Weiping Chen, Ph.D.

Staff Scientist: Genomics Core

Scientific Focus Areas: Genetics and Genomics, Molecular Biology and Biochemistry, Clinical Research, Cell Biology, Computational Biology

weipingchen@niddk.nih.gov Add to Contacts

Publications

A selection of recent and significant publications can be viewed below.

Susceptibility to kidney fibrosis in mice is associated with early growth response-2 protein and tissue inhibitor of metalloproteinase-1 expression.

Kökény G, Németh Á, Kopp JB, Chen W, Oler AJ, Manzéger A, Rosivall L, Mózes MM.

Kidney Int (2022 Aug) 102:337-354. Abstract/Full Text

Salt-Inducible Kinase 1 is a potential therapeutic target in Desmoplastic Small Round Cell Tumor.

Hartono AB, Kang HJ, Shi L, Phipps W, Ungerleider N, Giardina A, Chen W, Spraggon L, Somwar R, Moroz K, Drewry DH, Burow ME, Flemington E, Ladanyi M, Lee SB.

Oncogenesis (2022 Apr 20) 11:18. Abstract/Full Text

Sirt1 deficiency upregulates glutathione metabolism to prevent hepatocellular carcinoma initiation in mice.

Qiu P, Hou W, Wang H, Lei KKW, Wang S, Chen W, Pardeshi LA, Prothro K, Shukla Y, Su SSM, Schrump DS, Chen Q, Deng CX, Xu X, Wang R.

Oncogene (2021 Oct) 40:6023-6033. Abstract/Full Text

The metabolic footprint during adipocyte commitment highlights ceramide modulation as an adequate approach for obesity treatment.

Hou W, Chen Q, Wang H, Qiu P, Lyu X, Chen W, Chua MLK, Chinn YE, Deng CX, Wang R.

EBioMedicine (2020 Jan) 51:102605. Abstract/Full Text

BRCA1 represses DNA replication initiation through antagonizing estrogen signaling and maintains genome stability in parallel with WEE1-MCM2 signaling during pregnancy.

Xu X, Chen E, Mo L, Zhang L, Shao F, Miao K, Liu J, Su SM, Valecha M, Chan UI, Zheng H, Chen M, Chen W, Chen Q, Fu H, Aladjem MI, He Y, Deng CX.

Hum Mol Genet (2019 Mar 1) 28:842-857. Abstract/Full Text

TGF-β receptor 1 regulates progenitors that promote browning of white fat.

Wankhade UD, Lee JH, Dagur PK, Yadav H, Shen M, Chen W, Kulkarni AB, McCoy JP, Finkel T, Cypess AM, Rane SG.

Mol Metab (2018 Oct) 16:160-171. Abstract/Full Text

Hepatitis B Virus Deregulates the Cell Cycle To Promote Viral Replication and a Premalignant Phenotype.

Xia Y, Cheng X, Li Y, Valdez K, Chen W, Liang TJ.

J Virol (2018 Oct 1) 92. Abstract/Full Text

Molecular Changes of Lung Malignancy in HIV Infection.

Zheng J, Wang L, Cheng Z, Pei Z, Zhang Z, Li Z, Zhang X, Yan D, Xia Q, Feng Y, Song Y, Chen W, Zhang X, Xu J, Wang J.

Sci Rep (2018 Sep 3) 8:13128. Abstract/Full Text

Targeting Notch1 and IKKα Enhanced NF-κB Activation in CD133(+) Skin Cancer Stem Cells.

Quan XX, Hawk NV, Chen W, Coupar J, Lee SK, Petersen DW, Meltzer PS, Montemarano A, Braun M, Chen Z, Van Waes C.

Mol Cancer Ther (2018 Sep) 17:2034-2048. Abstract/Full Text

O-GlcNAc in cancer: An Oncometabolism-fueled vicious cycle.

Hanover JA, Chen W, Bond MR.

