Jeffrey B. Kopp, M.D.

Photo of Jeffrey Kopp
Scientific Focus Areas: Cell Biology, Clinical Research, Genetics and Genomics, Health Disparities

Publications

A selection of recent and significant publications can be viewed below.

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Apolipoprotein L1 gene variants associate with hypertension-attributed nephropathy and the rate of kidney function decline in African Americans.
Lipkowitz MS, Freedman BI, Langefeld CD, Comeau ME, Bowden DW, Kao WH, Astor BC, Bottinger EP, Iyengar SK, Klotman PE, Freedman RG, Zhang W, Parekh RS, Choi MJ, Nelson GW, Winkler CA, Kopp JB, SK Investigators..
Kidney Int (2013 Jan) 83:114-20. Abstract/Full Text
APOL1 genetic variants in focal segmental glomerulosclerosis and HIV-associated nephropathy.
Kopp JB, Nelson GW, Sampath K, Johnson RC, Genovese G, An P, Friedman D, Briggs W, Dart R, Korbet S, Mokrzycki MH, Kimmel PL, Limou S, Ahuja TS, Berns JS, Fryc J, Simon EE, Smith MC, Trachtman H, Michel DM, Schelling JR, Vlahov D, Pollak M, Winkler CA.
J Am Soc Nephrol (2011 Nov) 22:2129-37. Abstract/Full Text
MYH9 is a major-effect risk gene for focal segmental glomerulosclerosis.
Kopp JB, Smith MW, Nelson GW, Johnson RC, Freedman BI, Bowden DW, Oleksyk T, McKenzie LM, Kajiyama H, Ahuja TS, Berns JS, Briggs W, Cho ME, Dart RA, Kimmel PL, Korbet SM, Michel DM, Mokrzycki MH, Schelling JR, Simon E, Trachtman H, Vlahov D, Winkler CA.
Nat Genet (2008 Oct) 40:1175-84. Abstract/Full Text
Human immunodeficiency virus (HIV)-1 viral protein R suppresses transcriptional activity of peroxisome proliferator-activated receptor {gamma} and inhibits adipocyte differentiation: implications for HIV-associated lipodystrophy.
Shrivastav S, Kino T, Cunningham T, Ichijo T, Schubert U, Heinklein P, Chrousos GP, Kopp JB.
Mol Endocrinol (2008 Feb) 22:234-47. Abstract/Full Text
Pirfenidone slows renal function decline in patients with focal segmental glomerulosclerosis.
Cho ME, Smith DC, Branton MH, Penzak SR, Kopp JB.
Clin J Am Soc Nephrol (2007 Sep) 2:906-13. Abstract/Full Text

Additional Publications

Association of APOL1 With Heart Failure With Preserved Ejection Fraction in Postmenopausal African American Women.
Franceschini N, Kopp JB, Barac A, Martin LW, Li Y, Qian H, Reiner AP, Pollak M, Wallace RB, Rosamond WD, Winkler CA.
JAMA Cardiol (2018 Aug 1) 3:712-720. Abstract/Full Text
ApoL1 renal risk variants induce aberrant THP-1 monocyte differentiation and increase eicosanoid production via enhanced expression of cyclooxygenase-2.
Lee H, Roshanravan H, Wang Y, Okamoto K, Ryu J, Shrivastav S, Qu P, Kopp JB.
Am J Physiol Renal Physiol (2018 Jul 1) 315:F140-F150. Abstract/Full Text
Association of Sickle Cell Trait With Ischemic Stroke Among African Americans: A Meta-analysis.
Hyacinth HI, Carty CL, Seals SR, Irvin MR, Naik RP, Burke GL, Zakai NA, Wilson JG, Franceschini N, Winkler CA, David VA, Kopp JB, Judd SE, Adams RJ, Longstreth WT Jr, Egede L, Lackland DT, Taylor H, Manson JE, Howard V, Allison M, Gee BE, Correa A, Safford MM, Arnett DK, Howard G, Reiner AP, Cushman M.
