Kong Y. Chen, Ph.D., MSCI
Photo of Kong Chen
Scientific Focus Areas: Biomedical Engineering and Biophysics, Clinical Research, Epidemiology, Social and Behavioral Sciences


A selection of recent and significant publications can be viewed below.

Select Publications

Mapping of human brown adipose tissue in lean and obese young men.
Leitner BP, Huang S, Brychta RJ, Duckworth CJ, Baskin AS, McGehee S, Tal I, Dieckmann W, Gupta G, Kolodny GM, Pacak K, Herscovitch P, Cypess AM, Chen KY.
Proc Natl Acad Sci U S A (2017 Aug 8) 114:8649-8654. Abstract/Full Text
Brown fat activation mediates cold-induced thermogenesis in adult humans in response to a mild decrease in ambient temperature.
Chen KY, Brychta RJ, Linderman JD, Smith S, Courville A, Dieckmann W, Herscovitch P, Millo CM, Remaley A, Lee P, Celi FS.
J Clin Endocrinol Metab (2013 Jul) 98:E1218-23. Abstract/Full Text
Temperature-acclimated brown adipose tissue modulates insulin sensitivity in humans.
Lee P, Smith S, Linderman J, Courville AB, Brychta RJ, Dieckmann W, Werner CD, Chen KY, Celi FS.
Diabetes (2014 Nov) 63:3686-98. Abstract/Full Text
Brown Adipose Reporting Criteria in Imaging STudies (BARCIST 1.0): Recommendations for Standardized FDG-PET/CT Experiments in Humans.
Chen KY, Cypess AM, Laughlin MR, Haft CR, Hu HH, Bredella MA, Enerbäck S, Kinahan PE, Lichtenbelt Wv, Lin FI, Sunderland JJ, Virtanen KA, Wahl RL.
Cell Metab (2016 Aug 9) 24:210-22. Abstract/Full Text
RM-493, a melanocortin-4 receptor (MC4R) agonist, increases resting energy expenditure in obese individuals.
Chen KY, Muniyappa R, Abel BS, Mullins KP, Staker P, Brychta RJ, Zhao X, Ring M, Psota TL, Cone RD, Panaro BL, Gottesdiener KM, Van der Ploeg LH, Reitman ML, Skarulis MC.
J Clin Endocrinol Metab (2015 Apr) 100:1639-45. Abstract/Full Text

Additional Publications

Comparing ActiGraph equations for estimating energy expenditure in older adults.
Aguilar-Farias N, Peeters GMEEG, Brychta RJ, Chen KY, Brown WJ.
J Sports Sci (2019 Jan) 37:188-195. Abstract/Full Text
Regulation of Human Adipose Tissue Activation, Gallbladder Size, and Bile Acid Metabolism by a β3-Adrenergic Receptor Agonist.
Baskin AS, Linderman JD, Brychta RJ, McGehee S, Anflick-Chames E, Cero C, Johnson JW, O'Mara AE, Fletcher LA, Leitner BP, Duckworth CJ, Huang S, Cai H, Garraffo HM, Millo CM, Dieckmann W, Tolstikov V, Chen EY, Gao F, Narain NR, Kiebish MA, Walter PJ, Herscovitch P, Chen KY, Cypess AM.
Diabetes (2018 Oct) 67:2113-2125. Abstract/Full Text
Effects of Interrupting Sedentary Behavior With Short Bouts of Moderate Physical Activity on Glucose Tolerance in Children With Overweight and Obesity: A Randomized Crossover Trial.
Broadney MM, Belcher BR, Berrigan DA, Brychta RJ, Tigner IL Jr, Shareef F, Papachristopoulou A, Hattenbach JD, Davis EK, Brady SM, Bernstein SB, Courville AB, Drinkard BE, Smith KP, Rosing DR, Wolters PL, Chen KY, Yanovski JA.
Diabetes Care (2018 Oct) 41:2220-2228. Abstract/Full Text
Exercise decreases defensive responses to unpredictable, but not predictable, threat.
Lago TR, Hsiung A, Leitner BP, Duckworth CJ, Chen KY, Ernst M, Grillon C.
Depress Anxiety (2018 Sep) 35:868-875. Abstract/Full Text
Is activation of human brown adipose tissue a viable target for weight management?
Marlatt KL, Chen KY, Ravussin E.
Am J Physiol Regul Integr Comp Physiol (2018 Sep 1) 315:R479-R483. Abstract/Full Text
Metreleptin-mediated improvements in insulin sensitivity are independent of food intake in humans with lipodystrophy.
Brown RJ, Valencia A, Startzell M, Cochran E, Walter PJ, Garraffo HM, Cai H, Gharib AM, Ouwerkerk R, Courville AB, Bernstein S, Brychta RJ, Chen KY, Walter M, Auh S, Gorden P.
