Ann Dean, Ph.D.

Section Chief: Gene Regulation and Development Section, Laboratory of Cellular & Developmental Biology

Scientific Focus Areas: Chromosome Biology, Developmental Biology, Genetics and Genomics, Molecular Biology and Biochemistry, Stem Cell Biology

ann.dean@nih.gov 301-496-6068 Add to Contacts

View My Lab

Publications

A selection of recent and significant publications can be viewed below.

Select Publications

Long noncoding RNA GATA2AS influences human erythropoiesis by transcription factor and chromatin landscape regulation.

Liu G, Kim J, Nguyen NH, Zhou L, Dean A.

Blood (2024 Mar 6) Abstract/Full Text

Hemogen/BRG1 cooperativity modulates promoter and enhancer activation during erythropoiesis.

Guo X, Zhao Y, Kim J, Dean A.

Blood (2022 Jun 16) 139:3532-3545. Abstract/Full Text

Enhancers navigate the three-dimensional genome to direct cell fate decisions.

Kim J, Dean A.

Curr Opin Struct Biol (2021 Dec) 71:101-109. Abstract/Full Text

Embryonic erythropoiesis and hemoglobin switching require transcriptional repressor ETO2 to modulate chromatin organization.

Guo X, Plank-Bazinet J, Krivega I, Dale RK, Dean A.

Nucleic Acids Res (2020 Oct 9) 48:10226-10240. Abstract/Full Text

Enhancers, gene regulation, and genome organization.

Dean A, Larson DR, Sartorelli V.

Genes Dev (2021 Apr 1) 35:427-432. Abstract/Full Text

Additional Publications

An enhancer RNA recruits MLL1 to regulate transcription of Myb.

Kim J, Diaz LF, Miller MJ, Leadem B, Krivega I, Dean A.

bioRxiv (2023 Oct 12) Abstract/Full Text

Enhancer looping protein LDB1 regulates hepatocyte gene expression by cooperating with liver transcription factors.

Liu G, Wang L, Wess J, Dean A.

Nucleic Acids Res (2022 Sep 9) 50:9195-9211. Abstract/Full Text

A Zinc Finger Transcription Factor Faithfully Dedicated to Only a Single Target Gene in Erythroid Cells.

Kim J, Dean A.

Mol Cell (2021 Jan 21) 81:218-219. Abstract/Full Text

Crystal structure of human LDB1 in complex with SSBP2.

Wang H, Kim J, Wang Z, Yan XX, Dean A, Xu W.

Proc Natl Acad Sci U S A (2020 Jan 14) 117:1042-1048. Abstract/Full Text

LDB1-mediated enhancer looping can be established independent of mediator and cohesin.

Krivega I, Dean A.

Nucleic Acids Res (2017 Aug 21) 45:8255-8268. Abstract/Full Text

A tetrad of chromatin interactions for chromosome pairing in X inactivation.

Krivega I, Dean A.

Nat Struct Mol Biol (2017 Aug 3) 24:607-608. Abstract/Full Text

CTCF fences make good neighbours.

Krivega I, Dean A.

Nat Cell Biol (2017 Jul 28) 19:883-885. Abstract/Full Text

The LDB1 Complex Co-opts CTCF for Erythroid Lineage-Specific Long-Range Enhancer Interactions.

Lee J, Krivega I, Dale RK, Dean A.

Cell Rep (2017 Jun 20) 19:2490-2502. Abstract/Full Text

Chromatin looping as a target for altering erythroid gene expression.

Krivega I, Dean A.

Ann N Y Acad Sci (2016 Mar) 1368:31-9. Abstract/Full Text

Inhibition of G9a methyltransferase stimulates fetal hemoglobin production by facilitating LCR/γ-globin looping.

Krivega I, Byrnes C, de Vasconcellos JF, Lee YT, Kaushal M, Dean A, Miller JL.

Blood (2015 Jul 30) 126:665-72. Abstract/Full Text

Chromosome togetherness at the onset of ESC differentiation.

Krivega I, Dean A.

