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Joanna Klubo-Gwiezdzinska, M.D., Ph.D., M.H.Sc., Lasker Tenure Track Investigator

Acting Section Chief: Thyroid Tumors and Functional Thyroid Disorders, Metabolic Diseases Branch

Scientific Focus Areas: Cancer Biology, Cell Biology, Clinical Research

joanna.klubo-gwiezdzinska@nih.gov 301-496-5052 My LinkedIn My ResearchGate Add to Contacts

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Publications

A selection of recent and significant publications can be viewed below.

Incidence and Survival in Reproductive-Aged Women with Differentiated Thyroid Cancer: United States SEER 18 2000-2016.: Douglas EH, Rhoads A, Thomas A, Aloi J, Suhl J, Lycan T Jr, Oleson J, Conway KM, Klubo-Gwiezdzinska J, Lynch CF, Romitti PA.; Thyroid (2020 Dec) 30:1781-1791. Abstract/Full Text
Comprehensive guidance on the diagnosis and management of primary mesenchymal tumours of the thyroid gland.: Gubbi S, Thakur S, Avadhanula S, Araque KA, Filie AC, Raffeld M, Welch J, Del Rivero J, Kebebew E, Burman KD, Wartofsky L, Klubo-Gwiezdzinska J.; Lancet Oncol (2020 Nov) 21:e528-e537. Abstract/Full Text
Detection of BRAFV600E in Liquid Biopsy from Patients with Papillary Thyroid Cancer Is Associated with Tumor Aggressiveness and Response to Therapy.: Jensen K, Thakur S, Patel A, Mendonca-Torres MC, Costello J, Gomes-Lima CJ, Walter M, Wartofsky L, Burman KD, Bikas A, Ylli D, Vasko VV, Klubo-Gwiezdzinska J.; J Clin Med (2020 Aug 2) 9. Abstract/Full Text
Updates on the Management of Thyroid Cancer.: Araque KA, Gubbi S, Klubo-Gwiezdzinska J.; Horm Metab Res (2020 Aug) 52:562-577. Abstract/Full Text
Novel Targeted Therapies for Metastatic Thyroid Cancer-A Comprehensive Review.: Al-Jundi M, Thakur S, Gubbi S, Klubo-Gwiezdzinska J.; Cancers (Basel) (2020 Jul 29) 12. Abstract/Full Text
The Molecular Landscape of Hürthle Cell Thyroid Cancer Is Associated with Altered Mitochondrial Function-A Comprehensive Review.: Kumari S, Adewale R, Klubo-Gwiezdzinska J.; Cells (2020 Jun 27) 9. Abstract/Full Text
TSH Receptor Homodimerization in Regulation of cAMP Production in Human Thyrocytes in vitro.: Boutin A, Krieger CC, Marcus-Samuels B, Klubo-Gwiezdzinska J, Neumann S, Gershengorn MC.; Front Endocrinol (Lausanne) (2020) 11:276. Abstract/Full Text
Targeting Integrins with Radiolabeled RGD Analogues for Radiotheranostics of Metastatic Radioactive Iodine Nonresponsive Thyroid Cancer: New Avenues in Personalized Medicine.: Klubo-Gwiezdzinska J, Chen X.; Thyroid (2020 Apr) 30:476-478. Abstract/Full Text
Endocrine-Related Adverse Events Related to Immune Checkpoint Inhibitors: Proposed Algorithms for Management.: Del Rivero J, Cordes LM, Klubo-Gwiezdzinska J, Madan RA, Nieman LK, Gulley JL.; Oncologist (2020 Apr) 25:290-300. Abstract/Full Text
Assessment of Thyroid Function in Patients With Alkaptonuria.: Avadhanula S, Introne WJ, Auh S, Soldin SJ, Stolze B, Regier D, Ciccone C, Hannah-Shmouni F, Filie AC, Burman KD, Klubo-Gwiezdzinska J.; JAMA Netw Open (2020 Mar 2) 3:e201357. Abstract/Full Text
