William F. Simonds, M.D.
Section Chief:
Endocrine Signaling and Oncogenesis Section, Metabolic Diseases Branch
Scientific Focus Areas: Neuroscience, Molecular Pharmacology, Molecular Biology and Biochemistry, Cancer Biology, Genetics and Genomics
Publications
A selection of recent and significant publications can be viewed below.
Select Publications
- Molecular and Clinical Spectrum of Primary Hyperparathyroidism.
- Jha S, Simonds WF.
- Endocr Rev (2023 Sep 15) 44:779-818. Abstract/Full Text
- Genotype of CDC73 germline mutation determines risk of parathyroid cancer.
- Li Y, Zhang J, Adikaram PR, Welch J, Guan B, Weinstein LS, Chen H, Simonds WF.
- Endocr Relat Cancer (2020 Sep) 27:483-494. Abstract/Full Text
- Specific regulation of mechanical nociception by Gβ5 involves GABA-B receptors.
- Pandey M, Zhang JH, Adikaram PR, Kittock C, Lue N, Awe A, Degner K, Jacob N, Staples J, Thomas R, Kohnen AB, Ganesan S, Kabat J, Chen CK, Simonds WF.
- JCI Insight (2023 Jul 10) 8. Abstract/Full Text
- Ancestry-specific high-risk gene variant profiling unmasks diabetes-associated genes.
- Zhang J, Chen W, Chen G, Flannick J, Fikse E, Smerin G, Degner K, Yang Y, Xu C, Consortium AMP-T2D-GENES, Li Y, Hanover JA, Simonds WF.
- Hum Mol Genet (2024 Apr 8) 33:655-666. Abstract/Full Text
- The association of GNB5 with Alzheimer disease revealed by genomic analysis restricted to variants impacting gene function.
- Zhang J, Pandey M, Awe A, Lue N, Kittock C, Fikse E, Degner K, Staples J, Mokhasi N, Chen W, Yang Y, Adikaram P, Jacob N, Greenfest-Allen E, Thomas R, Bomeny L, Zhang Y, Petros TJ, Wang X, Li Y, Simonds WF.
- Am J Hum Genet (2024 Mar 7) 111:473-486. Abstract/Full Text
Additional Publications
- Two distinct classes of thymic tumors in patients with MEN1 show LOH at the MEN1 locus.
- Mandl A, Welch JM, Kapoor G, Parekh VI, Schrump DS, Ripley RT, Walter MF, Del Rivero J, Jha S, Simonds WF, Jensen RT, Weinstein LS, Blau JE, Agarwal SK.
- Endocr Relat Cancer (2021 Oct 4) 28:L15-L19. Abstract/Full Text
- Patients With MEN1 Are at an Increased Risk for Venous Thromboembolism.
- Lee ME, Ortega-Sustache YM, Agarwal SK, Tepede A, Welch J, Mandl A, Bansal R, Tirosh A, Piaggi P, Cochran C, Simonds WF, Weinstein LS, Blau JE.
- J Clin Endocrinol Metab (2021 Jan 23) 106:e460-e468. Abstract/Full Text
- Pitfalls of using denosumab preoperatively to treat refractory severe hypercalcaemia.
- Li Y, Fan CY, Manni A, Simonds WF.
- BMJ Case Rep (2020 Apr 28) 13. Abstract/Full Text
- Long-term remission of disseminated parathyroid cancer following immunotherapy.
- Sarquis M, Marx SJ, Beckers A, Bradwell AR, Simonds WF, Bicalho MAC, Daly AF, Betea D, Friedman E, De Marco L.
- Endocrine (2020 Jan) 67:204-208. Abstract/Full Text
- CDC73 Germline Mutation in a Family With Mixed Epithelial and Stromal Tumors.
- Vocke CD, Ricketts CJ, Ball MW, Schmidt LS, Metwalli AR, Middelton LA, Killian JK, Khan J, Meltzer PS, Simonds WF, Merino MJ, Linehan WM.
- Urology (2019 Feb) 124:91-97. Abstract/Full Text
- Endocrine neoplasms in familial syndromes of hyperparathyroidism.
- Li Y, Simonds WF.
- Endocr Relat Cancer (2016 Jun) 23:R229-47. Abstract/Full Text
- Optimization of genome editing through CRISPR-Cas9 engineering.
- Zhang JH, Adikaram P, Pandey M, Genis A, Simonds WF.