J Clin Invest (2018 Aug 1) 128:3504-3516. Abstract/Full Text
Relationship of Mindfulness to Distress and Cortisol Response in Adolescent Girls At-Risk for Type 2 Diabetes.
Skoranski A, Kelly NR, Radin RM, Thompson KA, Galescu O, Demidowich AP, Brady SM, Chen KY, Tanofsky-Kraff M, Yanovski JA, Shomaker LB.
J Child Fam Stud (2018 Jul) 27:2254-2264. Abstract/Full Text
Less screen time and more frequent vigorous physical activity is associated with lower risk of reporting negative mental health symptoms among Icelandic adolescents.
Hrafnkelsdottir SM, Brychta RJ, Rognvaldsdottir V, Gestsdottir S, Chen KY, Johannsson E, Guðmundsdottir SL, Arngrimsson SA.
PLoS One (2018) 13:e0196286. Abstract/Full Text
Identifying bedrest using 24-h waist or wrist accelerometry in adults.
Tracy JD, Acra S, Chen KY, Buchowski MS.
PLoS One (2018) 13:e0194461. Abstract/Full Text
[Physical activity and sleep in Icelandic adolescents].
Rognvaldsdottir V, Valdimarsdottir BM, Brychta RJ, Hrafnkelsdottir SM, Arngrimsson SA, Johannsson E, Chen KY, Gudmundsdottir SL.
Laeknabladid (2018 Feb) 104:79-85. Abstract/Full Text
Comparison of Summer and Winter Objectively Measured Physical Activity and Sedentary Behavior in Older Adults: Age, Gene/Environment Susceptibility Reykjavik Study.
Arnardottir NY, Oskarsdottir ND, Brychta RJ, Koster A, van Domelen DR, Caserotti P, Eiriksdottir G, Sverrisdottir JE, Johannsson E, Launer LJ, Gudnason V, Harris TB, Chen KY, Sveinsson T.
Int J Environ Res Public Health (2017 Oct 21) 14. Abstract/Full Text
Digital Diabetes Congress 2017.
Klonoff DC, Kerr D, Wong JC, Pavlovic Y, Koliwad S, Hu J, Salber P, Aguilera A, Long W, Hamilton G, Chen KY, Adi S.
J Diabetes Sci Technol (2017 Sep) 11:1045-1052. Abstract/Full Text
Sleep deficiency on school days in Icelandic youth, as assessed by wrist accelerometry.
Rognvaldsdottir V, Gudmundsdottir SL, Brychta RJ, Hrafnkelsdottir SM, Gestsdottir S, Arngrimsson SA, Chen KY, Johannsson E.
Sleep Med (2017 May) 33:103-108. Abstract/Full Text
Association of gene coding variation and resting metabolic rate in a multi-ethnic sample of children and adults.
Hellwege JN, Velez Edwards DR, Acra S, Chen K, Buchowski MS, Edwards TL.
BMC Obes (2017) 4:12. Abstract/Full Text
A Randomized Controlled Trial to Prevent Depression and Ameliorate Insulin Resistance in Adolescent Girls at Risk for Type 2 Diabetes.
Shomaker LB, Kelly NR, Pickworth CK, Cassidy OL, Radin RM, Shank LM, Vannucci A, Thompson KA, Armaiz-Flores SA, Brady SM, Demidowich AP, Galescu OA, Courville AB, Olsen C, Chen KY, Stice E, Tanofsky-Kraff M, Yanovski JA.
Ann Behav Med (2016 Oct) 50:762-774. Abstract/Full Text
Erratum: Metabolic adaptation following massive weight loss is related to the degree of energy imbalance and changes in circulating leptin.
Knuth ND, Johannsen DL, Tamboli RA, Marks-Shulman PA, Huizenga R, Chen KY, Abumrad NN, Ravussin E, Hall KD.
Obesity (Silver Spring) (2016 Oct) 24:2248. Abstract/Full Text
Comparison of Sedentary Estimates between activPAL and Hip- and Wrist-Worn ActiGraph.
Koster A, Shiroma EJ, Caserotti P, Matthews CE, Chen KY, Glynn NW, Harris TB.
Med Sci Sports Exerc (2016 Aug) 48:1514-1522. Abstract/Full Text
Persistent metabolic adaptation 6 years after "The Biggest Loser" competition.
Fothergill E, Guo J, Howard L, Kerns JC, Knuth ND, Brychta R, Chen KY, Skarulis MC, Walter M, Walter PJ, Hall KD.
Obesity (Silver Spring) (2016 Aug) 24:1612-9. Abstract/Full Text
Associations of sleep duration and quality with disinhibited eating behaviors in adolescent girls at-risk for type 2 diabetes.
