William F. Simonds, M.D.
William Simonds.
Scientific Focus Areas: Neuroscience, Molecular Pharmacology, Molecular Biology and Biochemistry, Cancer Biology, Genetics and Genomics


A selection of recent and significant publications can be viewed below.

Select Publications

Molecular and Clinical Spectrum of Primary Hyperparathyroidism.
Jha S, Simonds WF.
Endocr Rev (2023 Sep 15) 44:779-818. Abstract/Full Text
Genotype of CDC73 germline mutation determines risk of parathyroid cancer.
Li Y, Zhang J, Adikaram PR, Welch J, Guan B, Weinstein LS, Chen H, Simonds WF.
Endocr Relat Cancer (2020 Sep) 27:483-494. Abstract/Full Text
Specific regulation of mechanical nociception by Gβ5 involves GABA-B receptors.
Pandey M, Zhang JH, Adikaram PR, Kittock C, Lue N, Awe A, Degner K, Jacob N, Staples J, Thomas R, Kohnen AB, Ganesan S, Kabat J, Chen CK, Simonds WF.
JCI Insight (2023 Jul 10) 8. Abstract/Full Text
Ancestry-specific high-risk gene variant profiling unmasks diabetes-associated genes.
Zhang J, Chen W, Chen G, Flannick J, Fikse E, Smerin G, Degner K, Yang Y, Xu C, Consortium AMP-T2D-GENES, Li Y, Hanover JA, Simonds WF.
Hum Mol Genet (2024 Apr 8) 33:655-666. Abstract/Full Text
Knockout of G protein β5 impairs brain development and causes multiple neurologic abnormalities in mice.
Zhang JH, Pandey M, Seigneur EM, Panicker LM, Koo L, Schwartz OM, Chen W, Chen CK, Simonds WF.
J Neurochem (2011 Nov) 119:544-54. Abstract/Full Text

