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Joanna Klubo-Gwiezdzinska, M.D., Ph.D., M.H.Sc., Lasker Tenure Track Investigator

Publications

A selection of recent and significant publications can be viewed below.

Endocrine-Related Adverse Events Related to Immune Checkpoint Inhibitors: Proposed Algorithms for Management.
Del Rivero J, Cordes LM, Klubo-Gwiezdzinska J, Madan RA, Nieman LK, Gulley JL.
Oncologist (2019 Oct 10) Abstract/Full Text
Limited Utility of Circulating Cell-Free DNA Integrity as a Diagnostic Tool for Differentiating Between Malignant and Benign Thyroid Nodules With Indeterminate Cytology (Bethesda Category III).
Thakur S, Tobey A, Daley B, Auh S, Walter M, Patel D, Nilubol N, Kebebew E, Patel A, Jensen K, Vasko V, Klubo-Gwiezdzinska J.
Front Oncol (2019) 9:905. Abstract/Full Text
Thyroid emergencies.
Ylli D, Klubo-Gwiezdzinska J, Wartofsky L.
Pol Arch Intern Med (2019 Aug 29) 129:526-534. Abstract/Full Text
The role of an anti-diabetic drug metformin in the treatment of endocrine tumors.
Thakur S, Daley B, Klubo-Gwiezdzinska J.
J Mol Endocrinol (2019 Aug) 63:R17-R35. Abstract/Full Text
Arrestin-β-1 Physically Scaffolds TSH and IGF1 Receptors to Enable Crosstalk.
Krieger CC, Boutin A, Jang D, Morgan SJ, Banga JP, Kahaly GJ, Klubo-Gwiezdzinska J, Neumann S, Gershengorn MC.
Endocrinology (2019 Jun 1) 160:1468-1479. Abstract/Full Text
Association of Thyrotropin Suppression With Survival Outcomes in Patients With Intermediate- and High-Risk Differentiated Thyroid Cancer.
Klubo-Gwiezdzinska J, Auh S, Gershengorn M, Daley B, Bikas A, Burman K, Wartofsky L, Urken M, Dewey E, Smallridge R, Chindris AM, Kebebew E.
JAMA Netw Open (2019 Feb 1) 2:e187754. Abstract/Full Text
Do patients with familial nonmedullary thyroid cancer present with more aggressive disease? Implications for initial surgical treatment.
El Lakis M, Giannakou A, Nockel PJ, Wiseman D, Gara SK, Patel D, Sater ZA, Kushchayeva YY, Klubo-Gwiezdzinska J, Nilubol N, Merino MJ, Kebebew E.
Surgery (2019 Jan) 165:50-57. Abstract/Full Text
Lysyl Oxidase Is a Key Player in BRAF/MAPK Pathway-Driven Thyroid Cancer Aggressiveness.
Boufraqech M, Patel D, Nilubol N, Powers A, King T, Shell J, Lack J, Zhang L, Gara SK, Gunda V, Klubo-Gwiezdzinska J, Kumar S, Fagin J, Knauf J, Parangi S, Venzon D, Quezado M, Kebebew E.
Thyroid (2019 Jan) 29:79-92. Abstract/Full Text
Combined Immunosuppressive Therapy Induces Remission in Patients With Severe Type B Insulin Resistance: A Prospective Cohort Study.
Klubo-Gwiezdzinska J, Lange M, Cochran E, Semple RK, Gewert C, Brown RJ, Gorden P.
Diabetes Care (2018 Nov) 41:2353-2360. Abstract/Full Text
The effect of lithium on the progression-free and overall survival in patients with metastatic differentiated thyroid cancer undergoing radioactive iodine therapy.
Luo H, Tobey A, Auh S, Cochran C, Zemskova M, Reynolds J, Lima C, Burman K, Wartofsky L, Skarulis M, Kebebew E, Klubo-Gwiezdzinska J.
