Event Details
Agenda
Abstracts
Event Details
Meeting Objectives
The purpose of The Interface of Pancreatic Cancer with Diabetes, Obesity, and Inflammation: Research Gaps and Opportunities Workshop is to explore the relationships of diabetes, obesity, and inflammation on the mechanisms, diagnosis and possible treatment of pancreatic ductal adenocarcinoma (PDAC). We plan sessions which will focus on the role of diabetes and altered intracellular metabolism on the development of PDAC, the mechanisms and diagnosis of PDAC-caused diabetes, the role of obesity as a risk factor and cause of PDAC, and the role of inflammation and immune mechanisms on the development and possible treatment of PDAC. Recommendations which arise from the workshop will inform possible future funding initiatives of NIDDK.
In addition to presentations from an international faculty of experts, poster presentations selected from submitted abstracts will also be presented. Abstract requirements can be found on the registration website. Attendance at the workshop is without charge, but registration is required.
This meeting is being held in conjunction with The 2017 Annual Mid-Atlantic Diabetes Research Symposium.
Registration Deadline
October 05, 2017
Agenda
October 12, 2017
- 7:00 a.m. – 8:00 a.m.
- Registration
- 8:00 a.m. – 8:10 a.m.
- Welcome from Workshop Co-Chairs
James Abbruzzese, M.D., Duke University
Alvin Powers, M.D., Vanderbilt University
- 8:10 a.m. – 8:35 a.m.
- Overview Lecture: Diabetes and Anti-Diabetic Drugs as Risk Factors in Pancreatic Ductal Adenocarcinoma (PDAC), and the Rising Incidence of PDAC (Parallel to the Incidence of Obesity and Diabetes)
Peter Boyle, Ph.D., D.Sc., International Prevention Research Institute, Lyon, France
Session 1: The Role of Altered Energy Metabolism in PDAC
Moderators: James Abbruzzese, M.D., Duke University; and Alvin Powers, M.D., Vanderbilt University
- 8:35 a.m. – 8:50 a.m.
- Possible Mechanisms of Increased Risk for Developing PDAC in Patients with Long-Standing Type 2 Diabetes
Murray Korc, M.D., Indiana University School of Medicine
- 8:50 a.m. – 9:10 a.m.
- Effects of Metformin on PDAC Risk
Stephen Pandol, M.D., Cedars-Sinai Medical Center
- 9:10 a.m. – 9:35 a.m.
- Peptide and Other Mediators of PDAC
- 9:35 a.m. – 9:55 a.m.
- The Role of Altered Intracellular Metabolism in PDAC
Costas Lyssiotis, Ph.D., University of Michigan Medical School
- 9:55 a.m. – 10:10 a.m.
- Integrating Information from Rodent Models to Human Disease
Alvin Powers, M.D., Vanderbilt University School of Medicine
- 10:10 a.m. – 10:30 a.m.
- Break
Session 2: PDAC as a Cause of Diabetes
Moderators: Dana Andersen, M.D., NIDDK; and Suresh Chari, M.D., Mayo Clinic
- 10:30 a.m. – 10:50 a.m.
- Evidence for Possible Paraneoplastic Cause of Diabetes Mellitus (DM) in PDAC Patients
Suresh Chari, M.D., Mayo Clinic
- 10:50 a.m. – 11:10 a.m.
- Mechanisms of PDAC-Associated DM
Dana Andersen, M.D., NIDDK
- 11:10 a.m. – 11:35 a.m.
- Protein Biomarkers of PDAC-Associated DM, and Differentiation of PDAC-associated DM from Type 2 Diabetes Mellitus (T2DM)
Eithne Costello-Goldring, Ph.D., University of Liverpool, United Kingdom
- 11:35 a.m. – 12:00 p.m.
- Early Detection of PDAC and IPMN Using a Blood Sample
Carl Borrebaeck,Ph.D., Immunovia and Lund University, Sweden
- 12:00 p.m. – 12:50 p.m.
- Lunch and Poster Viewing
- 12:50 p.m. – 1:00 p.m.
- Welcome from NIDDK, NIH
Gregory Germino, M.D., Deputy Director, NIDDK
Session 3: Obesity as a Cause/Risk Factor for PDAC
Moderators: Zobeida Cruz-Monserrate, Ph.D., The Ohio State University; and Guido Eibl, M.D., University of California, Los Angeles
- 1:00 p.m. – 1:20 p.m.
- The Risk of Obesity: Lessons from Bariatric Surgery
Bruce Wolfe, M.D., Oregon Health & Science University
- 1:20 p.m. – 1:45 p.m.