Cell Stem Cell (2015 Mar 5) 16:213-4. Abstract/Full Text

Reactivation of developmentally silenced globin genes by forced chromatin looping.

Deng W, Rupon JW, Krivega I, Breda L, Motta I, Jahn KS, Reik A, Gregory PD, Rivella S, Dean A, Blobel GA.

Cell (2014 Aug 14) 158:849-860. Abstract/Full Text

Enhancer function: mechanistic and genome-wide insights come together.

Plank JL, Dean A.

Mol Cell (2014 Jul 3) 55:5-14. Abstract/Full Text

Role of LDB1 in the transition from chromatin looping to transcription activation.

Krivega I, Dale RK, Dean A.

Genes Dev (2014 Jun 15) 28:1278-90. Abstract/Full Text

The hematopoietic regulator TAL1 is required for chromatin looping between the β-globin LCR and human γ-globin genes to activate transcription.

Yun WJ, Kim YW, Kang Y, Lee J, Dean A, Kim A.

Nucleic Acids Res (2014 Apr) 42:4283-93. Abstract/Full Text

Ldb1-nucleated transcription complexes function as primary mediators of global erythroid gene activation.

Li L, Freudenberg J, Cui K, Dale R, Song SH, Dean A, Zhao K, Jothi R, Love PE.

Blood (2013 May 30) 121:4575-85. Abstract/Full Text

Enhancers: five essential questions.

Pennacchio LA, Bickmore W, Dean A, Nobrega MA, Bejerano G.

Nat Rev Genet (2013 Apr) 14:288-95. Abstract/Full Text

CTCF-mediated transcriptional regulation through cell type-specific chromosome organization in the β-globin locus.

Junier I, Dale RK, Hou C, Képès F, Dean A.

Nucleic Acids Res (2012 Sep) 40:7718-27. Abstract/Full Text

Ldb1 regulates carbonic anhydrase 1 during erythroid differentiation.

Song SH, Kim A, Dale R, Dean A.

Biochim Biophys Acta (2012 Aug) 1819:885-91. Abstract/Full Text

Chromatin loop formation in the β-globin locus and its role in globin gene transcription.

Kim A, Dean A.

Mol Cells (2012 Jul) 34:1-5. Abstract/Full Text

Controlling long-range genomic interactions at a native locus by targeted tethering of a looping factor.

Deng W, Lee J, Wang H, Miller J, Reik A, Gregory PD, Dean A, Blobel GA.

Cell (2012 Jun 8) 149:1233-44. Abstract/Full Text

The hypersensitive sites of the murine β-globin locus control region act independently to affect nuclear localization and transcriptional elongation.

Bender MA, Ragoczy T, Lee J, Byron R, Telling A, Dean A, Groudine M.

Blood (2012 Apr 19) 119:3820-7. Abstract/Full Text

Enhancer and promoter interactions-long distance calls.

Krivega I, Dean A.

Curr Opin Genet Dev (2012 Apr) 22:79-85. Abstract/Full Text

Distinct Ldb1/NLI complexes orchestrate γ-globin repression and reactivation through ETO2 in human adult erythroid cells.

Kiefer CM, Lee J, Hou C, Dale RK, Lee YT, Meier ER, Miller JL, Dean A.

Blood (2011 Dec 1) 118:6200-8. Abstract/Full Text

Insulators organize chromatin: emerging rules of the game.

Krivega M, Dean A.

Mol Cell (2011 Oct 7) 44:1-2. Abstract/Full Text

Identification of genetic elements that autonomously determine DNA methylation states.

Lienert F, Wirbelauer C, Som I, Dean A, Mohn F, Schübeler D.

Nat Genet (2011 Oct 2) 43:1091-7. Abstract/Full Text

In the loop: long range chromatin interactions and gene regulation.

Dean A.

Brief Funct Genomics (2011 Jan) 10:3-10. Abstract/Full Text

A requirement for Lim domain binding protein 1 in erythropoiesis.

Li L, Lee JY, Gross J, Song SH, Dean A, Love PE.

J Exp Med (2010 Nov 22) 207:2543-50. Abstract/Full Text

Multiple functions of Ldb1 required for beta-globin activation during erythroid differentiation.

