Ronald Ouwerkerk, Ph.D.
Headshot of Ronald Ouwerkerk, Ph.D.
Staff Scientist: Biomedical and Metabolic Imaging Branch
Scientific Focus Areas: Biomedical Engineering and Biophysics, Chemical Biology


A selection of recent and significant publications can be viewed below.

Water suppression in the human brain with hypergeometric RF pulses for single-voxel and multi-voxel MR spectroscopy.
Chan KL, Ouwerkerk R, Barker PB.
Magn Reson Med (2018 Oct) 80:1298-1306. Abstract/Full Text
Metreleptin-mediated improvements in insulin sensitivity are independent of food intake in humans with lipodystrophy.
Brown RJ, Valencia A, Startzell M, Cochran E, Walter PJ, Garraffo HM, Cai H, Gharib AM, Ouwerkerk R, Courville AB, Bernstein S, Brychta RJ, Chen KY, Walter M, Auh S, Gorden P.
J Clin Invest (2018 Aug 1) 128:3504-3516. Abstract/Full Text
Myocardial Fat Accumulation Is Independent of Measures of Insulin Sensitivity.
Muniyappa R, Noureldin R, Ouwerkerk R, Liu EY, Madan R, Abel BS, Mullins K, Walter MF, Skarulis MC, Gharib AM.
J Clin Endocrinol Metab (2015 Aug) 100:3060-8. Abstract/Full Text
Multiparametric and Multimodality Functional Radiological Imaging for Breast Cancer Diagnosis and Early Treatment Response Assessment.
Jacobs MA, Wolff AC, Macura KJ, Stearns V, Ouwerkerk R, El Khouli R, Bluemke DA, Wahl R.
J Natl Cancer Inst Monogr (2015 May) 2015:40-6. Abstract/Full Text
Metabolic effects of chronic cannabis smoking.
Muniyappa R, Sable S, Ouwerkerk R, Mari A, Gharib AM, Walter M, Courville A, Hall G, Chen KY, Volkow ND, Kunos G, Huestis MA, Skarulis MC.
Diabetes Care (2013 Aug) 36:2415-22. Abstract/Full Text
Spin-echo magnetic resonance spectroscopic imaging at 7 T with frequency-modulated refocusing pulses.
Zhu H, Soher BJ, Ouwerkerk R, Schär M, Barker PB.
Magn Reson Med (2013 May) 69:1217-25. Abstract/Full Text
Liver metabolite concentrations measured with 1H MR spectroscopy.
Ouwerkerk R, Pettigrew RI, Gharib AM.
Radiology (2012 Nov) 265:565-75. Abstract/Full Text
Monitoring of neoadjuvant chemotherapy using multiparametric, ²³Na sodium MR, and multimodality (PET/CT/MRI) imaging in locally advanced breast cancer.
Jacobs MA, Ouwerkerk R, Wolff AC, Gabrielson E, Warzecha H, Jeter S, Bluemke DA, Wahl R, Stearns V.
Breast Cancer Res Treat (2011 Jul) 128:119-26. Abstract/Full Text
Use of perfluorocarbon nanoparticles for non-invasive multimodal cell tracking of human pancreatic islets.
Barnett BP, Ruiz-Cabello J, Hota P, Ouwerkerk R, Shamblott MJ, Lauzon C, Walczak P, Gilson WD, Chacko VP, Kraitchman DL, Arepally A, Bulte JW.
Contrast Media Mol Imaging (2011 Jul-Aug) 6:251-9. Abstract/Full Text
High resolution spectroscopic imaging of GABA at 3 Tesla.
Zhu H, Edden RA, Ouwerkerk R, Barker PB.
Magn Reson Med (2011 Mar) 65:603-9. Abstract/Full Text
Sodium MRI.
Ouwerkerk R.
Methods Mol Biol (2011) 711:175-201. Abstract/Full Text
Multiparametric magnetic resonance imaging, spectroscopy and multinuclear (²³Na) imaging monitoring of preoperative chemotherapy for locally advanced breast cancer.
Jacobs MA, Stearns V, Wolff AC, Macura K, Argani P, Khouri N, Tsangaris T, Barker PB, Davidson NE, Bhujwalla ZM, Bluemke DA, Ouwerkerk R.
Acad Radiol (2010 Dec) 17:1477-85. Abstract/Full Text
Dual-band water and lipid suppression for MR spectroscopic imaging at 3 Tesla.
Zhu H, Ouwerkerk R, Barker PB.
Magn Reson Med (2010 Jun) 63:1486-92. Abstract/Full Text
Myocardial fat quantification in humans: Evaluation by two-point water-fat imaging and localized proton spectroscopy.
Liu CY, Redheuil A, Ouwerkerk R, Lima JA, Bluemke DA.
Magn Reson Med (2010 Apr) 63:892-901. Abstract/Full Text
Spectrally selective B1-insensitive T2 magnetization preparation sequence.
Nezafat R, Ouwerkerk R, Derbyshire AJ, Stuber M, McVeigh ER.
