2017 Mid-Atlantic Diabetes Research Symposium

Event Details

Background

The 2017 Annual Mid-Atlantic Diabetes Research Symposium is co-sponsored by the Diabetes, Endocrinology, and Obesity Branch (DEOB) at the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH); the Mid-Atlantic Nutrition Obesity Research Center (NORC) at the Department of Medicine, University of Maryland; the Johns Hopkins University-University of Maryland Diabetes Research Center (JHU-UMD-DRC); and the Foundation for Advanced Education in the Sciences (FAES) at the NIH.

Meeting Objectives

The purposes of this meeting are to encourage collaborations and enhance interactions at the regional level through the sharing of both reagents and expertise.

Organizing Committee

Sam Cushman, Marc Reitman, Mehboob Hussain, Carol Haft, Kristina Rother, Artie Sherman, Ranganath Muniyappa, Sushil Rane, Connie Noguchi, Simeon Taylor

Registration Deadline

October 12, 2017

If your schedule permits arriving a day early, the NIDDK is also hosting The Interface of Pancreatic Cancer with Diabetes, Obesity, and Inflammation: Research Gaps and Opportunities Workshop on October 12 at the same location.

Agenda

October 13, 2017

7:30 a.m. – 8:20 a.m.

Registration and Poster Setup

Morning Session

Chair: Jesse Roth, M.D., Former Scientific Director, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

8:20 a.m. – 8:30 a.m.

Introductory Remarks
Jesse Roth, M.D., NIDDK

8:30 a.m. – 9:00 a.m.

Regulation of Glucose Metabolism: Evidence for Direct Effects of Surgery on the β-Cell
David D’Alessio, M.D., Duke University School of Medicine

9:00 a.m. – 9:15 a.m.

Short Talk: SOX9 Regulates Important Epithelial Genes in Pancreatic Progenitors
Hannah Edelman, Johns Hopkins University School of Medicine

9:15 a.m. – 9:30 a.m.

Short Talk: TMEM16A Chloride Channel Regulates β-cell Function in the Process of Repolarization
M Changhong Li, Ph.D., The Chil​dren’s Hospital of Philadelphia

9:30 a.m. – 10:00 a.m.

CTRP Family of Hormones and Metabolic Control
William Wong, Ph.D., Johns Hopkins University School of Medicine

10:00 a.m. – 10:15 a.m.

Short Talk: Glucose Signaling and the Regulation of Liver Metabolism
Rebecca Gelfer, University of Pennsylvania

10:15 a.m. – 10:20 a.m.

Welcoming Remarks
Griffin P. Rodgers, M.D., M.A.C.P., Director, NIDDK

10:20 a.m. – 10:50 a.m.

Break and Poster Discussion

10:50 a.m. – 11:05 a.m.

Short Talk: High-Fat Diet–Induced Glucose Intolerance, but Not Skeletal Muscle Insulin Resistance, Is Worse in Female Mice Compared to Males
Carol Witczak, Ph.D., East Carolina University

11:05 a.m. – 11:35 a.m.

Why Is Fat Important? Understanding Biology through the Study of Rare Diseases
Rebecca Brown, M.D., NIDDK

11:35 a.m. – 12:05 p.m.

