Understanding perturbed immunoregulation in diseases of autoimmunity and manipulating the balance between inflammatory and regulatory immune responses.

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Diapedesis-Induced Integrin Signaling via LFA-1 Facilitates Tissue Immunity by Inducing Intrinsic Complement C3 Expression in Immune Cells.
Kolev M, West EE, Kunz N, Chauss D, Moseman EA, Rahman J, Freiwald T, Balmer ML, Lötscher J, Dimeloe S, Rosser EC, Wedderburn LR, Mayer-Barber KD, Bohrer A, Lavender P, Cope A, Wang L, Kaplan MJ, Moutsopoulos NM, McGavern D, Holland SM, Hess C, Kazemian M, Afzali B, Kemper C.
Immunity (2020 Mar 17) 52:513-527.e8. Abstract/Full Text
Human retinoic acid-regulated CD161+ regulatory T cells support wound repair in intestinal mucosa.
Povoleri GAM, Nova-Lamperti E, Scottà C, Fanelli G, Chen YC, Becker PD, Boardman D, Costantini B, Romano M, Pavlidis P, McGregor R, Pantazi E, Chauss D, Sun HW, Shih HY, Cousins DJ, Cooper N, Powell N, Kemper C, Pirooznia M, Laurence A, Kordasti S, Kazemian M, Lombardi G, Afzali B.
Nat Immunol (2018 Dec) 19:1403-1414. Abstract/Full Text
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Lab Members

From left to right: Daniel Chauss (post-doctoral fellow), Huzaifah Qureshi (postbac fellow), Ben Afzali (principal investigator), Didier Portilla (research collaborator), Tilo Freiwald (post-doctoral fellow), Nardos Cheru (postbac fellow)
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