Understanding perturbed immunoregulation in diseases of autoimmunity and manipulating the balance between inflammatory and regulatory immune responses.

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C5a-licensed phagocytes drive sterilizing immunity during systemic fungal infection.
Desai JV, Kumar D, Freiwald T, Chauss D, Johnson MD, Abers MS, Steinbrink JM, Perfect JR, Alexander B, Matzaraki V, Snarr BD, Zarakas MA, Oikonomou V, Silva LM, Shivarathri R, Beltran E, Demontel LN, Wang L, Lim JK, Launder D, Conti HR, Swamydas M, McClain MT, Moutsopoulos NM, Kazemian M, Netea MG, Kumar V, Köhl J, Kemper C, Afzali B, Lionakis MS.
Cell (2023 Jun 22) 186:2802-2822.e22. Abstract/Full Text
Autocrine vitamin D signaling switches off pro-inflammatory programs of T(H)1 cells.
Chauss D, Freiwald T, McGregor R, Yan B, Wang L, Nova-Lamperti E, Kumar D, Zhang Z, Teague H, West EE, Vannella KM, Ramos-Benitez MJ, Bibby J, Kelly A, Malik A, Freeman AF, Schwartz DM, Portilla D, Chertow DS, John S, Lavender P, Kemper C, Lombardi G, Mehta NN, Cooper N, Lionakis MS, Laurence A, Kazemian M, Afzali B.
Nat Immunol (2022 Jan) 23:62-74. Abstract/Full Text
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Lab Members

Members of the Immunoregulation lab 2022

Top to bottom, left to right: Dhaneshwar Kumar, Daniel Chauss, Tilo Feiwald, Luis Trujillo-Ochoa, Maurice Fluitt, Didier Portilla, Ilayda Sen, Jianping Ma, Ben Afzali, Md Tajmul*
* collaborating post-doctoral fellow from the Kazemian lab, Purdue University

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Last Reviewed October 2023