In adults, the most widely-used equations for estimating glomerular filtration rate (GFR) from serum creatinine are the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation1 and the Modification of Diet in Renal Disease (MDRD) Study equation2. NKDEP’s calculators rely on creatinine determinations which are isotope dilution mass spectrometry (IDMS) traceable. All laboratories should be using creatinine methods calibrated to be IDMS traceable. Read more about creatinine standardization.
This CKD-EPI equation calculator should be used when Scr reported in µmol/L. This equation is recommended when eGFR values above 60 mL/min/1.73 m2 are desired.
GFR = 141 × min (Scr< /κ, 1)α × max(Scr /κ, 1)-1.209 × 0.993Age × 1.018 [if female] × 1.159 [if black]
Scr is serum creatinine in µmol/L,
κ is 61.9 for females and 79.6 for males,
α is -0.329 for females and -0.411 for males,
min indicates the minimum of Scr /κ or 1,
and max indicates the maximum of Scr /κ or 1.
The equation does not require weight because the results are reported normalized to 1.73 m2 body surface area, which is an accepted average adult surface area.