Weiping Chen, Ph.D.

Staff Scientist: Genomics Core, Cores and Support Services

Scientific Focus Areas: Genetics and Genomics, Molecular Biology and Biochemistry, Clinical Research, Cell Biology, Computational Biology

weipingchen@niddk.nih.gov 301-496-0175 Add to Contacts

Publications

A selection of recent and significant publications can be viewed below.

The metabolic footprint during adipocyte commitment highlights ceramide modulation as an adequate approach for obesity treatment.

Hou W, Chen Q, Wang H, Qiu P, Lyu X, Chen W, Chua MLK, Chinn YE, Deng CX, Wang R.

EBioMedicine (2020 Jan) 51:102605. Abstract/Full Text

BRCA1 represses DNA replication initiation through antagonizing estrogen signaling and maintains genome stability in parallel with WEE1-MCM2 signaling during pregnancy.

Xu X, Chen E, Mo L, Zhang L, Shao F, Miao K, Liu J, Su SM, Valecha M, Chan UI, Zheng H, Chen M, Chen W, Chen Q, Fu H, Aladjem MI, He Y, Deng CX.

Hum Mol Genet (2019 Mar 1) 28:842-857. Abstract/Full Text

TGF-β receptor 1 regulates progenitors that promote browning of white fat.

Wankhade UD, Lee JH, Dagur PK, Yadav H, Shen M, Chen W, Kulkarni AB, McCoy JP, Finkel T, Cypess AM, Rane SG.

Mol Metab (2018 Oct) 16:160-171. Abstract/Full Text

Hepatitis B Virus Deregulates the Cell Cycle To Promote Viral Replication and a Premalignant Phenotype.

Xia Y, Cheng X, Li Y, Valdez K, Chen W, Liang TJ.

J Virol (2018 Oct 1) 92. Abstract/Full Text

Molecular Changes of Lung Malignancy in HIV Infection.

Zheng J, Wang L, Cheng Z, Pei Z, Zhang Z, Li Z, Zhang X, Yan D, Xia Q, Feng Y, Song Y, Chen W, Zhang X, Xu J, Wang J.

Sci Rep (2018 Sep 3) 8:13128. Abstract/Full Text

Targeting Notch1 and IKKα Enhanced NF-κB Activation in CD133⁺ Skin Cancer Stem Cells.

Quan XX, Hawk NV, Chen W, Coupar J, Lee SK, Petersen DW, Meltzer PS, Montemarano A, Braun M, Chen Z, Van Waes C.

Mol Cancer Ther (2018 Sep) 17:2034-2048. Abstract/Full Text

O-GlcNAc in cancer: An Oncometabolism-fueled vicious cycle.

Hanover JA, Chen W, Bond MR.

J Bioenerg Biomembr (2018 Jun) 50:155-173. Abstract/Full Text

Mesenchyme homeobox 1 mediates transforming growth factor-β (TGF-β)-induced smooth muscle cell differentiation from mouse mesenchymal progenitors.

Dong K, Guo X, Chen W, Hsu AC, Shao Q, Chen JF, Chen SY.

J Biol Chem (2018 Jun 1) 293:8712-8719. Abstract/Full Text

SIRT6 Is Essential for Adipocyte Differentiation by Regulating Mitotic Clonal Expansion.

Chen Q, Hao W, Xiao C, Wang R, Xu X, Lu H, Chen W, Deng CX.

Cell Rep (2017 Mar 28) 18:3155-3166. Abstract/Full Text

Ammonium tetrathiomolybdate treatment targets the copper transporter ATP7A and enhances sensitivity of breast cancer to cisplatin.

Chisholm CL, Wang H, Wong AH, Vazquez-Ortiz G, Chen W, Xu X, Deng CX.

Oncotarget (2016 Dec 20) 7:84439-84452. Abstract/Full Text

EZH1 and EZH2 promote skeletal growth by repressing inhibitors of chondrocyte proliferation and hypertrophy.

Lui JC, Garrison P, Nguyen Q, Ad M, Keembiyehetty C, Chen W, Jee YH, Landman E, Nilsson O, Barnes KM, Baron J.

