Using chemical biology to develop new tools to interrogate cell surface proteins and their signaling

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Highly biased agonism for GPCR ligands via nanobody tethering.
Sachdev S, Creemer BA, Gardella TJ, Cheloha RW.
Nat Commun (2024 Jun 1) 15:4687. Abstract/Full Text
Nanobody-Based Bioconjugates as Potent and Broadly Active Inhibitors of HIV Entry.
Saha SJ, Kumariya R, Davis PA, Tourtellott E, Doria-Rose N, Bewley CA, Cheloha RW.
J Am Chem Soc (2026 Feb 11) 148:5793-5806. Abstract/Full Text
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Last Reviewed February 2025