Mengli Cai, Ph.D.

Scientific Focus Areas: Molecular Biology and Biochemistry, Structural Biology


A selection of recent and significant publications can be viewed below.

The complete mitochondrial genome of Gryllotalpa unispina Saussure, 1874 (Orthoptera: Gryllotalpoidea: Gryllotalpidae).
Zhang Y, Shao D, Cai M, Yin H, Zhang D.
Mitochondrial DNA A DNA Mapp Seq Anal (2016) 27:159-60. Abstract/Full Text
Overexpression of p300 correlates with poor prognosis in patients with cutaneous squamous cell carcinoma.
Chen MK, Cai MY, Luo RZ, Tian X, Liao QM, Zhang XY, Han JD.
Br J Dermatol (2015 Jan) 172:111-9. Abstract/Full Text
The effect of L-bupivacaine on BIS levels in the maintenance doses of propofol and fentanyl during general anesthesia in Chinese people.
Li X, Cai M.
Drug Res (Stuttg) (2014 Dec) 64:675-9. Abstract/Full Text
The renoprotective effects of berberine via the EP4-Gαs-cAMP signaling pathway in different stages of diabetes in rats.
Yang Y, Ni W, Cai M, Tang L, Wei W.
J Recept Signal Transduct Res (2014 Dec) 34:445-55. Abstract/Full Text
Thoracic CT after peroral endoscopic myotomy for the treatment of achalasia.
Cai MY, Zhou PH, Yao LQ, Zhu BQ, Liang L, Li QL.
Gastrointest Endosc (2014 Dec) 80:1046-55. Abstract/Full Text
Seohaeicola nanhaiensis sp. nov., a moderately halophilic bacterium isolated from the benthic sediment of South China Sea.
Xie BS, Lv XL, Cai M, Tang YQ, Wang YN, Cui HL, Liu XY, Tan Y, Wu XL.
Curr Microbiol (2014 Dec) 69:802-8. Abstract/Full Text
Systemic lupus erythematosus patients in the low-latitude plateau of China: altitudinal influences.
Qian G, Ran X, Zhou CX, Deng DQ, Zhang PL, Guo Y, Luo JH, Zhou XH, Xie H, Cai M.
Lupus (2014 Dec) 23:1537-45. Abstract/Full Text
Heat shock protein 90 maintains the stability and function of transcription factor Broad Z7 by interacting with its Broad-Complex-Tramtrack-Bric-a-brac domain.
Cai MJ, Li XR, Pei XY, Liu W, Wang JX, Zhao XF.
Insect Mol Biol (2014 Dec) 23:720-32. Abstract/Full Text
The telomere/telomerase binding factor PinX1 regulates paclitaxel sensitivity depending on spindle assembly checkpoint in human cervical squamous cell carcinomas.
Tian XP, Qian D, He LR, Huang H, Mai SJ, Li CP, Huang XX, Cai MY, Liao YJ, Kung HF, Zeng YX, Xie D.
Cancer Lett (2014 Oct 10) 353:104-14. Abstract/Full Text
Immunosuppressive effect of compound K on islet transplantation in an STZ-induced diabetic mouse model.
Ma PF, Jiang J, Gao C, Cheng PP, Li JL, Huang X, Lin YY, Li Q, Peng YZ, Cai MC, Shao W, Zhu Q, Han S, Qin Q, Xia JJ, Qi ZQ.
Diabetes (2014 Oct) 63:3458-69. Abstract/Full Text
Potential toxicity of amphenicol antibiotic: binding of chloramphenicol to human serum albumin.
Chen H, Rao H, He P, Qiao Y, Wang F, Liu H, Cai M, Yao J.
Environ Sci Pollut Res Int (2014 Oct) 21:11340-8. Abstract/Full Text
Integrative metabolome and transcriptome profiling reveals discordant glycolysis process between osteosarcoma and normal osteoblastic cells.