Kelly NR, Shomaker LB, Radin RM, Thompson KA, Cassidy OL, Brady S, Mehari R, Courville AB, Chen KY, Galescu OA, Tanofsky-Kraff M, Yanovski JA.
Eat Behav (2016 Aug) 22:149-155. Abstract/Full Text
Energy expenditure and body composition changes after an isocaloric ketogenic diet in overweight and obese men.
Hall KD, Chen KY, Guo J, Lam YY, Leibel RL, Mayer LE, Reitman ML, Rosenbaum M, Smith SR, Walsh BT, Ravussin E.
Am J Clin Nutr (2016 Aug) 104:324-33. Abstract/Full Text
Challenges Associated With Exercise Studies in Type 1 Diabetes.
Colberg SR, Bevier WC, Pinsker JE, Lee JB, Ehrlich B, Dassau E, Doyle FJ 3rd, Chen KY, Kerr D.
J Diabetes Sci Technol (2016 Jul) 10:993-4. Abstract/Full Text
Influence of Day Length and Physical Activity on Sleep Patterns in Older Icelandic Men and Women.
Brychta RJ, Arnardottir NY, Johannsson E, Wright EC, Eiriksdottir G, Gudnason V, Marinac CR, Davis M, Koster A, Caserotti P, Sveinsson T, Harris T, Chen KY.
J Clin Sleep Med (2016 Feb) 12:203-13. Abstract/Full Text
Association of change in brain structure to objectively measured physical activity and sedentary behavior in older adults: Age, Gene/Environment Susceptibility-Reykjavik Study.
Arnardottir NY, Koster A, Domelen DRV, Brychta RJ, Caserotti P, Eiriksdottir G, Sverrisdottir JE, Sigurdsson S, Johannsson E, Chen KY, Gudnason V, Harris TB, Launer LJ, Sveinsson T.
Behav Brain Res (2016 Jan 1) 296:118-124. Abstract/Full Text
Concurrent and aerobic exercise training promote similar benefits in body composition and metabolic profiles in obese adolescents.
Monteiro PA, Chen KY, Lira FS, Saraiva BT, Antunes BM, Campos EZ, Freitas IF Jr.
Lipids Health Dis (2015 Nov 26) 14:153. Abstract/Full Text
Effects of Interrupting Children's Sedentary Behaviors With Activity on Metabolic Function: A Randomized Trial.
Belcher BR, Berrigan D, Papachristopoulou A, Brady SM, Bernstein SB, Brychta RJ, Hattenbach JD, Tigner IL Jr, Courville AB, Drinkard BE, Smith KP, Rosing DR, Wolters PL, Chen KY, Yanovski JA.
J Clin Endocrinol Metab (2015 Oct) 100:3735-43. Abstract/Full Text
Mindfulness and eating behavior in adolescent girls at risk for type 2 diabetes.
Pivarunas B, Kelly NR, Pickworth CK, Cassidy O, Radin RM, Shank LM, Vannucci A, Courville AB, Chen KY, Tanofsky-Kraff M, Yanovski JA, Shomaker LB.
Int J Eat Disord (2015 Sep) 48:563-9. Abstract/Full Text
Calorie for Calorie, Dietary Fat Restriction Results in More Body Fat Loss than Carbohydrate Restriction in People with Obesity.
Hall KD, Bemis T, Brychta R, Chen KY, Courville A, Crayner EJ, Goodwin S, Guo J, Howard L, Knuth ND, Miller BV 3rd, Prado CM, Siervo M, Skarulis MC, Walter M, Walter PJ, Yannai L.
Cell Metab (2015 Sep 1) 22:427-36. Abstract/Full Text
Does Visceral Fat Estimated by Dual-Energy X-ray Absorptiometry Independently Predict Cardiometabolic Risks in Adults?
Sasai H, Brychta RJ, Wood RP, Rothney MP, Zhao X, Skarulis MC, Chen KY.
J Diabetes Sci Technol (2015 Jul) 9:917-24. Abstract/Full Text
Ability of thigh-worn ActiGraph and activPAL monitors to classify posture and motion.
Steeves JA, Bowles HR, McClain JJ, Dodd KW, Brychta RJ, Wang J, Chen KY.
Med Sci Sports Exerc (2015 May) 47:952-9. Abstract/Full Text
Metabolic adaptation following massive weight loss is related to the degree of energy imbalance and changes in circulating leptin.
Knuth ND, Johannsen DL, Tamboli RA, Marks-Shulman PA, Huizenga R, Chen KY, Abumrad NN, Ravussin E, Hall KD.
Obesity (Silver Spring) (2014 Dec) 22:2563-9. Abstract/Full Text
Midlife determinants associated with sedentary behavior in old age.
van der Berg JD, Bosma H, Caserotti P, Eiriksdottir G, Arnardottir NY, Martin KR, Brychta RJ, Chen KY, Sveinsson T, Johannsson E, Launer LJ, Gudnason V, Jonsson PV, Stehouwer CD, Harris TB, Koster A.
