Event Details
Agenda
Event Details
Meeting Objectives
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) announces a workshop focused on elucidating the roles of recently described brown and beige/brite fat in people. Speakers will describe state-of-the-art technology for monitoring human brown adipose tissue (hBAT) mass and function, and present recent basic and clinical data. Plenary talks, selected “hot topic” presentations, and a poster session will provide a forum for interactions among basic scientists and clinical researchers.
Scientific Focus
- Physiological Functions and Clinical Relevance of hBAT: The 2013 Perspective
- Classical and Inducible Brown, Beige, Brite, B/B Fat in Humans
- Measuring hBAT Activity: Pushing the Limits of Position Emission Tomography/Computed Tomography (PET/CT)
- hBAT as a Therapeutic Target: Investigations in Different Populations
- Measuring hBAT Mass and Activity: Emerging Approaches
- Novel Roles of hBAT: Thinking Outside the Box
Planning Committee
- Aaron Cypess (Joslin Diabetes Center, Harvard University)
- Carol Haft (NIDDK, NIH, HSS)
- Houchun Harry Hu (Children’s Hospital Los Angeles)
- Maren Laughlin (NIDDK, NIH, HHS)
Meeting Outcomes
Brown Fat in Humans Consensus Points and Experimental Guidelines.pdf (PDF, 102.79 KB)
The attendees list is available for download here.
Participants List-2-11-14 FINAL.pdf (PDF, 319.5 KB)
Agenda
Agenda available for download
Download the Agenda (PDF, 316.28 KB) .
February 25, 2014
- 7:30 a.m.
- Registration (Lister Hill Auditorium, NIH Campus)
- 8:15 a.m.
- Opening Remarks
Griffin Rodgers, NIDDK, NIH
- Meeting Overview
Carol Haft and Maren Laughlin, NIDDK, NIH
Aaron Cypess, Joslin Diabetes Center, Harvard University
Houchun Harry Hu, Children’s Hospital, Los Angeles
Session I: Physiological Functions and Clinical Relevance of Human BAT: The 2013 Perspective
Kong Chen (Moderator)
- 8:30 a.m.
- Six Years with Adult Human Brown Adipose Tissue and Many More to Come
Jan Nedergaard, Stockholm University, Sweden
- 9:00 a.m.
- Treating Metabolic Disease Through Pharmacological Activation of Human BAT
Aaron Cypess, Joslin Diabetes Center, Harvard University
- 9:30 a.m.
- Fat Depots and Bone: the Role of Human BAT
Miriam Bredella, Massachusetts General Hospital
- 10:00 a.m.
- Brown and Beige Fat: Basic Biology and Novel Therapeutic Opportunities
Bruce Spiegelman, Dana Farber Cancer Institute, Harvard Medical School
- 10:30–11:00 a.m.
- Break
Session II: Measuring Human BAT Activity: Pushing the Limits of PET/CT
Richard Wahl (Moderator)
- 11:00 a.m.
- Does Cold-Activated Brown Fat Contribute Significantly to Daily Energy Expenditure?
Otto Muzik, Wayne State University School of Medicine
- 11:15 a.m.
- Novel Approaches for Investigating Fatty Acid Metabolism in Human BAT
Kirsi Virtanen, University of Turku and Turku University Hospital, Finland
- 11:30 a.m.
- The Norepinephrine Transporter: A Novel Target for Imaging Brown Adipose Tissue
Yu-Shin Ding, New York University School of Medicine
- 11:45 a.m.
- Insight into the Functional Organization of Human BAT
Igal Madar, Johns Hopkins University School of Medicine
- 12:00 p.m.
- Imaging of Brown Fat Metabolism using Hyperpolarized Carbon-13 MRI
Lanette Friesen-Waldner, University of Western Ontario, London
- 12:15–2:00 p.m.
- Poster Session and Lunch Buffet in Atrium
Session III: Classical and Inducible Brown, Beige, Brite, B/B Fat in Humans
Barbara Cannon (Moderator)
- 2:00 p.m.
- Deciphering Brown Adipogenesis from a Progenitor and Inductive Signaling Perspective
Yu-Hua Tseng, Joslin Diabetes Center, Harvard Medical School
- 2:30 p.m.
- Pharmacological Approaches to Induce Brown and Beige Fat Cell Development
Shingo Kajimura, University of California, San Francisco
- 3:00 p.m.
- The Role of FGF21 in Brown Fat
Alexei Kharitonenkov, Lilly Research Laboratories, Indianapolis
- 3:20 p.m.