Magn Reson Med (2009 Jun) 61:1326-35. Abstract/Full Text
Quantitative cardiac 31P spectroscopy at 3 Tesla using adiabatic pulses.
El-Sharkawy AM, Schär M, Ouwerkerk R, Weiss RG, Bottomley PA.
Magn Reson Med (2009 Apr) 61:785-95. Abstract/Full Text
Proton, diffusion-weighted imaging, and sodium (23Na) MRI of uterine leiomyomata after MR-guided high-intensity focused ultrasound: a preliminary study.
Jacobs MA, Ouwerkerk R, Kamel I, Bottomley PA, Bluemke DA, Kim HS.
J Magn Reson Imaging (2009 Mar) 29:649-56. Abstract/Full Text
Diffusion-weighted imaging with apparent diffusion coefficient mapping and spectroscopy in prostate cancer.
Jacobs MA, Ouwerkerk R, Petrowski K, Macura KJ.
Top Magn Reson Imaging (2008 Dec) 19:261-72. Abstract/Full Text
Tissue sodium concentration in myocardial infarction in humans: a quantitative 23Na MR imaging study.
Ouwerkerk R, Bottomley PA, Solaiyappan M, Spooner AE, Tomaselli GF, Wu KC, Weiss RG.
Radiology (2008 Jul) 248:88-96. Abstract/Full Text
Elevated tissue sodium concentration in malignant breast lesions detected with non-invasive 23Na MRI.
Ouwerkerk R, Jacobs MA, Macura KJ, Wolff AC, Stearns V, Mezban SD, Khouri NF, Bluemke DA, Bottomley PA.
Breast Cancer Res Treat (2007 Dec) 106:151-60. Abstract/Full Text
Sodium magnetic resonance imaging: from research to clinical use.
Ouwerkerk R.
J Am Coll Radiol (2007 Oct) 4:739-41. Abstract/Full Text
AAPM/RSNA physics tutorials for residents: MR imaging: brief overview and emerging applications.
Jacobs MA, Ibrahim TS, Ouwerkerk R.
Radiographics (2007 Jul-Aug) 27:1213-29. Abstract/Full Text
Patterns of enhancement on breast MR images: interpretation and imaging pitfalls.
Macura KJ, Ouwerkerk R, Jacobs MA, Bluemke DA.
Radiographics (2006 Nov-Dec) 26:1719-34; quiz 1719. Abstract/Full Text
B1-insensitive T2 preparation for improved coronary magnetic resonance angiography at 3 T.
Nezafat R, Stuber M, Ouwerkerk R, Gharib AM, Desai MY, Pettigrew RI.
Magn Reson Med (2006 Apr) 55:858-64. Abstract/Full Text
Quantifying in vivo MR spectra with circles.
Gabr RE, Ouwerkerk R, Bottomley PA.
J Magn Reson (2006 Mar) 179:152-63. Abstract/Full Text
Xanthine oxidase inhibitors improve energetics and function after infarction in failing mouse hearts.
Naumova AV, Chacko VP, Ouwerkerk R, Stull L, Marbán E, Weiss RG.
Am J Physiol Heart Circ Physiol (2006 Feb) 290:H837-43. Abstract/Full Text
Measuring human cardiac tissue sodium concentrations using surface coils, adiabatic excitation, and twisted projection imaging with minimal T2 losses.
Ouwerkerk R, Weiss RG, Bottomley PA.
J Magn Reson Imaging (2005 May) 21:546-55. Abstract/Full Text
MR imaging of biodegradable polymeric microparticles: a potential method of monitoring local drug delivery.
Chen HH, Le Visage C, Qiu B, Du X, Ouwerkerk R, Leong KW, Yang X.
Magn Reson Med (2005 Mar) 53:614-20. Abstract/Full Text
Combined dynamic contrast enhanced breast MR and proton spectroscopic imaging: a feasibility study.
Jacobs MA, Barker PB, Argani P, Ouwerkerk R, Bhujwalla ZM, Bluemke DA.
J Magn Reson Imaging (2005 Jan) 21:23-8. Abstract/Full Text
Multiparametric and multinuclear magnetic resonance imaging of human breast cancer: current applications.
Jacobs MA, Ouwerkerk R, Wolff AC, Stearns V, Bottomley PA, Barker PB, Argani P, Khouri N, Davidson NE, Bhujwalla ZM, Bluemke DA.
Technol Cancer Res Treat (2004 Dec) 3:543-50. Abstract/Full Text
Tissue sodium concentration in human brain tumors as measured with 23Na MR imaging.
Ouwerkerk R, Bleich KB, Gillen JS, Pomper MG, Bottomley PA.
Radiology (2003 May) 227:529-37. Abstract/Full Text
Four-angle saturation transfer (FAST) method for measuring creatine kinase reaction rates in vivo.
Bottomley PA, Ouwerkerk R, Lee RF, Weiss RG.
Magn Reson Med (2002 May) 47:850-63. Abstract/Full Text