JAMA Neurol (2018 Jul 1) 75:802-807. Abstract/Full Text
APOL1 Nephropathy Risk Variants and Incident Cardiovascular Disease Events in Community-Dwelling Black Adults.
Gutiérrez OM, Irvin MR, Chaudhary NS, Cushman M, Zakai NA, David VA, Limou S, Pamir N, Reiner AP, Naik RP, Sale MM, Safford MM, Hyacinth HI, Judd SE, Kopp JB, Winkler CA.
Circ Genom Precis Med (2018 Jun) 11:e002098. Abstract/Full Text
Apolipoprotein L1 nephropathies: 2017 in review.
Kopp JB, Roshanravan H, Okamoto K.
Curr Opin Nephrol Hypertens (2018 May) 27:153-158. Abstract/Full Text
APOL1 Genotype and Renal Function of Black Living Donors.
Doshi MD, Ortigosa-Goggins M, Garg AX, Li L, Poggio ED, Winkler CA, Kopp JB.
J Am Soc Nephrol (2018 Apr) 29:1309-1316. Abstract/Full Text
APOL1 nephropathy risk variants do not associate with subclinical atherosclerosis or left ventricular mass in middle-aged black adults.
Gutiérrez OM, Limou S, Lin F, Peralta CA, Kramer HJ, Carr JJ, Bibbins-Domingo K, Winkler CA, Lewis CE, Kopp JB.
Kidney Int (2018 Mar) 93:727-732. Abstract/Full Text
Kidney Diseases Associated with Human Immunodeficiency Virus Infection.
Cohen SD, Kopp JB, Kimmel PL.
N Engl J Med (2017 Dec 14) 377:2363-2374. Abstract/Full Text
APOL1 Renal Risk Variants: Fertile Soil for HIV-Associated Nephropathy.
Kopp JB, Heymann J, Winkler CA.
Semin Nephrol (2017 Nov) 37:514-519. Abstract/Full Text
APOL1 genetic variants are not associated with longitudinal blood pressure in young black adults.
Chen TK, Estrella MM, Vittinghoff E, Lin F, Gutierrez OM, Kramer H, Lewis CE, Kopp JB, Allen NB, Winkler CA, Bibbins-Domingo KB, Peralta CA.
Kidney Int (2017 Oct) 92:964-971. Abstract/Full Text
Chronic Kidney Disease in the Aging Human Immunodeficiency Virus-Infected Population.
Kopp JB.
J Infect Dis (2017 Sep 15) 216:619-621. Abstract/Full Text
APOL1 Risk Variants Independently Associated With Early Cardiovascular Disease Death.
Hughson MD, Hoy WE, Mott SA, Bertram JF, Winkler CA, Kopp JB.
Kidney Int Rep (2018 Jan) 3:89-98. Abstract/Full Text
A tripartite complex of suPAR, APOL1 risk variants and αvβ3 integrin on podocytes mediates chronic kidney disease.
Hayek SS, Koh KH, Grams ME, Wei C, Ko YA, Li J, Samelko B, Lee H, Dande RR, Lee HW, Hahm E, Peev V, Tracy M, Tardi NJ, Gupta V, Altintas MM, Garborcauskas G, Stojanovic N, Winkler CA, Lipkowitz MS, Tin A, Inker LA, Levey AS, Zeier M, Freedman BI, Kopp JB, Skorecki K, Coresh J, Quyyumi AA, Sever S, Reiser J.
Nat Med (2017 Aug) 23:945-953. Abstract/Full Text
Sickle Cell Trait and the Risk of ESRD in Blacks.
Naik RP, Irvin MR, Judd S, Gutiérrez OM, Zakai NA, Derebail VK, Peralta C, Lewis MR, Zhi D, Arnett D, McClellan W, Wilson JG, Reiner AP, Kopp JB, Winkler CA, Cushman M.
J Am Soc Nephrol (2017 Jul) 28:2180-2187. Abstract/Full Text
APOL1-associated glomerular disease among African-American children: a collaboration of the Chronic Kidney Disease in Children (CKiD) and Nephrotic Syndrome Study Network (NEPTUNE) cohorts.
Ng DK, Robertson CC, Woroniecki RP, Limou S, Gillies CE, Reidy KJ, Winkler CA, Hingorani S, Gibson KL, Hjorten R, Sethna CB, Kopp JB, Moxey-Mims M, Furth SL, Warady BA, Kretzler M, Sedor JR, Kaskel FJ, Sampson MG.
Nephrol Dial Transplant (2017 Jun 1) 32:983-990. Abstract/Full Text
Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in mice.
Beckerman P, Bi-Karchin J, Park AS, Qiu C, Dummer PD, Soomro I, Boustany-Kari CM, Pullen SS, Miner JH, Hu CA, Rohacs T, Inoue K, Ishibe S, Saleem MA, Palmer MB, Cuervo AM, Kopp JB, Susztak K.
Nat Med (2017 Apr) 23:429-438. Abstract/Full Text
Absence of APOL1 risk alleles in a remote living Australian Aboriginal group with high rates of CKD, hypertension, diabetes, and cardiovascular disease.
Hoy WE, Kopp JB, Mott SA, Winkler CA.
Kidney Int (2017 Apr) 91:990. Abstract/Full Text
Therapeutics for APOL1 nephropathies: putting out the fire in the podocyte.
Heymann J, Winkler CA, Hoek M, Susztak K, Kopp JB.
Nephrol Dial Transplant (2017 Jan 1) 32:i65-i70. Abstract/Full Text
Renal and Cardiovascular Morbidities Associated with APOL1 Status among African-American and Non-African-American Children with Focal Segmental Glomerulosclerosis.
Woroniecki RP, Ng DK, Limou S, Winkler CA, Reidy KJ, Mitsnefes M, Sampson MG, Wong CS, Warady BA, Furth SL, Kopp JB, Kaskel FJ.
Front Pediatr (2016) 4:122. Abstract/Full Text
Combined Effects of GSTM1 Null Allele and APOL1 Renal Risk Alleles in CKD Progression in the African American Study of Kidney Disease and Hypertension Trial.
Bodonyi-Kovacs G, Ma JZ, Chang J, Lipkowitz MS, Kopp JB, Winkler CA, Le TH.
J Am Soc Nephrol (2016 Oct) 27:3140-3152. Abstract/Full Text
Brief Report: APOL1 Renal Risk Variants Are Associated With Chronic Kidney Disease in Children and Youth With Perinatal HIV Infection.
Purswani MU, Patel K, Winkler CA, Spector SA, Hazra R, Seage GR 3rd, Mofenson L, Karalius B, Scott GB, Van Dyke RB, Kopp JB, Pediatric HIVAIDS Cohort Study..
J Acquir Immune Defic Syndr (2016 Sep 1) 73:63-8. Abstract/Full Text
APOL1 Risk Alleles are Associated with More Severe Arteriosclerosis in Renal Resistance Vessels with Aging and Hypertension.
Hughson MD, Hoy WE, Mott SA, Puelles VG, Bertram JF, Winkler CL, Kopp JB.
Kidney Int Rep (2016 May) 1:10-23. Abstract/Full Text
A role for genetic susceptibility in sporadic focal segmental glomerulosclerosis.
Yu H, Artomov M, Brähler S, Stander MC, Shamsan G, Sampson MG, White JM, Kretzler M, Miner JH, Jain S, Winkler CA, Mitra RD, Kopp JB, Daly MJ, Shaw AS.
J Clin Invest (2016 Apr 1) 126:1603. Abstract/Full Text
Integrative Genomics Identifies Novel Associations with APOL1 Risk Genotypes in Black NEPTUNE Subjects.