A Novel Risk Stratification System for Thyroid Nodules With Indeterminate Cytology-A Pilot Cohort Study.: Gomes-Lima CJ, Auh S, Thakur S, Zemskova M, Cochran C, Merkel R, Filie AC, Raffeld M, Patel SB, Xi L, Wartofsky L, Burman KD, Klubo-Gwiezdzinska J.; Front Endocrinol (Lausanne) (2020) 11:53. Abstract/Full Text
Thyrotropin, but Not Thyroid-Stimulating Antibodies, Induces Biphasic Regulation of Gene Expression in Human Thyrocytes.: Jang D, Morgan SJ, Klubo-Gwiezdzinska J, Banga JP, Neumann S, Gershengorn MC.; Thyroid (2020 Feb) 30:270-276. Abstract/Full Text
Thyrotropin Causes Dose-dependent Biphasic Regulation of cAMP Production Mediated by G_s and G_i/o Proteins.: Neumann S, Malik SS, Marcus-Samuels B, Eliseeva E, Jang D, Klubo-Gwiezdzinska J, Krieger CC, Gershengorn MC.; Mol Pharmacol (2020 Jan) 97:2-8. Abstract/Full Text
Breathing the air of mitochondrial respiration via an important oncotarget - mitochondrial glycerophosphate dehydrogenase (mGPDH).: Thakur S, Klubo-Gwiezdzinska J.; Oncotarget (2019 Nov 5) 10:6400-6402. Abstract/Full Text
The Role of Lithium in Management of Endocrine Tumors-A Comprehensive Review.: Thakur S, Tobey A, Klubo-Gwiezdzinska J.; Front Oncol (2019) 9:1092. Abstract/Full Text
Limited Utility of Circulating Cell-Free DNA Integrity as a Diagnostic Tool for Differentiating Between Malignant and Benign Thyroid Nodules With Indeterminate Cytology (Bethesda Category III).: Thakur S, Tobey A, Daley B, Auh S, Walter M, Patel D, Nilubol N, Kebebew E, Patel A, Jensen K, Vasko V, Klubo-Gwiezdzinska J.; Front Oncol (2019) 9:905. Abstract/Full Text
Thyroid emergencies.: Ylli D, Klubo-Gwiezdzinska J, Wartofsky L.; Pol Arch Intern Med (2019 Aug 29) 129:526-534. Abstract/Full Text
The role of an anti-diabetic drug metformin in the treatment of endocrine tumors.: Thakur S, Daley B, Klubo-Gwiezdzinska J.; J Mol Endocrinol (2019 Aug) 63:R17-R35. Abstract/Full Text
Arrestin-β-1 Physically Scaffolds TSH and IGF1 Receptors to Enable Crosstalk.: Krieger CC, Boutin A, Jang D, Morgan SJ, Banga JP, Kahaly GJ, Klubo-Gwiezdzinska J, Neumann S, Gershengorn MC.; Endocrinology (2019 Jun 1) 160:1468-1479. Abstract/Full Text
Association of Thyrotropin Suppression With Survival Outcomes in Patients With Intermediate- and High-Risk Differentiated Thyroid Cancer.: Klubo-Gwiezdzinska J, Auh S, Gershengorn M, Daley B, Bikas A, Burman K, Wartofsky L, Urken M, Dewey E, Smallridge R, Chindris AM, Kebebew E.; JAMA Netw Open (2019 Feb 1) 2:e187754. Abstract/Full Text
Do patients with familial nonmedullary thyroid cancer present with more aggressive disease? Implications for initial surgical treatment.: El Lakis M, Giannakou A, Nockel PJ, Wiseman D, Gara SK, Patel D, Sater ZA, Kushchayeva YY, Klubo-Gwiezdzinska J, Nilubol N, Merino MJ, Kebebew E.; Surgery (2019 Jan) 165:50-57. Abstract/Full Text