Song SH, Kim A, Ragoczy T, Bender MA, Groudine M, Dean A.

Blood (2010 Sep 30) 116:2356-64. Abstract/Full Text

Cell type specificity of chromatin organization mediated by CTCF and cohesin.

Hou C, Dale R, Dean A.

Proc Natl Acad Sci U S A (2010 Feb 23) 107:3651-6. Abstract/Full Text

Cytokine-mediated increases in fetal hemoglobin are associated with globin gene histone modification and transcription factor reprogramming.

Sripichai O, Kiefer CM, Bhanu NV, Tanno T, Noh SJ, Goh SH, Russell JE, Rognerud CL, Ou CN, Oneal PA, Meier ER, Gantt NM, Byrnes C, Lee YT, Dean A, Miller JL.

Blood (2009 Sep 10) 114:2299-306. Abstract/Full Text

Short-chain fatty acid-mediated effects on erythropoiesis in primary definitive erythroid cells.

Bhatia H, Hallock JL, Dutta A, Karkashon S, Sterner LS, Miyazaki T, Dean A, Little JA.

Blood (2009 Jun 18) 113:6440-8. Abstract/Full Text

BRG1 requirement for long-range interaction of a locus control region with a downstream promoter.

Kim SI, Bultman SJ, Kiefer CM, Dean A, Bresnick EH.

Proc Natl Acad Sci U S A (2009 Feb 17) 106:2259-64. Abstract/Full Text

CTCF-dependent enhancer-blocking by alternative chromatin loop formation.

Hou C, Zhao H, Tanimoto K, Dean A.

Proc Natl Acad Sci U S A (2008 Dec 23) 105:20398-403. Abstract/Full Text

Epigenetics of beta-globin gene regulation.

Kiefer CM, Hou C, Little JA, Dean A.

Mutat Res (2008 Dec 1) 647:68-76. Abstract/Full Text

The role of transcriptional activator GATA-1 at human beta-globin HS2.

Cho Y, Song SH, Lee JJ, Choi N, Kim CG, Dean A, Kim A.

Nucleic Acids Res (2008 Aug) 36:4521-8. Abstract/Full Text

A positive role for NLI/Ldb1 in long-range beta-globin locus control region function.

Song SH, Hou C, Dean A.

Mol Cell (2007 Dec 14) 28:810-22. Abstract/Full Text

Beta-globin intergenic transcription and histone acetylation dependent on an enhancer.

Kim A, Zhao H, Ifrim I, Dean A.

Mol Cell Biol (2007 Apr) 27:2980-6. Abstract/Full Text

Distinctive signatures of histone methylation in transcribed coding and noncoding human beta-globin sequences.

Kim A, Kiefer CM, Dean A.

Mol Cell Biol (2007 Feb) 27:1271-9. Abstract/Full Text

Nucleosome and transcription activator antagonism at human beta-globin locus control region DNase I hypersensitive sites.

Kim A, Song SH, Brand M, Dean A.

Nucleic Acids Res (2007) 35:5831-8. Abstract/Full Text

Enhancer blocking by chicken beta-globin 5'-HS4: role of enhancer strength and insulator nucleosome depletion.

Zhao H, Kim A, Song SH, Dean A.

J Biol Chem (2006 Oct 13) 281:30573-80. Abstract/Full Text

On a chromosome far, far away: LCRs and gene expression.

Dean A.

Trends Genet (2006 Jan) 22:38-45. Abstract/Full Text

Organizing the genome: enhancers and insulators.

Zhao H, Dean A.

Biochem Cell Biol (2005 Aug) 83:516-24. Abstract/Full Text

An insulator blocks spreading of histone acetylation and interferes with RNA polymerase II transfer between an enhancer and gene.

Zhao H, Dean A.

Nucleic Acids Res (2004) 32:4903-19. Abstract/Full Text

Developmental stage differences in chromatin subdomains of the beta-globin locus.

Kim A, Dean A.

Proc Natl Acad Sci U S A (2004 May 4) 101:7028-33. Abstract/Full Text