Arthur Sherman, Ph.D.

Photo of Dr. Arthur Sherman
Scientific Focus Areas: Cell Biology, Computational Biology, Neuroscience

Publications

A selection of recent and significant publications can be viewed below.

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Modeling the pancreatic α-cell: dual mechanisms of glucose suppression of glucagon secretion.
Watts M, Sherman A.
Biophys J (2014 Feb 4) 106:741-51. Abstract/Full Text
A Mathematical Model of the Pathogenesis, Prevention, and Reversal of Type 2 Diabetes.
Ha J, Satin LS, Sherman AS.
Endocrinology (2016 Feb) 157:624-35. Abstract/Full Text
Ca2+ Effects on ATP Production and Consumption Have Regulatory Roles on Oscillatory Islet Activity.
McKenna JP, Ha J, Merrins MJ, Satin LS, Sherman A, Bertram R.
Biophys J (2016 Feb 2) 110:733-742. Abstract/Full Text
Time to glucose peak during an oral glucose tolerance test identifies prediabetes risk.
Chung ST, Ha J, Onuzuruike AU, Kasturi K, Galvan-De La Cruz M, Bingham BA, Baker RL, Utumatwishima JN, Mabundo LS, Ricks M, Sherman AS, Sumner AE.
Clin Endocrinol (Oxf) (2017 Nov) 87:484-491. Abstract/Full Text
Closing in on the Mechanisms of Pulsatile Insulin Secretion.
Bertram R, Satin LS, Sherman AS.
Diabetes (2018 Mar) 67:351-359. Abstract/Full Text