J Bioenerg Biomembr (2018 Jun) 50:155-173. Abstract/Full Text

Mesenchyme homeobox 1 mediates transforming growth factor-β (TGF-β)-induced smooth muscle cell differentiation from mouse mesenchymal progenitors.

Dong K, Guo X, Chen W, Hsu AC, Shao Q, Chen JF, Chen SY.

J Biol Chem (2018 Jun 1) 293:8712-8719. Abstract/Full Text

SIRT6 Is Essential for Adipocyte Differentiation by Regulating Mitotic Clonal Expansion.

Chen Q, Hao W, Xiao C, Wang R, Xu X, Lu H, Chen W, Deng CX.

Cell Rep (2017 Mar 28) 18:3155-3166. Abstract/Full Text

Ammonium tetrathiomolybdate treatment targets the copper transporter ATP7A and enhances sensitivity of breast cancer to cisplatin.

Chisholm CL, Wang H, Wong AH, Vazquez-Ortiz G, Chen W, Xu X, Deng CX.

Oncotarget (2016 Dec 20) 7:84439-84452. Abstract/Full Text

EZH1 and EZH2 promote skeletal growth by repressing inhibitors of chondrocyte proliferation and hypertrophy.

Lui JC, Garrison P, Nguyen Q, Ad M, Keembiyehetty C, Chen W, Jee YH, Landman E, Nilsson O, Barnes KM, Baron J.

Nat Commun (2016 Nov 29) 7:13685. Abstract/Full Text

Olfactomedin 4 deletion induces colon adenocarcinoma in Apc(Min/+) mice.

Liu W, Li H, Hong SH, Piszczek GP, Chen W, Rodgers GP.

Oncogene (2016 Oct 6) 35:5237-5247. Abstract/Full Text

Negative reciprocal regulation between Sirt1 and Per2 modulates the circadian clock and aging.

Wang RH, Zhao T, Cui K, Hu G, Chen Q, Chen W, Wang XW, Soto-Gutierrez A, Zhao K, Deng CX.

Sci Rep (2016 Jun 27) 6:28633. Abstract/Full Text

Sphingosine-1-phosphate Phosphatase 2 Regulates Pancreatic Islet β-Cell Endoplasmic Reticulum Stress and Proliferation.

Taguchi Y, Allende ML, Mizukami H, Cook EK, Gavrilova O, Tuymetova G, Clarke BA, Chen W, Olivera A, Proia RL.

J Biol Chem (2016 Jun 3) 291:12029-38. Abstract/Full Text

Olfactomedin 4 deficiency promotes prostate neoplastic progression and is associated with upregulation of the hedgehog-signaling pathway.

Li H, Liu W, Chen W, Zhu J, Deng CX, Rodgers GP.

Sci Rep (2015 Nov 19) 5:16974. Abstract/Full Text

Polyamines Stimulate the Level of the σ38 Subunit (RpoS) of Escherichia coli RNA Polymerase, Resulting in the Induction of the Glutamate Decarboxylase-dependent Acid Response System via the gadE Regulon.

Chattopadhyay MK, Keembiyehetty CN, Chen W, Tabor H.

J Biol Chem (2015 Jul 17) 290:17809-17821. Abstract/Full Text

Identification of Wnt Pathway Target Genes Regulating the Division and Differentiation of Larval Seam Cells and Vulval Precursor Cells in Caenorhabditis elegans.

Gorrepati L, Krause MW, Chen W, Brodigan TM, Correa-Mendez M, Eisenmann DM.

G3 (Bethesda) (2015 Jun 5) 5:1551-66. Abstract/Full Text

Spatial regulation of gene expression during growth of articular cartilage in juvenile mice.

Lui JC, Chau M, Chen W, Cheung CS, Hanson J, Rodriguez-Canales J, Nilsson O, Baron J.

Pediatr Res (2015 Mar) 77:406-15. Abstract/Full Text

Enhancing mammary differentiation by overcoming lineage-specific epigenetic modification and signature gene expression of fibroblast-derived iPSCs.

