Min Chen, M.D., Ph.D.


A selection of recent and significant publications can be viewed below.

The stimulatory G protein Gsα is required in melanocortin 4 receptor-expressing cells for normal energy balance, thermogenesis, and glucose metabolism.
Podyma B, Sun H, Wilson EA, Carlson B, Pritikin E, Gavrilova O, Weinstein LS, Chen M.
J Biol Chem (2018 Jul 13) 293:10993-11005. Abstract/Full Text
Gsα deficiency in the dorsomedial hypothalamus underlies obesity associated with Gsα mutations.
Chen M, Shrestha YB, Podyma B, Cui Z, Naglieri B, Sun H, Ho T, Wilson EA, Li YQ, Gavrilova O, Weinstein LS.
J Clin Invest (2017 Feb 1) 127:500-510. Abstract/Full Text
Gsα Deficiency in the Ventromedial Hypothalamus Enhances Leptin Sensitivity and Improves Glucose Homeostasis in Mice on a High-Fat Diet.
Berger A, Kablan A, Yao C, Ho T, Podyma B, Weinstein LS, Chen M.
Endocrinology (2016 Feb) 157:600-10. Abstract/Full Text
Inactivation of a Gα(s)-PKA tumour suppressor pathway in skin stem cells initiates basal-cell carcinogenesis.
Iglesias-Bartolome R, Torres D, Marone R, Feng X, Martin D, Simaan M, Chen M, Weinstein LS, Taylor SS, Molinolo AA, Gutkind JS.
Nat Cell Biol (2015 Jun) 17:793-803. Abstract/Full Text
G-protein stimulatory subunit alpha and Gq/11α G-proteins are both required to maintain quiescent stem-like chondrocytes.
Chagin AS, Vuppalapati KK, Kobayashi T, Guo J, Hirai T, Chen M, Offermanns S, Weinstein LS, Kronenberg HM.
Nat Commun (2014 Apr 30) 5:3673. Abstract/Full Text
Activation of Hedgehog signaling by loss of GNAS causes heterotopic ossification.
Regard JB, Malhotra D, Gvozdenovic-Jeremic J, Josey M, Chen M, Weinstein LS, Lu J, Shore EM, Kaplan FS, Yang Y.
Nat Med (2013 Nov) 19:1505-12. Abstract/Full Text
Agonist-independent GPCR activity regulates anterior-posterior targeting of olfactory sensory neurons.
Nakashima A, Takeuchi H, Imai T, Saito H, Kiyonari H, Abe T, Chen M, Weinstein LS, Yu CR, Storm DR, Nishizumi H, Sakano H.
Cell (2013 Sep 12) 154:1314-25. Abstract/Full Text
Myelopoiesis is regulated by osteocytes through Gsα-dependent signaling.
Fulzele K, Krause DS, Panaroni C, Saini V, Barry KJ, Liu X, Lotinun S, Baron R, Bonewald L, Feng JQ, Chen M, Weinstein LS, Wu JY, Kronenberg HM, Scadden DT, Divieti Pajevic P.
Blood (2013 Feb 7) 121:930-9. Abstract/Full Text
Gsα deficiency in the paraventricular nucleus of the hypothalamus partially contributes to obesity associated with Gsα mutations.
Chen M, Berger A, Kablan A, Zhang J, Gavrilova O, Weinstein LS.
Endocrinology (2012 Sep) 153:4256-65. Abstract/Full Text
Impaired glucose tolerance in the absence of adenosine A1 receptor signaling.
Faulhaber-Walter R, Jou W, Mizel D, Li L, Zhang J, Kim SM, Huang Y, Chen M, Briggs JP, Gavrilova O, Schnermann JB.
Diabetes (2011 Oct) 60:2578-87. Abstract/Full Text
Improved fatigue resistance in Gsα-deficient and aging mouse skeletal muscles due to adaptive increases in slow fibers.
Feng HZ, Chen M, Weinstein LS, Jin JP.
J Appl Physiol (1985) (2011 Sep) 111:834-43. Abstract/Full Text
Absence of the glucagon-like peptide-1 receptor does not affect the metabolic phenotype of mice with liver-specific G(s)α deficiency.
Chen M, Mema E, Kelleher J, Nemechek N, Berger A, Wang J, Xie T, Gavrilova O, Drucker DJ, Weinstein LS.
Endocrinology (2011 Sep) 152:3343-50. Abstract/Full Text
Gsα enhances commitment of mesenchymal progenitors to the osteoblast lineage but restrains osteoblast differentiation in mice.
Wu JY, Aarnisalo P, Bastepe M, Sinha P, Fulzele K, Selig MK, Chen M, Poulton IJ, Purton LE, Sims NA, Weinstein LS, Kronenberg HM.