Lysyl Oxidase Is a Key Player in BRAF/MAPK Pathway-Driven Thyroid Cancer Aggressiveness.: Boufraqech M, Patel D, Nilubol N, Powers A, King T, Shell J, Lack J, Zhang L, Gara SK, Gunda V, Klubo-Gwiezdzinska J, Kumar S, Fagin J, Knauf J, Parangi S, Venzon D, Quezado M, Kebebew E.; Thyroid (2019 Jan) 29:79-92. Abstract/Full Text
Combined Immunosuppressive Therapy Induces Remission in Patients With Severe Type B Insulin Resistance: A Prospective Cohort Study.: Klubo-Gwiezdzinska J, Lange M, Cochran E, Semple RK, Gewert C, Brown RJ, Gorden P.; Diabetes Care (2018 Nov) 41:2353-2360. Abstract/Full Text
The effect of lithium on the progression-free and overall survival in patients with metastatic differentiated thyroid cancer undergoing radioactive iodine therapy.: Luo H, Tobey A, Auh S, Cochran C, Zemskova M, Reynolds J, Lima C, Burman K, Wartofsky L, Skarulis M, Kebebew E, Klubo-Gwiezdzinska J.; Clin Endocrinol (Oxf) (2018 Oct) 89:481-488. Abstract/Full Text
The Role of Molecular Diagnostics in the Management of Indeterminate Thyroid Nodules.: Klubo-Gwiezdzinska J, Wartofsky L.; J Clin Endocrinol Metab (2018 Sep 1) 103:3507-3510. Abstract/Full Text
Metformin Targets Mitochondrial Glycerophosphate Dehydrogenase to Control Rate of Oxidative Phosphorylation and Growth of Thyroid Cancer In Vitro and In Vivo.: Thakur S, Daley B, Gaskins K, Vasko VV, Boufraqech M, Patel D, Sourbier C, Reece J, Cheng SY, Kebebew E, Agarwal S, Klubo-Gwiezdzinska J.; Clin Cancer Res (2018 Aug 15) 24:4030-4043. Abstract/Full Text
Amifostine does not protect thyroid cancer cells in DNA damaging in vitro models.: Klubo-Gwiezdzinska J, Costello J Jr, Jensen K, Patel A, Tkavc R, Van Nostrand D, Burman KD, Wartofsky L, Vasko V.; Endocr Connect (2017 Oct) 6:469-478. Abstract/Full Text
Novel biomarker SYT12 may contribute to predicting papillary thyroid cancer outcomes.: Jonklaas J, Murthy S, Liu D, Klubo-Gwiezdzinska J, Krishnan J, Burman KD, Boyle L, Carrol N, Felger E, Loh YP.; Future Sci OA (2018 Jan) 4:FSO249. Abstract/Full Text
Results of Screening in Familial Non-Medullary Thyroid Cancer.: Klubo-Gwiezdzinska J, Yang L, Merkel R, Patel D, Nilubol N, Merino MJ, Skarulis M, Sadowski SM, Kebebew E.; Thyroid (2017 Aug) 27:1017-1024. Abstract/Full Text
MicroRNAs in the thyroid.: Boufraqech M, Klubo-Gwiezdzinska J, Kebebew E.; Best Pract Res Clin Endocrinol Metab (2016 Oct) 30:603-619. Abstract/Full Text
The Rate and Clinical Significance of Incidental Thyroid Uptake as Detected by Gallium-68 DOTATATE Positron Emission Tomography/Computed Tomography.: Nockel P, Millo C, Keutgen X, Klubo-Gwiezdzinska J, Shell J, Patel D, Nilubol N, Herscovitch P, Sadowski SM, Kebebew E.; Thyroid (2016 Jun) 26:831-5. Abstract/Full Text
Glucose-deprivation increases thyroid cancer cells sensitivity to metformin.: Bikas A, Jensen K, Patel A, Costello J Jr, McDaniel D, Klubo-Gwiezdzinska J, Larin O, Hoperia V, Burman KD, Boyle L, Wartofsky L, Vasko V.; Endocr Relat Cancer (2015 Dec) 22:919-32. Abstract/Full Text