Li Y, Hong N, Zhang A, Chen W, Wang RH, Xu XL, Deng CX.

Cell Death Dis (2014 Dec 4) 5:e1550. Abstract/Full Text

Podocyte injury caused by indoxyl sulfate, a uremic toxin and aryl-hydrocarbon receptor ligand.

Ichii O, Otsuka-Kanazawa S, Nakamura T, Ueno M, Kon Y, Chen W, Rosenberg AZ, Kopp JB.

PLoS One (2014) 9:e108448. Abstract/Full Text

Synergistic therapeutic effect of cisplatin and phosphatidylinositol 3-kinase (PI3K) inhibitors in cancer growth and metastasis of Brca1 mutant tumors.

Vassilopoulos A, Xiao C, Chisholm C, Chen W, Xu X, Lahusen TJ, Bewley C, Deng CX.

J Biol Chem (2014 Aug 29) 289:24202-14. Abstract/Full Text

EWS-WT1 oncoprotein activates neuronal reprogramming factor ASCL1 and promotes neural differentiation.

Kang HJ, Park JH, Chen W, Kang SI, Moroz K, Ladanyi M, Lee SB.

Cancer Res (2014 Aug 15) 74:4526-35. Abstract/Full Text

Genome-wide analyses reveal the extent of opportunistic STAT5 binding that does not yield transcriptional activation of neighboring genes.

Zhu BM, Kang K, Yu JH, Chen W, Smith HE, Lee D, Sun HW, Wei L, Hennighausen L.

Nucleic Acids Res (2012 May) 40:4461-72. Abstract/Full Text

HCV infection induces a unique hepatic innate immune response associated with robust production of type III interferons.

Thomas E, Gonzalez VD, Li Q, Modi AA, Chen W, Noureddin M, Rotman Y, Liang TJ.

Gastroenterology (2012 Apr) 142:978-88. Abstract/Full Text

Protection from obesity and diabetes by blockade of TGF-β/Smad3 signaling.

Yadav H, Quijano C, Kamaraju AK, Gavrilova O, Malek R, Chen W, Zerfas P, Zhigang D, Wright EC, Stuelten C, Sun P, Lonning S, Skarulis M, Sumner AE, Finkel T, Rane SG.

Cell Metab (2011 Jul 6) 14:67-79. Abstract/Full Text

The transcription factors signal transducer and activator of transcription 5A (STAT5A) and STAT5B negatively regulate cell proliferation through the activation of cyclin-dependent kinase inhibitor 2b (Cdkn2b) and Cdkn1a expression.

Yu JH, Zhu BM, Wickre M, Riedlinger G, Chen W, Hosui A, Robinson GW, Hennighausen L.

Hepatology (2010 Nov) 52:1808-18. Abstract/Full Text

The gene encoding the hematopoietic stem cell regulator CCN3/NOV is under direct cytokine control through the transcription factors STAT5A/B.

Kimura 木村丹香子 A, Martin C, Robinson GW, Simone JM, Chen W, Wickre MC, O'Shea JJ, Hennighausen L.

J Biol Chem (2010 Oct 22) 285:32704-32709. Abstract/Full Text

Changes in gene expression associated with aging commonly originate during juvenile growth.

Lui JC, Chen W, Barnes KM, Baron J.

Mech Ageing Dev (2010 Oct) 131:641-9. Abstract/Full Text

Coordinated postnatal down-regulation of multiple growth-promoting genes: evidence for a genetic program limiting organ growth.

Lui JC, Forcinito P, Chang M, Chen W, Barnes KM, Baron J.

FASEB J (2010 Aug) 24:3083-92. Abstract/Full Text

Spatial and temporal regulation of gene expression in the mammalian growth plate.

Lui JC, Andrade AC, Forcinito P, Hegde A, Chen W, Baron J, Nilsson O.

