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Understanding the Biological Mechanisms Underlying the Health Consequences of Racism, Marginalization, and Discrimination

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Event Details

Purpose

To convene people from diverse populations living with or at risk for diabetes and digestive and kidney diseases and conditions, as well as researchers and clinicians from across disciplines, to understand the state of the science and identify opportunities for considering common biological pathways underlying the consequences of racism, marginalization, and discrimination across population groups and disease areas. The focus on interdisciplinary research is intended to foster the cross-pollination of ideas and shared learning, as well as to promote consideration of intersectionality across marginalized identities and the multidimensional research framework.

Background

The marginalization of groups based on socially constructed categories of race, ethnicity, sexual orientation, gender, and other identities produces biological consequences that contribute to health disparities in a variety of diseases and conditions, including many under the purview of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). For example, substantial racial and ethnic disparities exist in obesity, diabetes, and end-stage kidney disease. Racism, marginalization, and discrimination (RMD) is embedded into the structure of American society, which increases exposure to adverse social determinants of health—or social risks—for marginalized populations. These social risks are known to affect health outcomes by constraining or modifying health-related behaviors (e.g., diet, physical activity, smoking). However, experiences with RMD—as well as exposure to social risk—may also directly alter biology by triggering stress pathways and modifying biological homeostasis.

Meeting Objectives

Research questions to be addressed in the workshop include:

  • What are the direct biological mechanisms and pathways underlying the relationship between RMD, social risks, and NIDDK diseases/conditions? How do these biological mechanisms interact with social and behavioral drivers of disease? 
  • Specific biological mechanisms, pathways, and systems of potential interest for this workshop include, but are not limited to, weathering, stress, allostatic load, hypothalamic-pituitary-adrenal axis, developmental programming, epigenetics, microbiome, immune function, inflammation, neuroendocrine status, endocrine disruption, and telomere shortening, among others.  
  • How do these biological mechanisms/pathways differ or overlap across the various population groups that experience RMD? How do these mechanisms combine for populations crossing multiple intersecting, marginalized identities (e.g., class, sex, gender, race)? How can we use an intersectionality lens to examine risk and protective factors? 
  • How do these biological mechanisms/pathways differ or overlap in the context of structural versus interpersonal forms of RMD, as well as between RMD and associated social risks? 
  • What biopsychosocial factors confer resilience to disease despite exposure to structural and interpersonal RMD, and what are the biological mechanisms through which this resilience occurs? 
  • How do we identify biological marker(s) to describe the experience of RMD? 
  • Does RMD contribute to the population-level differences in markers of key biological functions (e.g., differences in serum creatinine observed between Black and non-Black people in the United States)?
  • What tools (e.g., measures, assessments, assays, wearables, apps) do we need to employ or develop to assess the impact that RMD may have on biology and health outcomes? 

Co-Sponsors/Organizing Committee

  • NIA, NHLBI, NICHD, NIMHD, NINDS, NINR, OBSSR, ODP, ONR, ORWH, SGMRO, All of Us Research Program
    • Shakira Suglia, ScD, Emory University (Co-chair)
    • Tracy Bale, University of Maryland (Co-chair)
    • Glenda Roberts, Kidney Research Institute- University of Washington
    • Phyllis Harris, LGBT Cleveland
    • Keith Norris, M.D., Ph.D., University of California, Los Angeles
    • Sheena Martenies, Ph.D., University of Michigan
    • Nicole VanKim, Ph.D., University of Massachusetts
    • Lisa Diamond, Ph.D., University of Utah
    • David Chae, ScD, M.A., Tulane University
    • John Carethers, M.D., University of Michigan
    • Debra MacKenzie, Ph.D., University of New Mexico
    • Oluwaferanmi Okanlami, M.D., M.S., University of Michigan

Registration Deadline

April 16, 2024

Event Logistics

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Location

Washington Dulles Airport Marriott
45020 Aviation Dr
Dulles, VA 20166

Contacts

Program Contact
Jenna Norton
NIDDK
301-928-5509

Meeting Logistics
Allison Hurst
The Scientific Consulting Group, Inc.
T: 301-670-4990

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