Event Details
Agenda
Event Details
Meeting Objectives
The purpose of the Mechanisms of Organ Repair & Regeneration Meeting is to bring together experts from cancer, angiogenesis, development, stem cell biology and innate immunity to discuss and stimulate debate on injury response mechanisms and facilitate the building of cross-disciplinary approaches towards understanding kidney and urinary tract organ repair and regeneration.
Agenda
September 13, 2011
- 5:00 - 7:00 p.m.
- Registration
- 7:00 - 9:00 p.m.
- Welcome Reception
September 14, 2011
- 7:00 a.m.
- Registration and Continental Breakfast
- 8:45 a.m.
- Opening Remarks
Robert Star, Director of the Division of Kidney, Urologic, and Hematologic Diseases (KUH)/NIDDK, USA
Session 1: Classical Regeneration Systems
- 9:00 a.m.
- Regeneration in Planaria
Alejandro Sanchez Alvarado, Howard Hughes Medical Institute and Stowers Institute for Medical Research, USA
- Lens Regeneration in the Newt
Panagiotis A. Tsonis, University of Dayton, Ohio, USA
- Imaginal Disc Regeneration in Drosophila
Iswar Hariharan, University of California, Berkeley, USA
- 10:30 a.m.
- Moderator Discussion and Break
Session 2: Regeneration of Whole Organs in Vertebrates
- 11:00 a.m.
- Driving Heart Progenitor Fate In Vivo With Modified mRNA
Kenneth Chien, Massachusetts General Hospital/Harvard Medical School, USA
- Bioelectrical Controls of Growth and Form: New Tools and Opportunities for Regenerative Medicine
Michael Levin, Tufts University, USA
- Cell Division Kinetics of Mouse Mammary Stem Cells
John Stingl, University of Cambridge, UK
- Regeneration of Vertebrate Skeletal Muscle
Gabrielle Kardon, University of Utah, USA
- 12:30 p.m.
- Moderator Discussion
- 12:45 p.m.
- Lunch
Session 3: What can Regenerative Medicine Learn from Cancer Growth?
- 2:00 p.m.
- Molecular Regulation of Angiogenic Sprouting
Ralf Adams, Max Planck Institute for Molecular Biomedicine, Germany
- Monocyte and Macrophage Diversity Promotes Tumor Progression and Metastasis
Jeff Pollard, Albert Einstein College of Medicine, USA
- Hh/Wnt Signaling Between Epithelium and Stroma in Bladder Regeneration
Phillip Beachy, Stanford University, USA
- Stromal Regenerative Changes in Tumors
Raghu Kalluri, Harvard Medical School, USA
- 4:00 p.m.
- Moderator Discussion and Break
- 4:30 p.m.
- Debate: Quiescent Progenitor Cells in Solid Organs: Do They Exist and Can They Be Harnessed to Regenerate Tissues?
Moderator: Robert Handin, Harvard Medical School, USA
Discussants: Panagiotis Tsonis, Alejandro Sanchez Alvarado, Raghu Kalluri, and Neil Hukriede
- 5:30 - 7:00 p.m.
- Poster Session
Banquet Dinner at Turf Valley
September 15, 2011
- 7:00 a.m.
- Registration and Continental Breakfast
Session 4: Vertebrate Developmental Pathways and Their Activation in Repair and Regeneration
- 8:00 a.m.
- Development, Damage, and Repair Responses in the Mammalian Kidney
Andrew McMahon, Harvard University, USA
- Monocytes in the Gut Stem Cell Niche and Regeneration
Thaddeus Stappenbeck, Washington University, USA
- Vascular Stem/Progenitor Cells in the Aventitia of Blood Vessels
Mark Majesky, Seattle Children's Research Institute, USA
- 10:00 a.m.
- Moderator Discussion and Break
Session 5: Vascular Repair and Regeneration
- 10:30 a.m.
- Mechanisms of Ocular Angiogenesis
Marty Friedlander, The Scripps Research Institute, USA
- Genetics of Blood Vessel Formation and Remodeling
Luisa Iruela-Arispe, University of California, Los Angeles, USA
- The Role of Pericytes in Vessel Formation and Stability
Patricia D'Amore, Schepens Eye Research Institute, USA
- Pericyte-regulated Vascular Tube Morphogenesis and Stabilization
George Davis, University of Missouri-Columbia, USA
- 12:30 p.m.
- Moderator Discussion
- 1:00 p.m.
- Lunch
Session 6: Resolution of Inflammation and Fibrosis
- 2:00 p.m.
- Can We Harness Natural Anti-Inflammatory & Pro-Resolving Mediators of Control Inflammation?
Charles Serhan, Harvard Medical School, USA
- Apoptosis, Phagocytosis and TGF-beta: Harnessing Innate Immunity to Promote Repair
Adam Lacy-Hulbert, Harvard Medical School, USA
- Resolution of Fibrosis - Reality or a Dream?
Scott Friedman, Mount Sinai School of Medicine, USA
- 3:30 p.m.
- Moderator Discussion and Break
- 4:00 p.m.
- Debate: What Are the Origins of Endothelial Progenitor Cells? And How Do We Define Them?
Moderators: Martin Friedlander and Luisa Iruela-Arispe
Discussants: Patricia D'Amore, George Davis, and Ralf Adams
- 5:00 - 6:00 p.m.
- Poster Session
- 6:00 - 7:15 p.m.
- Soccer Match
- 7:30 p.m.
- Dinner
September 16, 2011
- 7:00 - 8:00 a.m.
- Continental Breakfast
Session 7: Myeloid Cells in Repair/Regeneration
- 8:00 a.m.
- Macophage Wnt Ligands in Development and Regeneration
Richard Lang, Cincinnati Children's Hospital, USA
- Bone Marrow Progenitor Cell Recruitment to the Neovasculature
Doug Losordo, Northwestern University, USA
- Evidence for Developmental Pathways in Adult Kidney and Other Organ Repair
Jeremy Duffield, University of Washington, USA
- 9:30 a.m.
- Moderator Discussion and Break
Session 8: Stem Cells, Telomeres and iPS Cells:Can We Modify Available Cells to Grow New Organ Units?
- 10:00 a.m.
- Role of Intestinal Stem/Progenitor Cells in Homeostasis and Repair
Calvin Kuo, Stanford University, USA
- Directed Differentiation of Human Pluripotent Stem Cells Into Intestinal Tissues In Vitro
Jason Spence, University of Michigan Medical School, USA
- Mesenchymal Stem Cells in Adult Human Organs: Identification, Purification, and Therapeutic Use
Bruno Peault, University of California, Los Angeles, USA
- Telomerase in Epithelial Regeneration and Stem Cell Self-Renewal
Steven Artandi, Stanford University, USA
- Final Discussion
- 12:00 - 1:30 p.m.
- Lunch
