Behdad (Ben) Afzali, M.D. Ph.D., Stadtman Tenure-Track Investigator

Photo of Ben Afzali
Scientific Focus Areas: Cell Biology, Immunology, Molecular Biology and Biochemistry

Publications

A selection of recent and significant publications can be viewed below.

Select Publications

Human retinoic acid-regulated CD161+ regulatory T cells support wound repair in intestinal mucosa.
Povoleri GAM, Nova-Lamperti E, Scottà C, Fanelli G, Chen YC, Becker PD, Boardman D, Costantini B, Romano M, Pavlidis P, McGregor R, Pantazi E, Chauss D, Sun HW, Shih HY, Cousins DJ, Cooper N, Powell N, Kemper C, Pirooznia M, Laurence A, Kordasti S, Kazemian M, Lombardi G, Afzali B.
Nat Immunol (2018 Dec) 19:1403-1414. Abstract/Full Text
BACH2 immunodeficiency illustrates an association between super-enhancers and haploinsufficiency.
Afzali B, Grönholm J, Vandrovcova J, O'Brien C, Sun HW, Vanderleyden I, Davis FP, Khoder A, Zhang Y, Hegazy AN, Villarino AV, Palmer IW, Kaufman J, Watts NR, Kazemian M, Kamenyeva O, Keith J, Sayed A, Kasperaviciute D, Mueller M, Hughes JD, Fuss IJ, Sadiyah MF, Montgomery-Recht K, McElwee J, Restifo NP, Strober W, Linterman MA, Wingfield PT, Uhlig HH, Roychoudhuri R, Aitman TJ, Kelleher P, Lenardo MJ, O'Shea JJ, Cooper N, Laurence ADJ.
Nat Immunol (2017 Jul) 18:813-823. Abstract/Full Text
Thymic versus induced regulatory T cells - who regulates the regulators?
Povoleri GA, Scottà C, Nova-Lamperti EA, John S, Lombardi G, Afzali B.
Front Immunol (2013) 4:169. Abstract/Full Text
Intracellular complement activation sustains T cell homeostasis and mediates effector differentiation.
Liszewski MK, Kolev M, Le Friec G, Leung M, Bertram PG, Fara AF, Subias M, Pickering MC, Drouet C, Meri S, Arstila TP, Pekkarinen PT, Ma M, Cope A, Reinheckel T, Rodriguez de Cordoba S, Afzali B, Atkinson JP, Kemper C.
Immunity (2013 Dec 12) 39:1143-57. Abstract/Full Text
Complement Regulates Nutrient Influx and Metabolic Reprogramming during Th1 Cell Responses.
Kolev M, Dimeloe S, Le Friec G, Navarini A, Arbore G, Povoleri GA, Fischer M, Belle R, Loeliger J, Develioglu L, Bantug GR, Watson J, Couzi L, Afzali B, Lavender P, Hess C, Kemper C.
Immunity (2015 Jun 16) 42:1033-47. Abstract/Full Text

Additional Publications

Complement receptor CD46 co-stimulates optimal human CD8+ T cell effector function via fatty acid metabolism.
Arbore G, West EE, Rahman J, Le Friec G, Niyonzima N, Pirooznia M, Tunc I, Pavlidis P, Powell N, Li Y, Liu P, Servais A, Couzi L, Fremeaux-Bacchi V, Placais L, Ferraro A, Walsh PR, Kavanagh D, Afzali B, Lavender P, Lachmann HJ, Kemper C.
Nat Commun (2018 Oct 10) 9:4186. Abstract/Full Text
Unexpected Roles for Intracellular Complement in the Regulation of Th1 Responses.
West EE, Afzali B, Kemper C.
Adv Immunol (2018) 138:35-70. Abstract/Full Text
T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4⁺ T cells.
Arbore G, West EE, Spolski R, Robertson AAB, Klos A, Rheinheimer C, Dutow P, Woodruff TM, Yu ZX, O'Neill LA, Coll RC, Sher A, Leonard WJ, Köhl J, Monk P, Cooper MA, Arno M, Afzali B, Lachmann HJ, Cope AP, Mayer-Barber KD, Kemper C.
Science (2016 Jun 17) 352:aad1210. Abstract/Full Text
Regulatory T-cell therapy in the induction of transplant tolerance: the issue of subpopulations.
Edozie FC, Nova-Lamperti EA, Povoleri GA, Scottà C, John S, Lombardi G, Afzali B.
Transplantation (2014 Aug 27) 98:370-9. Abstract/Full Text
Vitamin D in renal transplantation - from biological mechanisms to clinical benefits.
McGregor R, Li G, Penny H, Lombardi G, Afzali B, Goldsmith DJ.
Am J Transplant (2014 Jun) 14:1259-70. Abstract/Full Text