Additional Publications

Two distinct classes of thymic tumors in patients with MEN1 show LOH at the MEN1 locus.
Mandl A, Welch JM, Kapoor G, Parekh VI, Schrump DS, Ripley RT, Walter MF, Del Rivero J, Jha S, Simonds WF, Jensen RT, Weinstein LS, Blau JE, Agarwal SK.
Endocr Relat Cancer (2021 Oct 4) 28:L15-L19. Abstract/Full Text
Patients With MEN1 Are at an Increased Risk for Venous Thromboembolism.
Lee ME, Ortega-Sustache YM, Agarwal SK, Tepede A, Welch J, Mandl A, Bansal R, Tirosh A, Piaggi P, Cochran C, Simonds WF, Weinstein LS, Blau JE.
J Clin Endocrinol Metab (2021 Jan 23) 106:e460-e468. Abstract/Full Text
Pitfalls of using denosumab preoperatively to treat refractory severe hypercalcaemia.
Li Y, Fan CY, Manni A, Simonds WF.
BMJ Case Rep (2020 Apr 28) 13. Abstract/Full Text
Long-term remission of disseminated parathyroid cancer following immunotherapy.
Sarquis M, Marx SJ, Beckers A, Bradwell AR, Simonds WF, Bicalho MAC, Daly AF, Betea D, Friedman E, De Marco L.
Endocrine (2020 Jan) 67:204-208. Abstract/Full Text
CDC73 Germline Mutation in a Family With Mixed Epithelial and Stromal Tumors.
Vocke CD, Ricketts CJ, Ball MW, Schmidt LS, Metwalli AR, Middelton LA, Killian JK, Khan J, Meltzer PS, Simonds WF, Merino MJ, Linehan WM.
Urology (2019 Feb) 124:91-97. Abstract/Full Text
Endocrine neoplasms in familial syndromes of hyperparathyroidism.
Li Y, Simonds WF.
Endocr Relat Cancer (2016 Jun) 23:R229-47. Abstract/Full Text
Optimization of genome editing through CRISPR-Cas9 engineering.
Zhang JH, Adikaram P, Pandey M, Genis A, Simonds WF.
Bioengineered (2016 Apr) 7:166-74. Abstract/Full Text
Results of (68)Gallium-DOTATATE PET/CT Scanning in Patients with Multiple Endocrine Neoplasia Type 1.
Sadowski SM, Millo C, Cottle-Delisle C, Merkel R, Yang LA, Herscovitch P, Pacak K, Simonds WF, Marx SJ, Kebebew E.
J Am Coll Surg (2015 Aug) 221:509-17. Abstract/Full Text
Hyperparathyroidism-jaw tumor syndrome: Results of operative management.
Mehta A, Patel D, Rosenberg A, Boufraqech M, Ellis RJ, Nilubol N, Quezado MM, Marx SJ, Simonds WF, Kebebew E.
Surgery (2014 Dec) 156:1315-24; discussion 1324-5. Abstract/Full Text
Improving the specificity and efficacy of CRISPR/CAS9 and gRNA through target specific DNA reporter.
Zhang JH, Pandey M, Kahler JF, Loshakov A, Harris B, Dagur PK, Mo YY, Simonds WF.
J Biotechnol (2014 Nov 10) 189:1-8. Abstract/Full Text
Aromatase inhibitor treatment of menorrhagia and subsequent pregnancy in a patient with familial hyperparathyroidism-jaw tumor syndrome.
Wolff EF, Hill MJ, Simonds WF, Segars JH.
Fertil Steril (2012 Dec) 98:1616-9. Abstract/Full Text
Cushing's syndrome in multiple endocrine neoplasia type 1.
Simonds WF, Varghese S, Marx SJ, Nieman LK.
Clin Endocrinol (Oxf) (2012 Mar) 76:379-86. Abstract/Full Text
The EIF4EBP3 translational repressor is a marker of CDC73 tumor suppressor haploinsufficiency in a parathyroid cancer syndrome.
Zhang JH, Seigneur EM, Pandey M, Loshakov A, Dagur PK, Connelly PS, Koo L, Panicker LM, Simonds WF.
Cell Death Dis (2012 Feb 2) 3:266. Abstract/Full Text
A new look at vitamin D metabolism and "idiopathic" hypercalcemia.
Simonds WF.
J Clin Endocrinol Metab (2012 Feb) 97:384-6. Abstract/Full Text
Parathyroid cancer.
Sharretts JM, Kebebew E, Simonds WF.
Semin Oncol (2010 Dec) 37:580-90. Abstract/Full Text
Cytoplasmic polyadenylation element binding protein is a conserved target of tumor suppressor HRPT2/CDC73.
Zhang JH, Panicker LM, Seigneur EM, Lin L, House CD, Morgan W, Chen WC, Mehta H, Haj-Ali M, Yu ZX, Simonds WF.
Cell Death Differ (2010 Oct) 17:1551-65. Abstract/Full Text
Defective nucleolar localization and dominant interfering properties of a parafibromin L95P missense mutant causing the hyperparathyroidism-jaw tumor syndrome.
Panicker LM, Zhang JH, Dagur PK, Gastinger MJ, Simonds WF.
Endocr Relat Cancer (2010 Jun) 17:513-24. Abstract/Full Text
The parafibromin tumor suppressor protein inhibits cell proliferation by repression of the c-myc proto-oncogene.
Lin L, Zhang JH, Panicker LM, Simonds WF.
Proc Natl Acad Sci U S A (2008 Nov 11) 105:17420-5. Abstract/Full Text
The parathyroid/pituitary variant of multiple endocrine neoplasia type 1 usually has causes other than p27Kip1 mutations.
Ozawa A, Agarwal SK, Mateo CM, Burns AL, Rice TS, Kennedy PA, Quigley CM, Simonds WF, Weinstein LS, Chandrasekharappa SC, Collins FS, Spiegel AM, Marx SJ.
J Clin Endocrinol Metab (2007 May) 92:1948-51. Abstract/Full Text
Nuclear localization of the parafibromin tumor suppressor protein implicated in the hyperparathyroidism-jaw tumor syndrome enhances its proapoptotic function.
Lin L, Czapiga M, Nini L, Zhang JH, Simonds WF.
Mol Cancer Res (2007 Feb) 5:183-93. Abstract/Full Text
Last Reviewed November 2023