- Assistant Professor of Medicine, Biomedical Engineering, and Surgery, Vanderbilt University, 1997-2006
- M.S., Vanderbilt University, 2002
- Ph.D., Vanderbilt University, 1997
The purpose of our research is to understand how human energy metabolism and physical activity are regulated, and how they impact diseases such as obesity.
My laboratory focuses on human energy metabolism as it relates to health and disease. We have developed advanced techniques such as the whole-room indirect calorimeters (also called respiration or metabolic chambers) that we use to measure the rate of energy expenditure at the minute-by-minute level and substrate oxidation for several hours or for several days. We can also simultaneously measure movement and physiological parameters in this well-controlled environment to study the impacts of physical activities, diets, medications, and environmental temperatures on energy metabolism, heart rate, and hormonal responses. Currently, my laboratory focuses on the cold-induced thermogenesis, brown adipose tissue, muscle and autonomic nervous system activities, and body and skin temperature in response to subtle changes in environmental temperature in different populations. Another area of interest is the effect of pharmacological and dietary interventions on human energy metabolism and obesity. We are also developing new technologies for measuring energy metabolism, body composition, sleep, and physical activity in humans.
Applying our Research
The obesity epidemic has increased the general interests in metabolism, physical activity, sleep, and diet. By studying both normal healthy volunteers, subjects who are obese, and patients who have metabolic conditions, we can better understand how energy balance is regulated. This may lead to better treatment and prevention strategies.
Need for Further Study
The dynamic responses of energy metabolism under different stimuli are not well understood.
- Quantification of the Capacity for Cold-Induced Thermogenesis in Young Men With and Without Obesity.
- Brychta RJ, Huang S, Wang J, Leitner BP, Hattenbach JD, Bell SL, Fletcher LA, Perron Wood R, Idelson CR, Duckworth CJ, McGehee S, Courville AB, Bernstein SB, Reitman ML, Cypess AM, Chen KY.
- J Clin Endocrinol Metab (2019 Oct 1) 104:4865-4878. Abstract/Full Text
- Opportunities and challenges in the therapeutic activation of human energy expenditure and thermogenesis to manage obesity.
- Chen KY, Brychta RJ, Abdul Sater Z, Cassimatis TM, Cero C, Fletcher LA, Israni NS, Johnson JW, Lea HJ, Linderman JD, O'Mara AE, Zhu KY, Cypess AM.
- J Biol Chem (2020 Feb 14) 295:1926-1942. Abstract/Full Text
Research in Plain Language
Like all animals, humans have to regulate energy usage or “metabolic rate” to perform functions. The food we take in provides us with fuel. In my laboratory, we have built specialized instruments that can accurately measure how many calories we use by measuring the air we breathe. From these studies, we can determine the amount of energy needed for resting or physical activities, and where the energy comes from. Energy can come from either fat or carbohydrates. We are also interested in studying how environmental factors, such as changes in environmental temperature, can alter our metabolic rates by changing metabolic activities of tissues such as the heart, muscle, and specially certain fat.