- Possible Mechanisms of Obesity Risk for PDAC
Zobeida Cruz-Monserrate, Ph.D., The Ohio State University
- 1:45 p.m. – 2:10 p.m.
- Are RAS and RAGE Co-Conspirators in Diabetes-Associated Pancreatic Cancer?
Craig Logsdon, Ph.D., The University of Texas MD Anderson Cancer Center
- 2:10 p.m. – 2:35 p.m.
- The Role of Visceral/Peri-Pancreatic Fat on Carcinogenesis
Guido Eibl, M.D., University of California, Los Angeles
- 2:35 p.m. – 3:00 p.m.
- Pancreatic Cancer and the Microbiome
William Fisher, M.D., Baylor University College of Medicine
- 3:00 p.m. – 3:20 p.m.
- Break
Session 4: Inflammation and the Immune System as a Cause/Mediator of PDAC
Moderators: Aida Habtezion, M.D., M.Sc., Stanford University; and Edgar Engleman, M.D., Stanford University
- 3:20 p.m. – 3:45 p.m.
- Role of Chronic Inflammation, Activated Pancreatic Stellate Cells, and Environmental Factors on PDAC Development
Aida Habtezion, M.D., M.Sc., Stanford University
- 3:45 p.m. – 4:10 p.m.
- Deciphering the Roles of Immune Cells in the Growth and Treatment of Pancreatic Ductal Adenocarcinoma
Edgar Engleman, M.D., Stanford University
- 4:10 p.m. – 4:35 p.m.
- Epithelial Plasticity in Metastatic Pancreatic Ductal Carcinoma
Anil Rustgi, M.D., University of Pennsylvania
- 4:35 p.m. – 5:00 p.m.
- The Role of Anti-Inflammatory Agents and Immunotherapy on PDAC Formation
Elizabeth Jaffee, M.D., Johns Hopkins University
- 5:00 p.m. – 5:30 p.m.
- Panel Discussion and Q&A
Moderators: James Abbruzzese, M.D., Duke University; and Alvin Powers, M.D., Vanderbilt University
- 5:30 p.m.
- Adjournment
Abstracts
Participants in the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Workshop, The Interface of Pancreatic Cancer with Diabetes, Obesity, and Inflammation: Research Gaps and Opportunities—are encouraged to submit abstracts of their research activities. In addition to an opportunity to present their research in a poster session, conference attendees will find additional career development and networking opportunities with other researchers.
Submission Deadline
September 21, 2017
Submitting Abstracts
All abstracts must be submitted via email to to Mark Dennis of The Scientific Consulting Group, Inc. at mdennis@scgcorp.com with "Interface of Pancreatic Cancer Abstract” in the subject line. Abstract submissions should be no longer than 250 words (not including name and affiliation). Click here (DOCX, 24.67 KB) to download the template.
Abstract Organization
Organize the body of the abstract as follows:
- Statement of the purpose of the study/program/project
- Statement of the methods used
- Summary of the results presented in sufficient detail to support the conclusion
- Statement of the conclusions reached
Formatting Requirements
Please follow the instructions below to format an abstract. (Note: Submissions will not be edited for spelling or grammar and will be accepted “as is.”)
- The abstract should be an MS Word document typed single-spaced using Times New Roman font. Everything but the title should be in normal, 12-point font.
- The abstract’s title should be Bold, 16-Point, Title Case font and should clearly represent the nature of the investigation.
- On the line after the title, list the author’s first and last names, degree, affiliation, city, state, and country.
- Separate multiple authors with a semicolon, and underline the primary author’s name (one primary author per abstract).
- Use one blank line between the title and the body of the abstract and between paragraphs.
- The abstract file name should follow this format: primary author’s LastName_FirstWordOfTitle (e.g., Zucker_Effects).
- Please ensure that your abstract is the correct length and use 1-inch margins
- Use of standard abbreviations is desirable (e.g., RBC), as well as standard symbols for units of measure (e.g., kg, g, mg, mL, L, and %). Place a special or unusual abbreviation in parentheses after the full word the first time that it appears. Use numerals to indicate numbers except to begin sentences. Do not use subtitles (e.g., Methods, Results).
- Simple tables or graphs may be included; however, they must fit within the designated abstract space of one page.
Poster Presentations
Poster presentations will be displayed on 4-foot-high by 6-foot-wide poster boards. Pushpins and Velcro will be provided onsite.
Space will be available for up to 40 posters.
All presenters must register in advance for the conference.