Chen K, Zhu C, Cai M, Fu D, Cheng B, Cai Z, Li G, Liu J.
J Cancer Res Clin Oncol (2014 Oct) 140:1715-21. Abstract/Full Text
Overexpression of RFC3 is correlated with ovarian tumor development and poor prognosis.
Shen H, Cai M, Zhao S, Wang H, Li M, Yao S, Jiang N.
Tumour Biol (2014 Oct) 35:10259-66. Abstract/Full Text
Cloning, expression, purification, antiserum preparation and its characteristics of the truncated UL6 protein of herpes simplex virus 1.
Li M, Cui W, Mo C, Wang J, Zhao Z, Cai M.
Mol Biol Rep (2014 Sep) 41:5997-6002. Abstract/Full Text
Molecular modeling studies of atorvastatin analogues as HMGR inhibitors using 3D-QSAR, molecular docking and molecular dynamics simulations.
Wang Z, Cheng L, Kai Z, Wu F, Liu Z, Cai M.
Bioorg Med Chem Lett (2014 Aug 15) 24:3869-76. Abstract/Full Text
OsLOX2, a rice type I lipoxygenase, confers opposite effects on seed germination and longevity.
Huang J, Cai M, Long Q, Liu L, Lin Q, Jiang L, Chen S, Wan J.
Transgenic Res (2014 Aug) 23:643-55. Abstract/Full Text
Association of LEP A19G polymorphism with cancer risk: a systematic review and pooled analysis.
Liu P, Shi H, Huang C, Shu H, Liu R, Yang Y, Gong J, Yang Y, Cai M.
Tumour Biol (2014 Aug) 35:8133-41. Abstract/Full Text
DNA sequencing and CRISPR-Cas9 gene editing for target validation in mammalian cells.
Smurnyy Y, Cai M, Wu H, McWhinnie E, Tallarico JA, Yang Y, Feng Y.
Nat Chem Biol (2014 Aug) 10:623-5. Abstract/Full Text
Regulation of EGFR nanocluster formation by ionic protein-lipid interaction.
Wang Y, Gao J, Guo X, Tong T, Shi X, Li L, Qi M, Wang Y, Cai M, Jiang J, Xu C, Ji H, Wang H.
Cell Res (2014 Aug) 24:959-76. Abstract/Full Text
Spontaneous arteriovenous fistula of the superficial temporal artery: Diagnosis and treatment.
Yang M, Pan L, Cai MJ, Ma LT, Xu GZ, Li J, Chen G, Wu J, Huang SY, Wen YX.
Clin Neurol Neurosurg (2014 Aug) 123:18-24. Abstract/Full Text
CYR61 overexpression associated with the development and poor prognosis of ovarian carcinoma.
Shen H, Cai M, Zhao S, Wang H, Li M, Yao S, Jiang N.
Med Oncol (2014 Aug) 31:117. Abstract/Full Text
Core-shell-corona-structured polyelectrolyte brushes-grafting magnetic nanoparticles for water harvesting.
Liu G, Cai M, Wang X, Zhou F, Liu W.
ACS Appl Mater Interfaces (2014 Jul 23) 6:11625-32. Abstract/Full Text
NF-κB signaling and vesicle transport are correlated with the reactivation of the memory trace of morphine dependence.
Ye J, Yang Z, Li C, Cai M, Zhou D, Zhang Q, Wei Y, Wang T, Liu Y.
Diagn Pathol (2014 Jul 10) 9:142. Abstract/Full Text
Novel amphiphilic polymeric ionic liquid-solid phase micro-extraction membrane for the preconcentration of aniline as degradation product of azo dye Orange G under sonication by liquid chromatography-tandem mass spectrometry.
Cai MQ, Wei XQ, Du CH, Ma XM, Jin MC.
J Chromatogr A (2014 Jul 4) 1349:24-9. Abstract/Full Text
Boost up mobility of solution-processed metal oxide thin-film transistors via confining structure on electron pathways.