Additional Publications

Common and diverse elements of ion channels and receptors underlying electrical activity in endocrine pituitary cells.
Fletcher PA, Sherman A, Stojilkovic SS.
Mol Cell Endocrinol (2018 Mar 5) 463:23-36. Abstract/Full Text
How Adaptation Makes Low Firing Rates Robust.
Sherman AS, Ha J.
J Math Neurosci (2017 Dec) 7:4. Abstract/Full Text
Hemoglobin Glycation Index Is Associated With Cardiovascular Diseases in People With Impaired Glucose Metabolism.
Ahn CH, Min SH, Lee DH, Oh TJ, Kim KM, Moon JH, Choi SH, Park KS, Jang HC, Ha J, Sherman AS, Lim S.
J Clin Endocrinol Metab (2017 Aug 1) 102:2905-2913. Abstract/Full Text
Deciphering the regulation of P2X4 receptor channel gating by ivermectin using Markov models.
Mackay L, Zemkova H, Stojilkovic SS, Sherman A, Khadra A.
PLoS Comput Biol (2017 Jul) 13:e1005643. Abstract/Full Text
Modeling the diversity of spontaneous and agonist-induced electrical activity in anterior pituitary corticotrophs.
Fletcher PA, Zemkova H, Stojilkovic SS, Sherman A.
J Neurophysiol (2017 Jun 1) 117:2298-2311. Abstract/Full Text
Ca2+ channel clustering with insulin-containing granules is disturbed in type 2 diabetes.
Gandasi NR, Yin P, Riz M, Chibalina MV, Cortese G, Lund PE, Matveev V, Rorsman P, Sherman A, Pedersen MG, Barg S.
J Clin Invest (2017 Jun 1) 127:2353-2364. Abstract/Full Text
Islets Transplanted Into the Eye: Do They Improve Our Insight Into Islet Adaptation to Insulin Resistance?
Satin LS, Ha J, Sherman AS.
Diabetes (2016 Sep) 65:2470-2. Abstract/Full Text
Paracrine regulation of glucagon secretion: the β/α/δ model.
Watts M, Ha J, Kimchi O, Sherman A.
Am J Physiol Endocrinol Metab (2016 Apr 15) 310:E597-E611. Abstract/Full Text
Phase Analysis of Metabolic Oscillations and Membrane Potential in Pancreatic Islet β-Cells.
Merrins MJ, Poudel C, McKenna JP, Ha J, Sherman A, Bertram R, Satin LS.
Biophys J (2016 Feb 2) 110:691-699. Abstract/Full Text
Chronic Glucose Exposure Systematically Shifts the Oscillatory Threshold of Mouse Islets: Experimental Evidence for an Early Intrinsic Mechanism of Compensation for Hyperglycemia.
Glynn E, Thompson B, Vadrevu S, Lu S, Kennedy RT, Ha J, Sherman A, Satin LS.
Endocrinology (2016 Feb) 157:611-23. Abstract/Full Text
Modeling of glucose-induced cAMP oscillations in pancreatic β cells: cAMP rocks when metabolism rolls.
Peercy BE, Sherman AS, Bertram R.
Biophys J (2015 Jul 21) 109:439-49. Abstract/Full Text
Allosteric regulation of the P2X4 receptor channel pore dilation.
Zemkova H, Khadra A, Rokic MB, Tvrdonova V, Sherman A, Stojilkovic SS.
Pflugers Arch (2015 Apr) 467:713-26. Abstract/Full Text
Pulsatile insulin secretion, impaired glucose tolerance and type 2 diabetes.
Satin LS, Butler PC, Ha J, Sherman AS.
Mol Aspects Med (2015 Apr) 42:61-77. Abstract/Full Text
Subcutaneous adipose cell size and distribution: relationship to insulin resistance and body fat.
McLaughlin T, Lamendola C, Coghlan N, Liu TC, Lerner K, Sherman A, Cushman SW.
Obesity (Silver Spring) (2014 Mar) 22:673-80. Abstract/Full Text
Calcium and Metabolic Oscillations in Pancreatic Islets: Who's Driving the Bus?*
Watts M, Fendler B, Merrins MJ, Satin LS, Bertram R, Sherman A.
SIAM J Appl Dyn Syst (2014) 13:683-703. Abstract/Full Text
Slow oscillations of KATP conductance in mouse pancreatic islets provide support for electrical bursting driven by metabolic oscillations.
Ren J, Sherman A, Bertram R, Goforth PB, Nunemaker CS, Waters CD, Satin LS.
Am J Physiol Endocrinol Metab (2013 Oct 1) 305:E805-17. Abstract/Full Text
Dual gating mechanism and function of P2X7 receptor channels.
Khadra A, Tomić M, Yan Z, Zemkova H, Sherman A, Stojilkovic SS.
Biophys J (2013 Jun 18) 104:2612-21. Abstract/Full Text
CROSS-CURRENTS BETWEEN BIOLOGY AND MATHEMATICS: THE CODIMENSION OF PSEUDO-PLATEAU BURSTING.
Osinga HM, Sherman A, Tsaneva-Atanasova K.
Discrete Contin Dyn Syst Ser A (2012 Aug) 32:2853-2877. Abstract/Full Text
The size of large adipose cells is a predictor of insulin resistance in first-degree relatives of type 2 diabetic patients.
Yang J, Eliasson B, Smith U, Cushman SW, Sherman AS.
Obesity (Silver Spring) (2012 May) 20:932-8. Abstract/Full Text
Gating properties of the P2X2a and P2X2b receptor channels: experiments and mathematical modeling.
Khadra A, Yan Z, Coddou C, Tomić M, Sherman A, Stojilkovic SS.
J Gen Physiol (2012 May) 139:333-48. Abstract/Full Text
Phosphofructo-2-kinase/fructose-2,6-bisphosphatase modulates oscillations of pancreatic islet metabolism.
Merrins MJ, Bertram R, Sherman A, Satin LS.
PLoS One (2012) 7:e34036. Abstract/Full Text
Calcium-dependent block of P2X7 receptor channel function is allosteric.
Yan Z, Khadra A, Sherman A, Stojilkovic SS.
J Gen Physiol (2011 Oct) 138:437-52. Abstract/Full Text
Dynamical systems theory in physiology.
