Weiping Chen, Ph.D.
Staff Scientist:
Genomics Core, Cores and Support Services
Scientific Focus Areas: Genetics and Genomics, Molecular Biology and Biochemistry, Clinical Research, Cell Biology, Computational Biology
Publications
A selection of recent and significant publications can be viewed below.
- TGF-β receptor 1 regulates progenitors that promote browning of white fat.
- Wankhade UD, Lee JH, Dagur PK, Yadav H, Shen M, Chen W, Kulkarni AB, McCoy JP, Finkel T, Cypess AM, Rane SG.
- Mol Metab (2018 Oct) 16:160-171. Abstract/Full Text
- Hepatitis B Virus Deregulates the Cell Cycle To Promote Viral Replication and a Premalignant Phenotype.
- Xia Y, Cheng X, Li Y, Valdez K, Chen W, Liang TJ.
- J Virol (2018 Oct 1) 92. Abstract/Full Text
- Molecular Changes of Lung Malignancy in HIV Infection.
- Zheng J, Wang L, Cheng Z, Pei Z, Zhang Z, Li Z, Zhang X, Yan D, Xia Q, Feng Y, Song Y, Chen W, Zhang X, Xu J, Wang J.
- Sci Rep (2018 Sep 3) 8:13128. Abstract/Full Text
- Targeting Notch1 and IKKα Enhanced NF-κB Activation in CD133+ Skin Cancer Stem Cells.
- Quan XX, Hawk NV, Chen W, Coupar J, Lee SK, Petersen DW, Meltzer PS, Montemarano A, Braun M, Chen Z, Van Waes C.
- Mol Cancer Ther (2018 Sep) 17:2034-2048. Abstract/Full Text
- O-GlcNAc in cancer: An Oncometabolism-fueled vicious cycle.
- Hanover JA, Chen W, Bond MR.
- J Bioenerg Biomembr (2018 Jun) 50:155-173. Abstract/Full Text
- Mesenchyme homeobox 1 mediates transforming growth factor-β (TGF-β)-induced smooth muscle cell differentiation from mouse mesenchymal progenitors.
- Dong K, Guo X, Chen W, Hsu AC, Shao Q, Chen JF, Chen SY.
- J Biol Chem (2018 Jun 1) 293:8712-8719. Abstract/Full Text
- SIRT6 Is Essential for Adipocyte Differentiation by Regulating Mitotic Clonal Expansion.
- Chen Q, Hao W, Xiao C, Wang R, Xu X, Lu H, Chen W, Deng CX.
- Cell Rep (2017 Mar 28) 18:3155-3166. Abstract/Full Text
- Ammonium tetrathiomolybdate treatment targets the copper transporter ATP7A and enhances sensitivity of breast cancer to cisplatin.
- Chisholm CL, Wang H, Wong AH, Vazquez-Ortiz G, Chen W, Xu X, Deng CX.
- Oncotarget (2016 Dec 20) 7:84439-84452. Abstract/Full Text
- EZH1 and EZH2 promote skeletal growth by repressing inhibitors of chondrocyte proliferation and hypertrophy.
- Lui JC, Garrison P, Nguyen Q, Ad M, Keembiyehetty C, Chen W, Jee YH, Landman E, Nilsson O, Barnes KM, Baron J.
- Nat Commun (2016 Nov 29) 7:13685. Abstract/Full Text
- Olfactomedin 4 deletion induces colon adenocarcinoma in ApcMin/+ mice.
- Liu W, Li H, Hong SH, Piszczek GP, Chen W, Rodgers GP.
- Oncogene (2016 Oct 6) 35:5237-5247. Abstract/Full Text
- Negative reciprocal regulation between Sirt1 and Per2 modulates the circadian clock and aging.
- Wang RH, Zhao T, Cui K, Hu G, Chen Q, Chen W, Wang XW, Soto-Gutierrez A, Zhao K, Deng CX.
- Sci Rep (2016 Jun 27) 6:28633. Abstract/Full Text
- Sphingosine-1-phosphate Phosphatase 2 Regulates Pancreatic Islet β-Cell Endoplasmic Reticulum Stress and Proliferation.
- Taguchi Y, Allende ML, Mizukami H, Cook EK, Gavrilova O, Tuymetova G, Clarke BA, Chen W, Olivera A, Proia RL.
- J Biol Chem (2016 Jun 3) 291:12029-38. Abstract/Full Text
- Olfactomedin 4 deficiency promotes prostate neoplastic progression and is associated with upregulation of the hedgehog-signaling pathway.
- Li H, Liu W, Chen W, Zhu J, Deng CX, Rodgers GP.
- Sci Rep (2015 Nov 19) 5:16974. Abstract/Full Text
- Polyamines Stimulate the Level of the σ38 Subunit (RpoS) of Escherichia coli RNA Polymerase, Resulting in the Induction of the Glutamate Decarboxylase-dependent Acid Response System via the gadE Regulon.
- Chattopadhyay MK, Keembiyehetty CN, Chen W, Tabor H.
- J Biol Chem (2015 Jul 17) 290:17809-21. Abstract/Full Text
- Identification of Wnt Pathway Target Genes Regulating the Division and Differentiation of Larval Seam Cells and Vulval Precursor Cells in Caenorhabditis elegans.
- Gorrepati L, Krause MW, Chen W, Brodigan TM, Correa-Mendez M, Eisenmann DM.
- G3 (Bethesda) (2015 Jun 5) 5:1551-66. Abstract/Full Text
- Spatial regulation of gene expression during growth of articular cartilage in juvenile mice.
- Lui JC, Chau M, Chen W, Cheung CS, Hanson J, Rodriguez-Canales J, Nilsson O, Baron J.
- Pediatr Res (2015 Mar) 77:406-15. Abstract/Full Text
- Enhancing mammary differentiation by overcoming lineage-specific epigenetic modification and signature gene expression of fibroblast-derived iPSCs.
- Li Y, Hong N, Zhang A, Chen W, Wang RH, Xu XL, Deng CX.
- Cell Death Dis (2014 Dec 4) 5:e1550. Abstract/Full Text
- Podocyte injury caused by indoxyl sulfate, a uremic toxin and aryl-hydrocarbon receptor ligand.
- Ichii O, Otsuka-Kanazawa S, Nakamura T, Ueno M, Kon Y, Chen W, Rosenberg AZ, Kopp JB.
- PLoS One (2014) 9:e108448. Abstract/Full Text
- Synergistic therapeutic effect of cisplatin and phosphatidylinositol 3-kinase (PI3K) inhibitors in cancer growth and metastasis of Brca1 mutant tumors.
- Vassilopoulos A, Xiao C, Chisholm C, Chen W, Xu X, Lahusen TJ, Bewley C, Deng CX.
- J Biol Chem (2014 Aug 29) 289:24202-14. Abstract/Full Text
- EWS-WT1 oncoprotein activates neuronal reprogramming factor ASCL1 and promotes neural differentiation.
- Kang HJ, Park JH, Chen W, Kang SI, Moroz K, Ladanyi M, Lee SB.
- Cancer Res (2014 Aug 15) 74:4526-35. Abstract/Full Text