J Clin Invest (2011 Sep) 121:3492-504. Abstract/Full Text
Effects of deficiency of the G protein Gsα on energy and glucose homeostasis.
Chen M, Nemechek NM, Mema E, Wang J, Weinstein LS.
Eur J Pharmacol (2011 Jun 11) 660:119-24. Abstract/Full Text
Pancreas-specific Gsalpha deficiency has divergent effects on pancreatic alpha- and beta-cell proliferation.
Xie T, Chen M, Weinstein LS.
J Endocrinol (2010 Sep) 206:261-9. Abstract/Full Text
Stimulation of renin secretion by angiotensin II blockade is Gsalpha-dependent.
Chen L, Kim SM, Eisner C, Oppermann M, Huang Y, Mizel D, Li L, Chen M, Sequeira Lopez ML, Weinstein LS, Gomez RA, Schnermann J, Briggs JP.
J Am Soc Nephrol (2010 Jun) 21:986-92. Abstract/Full Text
G(s)alpha deficiency in adipose tissue leads to a lean phenotype with divergent effects on cold tolerance and diet-induced thermogenesis.
Chen M, Chen H, Nguyen A, Gupta D, Wang J, Lai EW, Pacak K, Gavrilova O, Quon MJ, Weinstein LS.
Cell Metab (2010 Apr 7) 11:320-30. Abstract/Full Text
The role of GNAS and other imprinted genes in the development of obesity.
Weinstein LS, Xie T, Qasem A, Wang J, Chen M.
Int J Obes (Lond) (2010 Jan) 34:6-17. Abstract/Full Text
Renal failure in mice with Gsalpha deletion in juxtaglomerular cells.
Chen L, Faulhaber-Walter R, Wen Y, Huang Y, Mizel D, Chen M, Sequeira Lopez ML, Weinstein LS, Gomez RA, Briggs JP, Schnermann J.
Am J Nephrol (2010) 32:83-94. Abstract/Full Text
Central nervous system imprinting of the G protein G(s)alpha and its role in metabolic regulation.
Chen M, Wang J, Dickerson KE, Kelleher J, Xie T, Gupta D, Lai EW, Pacak K, Gavrilova O, Weinstein LS.
Cell Metab (2009 Jun) 9:548-55. Abstract/Full Text
Haematopoietic stem cells depend on Galpha(s)-mediated signalling to engraft bone marrow.
Adams GB, Alley IR, Chung UI, Chabner KT, Jeanson NT, Lo Celso C, Marsters ES, Chen M, Weinstein LS, Lin CP, Kronenberg HM, Scadden DT.
Nature (2009 May 7) 459:103-7. Abstract/Full Text
Development of vascular renin expression in the kidney critically depends on the cyclic AMP pathway.
Neubauer B, Machura K, Chen M, Weinstein LS, Oppermann M, Sequeira-Lopez ML, Gomez RA, Schnermann J, Castrop H, Kurtz A, Wagner C.
Am J Physiol Renal Physiol (2009 May) 296:F1006-12. Abstract/Full Text
G(s)alpha deficiency in skeletal muscle leads to reduced muscle mass, fiber-type switching, and glucose intolerance without insulin resistance or deficiency.
Chen M, Feng HZ, Gupta D, Kelleher J, Dickerson KE, Wang J, Hunt D, Jou W, Gavrilova O, Jin JP, Weinstein LS.
Am J Physiol Cell Physiol (2009 Apr) 296:C930-40. Abstract/Full Text
Removal of the N-terminal extension of cardiac troponin I as a functional compensation for impaired myocardial beta-adrenergic signaling.
Feng HZ, Chen M, Weinstein LS, Jin JP.
J Biol Chem (2008 Nov 28) 283:33384-93. Abstract/Full Text
Severe obesity and insulin resistance due to deletion of the maternal Gsalpha allele is reversed by paternal deletion of the Gsalpha imprint control region.
Xie T, Chen M, Gavrilova O, Lai EW, Liu J, Weinstein LS.
Endocrinology (2008 May) 149:2443-50. Abstract/Full Text
Beta cell-specific deficiency of the stimulatory G protein alpha-subunit Gsalpha leads to reduced beta cell mass and insulin-deficient diabetes.
Xie T, Chen M, Zhang QH, Ma Z, Weinstein LS.
Proc Natl Acad Sci U S A (2007 Dec 4) 104:19601-6. Abstract/Full Text
Regulation of renin in mice with Cre recombinase-mediated deletion of G protein Gsalpha in juxtaglomerular cells.