Bone (2010 May) 46:1380-90. Abstract/Full Text

The transcription factors STAT5A/B regulate GM-CSF-mediated granulopoiesis.

Kimura A, Rieger MA, Simone JM, Chen W, Wickre MC, Zhu BM, Hoppe PS, O'Shea JJ, Schroeder T, Hennighausen L.

Blood (2009 Nov 19) 114:4721-8. Abstract/Full Text

Development of mammary luminal progenitor cells is controlled by the transcription factor STAT5A.

Yamaji D, Na R, Feuermann Y, Pechhold S, Chen W, Robinson GW, Hennighausen L.

Genes Dev (2009 Oct 15) 23:2382-7. Abstract/Full Text

Microarray studies on the genes responsive to the addition of spermidine or spermine to a Saccharomyces cerevisiae spermidine synthase mutant.

Chattopadhyay MK, Chen W, Poy G, Cam M, Stiles D, Tabor H.

Yeast (2009 Oct) 26:531-44. Abstract/Full Text

Hepatic gene expression during treatment with peginterferon and ribavirin: Identifying molecular pathways for treatment response.

Feld JJ, Nanda S, Huang Y, Chen W, Cam M, Pusek SN, Schweigler LM, Theodore D, Zacks SL, Liang TJ, Fried MW.

Hepatology (2007 Nov) 46:1548-63. Abstract/Full Text

The effect of temperature on gene silencing by siRNAs: implications for silencing in the anterior chamber of the eye.

Russell P, Walsh E, Chen W, Goldwich A, Tamm ER.

Exp Eye Res (2006 Jun) 82:1011-6. Abstract/Full Text

The rat arylalkylamine N-acetyltransferase E-box: differential use in a master vs. a slave oscillator.

Chen W, Baler R.

Brain Res Mol Brain Res (2000 Sep 30) 81:43-50. Abstract/Full Text

Ischemic preconditioning activates phosphatidylinositol-3-kinase upstream of protein kinase C.

Tong H, Chen W, Steenbergen C, Murphy E.

Circ Res (2000 Aug 18) 87:309-15. Abstract/Full Text

Identification of a methylation imprint mark within the mouse Gnas locus.

Liu J, Yu S, Litman D, Chen W, Weinstein LS.

Mol Cell Biol (2000 Aug) 20:5808-17. Abstract/Full Text

Age-related decline in Ras/ERK mitogen-activated protein kinase cascade is linked to a reduced association between Shc and EGF receptor.

Hutter D, Yo Y, Chen W, Liu P, Holbrook NJ, Roth GS, Liu Y.

J Gerontol A Biol Sci Med Sci (2000 Mar) 55:B125-34. Abstract/Full Text

Dissecting the multifactorial causes of immunodominance in class I-restricted T cell responses to viruses.

Chen W, Antón LC, Bennink JR, Yewdell JW.

Immunity (2000 Jan) 12:83-93. Abstract/Full Text

The antiapoptotic gene mcl-1 is up-regulated by the phosphatidylinositol 3-kinase/Akt signaling pathway through a transcription factor complex containing CREB.

Wang JM, Chao JR, Chen W, Kuo ML, Yen JJ, Yang-Yen HF.

Mol Cell Biol (1999 Sep) 19:6195-206. Abstract/Full Text

Modification of cysteine residues in vitro and in vivo affects the immunogenicity and antigenicity of major histocompatibility complex class I-restricted viral determinants.

Chen W, Yewdell JW, Levine RL, Bennink JR.

J Exp Med (1999 Jun 7) 189:1757-64. Abstract/Full Text

The 100-kDa proteolytic fragment of RB is retained predominantly within the nuclear compartment of apoptotic cells.

Chen WD, Geradts J, Keane MM, Lipkowitz S, Zajac-Kaye M, Kaye FJ.

Mol Cell Biol Res Commun (1999 Jun) 1:216-20. Abstract/Full Text