Ancillary Studies to Major Ongoing Clinical Studies
NIDDK invites investigator-initiated (R01) research project applications for ancillary studies to ongoing large-scale clinical trials and epidemiological studies (parent studies) and disease databases supported by the Institute, other Institutes and Centers of the National Institutes of Health, other government agencies, or the private sector. Applications for ancillary studies may be submitted to PA-19-056 or other appropriate funding opportunity announcements (FOAs).
Ancillary study proposals
- must extend knowledge of diseases being studied by parent study investigators under a defined protocol or study diseases and conditions outside of the original scope of the parent study but within the research areas and mission of NIDDK
- must abide by the procedures for conducting ancillary studies established by the parent study
- may require additional data or sample collection
- may not interfere with the primary objectives of the parent study
Parent Study Examples
Select NIDDK-sponsored parent studies that are eligible for ancillary study proposals are listed below. View each website for study-specific ancillary study procedures.
Diabetes Studies
- Action for Health in Diabetes (Look AHEAD)
- Clinical Islet Transplantation Consortium (CIT)
- Diabetes Prevention Program Outcomes Study (DPPOS)
- Epidemiology of Diabetes Interventions and Complications Study (EDIC)
- Environmental Determinants of Diabetes in the Young (TEDDY)
- Glycemic Reduction Approaches in Diabetes; A Comparative Effectiveness Study (GRADE)
- The Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Follow-up Study
- Restoring Insuln Secretion (RISE) Consortium
- SEARCH for Diabetes Youth Study
- Treatment Options for Type 2 diabetes in Adolescents and Youth (TODAY)
- Type 1 Diabetes TrialNet
- Vitamin D to Prevent Type 2 Diabetes (D2d)
Digestive Disease and Nutrition Studies
- Acute Liver Failure (ALF)
- Childhood Liver Diseases Research and Education Network (ChiLDREN)
- Clinical Outcomes Research Initiative (CORI)
- Consortium to Study Chronic Pancreatitis, Diabetes and Pancreatic Cancer
- Drug-Induced Liver Injury Network (DILIN)
- Gastroparesis Clinical Research Consortium (GpCRC)
- Hepatitis B Research Network (HBRN)
- Immunosuppression Withdrawal for Stable Pediatric Liver Transplant Recipients (iWITH)
- Inflammatory Bowel Disease Genetic Consortium (IBDGC)
- Irritable Bowel Syndrome Outcomes Study (IBSOS)
- L. reuteri for Pediatric Diarrhea in Peru: Growth, Enteropathy, and Microbiota (PRIDEC-Peru)
- Contact Dr. Margaret Kosek by email.
- Methotrexate in Induction and Maintenance of Steroid Free Remission in Ulcerative Colitis (Merit-UC)
- Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN)
- Pediatric Acute Liver Failure Study (PALF)
- Predicting Response to Standardized Pediatric Colitis Therapy (PROTECT)
- Stent vs. Indomethacin for Preventing Post-ERCP Pancreatitis (SVI)
Kidney, Urology and Hematology Studies
- Chronic Renal Insufficiency Cohort (CRIC) Study
- Chronic Kidney Disease in Children (CkiD) Study
- CKD Biomarkers Consortium
- Cure Glomerulonephropathy (CureGN)
- Multi-Disciplinary Approach to the Study of Chronic Pelvic Pain (MAPP)
- Nephrotic Syndrome Study Network (NEPTUNE)
- Porphyria Consortium
- Preventing Early Renal Loss in Type 1 Diabetes (PERL)
- Prevention of Urinary Stones with Hydration (PUSH)
- Prevention of Lower Urinary Tract Symptoms (PLUS)
- Rare Kidney Stone Consortium (RKSC)
- Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN)
Obesity Studies
- Action for Health in Diabetes (Look AHEAD)
- Adolescent Bariatrics: Assessing Health Benefits and Risks (Teen LABS)
- The Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Follow-up Study
- Lifestyle Interventions for Expectant Moms (LIFE Moms)
- Longitudinal Assessment of Bariatric Surgery (LABS)
- Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN)