Sandhoff Disease Mouse

Also known as: Hexbtm1Rlp, Hexb KO mouse

Hexb KO mice develop motor defects beginning at about 3 months of age. The defects progressively worsen and homozygous mice die by 4.5 months of age. Mice display gangliosidosis; mice abnormally accumulate GM2 and GA2 ganglioside and serve as a model of Sandhoff disease. Learn more on PubMed.

Mice can be obtained from Jackson Labs.

Resource Details

https://www.jax.org/strain/002914

tao@niddk.nih.gov

Proia, Richard

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Last Reviewed August 2024