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Cores & Support Services

NIDDK internal lab and branch staff have access to the cores and support services below. Cores and support services offer cutting-edge technology and consultative services that aim to improve research quality and cost efficiency.

Current NIH staff can view additional services through the NIH Collaborative Research Exchange (CREx) (login required).

Cores

Advanced Light Microscopy and Image Analysis Core
Provides NIDDK researchers and their collaborators with tools and training in the latest technologies and techniques associated with light microscopy (LM), particularly 3D fluorescence microscopy.

Advanced Mass Spectrometry Core
Assists NIDDK investigators with basic quality control, general problem solving, and discovery work using mass spectrometers.

Biotechnology Core
Specializes in large-scale production and purification of biological materials from various sources to advance research in fields such as vaccine development, drug development, and structural biology.

Clinical Laboratory Core
Collaborates with investigators from across the Clinical Research Program to provide sensitive, inexpensive, and reproducible analyses.

Clinical Mass Spectrometry Core
Collaborates with investigators from NIDDK and other institutes within NIH on quantitative mass spectrometry analyses.

Cryo-Electron Microscopy Core, NIDDK
Provides the NIDDK scientific community with equipment and training in preparing and imaging negative stain and Cryo-EM grids.

Cryo-Electron Microscopy Core, Multi-Institute
Provides the NHLBI, NIDDK, NIAMS, and NINDS scientific communities support in planning EM experiments, sample preparation and imaging, using equipment, and analyzing data.

Genomics Core
Provides next-generation sequencing (NGS) on a fee-for-service basis to the NIH community, with priority for NIDDK users.

Human Energy and Body Weight Regulation Core
Provides metabolic testing for the Metabolic Clinical Research Unit (MCRU) and throughout the NIH Clinical Center.

Mouse Metabolism Core
Supports NIDDK’s intramural investigators by characterizing and analyzing phenotypes of metabolic disease in genetically modified mice.

Support Services

Biostatistics Program
Provides advice to extramural and intramural NIDDK staff on the design and feasibility of proposed research studies and the conduct of ongoing studies.

Metabolic Clinical Research Unit
Supports clinical research protocols that focus on the regulation of human metabolism in healthy volunteers and patients with various metabolic conditions.

Laboratory of Animal Sciences Section
Provides support and guidance to the NIDDK’s intramural researchers for all phases of laboratory animal experimentation.

Mouse CRISPR/Cas9 Genome Editing Facility
Supports NIDDK intramural researchers in their efforts to generate genetically modified mice through CRISPR/Cas9 technology.

Regulatory Support Program
Provides regulatory support for all NIDDK-sponsored trials that require a U.S. or Canadian regulatory application for the use of an investigational drug or device in a clinical trial.

NIDDK Central Repository
Makes data and biospecimens from current and previously-funded NIDDK studies available to the broader scientific community.