Ross Cheloha, Ph.D., Stadtman Tenure-Track Investigator
Photo of Dr. Ross Cheloha.
Scientific Focus Areas: Chemical Biology, Immunology, Cell Biology, Biomedical Engineering and Biophysics, Molecular Biology and Biochemistry

Publications

A selection of recent and significant publications can be viewed below.

Exploring cellular biochemistry with nanobodies.
Cheloha RW, Harmand TJ, Wijne C, Schwartz TU, Ploegh HL.
J Biol Chem (2020 Nov 6) 295:15307-15327. Abstract/Full Text
In vivo detection of antigen-specific CD8+ T cells by immuno-positron emission tomography.
Woodham AW, Zeigler SH, Zeyang EL, Kolifrath SC, Cheloha RW, Rashidian M, Chaparro RJ, Seidel RD, Garforth SJ, Dearling JL, Mesyngier M, Duddempudi PK, Packard AB, Almo SC, Ploegh HL.
Nat Methods (2020 Oct) 17:1025-1032. Abstract/Full Text
Improved GPCR ligands from nanobody tethering.
Cheloha RW, Fischer FA, Woodham AW, Daley E, Suminski N, Gardella TJ, Ploegh HL.
Nat Commun (2020 Apr 29) 11:2087. Abstract/Full Text
A nanobody that recognizes a 14-residue peptide epitope in the E2 ubiquitin-conjugating enzyme UBC6e modulates its activity.
Ling J, Cheloha RW, McCaul N, Sun ZJ, Wagner G, Ploegh HL.
Mol Immunol (2019 Oct) 114:513-523. Abstract/Full Text
Recognition of Class II MHC Peptide Ligands That Contain β-Amino Acids.
Cheloha RW, Woodham AW, Bousbaine D, Wang T, Liu S, Sidney J, Sette A, Gellman SH, Ploegh HL.
J Immunol (2019 Sep 15) 203:1619-1628. Abstract/Full Text
Internalization of Influenza Virus and Cell Surface Proteins Monitored by Site-Specific Conjugation of Protease-Sensitive Probes.
Cheloha RW, Li Z, Bousbaine D, Woodham AW, Perrin P, Volarić J, Ploegh HL.
ACS Chem Biol (2019 Aug 16) 14:1836-1844. Abstract/Full Text
Receptor selectivity from minimal backbone modification of a polypeptide agonist.
Liu S, Cheloha RW, Watanabe T, Gardella TJ, Gellman SH.
Proc Natl Acad Sci U S A (2018 Dec 4) 115:12383-12388. Abstract/Full Text
Nanobody-Antigen Conjugates Elicit HPV-Specific Antitumor Immune Responses.
Woodham AW, Cheloha RW, Ling J, Rashidian M, Kolifrath SC, Mesyngier M, Duarte JN, Bader JM, Skeate JG, Da Silva DM, Kast WM, Ploegh HL.
Cancer Immunol Res (2018 Jul) 6:870-880. Abstract/Full Text
Development of Potent, Protease-Resistant Agonists of the Parathyroid Hormone Receptor with Broad β Residue Distribution.
Cheloha RW, Chen B, Kumar NN, Watanabe T, Thorne RG, Li L, Gardella TJ, Gellman SH.
J Med Chem (2017 Nov 9) 60:8816-8833. Abstract/Full Text
Rapid capture and labeling of cells on single domain antibodies-functionalized flow cell.
Chen GY, Li Z, Duarte JN, Esteban A, Cheloha RW, Theile CS, Fink GR, Ploegh HL.
Biosens Bioelectron (2017 Mar 15) 89:789-794. Abstract/Full Text
Backbone Modification of a Parathyroid Hormone Receptor-1 Antagonist/Inverse Agonist.
Cheloha RW, Watanabe T, Dean T, Gellman SH, Gardella TJ.
ACS Chem Biol (2016 Oct 21) 11:2752-2762. Abstract/Full Text
PTH receptor-1 signalling-mechanistic insights and therapeutic prospects.
Cheloha RW, Gellman SH, Vilardaga JP, Gardella TJ.
Nat Rev Endocrinol (2015 Dec) 11:712-24. Abstract/Full Text
Consequences of periodic α-to-β(3) residue replacement for immunological recognition of peptide epitopes.
Cheloha RW, Sullivan JA, Wang T, Sand JM, Sidney J, Sette A, Cook ME, Suresh M, Gellman SH.
ACS Chem Biol (2015 Mar 20) 10:844-54. Abstract/Full Text
Backbone modification of a polypeptide drug alters duration of action in vivo.
Cheloha RW, Maeda A, Dean T, Gardella TJ, Gellman SH.
Nat Biotechnol (2014 Jul) 32:653-5. Abstract/Full Text
A new dehydrogenase from Clostridium acetobutylicum for asymmetric synthesis: dynamic reductive kinetic resolution entry into the Taxotère side chain.
Applegate GA, Cheloha RW, Nelson DL, Berkowitz DB.
Chem Commun (Camb) (2011 Feb 28) 47:2420-2. Abstract/Full Text