Med Sci Sports Exerc (2014 Jul) 46:1359-65. Abstract/Full Text
Evolution of accelerometer methods for physical activity research.
Troiano RP, McClain JJ, Brychta RJ, Chen KY.
Br J Sports Med (2014 Jul) 48:1019-23. Abstract/Full Text
Changes in daily activity patterns with age in U.S. men and women: National Health and Nutrition Examination Survey 2003-04 and 2005-06.
Martin KR, Koster A, Murphy RA, Van Domelen DR, Hung MY, Brychta RJ, Chen KY, Harris TB.
J Am Geriatr Soc (2014 Jul) 62:1263-71. Abstract/Full Text
Separating bedtime rest from activity using waist or wrist-worn accelerometers in youth.
Tracy DJ, Xu Z, Choi L, Acra S, Chen KY, Buchowski MS.
PLoS One (2014) 9:e92512. Abstract/Full Text
Self-reported adherence to the physical activity recommendation and determinants of misperception in older adults.
Visser M, Brychta RJ, Chen KY, Koster A.
J Aging Phys Act (2014 Apr) 22:226-34. Abstract/Full Text
Is there a sex difference in accelerometer counts during walking in older adults?
Van Domelen DR, Caserotti P, Brychta RJ, Harris TB, Patel KV, Chen KY, Arnardóttir NÝ, Eirikdottir G, Launer LJ, Gudnason V, Sveinsson T, Jóhannsson E, Koster A.
J Phys Act Health (2014 Mar) 11:626-37. Abstract/Full Text
Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans.
Lee P, Linderman JD, Smith S, Brychta RJ, Wang J, Idelson C, Perron RM, Werner CD, Phan GQ, Kammula US, Kebebew E, Pacak K, Chen KY, Celi FS.
Cell Metab (2014 Feb 4) 19:302-9. Abstract/Full Text
Moderate weight loss is sufficient to affect thyroid hormone homeostasis and inhibit its peripheral conversion.
Agnihothri RV, Courville AB, Linderman JD, Smith S, Brychta R, Remaley A, Chen KY, Simchowitz L, Celi FS.
Thyroid (2014 Jan) 24:19-26. Abstract/Full Text
Randomized trial of nutrition education added to internet-based information and exercise at the work place for weight loss in a racially diverse population of overweight women.
Carnie A, Lin J, Aicher B, Leon B, Courville AB, Sebring NG, de Jesus J, Dellavalle DM, Fitzpatrick BD, Zalos G, Powell-Wiley TM, Chen KY, Cannon RO 3rd.
Nutr Diabetes (2013 Dec 23) 3:e98. Abstract/Full Text
Reduced insulin sensitivity in adults with pseudohypoparathyroidism type 1a.
Muniyappa R, Warren MA, Zhao X, Aney SC, Courville AB, Chen KY, Brychta RJ, Germain-Lee EL, Weinstein LS, Skarulis MC.
J Clin Endocrinol Metab (2013 Nov) 98:E1796-801. Abstract/Full Text
Metabolic effects of chronic cannabis smoking.
Muniyappa R, Sable S, Ouwerkerk R, Mari A, Gharib AM, Walter M, Courville A, Hall G, Chen KY, Volkow ND, Kunos G, Huestis MA, Skarulis MC.
Diabetes Care (2013 Aug) 36:2415-22. Abstract/Full Text
Measuring energy expenditure in clinical populations: rewards and challenges.
Psota T, Chen KY.
Eur J Clin Nutr (2013 May) 67:436-42. Abstract/Full Text
Cold-activated brown adipose tissue is an independent predictor of higher bone mineral density in women.
Lee P, Brychta RJ, Collins MT, Linderman J, Smith S, Herscovitch P, Millo C, Chen KY, Celi FS.
Osteoporos Int (2013 Apr) 24:1513-8. Abstract/Full Text
Objective measurements of daily physical activity patterns and sedentary behaviour in older adults: Age, Gene/Environment Susceptibility-Reykjavik Study.
Arnardottir NY, Koster A, Van Domelen DR, Brychta RJ, Caserotti P, Eiriksdottir G, Sverrisdottir JE, Launer LJ, Gudnason V, Johannsson E, Harris TB, Chen KY, Sveinsson T.
Age Ageing (2013 Mar) 42:222-9. Abstract/Full Text
Fatigability as a function of physical activity energy expenditure in older adults.
Buchowski MS, Simmons SF, Whitaker LE, Powers J, Beuscher L, Choi L, Ikizler TA, Chen K, Shnelle JF.
Age (Dordr) (2013 Feb) 35:179-87. Abstract/Full Text