Olga Protchenko, Ph.D.

Photo of Olga Protchenko
Scientific Focus Areas: Cell Biology, Chemical Biology, Genetics and Genomics, Microbiology and Infectious Diseases, Molecular Biology and Biochemistry
Scientific Focus Areas: Genetics/Genomics Molecular Biology/BiochemistryCell Biology/Cell SignalingChemistry/Chemical BiologyMicrobiology/Infectious Diseases (non-viral)


A selection of recent and significant publications can be viewed below.

Topologically conserved residues direct heme transport in HRG-1-related proteins.
Yuan X, Protchenko O, Philpott CC, Hamza I.
J Biol Chem (2012 Feb 10) 287:4914-24. Abstract/Full Text
Heme uptake by Leishmania amazonensis is mediated by the transmembrane protein LHR1.
Huynh C, Yuan X, Miguel DC, Renberg RL, Protchenko O, Philpott CC, Hamza I, Andrews NW.
PLoS Pathog (2012) 8:e1002795. Abstract/Full Text
Phosphatidylserine is involved in the ferrichrome-induced plasma membrane trafficking of Arn1 in Saccharomyces cerevisiae.
Guo Y, Au WC, Shakoury-Elizeh M, Protchenko O, Basrai M, Prinz WA, Philpott CC.
J Biol Chem (2010 Dec 10) 285:39564-73. Abstract/Full Text
Metabolic response to iron deficiency in Saccharomyces cerevisiae.
Shakoury-Elizeh M, Protchenko O, Berger A, Cox J, Gable K, Dunn TM, Prinz WA, Bard M, Philpott CC.
J Biol Chem (2010 May 7) 285:14823-33. Abstract/Full Text
Deficiency in frataxin homologue YFH1 in the yeast Pichia guilliermondii leads to missregulation of iron acquisition and riboflavin biosynthesis and affects sulfate assimilation.
Pynyaha YV, Boretsky YR, Fedorovych DV, Fayura LR, Levkiv AI, Ubiyvovk VM, Protchenko OV, Philpott CC, Sibirny AA.
Biometals (2009 Dec) 22:1051-61. Abstract/Full Text
Role of PUG1 in inducible porphyrin and heme transport in Saccharomyces cerevisiae.
Protchenko O, Shakoury-Elizeh M, Keane P, Storey J, Androphy R, Philpott CC.
Eukaryot Cell (2008 May) 7:859-71. Abstract/Full Text
Response to iron deprivation in Saccharomyces cerevisiae.
Philpott CC, Protchenko O.
Eukaryot Cell (2008 Jan) 7:20-7. Abstract/Full Text
Mutations and environmental factors affecting regulation of riboflavin synthesis and iron assimilation also cause oxidative stress in the yeast Pichia guilliermondii.
Boretsky YR, Protchenko OV, Prokopiv TM, Mukalov IO, Fedorovych DV, Sibirny AA.
J Basic Microbiol (2007 Oct) 47:371-7. Abstract/Full Text
Development of a transformation system for gene knock-out in the flavinogenic yeast Pichia guilliermondii.
Boretsky YR, Pynyaha YV, Boretsky VY, Kutsyaba VI, Protchenko OV, Philpott CC, Sibirny AA.
J Microbiol Methods (2007 Jul) 70:13-9. Abstract/Full Text
A screen for genes of heme uptake identifies the FLC family required for import of FAD into the endoplasmic reticulum.
Protchenko O, Rodriguez-Suarez R, Androphy R, Bussey H, Philpott CC.
J Biol Chem (2006 Jul 28) 281:21445-57. Abstract/Full Text
Regulation of intracellular heme levels by HMX1, a homologue of heme oxygenase, in Saccharomyces cerevisiae.
Protchenko O, Philpott CC.
J Biol Chem (2003 Sep 19) 278:36582-7. Abstract/Full Text
The response to iron deprivation in Saccharomyces cerevisiae: expression of siderophore-based systems of iron uptake.
Philpott CC, Protchenko O, Kim YW, Boretsky Y, Shakoury-Elizeh M.
Biochem Soc Trans (2002 Aug) 30:698-702. Abstract/Full Text
Three cell wall mannoproteins facilitate the uptake of iron in Saccharomyces cerevisiae.
Protchenko O, Ferea T, Rashford J, Tiedeman J, Brown PO, Botstein D, Philpott CC.
J Biol Chem (2001 Dec 28) 276:49244-50. Abstract/Full Text
[Synergistic effect of rib80 and hit mutations on riboflavin biosynthesis and iron transport in the yeast Pichia guilliermondii].
Fedorovich DV, Romaniuk TM, Protchenko OV, Gudz' SP.
Mikrobiologiia (2000 Mar-Apr) 69:180-4. Abstract/Full Text
Iron uptake by the yeast Pichia guilliermondii. Flavinogenesis and reductive iron assimilation are co-regulated processes.
Fedorovich D, Protchenko O, Lesuisse E.
Biometals (1999 Dec) 12:295-300. Abstract/Full Text