Nat Commun (2016 Nov 29) 7:13685. Abstract/Full Text

Olfactomedin 4 deletion induces colon adenocarcinoma in Apc^Min/+ mice.

Liu W, Li H, Hong SH, Piszczek GP, Chen W, Rodgers GP.

Oncogene (2016 Oct 6) 35:5237-5247. Abstract/Full Text

Negative reciprocal regulation between Sirt1 and Per2 modulates the circadian clock and aging.

Wang RH, Zhao T, Cui K, Hu G, Chen Q, Chen W, Wang XW, Soto-Gutierrez A, Zhao K, Deng CX.

Sci Rep (2016 Jun 27) 6:28633. Abstract/Full Text

Sphingosine-1-phosphate Phosphatase 2 Regulates Pancreatic Islet β-Cell Endoplasmic Reticulum Stress and Proliferation.

Taguchi Y, Allende ML, Mizukami H, Cook EK, Gavrilova O, Tuymetova G, Clarke BA, Chen W, Olivera A, Proia RL.

J Biol Chem (2016 Jun 3) 291:12029-38. Abstract/Full Text

Olfactomedin 4 deficiency promotes prostate neoplastic progression and is associated with upregulation of the hedgehog-signaling pathway.

Li H, Liu W, Chen W, Zhu J, Deng CX, Rodgers GP.

Sci Rep (2015 Nov 19) 5:16974. Abstract/Full Text

Polyamines Stimulate the Level of the σ38 Subunit (RpoS) of Escherichia coli RNA Polymerase, Resulting in the Induction of the Glutamate Decarboxylase-dependent Acid Response System via the gadE Regulon.

Chattopadhyay MK, Keembiyehetty CN, Chen W, Tabor H.

J Biol Chem (2015 Jul 17) 290:17809-17821. Abstract/Full Text

Identification of Wnt Pathway Target Genes Regulating the Division and Differentiation of Larval Seam Cells and Vulval Precursor Cells in Caenorhabditis elegans.

Gorrepati L, Krause MW, Chen W, Brodigan TM, Correa-Mendez M, Eisenmann DM.

G3 (Bethesda) (2015 Jun 5) 5:1551-66. Abstract/Full Text

Spatial regulation of gene expression during growth of articular cartilage in juvenile mice.

Lui JC, Chau M, Chen W, Cheung CS, Hanson J, Rodriguez-Canales J, Nilsson O, Baron J.

Pediatr Res (2015 Mar) 77:406-15. Abstract/Full Text

Enhancing mammary differentiation by overcoming lineage-specific epigenetic modification and signature gene expression of fibroblast-derived iPSCs.

Li Y, Hong N, Zhang A, Chen W, Wang RH, Xu XL, Deng CX.

Cell Death Dis (2014 Dec 4) 5:e1550. Abstract/Full Text

Podocyte injury caused by indoxyl sulfate, a uremic toxin and aryl-hydrocarbon receptor ligand.

Ichii O, Otsuka-Kanazawa S, Nakamura T, Ueno M, Kon Y, Chen W, Rosenberg AZ, Kopp JB.

PLoS One (2014) 9:e108448. Abstract/Full Text

Synergistic therapeutic effect of cisplatin and phosphatidylinositol 3-kinase (PI3K) inhibitors in cancer growth and metastasis of Brca1 mutant tumors.

Vassilopoulos A, Xiao C, Chisholm C, Chen W, Xu X, Lahusen TJ, Bewley C, Deng CX.

J Biol Chem (2014 Aug 29) 289:24202-14. Abstract/Full Text

EWS-WT1 oncoprotein activates neuronal reprogramming factor ASCL1 and promotes neural differentiation.

Kang HJ, Park JH, Chen W, Kang SI, Moroz K, Ladanyi M, Lee SB.

Cancer Res (2014 Aug 15) 74:4526-35. Abstract/Full Text

HCV infection induces a unique hepatic innate immune response associated with robust production of type III interferons.

Thomas E, Gonzalez VD, Li Q, Modi AA, Chen W, Noureddin M, Rotman Y, Liang TJ.

Gastroenterology (2012 Apr) 142:978-88. Abstract/Full Text