The HIV protease inhibitor nelfinavir down-regulates RET signaling and induces apoptosis in medullary thyroid cancer cells.: Kushchayeva Y, Jensen K, Recupero A, Costello J, Patel A, Klubo-Gwiezdzinska J, Boyle L, Burman K, Vasko V.; J Clin Endocrinol Metab (2014 May) 99:E734-45. Abstract/Full Text
Treatment with metformin is associated with higher remission rate in diabetic patients with thyroid cancer.: Klubo-Gwiezdzinska J, Costello J Jr, Patel A, Bauer A, Jensen K, Mete M, Burman KD, Wartofsky L, Vasko V.; J Clin Endocrinol Metab (2013 Aug) 98:3269-79. Abstract/Full Text
Potential use of recombinant human thyrotropin in the treatment of distant metastases in patients with differentiated thyroid cancer.: Klubo-Gwiezdzinska J, Burman KD, Van Nostrand D, Mete M, Jonklaas J, Wartofsky L.; Endocr Pract (2013 Jan-Feb) 19:139-48. Abstract/Full Text
The expression of translocator protein in human thyroid cancer and its role in the response of thyroid cancer cells to oxidative stress.: Klubo-Gwiezdzinska J, Jensen K, Bauer A, Patel A, Costello J Jr, Burman KD, Wartofsky L, Hardwick MJ, Vasko VV.; J Endocrinol (2012 Aug) 214:207-16. Abstract/Full Text
Metformin inhibits growth and decreases resistance to anoikis in medullary thyroid cancer cells.: Klubo-Gwiezdzinska J, Jensen K, Costello J, Patel A, Hoperia V, Bauer A, Burman KD, Wartofsky L, Vasko V.; Endocr Relat Cancer (2012 Jun) 19:447-56. Abstract/Full Text
Radioiodine treatment of metastatic thyroid cancer: relative efficacy and side effect profile of preparation by thyroid hormone withdrawal versus recombinant human thyrotropin.: Klubo-Gwiezdzinska J, Burman KD, Van Nostrand D, Mete M, Jonklaas J, Wartofsky L.; Thyroid (2012 Mar) 22:310-7. Abstract/Full Text
Thyroid emergencies.: Klubo-Gwiezdzinska J, Wartofsky L.; Med Clin North Am (2012 Mar) 96:385-403. Abstract/Full Text
BRAF(V600E) mutation analysis from May-Grünwald Giemsa-stained cytological samples as an adjunct in identification of high-risk papillary thyroid carcinoma.: Patel A, Klubo-Gwiezdzinska J, Hoperia V, Larin A, Jensen K, Bauer A, Vasko V.; Endocr Pathol (2011 Dec) 22:195-9. Abstract/Full Text
Efficacy of dosimetric versus empiric prescribed activity of 131I for therapy of differentiated thyroid cancer.: Klubo-Gwiezdzinska J, Van Nostrand D, Atkins F, Burman K, Jonklaas J, Mete M, Wartofsky L.; J Clin Endocrinol Metab (2011 Oct) 96:3217-25. Abstract/Full Text
Inhibition of gap junction transfer sensitizes thyroid cancer cells to anoikis.: Jensen K, Patel A, Klubo-Gwiezdzinska J, Bauer A, Vasko V.; Endocr Relat Cancer (2011 Oct) 18:613-26. Abstract/Full Text
Clinical review: Ectopic cervical thyroid carcinoma--review of the literature with illustrative case series.: Klubo-Gwiezdzinska J, Manes RP, Chia SH, Burman KD, Stathatos NA, Deeb ZE, Wartofsky L.; J Clin Endocrinol Metab (2011 Sep) 96:2684-91. Abstract/Full Text
Does an undetectable rhTSH-stimulated Tg level 12 months after initial treatment of thyroid cancer indicate remission?: Klubo-Gwiezdzinska J, Burman KD, Van Nostrand D, Wartofsky L.; Clin Endocrinol (Oxf) (2011 Jan) 74:111-7. Abstract/Full Text