Sampson MG, Robertson CC, Martini S, Mariani LH, Lemley KV, Gillies CE, Otto EA, Kopp JB, Randolph A, Vega-Warner V, Eichinger F, Nair V, Gipson DS, Cattran DC, Johnstone DB, O'Toole JF, Bagnasco SM, Song PX, Barisoni L, Troost JP, Kretzler M, Sedor JR, Nephrotic Syndrome Study Network..
J Am Soc Nephrol (2016 Mar) 27:814-23. Abstract/Full Text
APOL1 Genotype and Race Differences in Incident Albuminuria and Renal Function Decline.
Peralta CA, Bibbins-Domingo K, Vittinghoff E, Lin F, Fornage M, Kopp JB, Winkler CA.
J Am Soc Nephrol (2016 Mar) 27:887-93. Abstract/Full Text
A role for genetic susceptibility in sporadic focal segmental glomerulosclerosis.
Yu H, Artomov M, Brähler S, Stander MC, Shamsan G, Sampson MG, White JM, Kretzler M, Miner JH, Jain S, Winkler CA, Mitra RD, Kopp JB, Daly MJ, Shaw AS.
J Clin Invest (2016 Mar 1) 126:1067-78. Abstract/Full Text
Association of APOL1 Genotype with Renal Histology among Black HIV-Positive Patients Undergoing Kidney Biopsy.
Atta MG, Estrella MM, Skorecki KL, Kopp JB, Winkler CA, Wasser WG, Shemer R, Racusen LC, Kuperman M, Foy MC, Lucas GM, Fine DM.
Clin J Am Soc Nephrol (2016 Feb 5) 11:262-70. Abstract/Full Text
APOL1 Risk Alleles Are Associated with Exaggerated Age-Related Changes in Glomerular Number and Volume in African-American Adults: An Autopsy Study.
Hoy WE, Hughson MD, Kopp JB, Mott SA, Bertram JF, Winkler CA.
J Am Soc Nephrol (2015 Dec) 26:3179-89. Abstract/Full Text
APOL1 Risk Variants Are Strongly Associated with HIV-Associated Nephropathy in Black South Africans.
Kasembeli AN, Duarte R, Ramsay M, Mosiane P, Dickens C, Dix-Peek T, Limou S, Sezgin E, Nelson GW, Fogo AB, Goetsch S, Kopp JB, Winkler CA, Naicker S.
J Am Soc Nephrol (2015 Nov) 26:2882-90. Abstract/Full Text
Sequencing rare and common APOL1 coding variants to determine kidney disease risk.
Limou S, Nelson GW, Lecordier L, An P, O'hUigin CS, David VA, Binns-Roemer EA, Guiblet WM, Oleksyk TK, Pays E, Kopp JB, Winkler CA.
Kidney Int (2015 Oct) 88:754-63. Abstract/Full Text
APOL1 toxin, innate immunity, and kidney injury.
Limou S, Dummer PD, Nelson GW, Kopp JB, Winkler CA.
Kidney Int (2015 Jul) 88:28-34. Abstract/Full Text
Clinical Features and Histology of Apolipoprotein L1-Associated Nephropathy in the FSGS Clinical Trial.
Kopp JB, Winkler CA, Zhao X, Radeva MK, Gassman JJ, D'Agati VD, Nast CC, Wei C, Reiser J, Guay-Woodford LM, Pollak MR, Hildebrandt F, Moxey-Mims M, Gipson DS, Trachtman H, Friedman AL, Kaskel FJ, FSGS-CT Study Consortium..
J Am Soc Nephrol (2015 Jun) 26:1443-8. Abstract/Full Text
Copy Number Variation at the APOL1 Locus.
Ruchi R, Genovese G, Lee J, Charoonratana VT, Bernhardy AJ, Alper SL, Kopp JB, Thadhani R, Friedman DJ, Pollak MR.
PLoS One (2015) 10:e0125410. Abstract/Full Text
APOL1 Kidney Disease Risk Variants: An Evolving Landscape.
Dummer PD, Limou S, Rosenberg AZ, Heymann J, Nelson G, Winkler CA, Kopp JB.
