Hoi Sung Chung, Ph.D.

Acting Section Chief: Single-Molecule Biophysics Section, Laboratory of Chemical Physics

Scientific Focus Areas: Biomedical Engineering and Biophysics, Structural Biology

chunghoi@niddk.nih.gov 301-496-0202 Add to Contacts

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Publications

A selection of recent and significant publications can be viewed below.

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Disordered proteins follow diverse transition paths as they fold and bind to a partner.

Kim JY, Chung HS.

Science (2020 Jun 12) 368:1253-1257. Abstract/Full Text

Fast three-color single-molecule FRET using statistical inference.

Yoo J, Kim JY, Louis JM, Gopich IV, Chung HS.

Nat Commun (2020 Jul 3) 11:3336. Abstract/Full Text

Diffusion-limited association of disordered protein by non-native electrostatic interactions.

Kim JY, Meng F, Yoo J, Chung HS.

Nat Commun (2018 Nov 9) 9:4707. Abstract/Full Text

Highly Disordered Amyloid-β Monomer Probed by Single-Molecule FRET and MD Simulation.

Meng F, Bellaiche MMJ, Kim JY, Zerze GH, Best RB, Chung HS.

Biophys J (2018 Feb 27) 114:870-884. Abstract/Full Text

Oligomerization of the tetramerization domain of p53 probed by two- and three-color single-molecule FRET.

Chung HS, Meng F, Kim JY, McHale K, Gopich IV, Louis JM.

Proc Natl Acad Sci U S A (2017 Aug 15) 114:E6812-E6821. Abstract/Full Text

Additional Publications

Probing the mechanism of inhibition of amyloid-β(1-42)-induced neurotoxicity by the chaperonin GroEL.

Wälti MA, Steiner J, Meng F, Chung HS, Louis JM, Ghirlando R, Tugarinov V, Nath A, Clore GM.

Proc Natl Acad Sci U S A (2018 Dec 18) 115:E11924-E11932. Abstract/Full Text

Protein folding transition path times from single molecule FRET.

Chung HS, Eaton WA.

Curr Opin Struct Biol (2018 Feb) 48:30-39. Abstract/Full Text

Structural origin of slow diffusion in protein folding.

Chung HS, Piana-Agostinetti S, Shaw DE, Eaton WA.

Science (2015 Sep 25) 349:1504-10. Abstract/Full Text

Testing Landscape Theory for Biomolecular Processes with Single Molecule Fluorescence Spectroscopy.

Truex K, Chung HS, Louis JM, Eaton WA.

Phys Rev Lett (2015 Jul 3) 115:018101. Abstract/Full Text

Fast single-molecule FRET spectroscopy: theory and experiment.

Chung HS, Gopich IV.

Phys Chem Chem Phys (2014 Sep 21) 16:18644-57. Abstract/Full Text

Single-molecule fluorescence probes dynamics of barrier crossing.

Chung HS, Eaton WA.

Nature (2013 Oct 31) 502:685-8. Abstract/Full Text

Measuring ultrafast protein folding rates from photon-by-photon analysis of single molecule fluorescence trajectories.

Chung HS, Cellmer T, Louis JM, Eaton WA.

Chem Phys (2013 Aug 30) 422:229-237. Abstract/Full Text

Solution structure of the ESCRT-I and -II supercomplex: implications for membrane budding and scission.

Boura E, Różycki B, Chung HS, Herrick DZ, Canagarajah B, Cafiso DS, Eaton WA, Hummer G, Hurley JH.

Structure (2012 May 9) 20:874-86. Abstract/Full Text

Single-molecule fluorescence experiments determine protein folding transition path times.

Chung HS, McHale K, Louis JM, Eaton WA.

Science (2012 Feb 24) 335:981-4. Abstract/Full Text

Solution structure of the ESCRT-I complex by small-angle X-ray scattering, EPR, and FRET spectroscopy.

Boura E, Rózycki B, Herrick DZ, Chung HS, Vecer J, Eaton WA, Cafiso DS, Hummer G, Hurley JH.

Proc Natl Acad Sci U S A (2011 Jun 7) 108:9437-42. Abstract/Full Text

Extracting rate coefficients from single-molecule photon trajectories and FRET efficiency histograms for a fast-folding protein.

Chung HS, Gopich IV, McHale K, Cellmer T, Louis JM, Eaton WA.

J Phys Chem A (2011 Apr 28) 115:3642-56. Abstract/Full Text

Distinguishing between protein dynamics and dye photophysics in single-molecule FRET experiments.

Chung HS, Louis JM, Eaton WA.

Biophys J (2010 Feb 17) 98:696-706. Abstract/Full Text

Experimental determination of upper bound for transition path times in protein folding from single-molecule photon-by-photon trajectories.

Chung HS, Louis JM, Eaton WA.

Proc Natl Acad Sci U S A (2009 Jul 21) 106:11837-44. Abstract/Full Text

Probing the folding transition state of ubiquitin mutants by temperature-jump-induced downhill unfolding.

Chung HS, Shandiz A, Sosnick TR, Tokmakoff A.

Biochemistry (2008 Dec 30) 47:13870-7. Abstract/Full Text

Temperature-dependent downhill unfolding of ubiquitin. II. Modeling the free energy surface.

Chung HS, Tokmakoff A.

Proteins (2008 Jul) 72:488-97. Abstract/Full Text

Temperature-dependent downhill unfolding of ubiquitin. I. Nanosecond-to-millisecond resolved nonlinear infrared spectroscopy.

Chung HS, Tokmakoff A.

Proteins (2008 Jul) 72:474-87. Abstract/Full Text

Amide I two-dimensional infrared spectroscopy of proteins.

Ganim Z, Chung HS, Smith AW, Deflores LP, Jones KC, Tokmakoff A.

Acc Chem Res (2008 Mar) 41:432-41. Abstract/Full Text

Transient 2D IR spectroscopy of ubiquitin unfolding dynamics.

Chung HS, Ganim Z, Jones KC, Tokmakoff A.

Proc Natl Acad Sci U S A (2007 Sep 4) 104:14237-42. Abstract/Full Text

Transient two-dimensional IR spectrometer for probing nanosecond temperature-jump kinetics.

Chung HS, Khalil M, Smith AW, Tokmakoff A.

Rev Sci Instrum (2007 Jun) 78:063101. Abstract/Full Text

The anharmonic vibrational potential and relaxation pathways of the amide I and II modes of N-methylacetamide.

DeFlores LP, Ganim Z, Ackley SF, Chung HS, Tokmakoff A.

J Phys Chem B (2006 Sep 28) 110:18973-80. Abstract/Full Text

Visualization and characterization of the infrared active amide I vibrations of proteins.

Chung HS, Tokmakoff A.

J Phys Chem B (2006 Feb 16) 110:2888-98. Abstract/Full Text

Residual native structure in a thermally denatured beta-hairpin.

Smith AW, Chung HS, Ganim Z, Tokmakoff A.

J Phys Chem B (2005 Sep 15) 109:17025-7. Abstract/Full Text

Conformational changes during the nanosecond-to-millisecond unfolding of ubiquitin.

Chung HS, Khalil M, Smith AW, Ganim Z, Tokmakoff A.

Proc Natl Acad Sci U S A (2005 Jan 18) 102:612-7. Abstract/Full Text

Two-dimensional infrared spectroscopy of antiparallel beta-sheet secondary structure.

Demirdöven N, Cheatum CM, Chung HS, Khalil M, Knoester J, Tokmakoff A.

J Am Chem Soc (2004 Jun 30) 126:7981-90. Abstract/Full Text