Levothyroxine treatment in pregnancy: indications, efficacy, and therapeutic regimen.: Klubo-Gwiezdzinska J, Burman KD, Van Nostrand D, Wartofsky L.; J Thyroid Res (2011) 2011:843591. Abstract/Full Text
Salivary gland malignancy and radioiodine therapy for thyroid cancer.: Klubo-Gwiezdzinska J, Van Nostrand D, Burman KD, Vasko V, Chia S, Deng T, Kulkarni K, Wartofsky L.; Thyroid (2010 Jun) 20:647-51. Abstract/Full Text
Metastases of well-differentiated thyroid cancer to the gastrointestinal system.: Klubo-Gwiezdzinska J, Morowitz D, Van Nostrand D, Burman KD, Vasko V, Soberman M, Wartofsky L.; Thyroid (2010 Apr) 20:381-7. Abstract/Full Text
Thyrotropin blood levels, subclinical hypothyroidism, and the elderly patient.: Klubo-Gwiezdzinska J, Wartofsky L.; Arch Intern Med (2009 Nov 23) 169:1949-51. Abstract/Full Text
The comparison of serum vascular endothelial growth factor levels between patients with metastatic and non-metastatic thyroid cancer, and patients with nontoxic multinodular goiter.: Klubo-Gwiezdzinska J, Junik R, Kopczynska E, Juraniec O, Kardymowicz H.; Eur J Endocrinol (2007 Oct) 157:521-7. Abstract/Full Text

Books and Book Chapters

"Staging and Prognosis of Thyroid Cancer.": Klubo-Gwiezdzinska J.; Disorders of the Thyroid Gland: A Guide to Clinical Management. 1st Edition. Duntas L, Luster M, Wartofsky L.; Springer. (2017 - accepted, book in preparation).
"The Role of TSH Suppression in the Management of Thyroid Cancer.": Alrezk R, Klubo-Gwiezdzinska J.; Disorders of the Thyroid Gland: A Guide to Clinical Management. 1st Edition. Duntas L, Luster M, Wartofsky L.; Springer. (2017 - accepted, book in preparation).
"Familial Non-Medullary Thyroid Cancer.": Gara S, Kebebew E., Klubo-Gwiezdzinska J, Kushchayeva Y.; Practical Management of Thyroid Cancer - A Multidisciplinary Approach. 2nd Edition. Harmer C, Mallick UK.; Springer. (2017 - accepted, book in preparation).
"Management of the Thyroid Nodule: A Comparison of Published International Guidelines.": Klubo-Gwiezdzinska J.; Thyroid Cancer. 3rd Edition. Van Nostrand D, Wartofsky L.; Springer. (2015).
"A Summary of Rare Sites of Metastasis Secondary to Differentiated Thyroid Cancer.": Khorjekar GR, Klubo-Gwiezdzinska J, Van Nostrand D, and Wartofsky L.; Thyroid Cancer. 3rd Edition. Van Nostrand D, Wartofsky L.; Springer. (2015).
"Exercise and Thyroid Function.": Bernet VJ, Klubo-Gwiezdzinska J, Wartofsky L.; Endocrinology of Physical Activity and Sport. 2nd Edition. Constantini, N, Hackney, AC.; Contemporary Endocrinology, Humana Press Media (NY). (2013) 85-121.
"Thyrotoxic Storm.": Klubo-Gwiezdzinska J, Wartofsky L.; Oxford Textbook of Endocrinology and Diabetes. Stewart PM, Wass JAH.; Oxford University Press (NY). (2011) 454-461.
"Myxoedema Coma.": Klubo-Gwiezdzinska J, Wartofsky L.; Oxford Textbook of Endocrinology and Diabetes. Stewart PM, Wass JAH.; Oxford University Press (NY). (2011) 537-543.