Semin Nephrol (2015 May) 35:222-36. Abstract/Full Text
Innate immunity pathways regulate the nephropathy gene Apolipoprotein L1.
Nichols B, Jog P, Lee JH, Blackler D, Wilmot M, D'Agati V, Markowitz G, Kopp JB, Alper SL, Pollak MR, Friedman DJ.
Kidney Int (2015 Feb) 87:332-42. Abstract/Full Text
Renin lineage cells repopulate the glomerular mesangium after injury.
Starke C, Betz H, Hickmann L, Lachmann P, Neubauer B, Kopp JB, Sequeira-Lopez ML, Gomez RA, Hohenstein B, Todorov VT, Hugo CP.
J Am Soc Nephrol (2015 Jan) 26:48-54. Abstract/Full Text
Protective effects of aliskiren and valsartan in mice with diabetic nephropathy.
Wang W, Qiu L, Howard A, Solis N, Li C, Wang X, Kopp JB, Levi M.
J Renin Angiotensin Aldosterone Syst (2014 Dec) 15:384-95. Abstract/Full Text
Mutations in the gene that encodes the F-actin binding protein anillin cause FSGS.
Gbadegesin RA, Hall G, Adeyemo A, Hanke N, Tossidou I, Burchette J, Wu G, Homstad A, Sparks MA, Gomez J, Jiang R, Alonso A, Lavin P, Conlon P, Korstanje R, Stander MC, Shamsan G, Barua M, Spurney R, Singhal PC, Kopp JB, Haller H, Howell D, Pollak MR, Shaw AS, Schiffer M, Winn MP.
J Am Soc Nephrol (2014 Sep) 25:1991-2002. Abstract/Full Text
APOL1 kidney risk alleles: population genetics and disease associations.
Limou S, Nelson GW, Kopp JB, Winkler CA.
Adv Chronic Kidney Dis (2014 Sep) 21:426-33. Abstract/Full Text
Lipid biology of the podocyte--new perspectives offer new opportunities.
Fornoni A, Merscher S, Kopp JB.
Nat Rev Nephrol (2014 Jul) 10:379-88. Abstract/Full Text
Podocytes degrade endocytosed albumin primarily in lysosomes.
Carson JM, Okamura K, Wakashin H, McFann K, Dobrinskikh E, Kopp JB, Blaine J.
PLoS One (2014) 9:e99771. Abstract/Full Text
Evolution of the primate trypanolytic factor APOL1.
Thomson R, Genovese G, Canon C, Kovacsics D, Higgins MK, Carrington M, Winkler CA, Kopp J, Rotimi C, Adeyemo A, Doumatey A, Ayodo G, Alper SL, Pollak MR, Friedman DJ, Raper J.
Proc Natl Acad Sci U S A (2014 May 20) 111:E2130-9. Abstract/Full Text
Human podocytes perform polarized, caveolae-dependent albumin endocytosis.
Dobrinskikh E, Okamura K, Kopp JB, Doctor RB, Blaine J.
Am J Physiol Renal Physiol (2014 May 1) 306:F941-51. Abstract/Full Text
Increased mitochondrial activity in renal proximal tubule cells from young spontaneously hypertensive rats.
Lee H, Abe Y, Lee I, Shrivastav S, Crusan AP, Hüttemann M, Hopfer U, Felder RA, Asico LD, Armando I, Jose PA, Kopp JB.
Kidney Int (2014 Mar) 85:561-9. Abstract/Full Text
HIV-1 Vpr induces adipose dysfunction in vivo through reciprocal effects on PPAR/GR co-regulation.
Agarwal N, Iyer D, Patel SG, Sekhar RV, Phillips TM, Schubert U, Oplt T, Buras ED, Samson SL, Couturier J, Lewis DE, Rodriguez-Barradas MC, Jahoor F, Kino T, Kopp JB, Balasubramanyam A.
Sci Transl Med (2013 Nov 27) 5:213ra164. Abstract/Full Text