Chen L, Kim SM, Oppermann M, Faulhaber-Walter R, Huang Y, Mizel D, Chen M, Lopez ML, Weinstein LS, Gomez RA, Briggs JP, Schnermann J.
Am J Physiol Renal Physiol (2007 Jan) 292:F27-37. Abstract/Full Text
Increased glucose tolerance and reduced adiposity in the absence of fasting hypoglycemia in mice with liver-specific Gs alpha deficiency.
Chen M, Gavrilova O, Zhao WQ, Nguyen A, Lorenzo J, Shen L, Nackers L, Pack S, Jou W, Weinstein LS.
J Clin Invest (2005 Nov) 115:3217-27. Abstract/Full Text
Deficiency of the G-protein alpha-subunit G(s)alpha in osteoblasts leads to differential effects on trabecular and cortical bone.
Sakamoto A, Chen M, Nakamura T, Xie T, Karsenty G, Weinstein LS.
J Biol Chem (2005 Jun 3) 280:21369-75. Abstract/Full Text
Alternative Gnas gene products have opposite effects on glucose and lipid metabolism.
Chen M, Gavrilova O, Liu J, Xie T, Deng C, Nguyen AT, Nackers LM, Lorenzo J, Shen L, Weinstein LS.
Proc Natl Acad Sci U S A (2005 May 17) 102:7386-91. Abstract/Full Text
Identification of the control region for tissue-specific imprinting of the stimulatory G protein alpha-subunit.
Liu J, Chen M, Deng C, Bourc'his D, Nealon JG, Erlichman B, Bestor TH, Weinstein LS.
Proc Natl Acad Sci U S A (2005 Apr 12) 102:5513-8. Abstract/Full Text
Increased insulin sensitivity in paternal Gnas knockout mice is associated with increased lipid clearance.
Chen M, Haluzik M, Wolf NJ, Lorenzo J, Dietz KR, Reitman ML, Weinstein LS.
Endocrinology (2004 Sep) 145:4094-102. Abstract/Full Text
Tissue-specific imprinting of the G protein Gsalpha is associated with tissue-specific differences in histone methylation.
Sakamoto A, Liu J, Greene A, Chen M, Weinstein LS.
Hum Mol Genet (2004 Apr 15) 13:819-28. Abstract/Full Text
Increased insulin sensitivity in Gsalpha knockout mice.
Yu S, Castle A, Chen M, Lee R, Takeda K, Weinstein LS.
J Biol Chem (2001 Jun 8) 276:19994-8. Abstract/Full Text
Transient gene expression from yeast artificial chromosome DNA in mammalian cells is enhanced by adenovirus.
Chen M, Compton ST, Coviello VF, Green ED, Ashlock MA.
Nucleic Acids Res (1997 Nov 1) 25:4416-8. Abstract/Full Text
Renin and renin mRNA in proximal tubules of the rat kidney.
Chen M, Harris MP, Rose D, Smart A, He XR, Kretzler M, Briggs JP, Schnermann J.
J Clin Invest (1994 Jul) 94:237-43. Abstract/Full Text
Cyclic AMP selectively increases renin mRNA stability in cultured juxtaglomerular granular cells.
Chen M, Schnermann J, Smart AM, Brosius FC, Killen PD, Briggs JP.
J Biol Chem (1993 Nov 15) 268:24138-44. Abstract/Full Text
Endothelin-1 mRNA in glomerular and epithelial cells of kidney.
Chen M, Todd-Turla K, Wang WH, Cao X, Smart A, Brosius FC, Killen PD, Keiser JA, Briggs JP, Schnermann J.
Am J Physiol (1993 Oct) 265:F542-50. Abstract/Full Text
Time course of stimulation of renal renin messenger RNA by furosemide.
Chen M, Schnermann J, Malvin RL, Killen PD, Briggs JP.
Hypertension (1993 Jan) 21:36-41. Abstract/Full Text
Naloxone prevents increased vascular sensitivity in Goldblatt hypertensive rats.
Chen M, Webb RC, Malvin RL.
Clin Exp Hypertens A (1990) 12:1361-76. Abstract/Full Text
Clonidine and morphine increase atrial natriuretic peptide secretion in anesthetized rats.
Chen M, Lee J, Huang BS, Grekin RJ, Malvin RL.
Proc Soc Exp Biol Med (1989 Jul) 191:299-303. Abstract/Full Text
Central administration of aldosterone increases blood pressure in rats.
Chen M, Lee J, Malvin RL.
Clin Exp Hypertens A (1989) 11:459-72. Abstract/Full Text
Naloxone attenuates development of hypertension in two-kidney one-clip Goldblatt rats.
Chen M, Lee JG, Malvin RL, Huang BS.
Am J Physiol (1988 Dec) 255:E839-42. Abstract/Full Text