Rim YS, Chen H, Kou X, Duan HS, Zhou H, Cai M, Kim HJ, Yang Y.
Adv Mater (2014 Jul 2) 26:4273-8. Abstract/Full Text
Hepatocellular carcinoma with portal vein tumor thrombus: treatment with transarterial chemoembolization combined with sorafenib--a retrospective controlled study.
Zhu K, Chen J, Lai L, Meng X, Zhou B, Huang W, Cai M, Shan H.
Radiology (2014 Jul) 272:284-93. Abstract/Full Text
pH-Dependent accumulation of anticancer compound on mycelia in fermentation of marine fungus.
Zhou W, Cai M, Na K, Shen C, Zhang X, Zhou X, Zhao W, Zhang Y.
J Ind Microbiol Biotechnol (2014 Jul) 41:1169-73. Abstract/Full Text
A cyclin-like protein, ClgA, regulates development in Aspergillus nidulans.
Yu Z, Cai M, Hu W, Zhang Y, Zhou J, Zhou X, Zhang Y.
Res Microbiol (2014 Jul-Aug) 165:462-7. Abstract/Full Text
Fast Response, vertically oriented graphene nanosheet electric double layer capacitors synthesized from C(2)H(2).
Cai M, Outlaw RA, Quinlan RA, Premathilake D, Butler SM, Miller JR.
ACS Nano (2014 Jun 24) 8:5873-82. Abstract/Full Text
Response to letter regarding article, "dysregulation of hydrogen sulfide (H2S) producing enzyme cystathionine γ-lyase (CSE) contributes to maternal hypertension and placental abnormalities in preeclampsia".
Wang K, Ahmad S, Cai M, Rennie J, Fujisawa T, Crispi F, Baily J, Miller MR, Cudmore M, Hadoke PW, Wang R, Gratacós E, Buhimschi IA, Buhimschi CS, Ahmed A.
Circulation (2014 Jun 3) 129:e517-8. Abstract/Full Text
Inhibiting enhancer of zeste homolog 2 promotes cellular senescence in gastric cancer cells SGC-7901 by activation of p21 and p16.
Bai J, Chen J, Ma M, Cai M, Xu F, Wang G, Tao K, Shuai X.
DNA Cell Biol (2014 Jun) 33:337-44. Abstract/Full Text
Inhibition of ovarian cancer cell proliferation by Pien Tze Huang via the AKT-mTOR pathway.
He F, Wu HN, Cai MY, Li CP, Zhang X, Wan Q, Tang SB, Cheng JD.
Oncol Lett (2014 Jun) 7:2047-2052. Abstract/Full Text
Genetically shaping morphology of the filamentous fungus Aspergillus glaucus for production of antitumor polyketide aspergiolide A.
Cai M, Zhang Y, Hu W, Shen W, Yu Z, Zhou W, Jiang T, Zhou X, Zhang Y.
Microb Cell Fact (2014 May 20) 13:73. Abstract/Full Text
Chiral selection and frequency response of spiral waves in reaction-diffusion systems under a chiral electric field.
Li BW, Cai MC, Zhang H, Panfilov AV, Dierckx H.
J Chem Phys (2014 May 14) 140:184901. Abstract/Full Text
Phospholipase Cγ1 connects the cell membrane pathway to the nuclear receptor pathway in insect steroid hormone signaling.
Liu W, Cai MJ, Zheng CC, Wang JX, Zhao XF.
J Biol Chem (2014 May 9) 289:13026-41. Abstract/Full Text
Charged polymer brushes-grafted hollow silica nanoparticles as a novel promising material for simultaneous joint lubrication and treatment.
Liu G, Cai M, Zhou F, Liu W.
J Phys Chem B (2014 May 8) 118:4920-31. Abstract/Full Text
The prognostic effect of perineural invasion in esophageal squamous cell carcinoma.