Poster Blitz
Chair: Mehboob Hussain, M.D., Johns Hopkins Medical Institute

• Insulin Resistance Alters Functional Overload–Induced Increases in Glucose Metabolism, but Not Glucose Uptake, in Mouse Skeletal Muscle
  Luke Weyrauch, M.S.
• Oxidized Neutral Lipid Lipolysis as a Novel Regulator of Insulin Signaling During Acute Stress
  Katelyn Ahern
• Role of Beta-Arrestin-1 in Sulfonylurea-Induced Insulin Secretion from Pancreatic Beta-Cells
  Luiz Barella, Ph.D.
• Skeletal Muscle Beta-2 Adrenergic Receptors Regulate a Metabolic Switch That Improves Whole-Body Glucose Homeostasis
  Derek Bone, Ph.D.
• Erythropoietin in the Brain Reduces High-Fat Diet–Induced Microglial Activation and Regulates Glucose Metabolism
  Soumyadeep Dey, Ph.D.
• Use of Modified Human Mesenchymal Stromal Cells Improves Glucose Homeostasis
  Cleyton Domingues, Ph.D.
• Characterization of Diabetes-Related Phenotypes in a Zebrafish Model of Alström Syndrome
  Jessica Dunleavey, Ph.D.
• LOX-1 Blockade Improves Macrophage Biology in Atherosclerosis
  Ranjitha Gaddipati, M.S.
• Interaction of Exocrine and Endocrine Pancreas in Obesity Ciliopathies
  Timothy Hostelley
• Amylin Enhances the Blood Glucose–Lowering Effects of Insulin in Zucker Diabetic Fatty Rats as Detailed by Real-Time Continuous Glucose Monitoring
  Victor Howard
• Co-administration of a GLP-1 Receptor Agonist and Obeticholic Acid Activates Thermogenesis and Induces Synergistic Body Weight Loss and Hepatic Lipid Reduction in Diet-Induced Obese Mice
  Hani Jouihan, Ph.D.
• Targeted Drug Discovery and Development, from Molecular Signaling to the Global Market and Back Again, an NIDDK-Supported Educational Program at NYU School of Medicine; the 5-Year Metrics
  Gloria Lee
• Changes in Gut Microbiome After Medical Versus Surgical Weight Loss in a Randomized Trial
  Clare Lee, M.D., M.H.S.
• Effects of Metreleptin on Proteinuria in Patients with Lipodystrophy
  Ho Lim Lee
• Novel Activating Mutations of Glucokinase and Its Role in Regulation of Islet Function
  Changhong Li, M.D., Ph.D.
• Chronic Muscle Loading-Induced Glucose Uptake Is Not Dependent on GLUT4
  Shawna McMillin, M.S.
• An Investigation of Small Worldness in Pancreatic Islets
  Bradford Peercy, Ph.D.
• Inhibiting Adipose Tissue Lipolysis Improves Glucose Homeostasis During Acute Adrenergic Stress
  Vidisha Raje, Ph.D.

12:05 p.m. – 2:00 p.m.

Lunch and Poster Discussion

Alpha Cell to Beta Cell Transdifferentiation and Autoimmunity

George Gittes, M.D., University of Pittsburgh School of Medicine

2:00 p.m. – 2:30 p.m.

Team-based Research Planning Session and Working Lunch

2:30 p.m. – 2:45 p.m.

Short Talk: Intestinal Virome Changes Precede Autoimmunity in Type I Diabetes–Susceptible Children
Guoyan Zhao, Ph.D., Washington University in St. Louis School of Medicine

2:45 p.m. – 3:00 p.m.

Short Talk: The Phosphatidic Acid-Binding, Polybasic Domain Is Responsible for the Differences in the Phosphoregulation of Lipins 1 and 3
Salome Boroda, Ph.D., University of Virginia

3:00 p.m. – 3:30 p.m.

Break and Poster Discussion

3:30 p.m. – 3:45 p.m.

Short Talk: Differentiation of Primary Mouse Preadipocytes into Adipose Tissue in a Microfluidic Chip
Abhinav Bhushan, Ph.D., Illinois Institute of Technology

3:45 p.m. – 4:00 p.m.

Short Talk: Deletion of Prkar2a, with Its Exclusive Habenular Brain Expression, Confers Obesity Resistance through Decreased Hedonic Behavior and Increased Drive for Voluntary Exercise
Edra London, Ph.D., Eunice Kennedy Shriver National Institute of Child Health and Human Development

4:00 p.m. – 4:30 p.m.

Insights from Rare Diseases: Exploring Diabetes in the Obesity Ciliopathies
Norann Zaghloul, Ph.D., University of Maryland School of Medicine

4:30 p.m.

Adjournment and Poster Removal