Treatment for Exocrine Pancreatic Insufficiency

How do doctors treat EPI?

Doctors treat exocrine pancreatic insufficiency (EPI) with pancreatic enzyme replacement therapy (PERT) and lifestyle changes.

Doctors may recommend additional treatments for the diseases or conditions that cause EPI.


To treat EPI, doctors typically prescribe PERT. PERT involves taking pills that contain pancreatic enzymes. PERT can improve your symptoms and help you get enough nutrients from what you eat and drink.

PERT is taken during meals or snacks to help your small intestine with digestion. Follow your doctor’s instructions about how and when to take PERT.

A woman taking her medicine.Taking PERT during meals or snacks can help your body with digestion.

Lifestyle changes

Lifestyle changes can also help treat EPI. Your doctor may recommend you

How do doctors prevent and treat complications of EPI?

If you have EPI, your doctor may order tests to check for complications, such as

Doctors may recommend you take dietary supplements of fat-soluble vitamins or other nutrients to help prevent or treat these complications.

For safety reasons, talk with your doctor before using dietary supplements, such as vitamins, or any complementary or alternative medicines or medical practices.

Last Reviewed January 2023
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This content is provided as a service of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the National Institutes of Health. NIDDK translates and disseminates research findings to increase knowledge and understanding about health and disease among patients, health professionals, and the public. Content produced by NIDDK is carefully reviewed by NIDDK scientists and other experts.