Chen JW, Xie JD, Ling YH, Li P, Yan SM, Xi SY, Luo RZ, Yun JP, Xie D, Cai MY.
BMC Cancer (2014 May 5) 14:313. Abstract/Full Text
Expression of CD147 and Lewis y antigen in ovarian cancer and their relationship to drug resistance.
Gao J, Hu Z, Liu J, Liu D, Wang Y, Cai M, Zhang D, Tan M, Lin B.
Med Oncol (2014 May) 31:920. Abstract/Full Text
Application of a novel intraorally customized transport distraction device in the reconstruction of segmental mandibular defect.
Cai M, Lu X, Yang D, Cheng H, Shen G.
J Craniofac Surg (2014 May) 25:1015-8. Abstract/Full Text
[High risk indication of postoperative chemotherapy 
in early stage non-small cell lung cancer].
Mao F, Pan Y, Li Z, Cai M, Shen-Tu Y.
Zhongguo Fei Ai Za Zhi (2014 May) 17:411-6. Abstract/Full Text
A novel electrospun nerve conduit enhanced by carbon nanotubes for peripheral nerve regeneration.
Yu W, Jiang X, Cai M, Zhao W, Ye D, Zhou Y, Zhu C, Zhang X, Lu X, Zhang Z.
Nanotechnology (2014 Apr 25) 25:165102. Abstract/Full Text
Synthesis of indolyl imidazole derivatives via base-promoted tandem reaction of N-[2-(1-alkynyl)phenyl]carbodiimides with isocyanides.
Hao W, Jiang Y, Cai M.
J Org Chem (2014 Apr 18) 79:3634-40. Abstract/Full Text
[Clinical analysis of 156 patients with gastrointestinal stromal tumors receiving imatinib therapy].
Zhang L, Cai M, Deng J, Wang X, Wang B, Liu N, Pan Y, Zhang R, Cui Q, Liang H.
Zhonghua Wei Chang Wai Ke Za Zhi (2014 Apr) 17:331-4. Abstract/Full Text
Molecular cloning and characterization of pseudorabies virus EP0 gene.
Li ML, Cui W, Zhao ZY, Mo CC, Wang JL, Chen YL, Cai MS.
Indian J Biochem Biophys (2014 Apr) 51:100-14. Abstract/Full Text
Beclin 1 expression in ovarian tissues and its effects on ovarian cancer prognosis.
Cai M, Hu Z, Liu J, Gao J, Liu C, Liu D, Tan M, Zhang D, Lin B.
Int J Mol Sci (2014 Mar 26) 15:5292-303. Abstract/Full Text
The impact of COX-2 on invasion of osteosarcoma cell and its mechanism of regulation.
Wu X, Cai M, Ji F, Lou LM.
Cancer Cell Int (2014) 14:27. Abstract/Full Text
Molecular cloning and characterization of the pseudorabies virus UL31 gene.
Li ML, Zhao ZY, Cui W, Mo CC, Wang JL, Cai MS.
Genet Mol Res (2014 Mar 17) 13:1832-47. Abstract/Full Text
[Clinical diagnosis and therapy strategies of lung metastasis].
Cai M, Shen-Tu Y.
Zhongguo Fei Ai Za Zhi (2014 Mar) 17:282-5. Abstract/Full Text
[The application of mediastinoscopy in the differential diagnosis and preoperative staging on lung cancer].
Mao F, Zhang L, Cai M, Ding Z, Shen-Tu Y.
Zhongguo Fei Ai Za Zhi (2014 Feb) 17:171-4. Abstract/Full Text
Clinical features and outcomes of 210 patients with idiopathic pulmonary fibrosis.
Cai M, Zhu M, Ban C, Su J, Ye Q, Liu Y, Zhao W, Wang C, Dai H.
Chin Med J (Engl) (2014) 127:1868-73. Abstract/Full Text