Clin Endocrinol (Oxf) (2018 Oct) 89:481-488. Abstract/Full Text
The Role of Molecular Diagnostics in the Management of Indeterminate Thyroid Nodules.
Klubo-Gwiezdzinska J, Wartofsky L.
J Clin Endocrinol Metab (2018 Sep 1) 103:3507-3510. Abstract/Full Text
Metformin Targets Mitochondrial Glycerophosphate Dehydrogenase to Control Rate of Oxidative Phosphorylation and Growth of Thyroid Cancer In Vitro and In Vivo.
Thakur S, Daley B, Gaskins K, Vasko VV, Boufraqech M, Patel D, Sourbier C, Reece J, Cheng SY, Kebebew E, Agarwal S, Klubo-Gwiezdzinska J.
Clin Cancer Res (2018 Aug 15) 24:4030-4043. Abstract/Full Text
Amifostine does not protect thyroid cancer cells in DNA damaging in vitro models.
Klubo-Gwiezdzinska J, Costello J Jr, Jensen K, Patel A, Tkavc R, Van Nostrand D, Burman KD, Wartofsky L, Vasko V.
Endocr Connect (2017 Oct) 6:469-478. Abstract/Full Text
Novel biomarker SYT12 may contribute to predicting papillary thyroid cancer outcomes.
Jonklaas J, Murthy S, Liu D, Klubo-Gwiezdzinska J, Krishnan J, Burman KD, Boyle L, Carrol N, Felger E, Loh YP.
Future Sci OA (2018 Jan) 4:FSO249. Abstract/Full Text
Results of Screening in Familial Non-Medullary Thyroid Cancer.
Klubo-Gwiezdzinska J, Yang L, Merkel R, Patel D, Nilubol N, Merino MJ, Skarulis M, Sadowski SM, Kebebew E.
Thyroid (2017 Aug) 27:1017-1024. Abstract/Full Text
MicroRNAs in the thyroid.
Boufraqech M, Klubo-Gwiezdzinska J, Kebebew E.
Best Pract Res Clin Endocrinol Metab (2016 Oct) 30:603-619. Abstract/Full Text
The Rate and Clinical Significance of Incidental Thyroid Uptake as Detected by Gallium-68 DOTATATE Positron Emission Tomography/Computed Tomography.
Nockel P, Millo C, Keutgen X, Klubo-Gwiezdzinska J, Shell J, Patel D, Nilubol N, Herscovitch P, Sadowski SM, Kebebew E.
Thyroid (2016 Jun) 26:831-5. Abstract/Full Text
Glucose-deprivation increases thyroid cancer cells sensitivity to metformin.
Bikas A, Jensen K, Patel A, Costello J Jr, McDaniel D, Klubo-Gwiezdzinska J, Larin O, Hoperia V, Burman KD, Boyle L, Wartofsky L, Vasko V.
Endocr Relat Cancer (2015 Dec) 22:919-32. Abstract/Full Text
The HIV protease inhibitor nelfinavir down-regulates RET signaling and induces apoptosis in medullary thyroid cancer cells.
Kushchayeva Y, Jensen K, Recupero A, Costello J, Patel A, Klubo-Gwiezdzinska J, Boyle L, Burman K, Vasko V.
J Clin Endocrinol Metab (2014 May) 99:E734-45. Abstract/Full Text
Treatment with metformin is associated with higher remission rate in diabetic patients with thyroid cancer.
Klubo-Gwiezdzinska J, Costello J Jr, Patel A, Bauer A, Jensen K, Mete M, Burman KD, Wartofsky L, Vasko V.
J Clin Endocrinol Metab (2013 Aug) 98:3269-79. Abstract/Full Text
Potential use of recombinant human thyrotropin in the treatment of distant metastases in patients with differentiated thyroid cancer.
Klubo-Gwiezdzinska J, Burman KD, Van Nostrand D, Mete M, Jonklaas J, Wartofsky L.