Sherman A.
J Gen Physiol (2011 Jul) 138:13-9. Abstract/Full Text
Calcium cooperativity of exocytosis as a measure of Ca²+ channel domain overlap.
Matveev V, Bertram R, Sherman A.
Brain Res (2011 Jun 29) 1398:126-38. Abstract/Full Text
Investigating the role of T-cell avidity and killing efficacy in relation to type 1 diabetes prediction.
Khadra A, Pietropaolo M, Nepom GT, Sherman A.
PLoS One (2011 May 10) 6:e14796. Abstract/Full Text
Slow variable dominance and phase resetting in phantom bursting.
Watts M, Tabak J, Zimliki C, Sherman A, Bertram R.
J Theor Biol (2011 May 7) 276:218-28. Abstract/Full Text
Experimental characterization and mathematical modeling of P2X7 receptor channel gating.
Yan Z, Khadra A, Li S, Tomic M, Sherman A, Stojilkovic SS.
J Neurosci (2010 Oct 20) 30:14213-24. Abstract/Full Text
Differential adipogenic and inflammatory properties of small adipocytes in Zucker Obese and Lean rats.
Liu A, Sonmez A, Yee G, Bazuine M, Arroyo M, Sherman A, McLaughlin T, Reaven G, Cushman S, Tsao P.
Diab Vasc Dis Res (2010 Oct) 7:311-8. Abstract/Full Text
Lessons from models of pancreatic beta cells for engineering glucose-sensing cells.
Sherman A.
Math Biosci (2010 Sep) 227:12-9. Abstract/Full Text
Cellularity and adipogenic profile of the abdominal subcutaneous adipose tissue from obese adolescents: association with insulin resistance and hepatic steatosis.
Kursawe R, Eszlinger M, Narayan D, Liu T, Bazuine M, Cali AM, D'Adamo E, Shaw M, Pierpont B, Shulman GI, Cushman SW, Sherman A, Caprio S.
Diabetes (2010 Sep) 59:2288-96. Abstract/Full Text
How pancreatic beta-cells discriminate long and short timescale cAMP signals.
Peercy BE, Sherman AS.
Biophys J (2010 Jul 21) 99:398-406. Abstract/Full Text
Metabolic oscillations in pancreatic islets depend on the intracellular Ca2+ level but not Ca2+ oscillations.
Merrins MJ, Fendler B, Zhang M, Sherman A, Bertram R, Satin LS.
Biophys J (2010 Jul 7) 99:76-84. Abstract/Full Text
Full system bifurcation analysis of endocrine bursting models.
Tsaneva-Atanasova K, Osinga HM, Riess T, Sherman A.
J Theor Biol (2010 Jun 21) 264:1133-46. Abstract/Full Text
Pioglitazone increases the proportion of small cells in human abdominal subcutaneous adipose tissue.
McLaughlin TM, Liu T, Yee G, Abbasi F, Lamendola C, Reaven GM, Tsao P, Cushman SW, Sherman A.
Obesity (Silver Spring) (2010 May) 18:926-31. Abstract/Full Text
Inflammation in subcutaneous adipose tissue: relationship to adipose cell size.
McLaughlin T, Deng A, Yee G, Lamendola C, Reaven G, Tsao PS, Cushman SW, Sherman A.
Diabetologia (2010 Feb) 53:369-77. Abstract/Full Text
Electrical bursting, calcium oscillations, and synchronization of pancreatic islets.
Bertram R, Sherman A, Satin LS.
Adv Exp Med Biol (2010) 654:261-79. Abstract/Full Text
Glucose metabolism, islet architecture, and genetic homogeneity in imprinting of [Ca2+](i) and insulin rhythms in mouse islets.
Nunemaker CS, Dishinger JF, Dula SB, Wu R, Merrins MJ, Reid KR, Sherman A, Kennedy RT, Satin LS.
PLoS One (2009 Dec 23) 4:e8428. Abstract/Full Text
Accounting for near-normal glucose sensitivity in Kir6.2[AAA] transgenic mice.
Tsaneva-Atanasova K, Sherman A.
Biophys J (2009 Nov 4) 97:2409-18. Abstract/Full Text
Differential intra-abdominal adipose tissue profiling in obese, insulin-resistant women.
Liu A, McLaughlin T, Liu T, Sherman A, Yee G, Abbasi F, Lamendola C, Morton J, Cushman SW, Reaven GM, Tsao PS.
Obes Surg (2009 Nov) 19:1564-73. Abstract/Full Text
Ca2+ current versus Ca2+ channel cooperativity of exocytosis.
Matveev V, Bertram R, Sherman A.
J Neurosci (2009 Sep 30) 29:12196-209. Abstract/Full Text
Newcomer insulin secretory granules as a highly calcium-sensitive pool.
Pedersen MG, Sherman A.
Proc Natl Acad Sci U S A (2009 May 5) 106:7432-6. Abstract/Full Text
Insulin resistance is associated with a modest increase in inflammation in subcutaneous adipose tissue of moderately obese women.
McLaughlin T, Deng A, Gonzales O, Aillaud M, Yee G, Lamendola C, Abbasi F, Connolly AJ, Sherman A, Cushman SW, Reaven G, Tsao PS.
Diabetologia (2008 Dec) 51:2303-8. Abstract/Full Text
Long lasting synchronization of calcium oscillations by cholinergic stimulation in isolated pancreatic islets.
Zhang M, Fendler B, Peercy B, Goel P, Bertram R, Sherman A, Satin L.
Biophys J (2008 Nov 15) 95:4676-88. Abstract/Full Text
Identifying the targets of the amplifying pathway for insulin secretion in pancreatic beta-cells by kinetic modeling of granule exocytosis.
Chen YD, Wang S, Sherman A.
Biophys J (2008 Sep) 95:2226-41. Abstract/Full Text
Resetting behavior in a model of bursting in secretory pituitary cells: distinguishing plateaus from pseudo-plateaus.
Stern JV, Osinga HM, LeBeau A, Sherman A.
Bull Math Biol (2008 Jan) 70:68-88. Abstract/Full Text