 1) 104:3068-3076. Abstract/Full Text
Advanced Lipoprotein Analysis Shows Atherogenic Lipid Profile That Improves After Metreleptin in Patients with Lipodystrophy.
Kinzer AB, Shamburek RD, Lightbourne M, Muniyappa R, Brown RJ.
J Endocr Soc (2019 Aug 1) 3:1503-1517. Abstract/Full Text
Thyroid Abnormalities in Patients With Extreme Insulin Resistance Syndromes.
Kushchayeva YS, Kushchayev SV, Startzell M, Cochran E, Auh S, Dai Y, Lightbourne M, Skarulis M, Brown RJ.
J Clin Endocrinol Metab (2019 Jun 1) 104:2216-2228. Abstract/Full Text
Long-term effectiveness and safety of metreleptin in the treatment of patients with partial lipodystrophy.
Oral EA, Gorden P, Cochran E, Araújo-Vilar D, Savage DB, Long A, Fine G, Salinardi T, Brown RJ.
Endocrine (2019 Jun) 64:500-511. Abstract/Full Text
Celia's encephalopathy and c.974dupG in BSCL2 gene: a hidden change in a known variant.
Sánchez-Iglesias S, Crocker M, O'Callaghan M, Darling A, García-Cazorla A, Domingo-Jiménez R, Castro A, Fernández-Pombo A, Ruibal Á, Aguiar P, Garrido-Pumar M, Rodríguez-Núñez A, Álvarez-Escudero J, Brown RJ, Araújo-Vilar D.
Neurogenetics (2019 May) 20:73-82. Abstract/Full Text
Effects of metreleptin on proteinuria in patients with lipodystrophy.
Lee HL, Waldman MA, Auh S, Balow JE, Cochran EK, Gorden P, Brown RJ.
J Clin Endocrinol Metab (2019 Apr 16) Abstract/Full Text
Visceral fat does not contribute to metabolic disease in lipodystrophy.
Malandrino N, Reynolds JC, Brychta RJ, Chen KY, Auh S, Gharib AM, Startzell M, Cochran EK, Brown RJ.
Obes Sci Pract (2019 Feb) 5:75-82. Abstract/Full Text
Combined Immunosuppressive Therapy Induces Remission in Patients With Severe Type B Insulin Resistance: A Prospective Cohort Study.
Klubo-Gwiezdzinska J, Lange M, Cochran E, Semple RK, Gewert C, Brown RJ, Gorden P.
Diabetes Care (2018 Nov) 41:2353-2360. Abstract/Full Text
"Fat Shadows" From DXA for the Qualitative Assessment of Lipodystrophy: When a Picture Is Worth a Thousand Numbers.
Meral R, Ryan BJ, Malandrino N, Jalal A, Neidert AH, Muniyappa R, Akıncı B, Horowitz JF, Brown RJ, Oral EA.
Diabetes Care (2018 Oct) 41:2255-2258. Abstract/Full Text
JAK1/2 inhibition with baricitinib in the treatment of autoinflammatory interferonopathies.
Sanchez GAM, Reinhardt A, Ramsey S, Wittkowski H, Hashkes PJ, Berkun Y, Schalm S, Murias S, Dare JA, Brown D, Stone DL, Gao L, Klausmeier T, Foell D, de Jesus AA, Chapelle DC, Kim H, Dill S, Colbert RA, Failla L, Kost B, O'Brien M, Reynolds JC, Folio LR, Calvo KR, Paul SM, Weir N, Brofferio A, Soldatos A, Biancotto A, Cowen EW, Digiovanna JJ, Gadina M, Lipton AJ, Hadigan C, Holland SM, Fontana J, Alawad AS, Brown RJ, Rother KI, Heller T, Brooks KM, Kumar P, Brooks SR, Waldman M, Singh HK, Nickeleit V, Silk M, Prakash A, Janes JM, Ozen S, Wakim PG, Brogan PA, Macias WL, Goldbach-Mansky R.