Endocr Pract (2013 Jan-Feb) 19:139-48. Abstract/Full Text
The expression of translocator protein in human thyroid cancer and its role in the response of thyroid cancer cells to oxidative stress.
Klubo-Gwiezdzinska J, Jensen K, Bauer A, Patel A, Costello J Jr, Burman KD, Wartofsky L, Hardwick MJ, Vasko VV.
J Endocrinol (2012 Aug) 214:207-16. Abstract/Full Text
Metformin inhibits growth and decreases resistance to anoikis in medullary thyroid cancer cells.
Klubo-Gwiezdzinska J, Jensen K, Costello J, Patel A, Hoperia V, Bauer A, Burman KD, Wartofsky L, Vasko V.
Endocr Relat Cancer (2012 Jun) 19:447-56. Abstract/Full Text
Radioiodine treatment of metastatic thyroid cancer: relative efficacy and side effect profile of preparation by thyroid hormone withdrawal versus recombinant human thyrotropin.
Klubo-Gwiezdzinska J, Burman KD, Van Nostrand D, Mete M, Jonklaas J, Wartofsky L.
Thyroid (2012 Mar) 22:310-7. Abstract/Full Text
Thyroid emergencies.
Klubo-Gwiezdzinska J, Wartofsky L.
Med Clin North Am (2012 Mar) 96:385-403. Abstract/Full Text
BRAF(V600E) mutation analysis from May-Grünwald Giemsa-stained cytological samples as an adjunct in identification of high-risk papillary thyroid carcinoma.
Patel A, Klubo-Gwiezdzinska J, Hoperia V, Larin A, Jensen K, Bauer A, Vasko V.
Endocr Pathol (2011 Dec) 22:195-9. Abstract/Full Text
Efficacy of dosimetric versus empiric prescribed activity of 131I for therapy of differentiated thyroid cancer.
Klubo-Gwiezdzinska J, Van Nostrand D, Atkins F, Burman K, Jonklaas J, Mete M, Wartofsky L.
J Clin Endocrinol Metab (2011 Oct) 96:3217-25. Abstract/Full Text
Inhibition of gap junction transfer sensitizes thyroid cancer cells to anoikis.
Jensen K, Patel A, Klubo-Gwiezdzinska J, Bauer A, Vasko V.
Endocr Relat Cancer (2011 Oct) 18:613-26. Abstract/Full Text
Clinical review: Ectopic cervical thyroid carcinoma--review of the literature with illustrative case series.
Klubo-Gwiezdzinska J, Manes RP, Chia SH, Burman KD, Stathatos NA, Deeb ZE, Wartofsky L.
J Clin Endocrinol Metab (2011 Sep) 96:2684-91. Abstract/Full Text
Does an undetectable rhTSH-stimulated Tg level 12 months after initial treatment of thyroid cancer indicate remission?
Klubo-Gwiezdzinska J, Burman KD, Van Nostrand D, Wartofsky L.
Clin Endocrinol (Oxf) (2011 Jan) 74:111-7. Abstract/Full Text
Levothyroxine treatment in pregnancy: indications, efficacy, and therapeutic regimen.
Klubo-Gwiezdzinska J, Burman KD, Van Nostrand D, Wartofsky L.
J Thyroid Res (2011) 2011:843591. Abstract/Full Text
Salivary gland malignancy and radioiodine therapy for thyroid cancer.
Klubo-Gwiezdzinska J, Van Nostrand D, Burman KD, Vasko V, Chia S, Deng T, Kulkarni K, Wartofsky L.
Thyroid (2010 Jun) 20:647-51. Abstract/Full Text
Metastases of well-differentiated thyroid cancer to the gastrointestinal system.
Klubo-Gwiezdzinska J, Morowitz D, Van Nostrand D, Burman KD, Vasko V, Soberman M, Wartofsky L.
