Understanding perturbed immunoregulation in diseases of autoimmunity and manipulating the balance between inflammatory and regulatory immune responses.

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Diapedesis-Induced Integrin Signaling via LFA-1 Facilitates Tissue Immunity by Inducing Intrinsic Complement C3 Expression in Immune Cells.
Kolev M, West EE, Kunz N, Chauss D, Moseman EA, Rahman J, Freiwald T, Balmer ML, Lötscher J, Dimeloe S, Rosser EC, Wedderburn LR, Mayer-Barber KD, Bohrer A, Lavender P, Cope A, Wang L, Kaplan MJ, Moutsopoulos NM, McGavern D, Holland SM, Hess C, Kazemian M, Afzali B, Kemper C.
Immunity (2020 Mar 17) 52:513-527.e8. Abstract/Full Text
Human retinoic acid-regulated CD161+ regulatory T cells support wound repair in intestinal mucosa.
Povoleri GAM, Nova-Lamperti E, Scottà C, Fanelli G, Chen YC, Becker PD, Boardman D, Costantini B, Romano M, Pavlidis P, McGregor R, Pantazi E, Chauss D, Sun HW, Shih HY, Cousins DJ, Cooper N, Powell N, Kemper C, Pirooznia M, Laurence A, Kordasti S, Kazemian M, Lombardi G, Afzali B.
Nat Immunol (2018 Dec) 19:1403-1414. Abstract/Full Text
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Lab Members

Members of the Immunoregulation lab 2020.
 
Top to bottom, left to right: Daniel Chauss, Ben Afzali, Felipe Lopes de Assis*, Jianping Ma, Tilo Freiwald, Nardos Cheru, Maurice Fluitt, Jorge Luis Trujillo-Ochoa, Didier Portilla, Dhaneshwar Kumar
* collaborating post-doctoral fellow from the B cell Immunology Section, Laboratory of Immunoregulation, NIAID
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