J Clin Invest (2018 Jul 2) 128:3041-3052. Abstract/Full Text
Long-term effectiveness and safety of metreleptin in the treatment of patients with generalized lipodystrophy.
Brown RJ, Oral EA, Cochran E, Araújo-Vilar D, Savage DB, Long A, Fine G, Salinardi T, Gorden P.
Endocrine (2018 Jun) 60:479-489. Abstract/Full Text
Type B Insulin Resistance Masquerading as Ovarian Hyperthecosis.
Brown RJ, Joseph J, Cochran E, Gewert C, Semple R, Gorden P.
J Clin Endocrinol Metab (2017 Jun 1) 102:1789-1791. Abstract/Full Text
Genetics of Lipodystrophy.
Lightbourne M, Brown RJ.
Endocrinol Metab Clin North Am (2017 Jun) 46:539-554. Abstract/Full Text
Effects of Metreleptin in Pediatric Patients With Lipodystrophy.
Brown RJ, Meehan CA, Cochran E, Rother KI, Kleiner DE, Walter M, Gorden P.
J Clin Endocrinol Metab (2017 May 1) 102:1511-1519. Abstract/Full Text
Human biallelic MFN2 mutations induce mitochondrial dysfunction, upper body adipose hyperplasia, and suppression of leptin expression.
Rocha N, Bulger DA, Frontini A, Titheradge H, Gribsholt SB, Knox R, Page M, Harris J, Payne F, Adams C, Sleigh A, Crawford J, Gjesing AP, Bork-Jensen J, Pedersen O, Barroso I, Hansen T, Cox H, Reilly M, Rossor A, Brown RJ, Taylor SI, McHale D, Armstrong M, Oral EA, Saudek V, O'Rahilly S, Maher ER, Richelsen B, Savage DB, Semple RK.
Elife (2017 Apr 19) 6. Abstract/Full Text
Clinical Features and Management of Non-HIV-Related Lipodystrophy in Children: A Systematic Review.
Gupta N, Asi N, Farah W, Almasri J, Barrionuevo P, Alsawas M, Wang Z, Haymond MW, Brown RJ, Murad MH.
J Clin Endocrinol Metab (2017 Feb 1) 102:363-374. Abstract/Full Text
Metreleptin therapy lowers plasma angiopoietin-like protein 3 in patients with generalized lipodystrophy.
Muniyappa R, Abel BS, Asthana A, Walter MF, Cochran EK, Remaley AT, Skarulis MC, Gorden P, Brown RJ.
J Clin Lipidol (2017 Mar - Apr) 11:543-550. Abstract/Full Text
Management of Diabetic Ketoacidosis in Severe Insulin Resistance.
Robinson C, Cochran E, Gorden P, Brown RJ.
Diabetes Care (2016 Aug) 39:e116-8. Abstract/Full Text
Immunogenicity associated with metreleptin treatment in patients with obesity or lipodystrophy.
Chan JL, Koda J, Heilig JS, Cochran EK, Gorden P, Oral EA, Brown RJ.
Clin Endocrinol (Oxf) (2016 Jul) 85:137-49. Abstract/Full Text
Effect of Leptin Replacement on PCSK9 in ob/ob Mice and Female Lipodystrophic Patients.
Levenson AE, Haas ME, Miao J, Brown RJ, de Ferranti SD, Muniyappa R, Biddinger SB.
Endocrinology (2016 Apr) 157:1421-9. Abstract/Full Text
Effect of Leptin Administration on Circulating Apolipoprotein CIII levels in Patients With Lipodystrophy.
Kassai A, Muniyappa R, Levenson AE, Walter MF, Abel BS, Ring M, Taylor SI, Biddinger SB, Skarulis MC, Gorden P, Brown RJ.
J Clin Endocrinol Metab (2016 Apr) 101:1790-7. Abstract/Full Text
Lymphoma in acquired generalized lipodystrophy.
Brown RJ, Chan JL, Jaffe ES, Cochran E, DePaoli AM, Gautier JF, Goujard C, Vigouroux C, Gorden P.