Thyroid (2010 Apr) 20:381-7. Abstract/Full Text
Serum endostatin levels in patients with metastatic and non-metastatic well-differentiated thyroid cancer.
Kłubo-Gwieździńska J, Junik R, Kopczyńska E.
Endokrynol Pol (2010 Jan-Feb) 61:7-12. Abstract/Full Text
Thyrotropin blood levels, subclinical hypothyroidism, and the elderly patient.
Klubo-Gwiezdzinska J, Wartofsky L.
Arch Intern Med (2009 Nov 23) 169:1949-51. Abstract/Full Text
[The early treatment results of well differentiated thyroid cancer and its dependence on chosen factors].
Kłubo-Gwieździńska J, Junik R.
Endokrynol Pol (2008 Mar-Apr) 59:123-30. Abstract/Full Text
The comparison of serum vascular endothelial growth factor levels between patients with metastatic and non-metastatic thyroid cancer, and patients with nontoxic multinodular goiter.
Klubo-Gwiezdzinska J, Junik R, Kopczynska E, Juraniec O, Kardymowicz H.
Eur J Endocrinol (2007 Oct) 157:521-7. Abstract/Full Text
Papillary thyroid cancer with metastasis to the skin.
Junik R, Kłubo-Gwieździńska J, Zuchora Z, Zmyslowski W.
Clin Nucl Med (2006 Jul) 31:435-6. Abstract/Full Text
[Endocrine disorders as a result of alcohol abuse].
Junik R, Kłubo-Gwiezdzińska J.
Pol Arch Med Wewn (2004 May) 111:603-8. Abstract/Full Text

Books and Book Chapters

"Staging and Prognosis of Thyroid Cancer."
Klubo-Gwiezdzinska J.
Disorders of the Thyroid Gland: A Guide to Clinical Management. 1st Edition. Duntas L, Luster M, Wartofsky L.
Springer. (2017 - accepted, book in preparation).
"The Role of TSH Suppression in the Management of Thyroid Cancer."
Alrezk R, Klubo-Gwiezdzinska J.
Disorders of the Thyroid Gland: A Guide to Clinical Management. 1st Edition. Duntas L, Luster M, Wartofsky L.
Springer. (2017 - accepted, book in preparation).
"Familial Non-Medullary Thyroid Cancer."
Gara S, Kebebew E., Klubo-Gwiezdzinska J, Kushchayeva Y.
Practical Management of Thyroid Cancer - A Multidisciplinary Approach. 2nd Edition. Harmer C, Mallick UK.
Springer. (2017 - accepted, book in preparation).
"Management of the Thyroid Nodule: A Comparison of Published International Guidelines."
Klubo-Gwiezdzinska J.
Thyroid Cancer. 3rd Edition. Van Nostrand D, Wartofsky L.
Springer. (2015).
"A Summary of Rare Sites of Metastasis Secondary to Differentiated Thyroid Cancer."
Khorjekar GR, Klubo-Gwiezdzinska J, Van Nostrand D, and Wartofsky L.
Thyroid Cancer. 3rd Edition. Van Nostrand D, Wartofsky L.
Springer. (2015).
"Exercise and Thyroid Function."
Bernet VJ, Klubo-Gwiezdzinska J, Wartofsky L.
Endocrinology of Physical Activity and Sport. 2nd Edition. Constantini, N, Hackney, AC.
Contemporary Endocrinology, Humana Press Media (NY). (2013) 85-121.
"Thyrotoxic Storm."
Klubo-Gwiezdzinska J, Wartofsky L.
Oxford Textbook of Endocrinology and Diabetes. Stewart PM, Wass JAH.
Oxford University Press (NY). (2011) 454-461.
"Myxoedema Coma."
Klubo-Gwiezdzinska J, Wartofsky L.
Oxford Textbook of Endocrinology and Diabetes. Stewart PM, Wass JAH.
Oxford University Press (NY). (2011) 537-543.