Ramón A. Piñol, Ph.D.
Photo of Ramón Piñol.
Scientific Focus Areas: Neuroscience, Molecular Biology and Biochemistry


A selection of recent and significant publications can be viewed below.

A distinct hypothalamus-to-β cell circuit modulates insulin secretion.
Papazoglou I, Lee JH, Cui Z, Li C, Fulgenzi G, Bahn YJ, Staniszewska-Goraczniak HM, Piñol RA, Hogue IB, Enquist LW, Krashes MJ, Rane SG.
Cell Metab (2022 Feb 1) 34:285-298.e7. Abstract/Full Text
Cre Recombinase Driver Mice Reveal Lineage-Dependent and -Independent Expression of Brs3 in the Mouse Brain.
Mogul AS, Hadley CK, Province HS, Pauli J, Gavrilova O, Xiao C, Palmiter RD, Piñol RA, Reitman ML.
eNeuro (2021 Jul-Aug) 8. Abstract/Full Text
Preoptic BRS3 neurons increase body temperature and heart rate via multiple pathways.
Piñol RA, Mogul AS, Hadley CK, Saha A, Li C, Škop V, Province HS, Xiao C, Gavrilova O, Krashes MJ, Reitman ML.
Cell Metab (2021 Jul 6) 33:1389-1403.e6. Abstract/Full Text
Activation of neuronal adenosine A1 receptors causes hypothermia through central and peripheral mechanisms.
Province HS, Xiao C, Mogul AS, Sahoo A, Jacobson KA, Piñol RA, Gavrilova O, Reitman ML.
PLoS One (2020) 15:e0243986. Abstract/Full Text
BRS3 in both MC4R- and SIM1-expressing neurons regulates energy homeostasis in mice.
Xiao C, Liu N, Province H, Piñol RA, Gavrilova O, Reitman ML.
Mol Metab (2020 Jun) 36:100969. Abstract/Full Text
Cool(ing) brain stem GABA neurons.
Piñol RA, Reitman ML.
Cell Res (2019 Oct) 29:785-786. Abstract/Full Text
Brs3 neurons in the mouse dorsomedial hypothalamus regulate body temperature, energy expenditure, and heart rate, but not food intake.
Piñol RA, Zahler SH, Li C, Saha A, Tan BK, Škop V, Gavrilova O, Xiao C, Krashes MJ, Reitman ML.
Nat Neurosci (2018 Nov) 21:1530-1540. Abstract/Full Text
Melanotan II causes hypothermia in mice by activation of mast cells and stimulation of histamine 1 receptors.
Jain S, Panyutin A, Liu N, Xiao C, Piñol RA, Pundir P, Girardet C, Butler AA, Dong X, Gavrilova O, Reitman ML.
Am J Physiol Endocrinol Metab (2018 Sep 1) 315:E357-E366. Abstract/Full Text
Corrigendum to "Bombesin-like receptor 3 (Brs3) expression in glutamatergic, but not GABAergic, neurons is required for regulation of energy metabolism" [Mol Metabol 6 (2017) 1540-1550].
Xiao C, Piñol RA, Carlin JL, Li C, Deng C, Gavrilova O, Reitman ML.
Mol Metab (2018 Mar) 9:220. Abstract/Full Text
Bombesin-like receptor 3 (Brs3) expression in glutamatergic, but not GABAergic, neurons is required for regulation of energy metabolism.
Xiao C, Piñol RA, Carlin JL, Li C, Deng C, Gavrilova O, Reitman ML.
Mol Metab (2017 Nov) 6:1540-1550. Abstract/Full Text
Peripheral Adenosine A3 Receptor Activation Causes Regulated Hypothermia in Mice That Is Dependent on Central Histamine H1 Receptors.
Carlin JL, Tosh DK, Xiao C, Piñol RA, Chen Z, Salvemini D, Gavrilova O, Jacobson KA, Reitman ML.
J Pharmacol Exp Ther (2016 Feb) 356:474-82. Abstract/Full Text
Visualization of oxytocin release that mediates paired pulse facilitation in hypothalamic pathways to brainstem autonomic neurons.
Piñol RA, Jameson H, Popratiloff A, Lee NH, Mendelowitz D.
PLoS One (2014) 9:e112138. Abstract/Full Text
Chronic intermittent hypoxia and hypercapnia inhibit the hypothalamic paraventricular nucleus neurotransmission to parasympathetic cardiac neurons in the brain stem.
Dergacheva O, Dyavanapalli J, Piñol RA, Mendelowitz D.
Hypertension (2014 Sep) 64:597-603. Abstract/Full Text
Biphasic effect of melanocortin agonists on metabolic rate and body temperature.
Lute B, Jou W, Lateef DM, Goldgof M, Xiao C, Piñol RA, Kravitz AV, Miller NR, Huang YG, Girardet C, Butler AA, Gavrilova O, Reitman ML.
Cell Metab (2014 Aug 5) 20:333-45. Abstract/Full Text
Optogenetic stimulation of locus ceruleus neurons augments inhibitory transmission to parasympathetic cardiac vagal neurons via activation of brainstem α1 and β1 receptors.
Wang X, Piñol RA, Byrne P, Mendelowitz D.
J Neurosci (2014 Apr 30) 34:6182-9. Abstract/Full Text
Optogenetic approaches to characterize the long-range synaptic pathways from the hypothalamus to brain stem autonomic nuclei.
Piñol RA, Bateman R, Mendelowitz D.
J Neurosci Methods (2012 Sep 30) 210:238-46. Abstract/Full Text
5-HT2 receptors modulate excitatory neurotransmission to cardiac vagal neurons within the nucleus ambiguus evoked during and after hypoxia.
Dergacheva O, Kamendi H, Wang X, Pinol RA, Frank J, Gorini C, Jameson H, Lovett-Barr MR, Mendelowitz D.
Neuroscience (2009 Dec 15) 164:1191-8. Abstract/Full Text
Leptin regulation of the mesoaccumbens dopamine pathway.
Fulton S, Pissios P, Manchon RP, Stiles L, Frank L, Pothos EN, Maratos-Flier E, Flier JS.
Neuron (2006 Sep 21) 51:811-22. Abstract/Full Text
Last Reviewed July 2023