Leuk Lymphoma (2016) 57:45-50. Abstract/Full Text
Effects of Recombinant Human Leptin (Metreleptin) on Nocturnal Luteinizing Hormone Secretion in Lipodystrophy Patients.
Abel BS, Muniyappa R, Stratton P, Skarulis MC, Gorden P, Brown RJ.
Neuroendocrinology (2016) 103:402-7. Abstract/Full Text
Metreleptin for injection to treat the complications of leptin deficiency in patients with congenital or acquired generalized lipodystrophy.
Meehan CA, Cochran E, Kassai A, Brown RJ, Gorden P.
Expert Rev Clin Pharmacol (2016) 9:59-68. Abstract/Full Text
Leptin Does Not Mediate Hypertension Associated With Human Obesity.
Brown RJ, Meehan CA, Gorden P.
Cell (2015 Jul 30) 162:465-6. Abstract/Full Text
Lipid regulation in lipodystrophy versus the obesity-associated metabolic syndrome: the dissociation of HDL-C and triglycerides.
Joseph J, Shamburek RD, Cochran EK, Gorden P, Brown RJ.
J Clin Endocrinol Metab (2014 Sep) 99:E1676-80. Abstract/Full Text
Bone mineral content in patients with congenital generalized lipodystrophy is unaffected by metreleptin replacement therapy.
Christensen JD, Lungu AO, Cochran E, Collins MT, Gafni RI, Reynolds JC, Rother KI, Gorden P, Brown RJ.
J Clin Endocrinol Metab (2014 Aug) 99:E1493-500. Abstract/Full Text
Mutations disrupting the Kennedy phosphatidylcholine pathway in humans with congenital lipodystrophy and fatty liver disease.
Payne F, Lim K, Girousse A, Brown RJ, Kory N, Robbins A, Xue Y, Sleigh A, Cochran E, Adams C, Dev Borman A, Russel-Jones D, Gorden P, Semple RK, Saudek V, O'Rahilly S, Walther TC, Barroso I, Savage DB.
Proc Natl Acad Sci U S A (2014 Jun 17) 111:8901-6. Abstract/Full Text
Effects of leptin replacement therapy on pancreatic β-cell function in patients with lipodystrophy.
Muniyappa R, Brown RJ, Mari A, Joseph J, Warren MA, Cochran EK, Skarulis MC, Gorden P.
Diabetes Care (2014 Apr) 37:1101-7. Abstract/Full Text
Metreleptin improves blood glucose in patients with insulin receptor mutations.
Brown RJ, Cochran E, Gorden P.
J Clin Endocrinol Metab (2013 Nov) 98:E1749-56. Abstract/Full Text
The liver diseases of lipodystrophy: the long-term effect of leptin treatment.
Safar Zadeh E, Lungu AO, Cochran EK, Brown RJ, Ghany MG, Heller T, Kleiner DE, Gorden P.
J Hepatol (2013 Jul) 59:131-7. Abstract/Full Text
The clinical approach to the detection of lipodystrophy - an AACE consensus statement.
Handelsman Y, Oral EA, Bloomgarden ZT, Brown RJ, Chan JL, Einhorn D, Garber AJ, Garg A, Garvey WT, Grunberger G, Henry RR, Lavin N, Tapiador CD, Weyer C, American Association of Clinical Endocrinologists..
Endocr Pract (2013 Jan-Feb) 19:107-16. Abstract/Full Text
Syndromic insulin resistance: models for the therapeutic basis of the metabolic syndrome and other targets of insulin resistance.
Gorden P, Zadeh ES, Cochran E, Brown RJ.
Endocr Pract (2012 Sep-Oct) 18:763-71. Abstract/Full Text
Consequences of stopping and restarting leptin in an adolescent with lipodystrophy.
Kamran F, Rother KI, Cochran E, Safar Zadeh E, Gorden P, Brown RJ.
Horm Res Paediatr (2012) 78:320-5. Abstract/Full Text