- Bioengineered (2016 Apr) 7:166-74. Abstract/Full Text
- Results of (68)Gallium-DOTATATE PET/CT Scanning in Patients with Multiple Endocrine Neoplasia Type 1.
- Sadowski SM, Millo C, Cottle-Delisle C, Merkel R, Yang LA, Herscovitch P, Pacak K, Simonds WF, Marx SJ, Kebebew E.
- J Am Coll Surg (2015 Aug) 221:509-17. Abstract/Full Text
- Hyperparathyroidism-jaw tumor syndrome: Results of operative management.
- Mehta A, Patel D, Rosenberg A, Boufraqech M, Ellis RJ, Nilubol N, Quezado MM, Marx SJ, Simonds WF, Kebebew E.
- Surgery (2014 Dec) 156:1315-24; discussion 1324-5. Abstract/Full Text
- Improving the specificity and efficacy of CRISPR/CAS9 and gRNA through target specific DNA reporter.
- Zhang JH, Pandey M, Kahler JF, Loshakov A, Harris B, Dagur PK, Mo YY, Simonds WF.
- J Biotechnol (2014 Nov 10) 189:1-8. Abstract/Full Text
- Aromatase inhibitor treatment of menorrhagia and subsequent pregnancy in a patient with familial hyperparathyroidism-jaw tumor syndrome.
- Wolff EF, Hill MJ, Simonds WF, Segars JH.
- Fertil Steril (2012 Dec) 98:1616-9. Abstract/Full Text
- Cushing's syndrome in multiple endocrine neoplasia type 1.
- Simonds WF, Varghese S, Marx SJ, Nieman LK.
- Clin Endocrinol (Oxf) (2012 Mar) 76:379-86. Abstract/Full Text
- The EIF4EBP3 translational repressor is a marker of CDC73 tumor suppressor haploinsufficiency in a parathyroid cancer syndrome.
- Zhang JH, Seigneur EM, Pandey M, Loshakov A, Dagur PK, Connelly PS, Koo L, Panicker LM, Simonds WF.
- Cell Death Dis (2012 Feb 2) 3:266. Abstract/Full Text
- A new look at vitamin D metabolism and "idiopathic" hypercalcemia.
- Simonds WF.
- J Clin Endocrinol Metab (2012 Feb) 97:384-6. Abstract/Full Text
- Parathyroid cancer.
- Sharretts JM, Kebebew E, Simonds WF.
- Semin Oncol (2010 Dec) 37:580-90. Abstract/Full Text
- Cytoplasmic polyadenylation element binding protein is a conserved target of tumor suppressor HRPT2/CDC73.
- Zhang JH, Panicker LM, Seigneur EM, Lin L, House CD, Morgan W, Chen WC, Mehta H, Haj-Ali M, Yu ZX, Simonds WF.
- Cell Death Differ (2010 Oct) 17:1551-65. Abstract/Full Text
- Defective nucleolar localization and dominant interfering properties of a parafibromin L95P missense mutant causing the hyperparathyroidism-jaw tumor syndrome.
- Panicker LM, Zhang JH, Dagur PK, Gastinger MJ, Simonds WF.
- Endocr Relat Cancer (2010 Jun) 17:513-24. Abstract/Full Text
- The parafibromin tumor suppressor protein inhibits cell proliferation by repression of the c-myc proto-oncogene.
- Lin L, Zhang JH, Panicker LM, Simonds WF.
- Proc Natl Acad Sci U S A (2008 Nov 11) 105:17420-5. Abstract/Full Text
- The parathyroid/pituitary variant of multiple endocrine neoplasia type 1 usually has causes other than p27Kip1 mutations.
- Ozawa A, Agarwal SK, Mateo CM, Burns AL, Rice TS, Kennedy PA, Quigley CM, Simonds WF, Weinstein LS, Chandrasekharappa SC, Collins FS, Spiegel AM, Marx SJ.
- J Clin Endocrinol Metab (2007 May) 92:1948-51. Abstract/Full Text
- Nuclear localization of the parafibromin tumor suppressor protein implicated in the hyperparathyroidism-jaw tumor syndrome enhances its proapoptotic function.
- Lin L, Czapiga M, Nini L, Zhang JH, Simonds WF.
- Mol Cancer Res (2007 Feb) 5:183-93. Abstract/Full Text
Last Reviewed November 2024