- Brown Fat Dynamics: Elucidation of Molecular Drivers Based on the Innate Expertise of a Hibernator
Sandra L. Martin, University of Colorado School of Medicine, Aurora
- 3:40–4:00 p.m.
- Break
Session IV: Measuring Human BAT Mass and Activity: Emerging Approaches
Houchun Harry Hu (Moderator)
- 4:00 p.m.
- Brown Adipose Tissue Quantification Using Magnetic Resonance Imaging
E. Brian Welch, Vanderbilt University Medical Center
- 4:15 p.m.
- Brown Adipose Tissue Perfusion: From Mice to Men
Marielle Scherrer-Crosbie, Massachusetts General Hospital
- 4:30 p.m.
- Detecting BAT Mass and Thermogenic Activity by Using Nonlinear 1H MRI and Hyperpolarized 129Xe Gas MRI
Rosa Tamara Branca, University of North Carolina, Chapel Hill
- 4:45 p.m.
- Passive and Active Microwave Radiometry for Non-Invasive Detection of Human Brown Fat
Fred Sterzer, MMTC, Inc.
- 5:00 p.m.
- Peptide Probes for Targeted Brown Adipose Tissue Imaging
Mikhail G. Kolonin, University of Texas Health Science Center, Houston
- 5:15 p.m.
- Adjournment
February 26, 2014
- 7:30–8:00 a.m.
- Registration
(Lister Hill Auditorium, NIH Campus)
- 7:55 a.m.
- Opening Remarks
Session V: Human BAT as a Therapeutic Target
Rebecca Brown (Moderator)
- 8:00 a.m.
- Effect of Ambient Temperature on Human Brown Fat Activity and Recruitment
Wouter van Marken Lichtenbelt, Maastricht University Medical Center, The Netherlands
- 8:30 a.m.
- Exploring the Roles of Brown Fat in Children
Vicente Gilsanz, Children’s Hospital Los Angeles
- 9:00 a.m.
- Signal Transduction Pathways Converging to Promote “Brown(ing)” Adipocytes
Sheila Collins, Sanford-Burnham Medical Research Institute
- 9:30 a.m.
- Brown Adipose Tissue Improves Glucose Metabolism and Whole Body Insulin Sensitivity in Humans
Maria Chondronikola, University of Texas Medical Branch, Galveston
- 9:50–10:15 a.m.
- Break
- 10:15 a.m.
- Acute Cold Exposure Elicits Increases in BAT Oxidative Metabolism in Individuals with Type 2 Diabetes
Denis Blondin, Université de Sherbrooke
- 10:35 a.m.
- Autologous Matrix Assisted Cell Transplantation as a Strategy for the Expansion of Human BAT
Andreas Stahl, UC Berkeley
Session VI: Human BAT Research: Future Directions
Houchun Harry Hu and Aaron Cypess (Moderators)
- 11:00 a.m.
- Open Floor Discussion of Research Gaps and Opportunities
- What are the potential physiological roles for adults human BAT/beige/brite cells?
- What technologies, in addition to imaging or temperature detection, are needed to assess the role(s) of adult human BAT?
- Is there more to be learned from the mouse regarding the role(s) of adult human BAT?
- Are epidemiologic studies of human BAT needed?
- Impact of climate and environment
- Impact of exercise and diet
- Impact of age, gender, body composition, genetics
- Unique populations
- 12:00–1:30 p.m.
- Poster Session and Lunch Buffet
Session VII: Novel Role(s) of Human BAT: Thinking Outside the Box
Eric Ravussin (Moderator)
- 1:30 p.m.
- Hope for a Therapy Based on Thermogenic Drugs and BAT
Eric Ravussin, Pennington Biomedical Research Center, Louisiana State University System
- 2:00 p.m.
- Does hBAT Play a Role in Non-Shivering Thermogenesis?
Kong Chen, NIDDK, NIH
- 2:30 p.m.
- Insights From Understanding CNS Pathways in Regulating the Sympathetic Outflow to BAT
Shaun Morrison, Oregon Health and Science University
- 3:00 p.m.
- Brown Adipose Tissue and Sleep Regulation
Éva Szentirmai, Washington State University, Spokane
- 3:20 p.m.
- Does Sarcolipin and Muscle Based Thermogenesis Compensate in BAT Deficient Mammals?
Muthu Periasamy, Ohio State University, Columbus
- 3:40 p.m.
- Closing Remarks
- 4:00 p.m.
- Adjournment
