Maria Laura Allende, Ph.D.
Photo of Maria Allende.
Scientific Focus Areas: Cell Biology, Molecular Biology and Biochemistry


A selection of recent and significant publications can be viewed below.

The Ormdl genes regulate the sphingolipid synthesis pathway to ensure proper myelination and neurologic function in mice.
Clarke BA, Majumder S, Zhu H, Lee YT, Kono M, Li C, Khanna C, Blain H, Schwartz R, Huso VL, Byrnes C, Tuymetova G, Dunn TM, Allende ML, Proia RL.
Elife (2019 Dec 27) 8. Abstract/Full Text
Human GLB1 knockout cerebral organoids: A model system for testing AAV9-mediated GLB1 gene therapy for reducing GM1 ganglioside storage in GM1 gangliosidosis.
Latour YL, Yoon R, Thomas SE, Grant C, Li C, Sena-Esteves M, Allende ML, Proia RL, Tifft CJ.
Mol Genet Metab Rep (2019 Dec) 21:100513. Abstract/Full Text
Murine platelet production is suppressed by S1P release in the hematopoietic niche, not facilitated by blood S1P sensing.
Niazi H, Zoghdani N, Couty L, Leuci A, Nitzsche A, Allende ML, Mariko B, Ishaq R, Aslan Y, Becker PH, Gazit SL, Poirault-Chassac S, Decouture B, Baudrie V, De Candia E, Kono M, Benarab A, Gaussem P, Tharaux PL, Chun J, Provot S, Debili N, Therond P, Proia RL, Bachelot-Loza C, Camerer E.
Blood Adv (2019 Jun 11) 3:1702-1713. Abstract/Full Text
Cerebral organoids derived from Sandhoff disease-induced pluripotent stem cells exhibit impaired neurodifferentiation.
Allende ML, Cook EK, Larman BC, Nugent A, Brady JM, Golebiowski D, Sena-Esteves M, Tifft CJ, Proia RL.
J Lipid Res (2018 Mar) 59:550-563. Abstract/Full Text
De Novo Sphingolipid Biosynthesis Is Required for Adipocyte Survival and Metabolic Homeostasis.
Alexaki A, Clarke BA, Gavrilova O, Ma Y, Zhu H, Ma X, Xu L, Tuymetova G, Larman BC, Allende ML, Dunn TM, Proia RL.
J Biol Chem (2017 Mar 3) 292:3929-3939. Abstract/Full Text
Meta-analysis of rare and common exome chip variants identifies S1PR4 and other loci influencing blood cell traits.
CHARGE Consortium Hematology Working Group.
Nat Genet (2016 Aug) 48:867-76. Abstract/Full Text
Sphingosine-1-phosphate Phosphatase 2 Regulates Pancreatic Islet β-Cell Endoplasmic Reticulum Stress and Proliferation.
Taguchi Y, Allende ML, Mizukami H, Cook EK, Gavrilova O, Tuymetova G, Clarke BA, Chen W, Olivera A, Proia RL.
J Biol Chem (2016 Jun 3) 291:12029-38. Abstract/Full Text
Simplifying complexity: genetically resculpting glycosphingolipid synthesis pathways in mice to reveal function.
Allende ML, Proia RL.
Glycoconj J (2014 Dec) 31:613-22. Abstract/Full Text
Sphingosine-1-phosphate can promote mast cell hyper-reactivity through regulation of contactin-4 expression.
Olivera A, Kitamura Y, Wright LD, Allende ML, Chen W, Kaneko-Goto T, Yoshihara Y, Proia RL, Rivera J.
J Leukoc Biol (2013 Nov) 94:1013-24. Abstract/Full Text
Sphingosine-1-phosphate phosphatase 1 regulates keratinocyte differentiation and epidermal homeostasis.
Allende ML, Sipe LM, Tuymetova G, Wilson-Henjum KL, Chen W, Proia RL.
J Biol Chem (2013 Jun 21) 288:18381-91. Abstract/Full Text
Shaping the landscape: metabolic regulation of S1P gradients.
Olivera A, Allende ML, Proia RL.
Biochim Biophys Acta (2013 Jan) 1831:193-202. Abstract/Full Text
Sphingosine-1-phosphate lyase deficiency produces a pro-inflammatory response while impairing neutrophil trafficking.
Allende ML, Bektas M, Lee BG, Bonifacino E, Kang J, Tuymetova G, Chen W, Saba JD, Proia RL.
J Biol Chem (2011 Mar 4) 286:7348-58. Abstract/Full Text
S1P1 receptor directs the release of immature B cells from bone marrow into blood.
Allende ML, Tuymetova G, Lee BG, Bonifacino E, Wu YP, Proia RL.
J Exp Med (2010 May 10) 207:1113-24. Abstract/Full Text
Sphingosine kinase 1 and sphingosine-1-phosphate receptor 2 are vital to recovery from anaphylactic shock in mice.
Olivera A, Eisner C, Kitamura Y, Dillahunt S, Allende L, Tuymetova G, Watford W, Meylan F, Diesner SC, Li L, Schnermann J, Proia RL, Rivera J.
J Clin Invest (2010 May) 120:1429-40. Abstract/Full Text
Sphingosine 1-phosphate lyase deficiency disrupts lipid homeostasis in liver.
Bektas M, Allende ML, Lee BG, Chen W, Amar MJ, Remaley AT, Saba JD, Proia RL.
J Biol Chem (2010 Apr 2) 285:10880-9. Abstract/Full Text
Sphingosine-1-phosphate regulation of mammalian development.
Kono M, Allende ML, Proia RL.
Biochim Biophys Acta (2008 Sep) 1781:435-41. Abstract/Full Text
S1P1 receptor expression regulates emergence of NKT cells in peripheral tissues.
Allende ML, Zhou D, Kalkofen DN, Benhamed S, Tuymetova G, Borowski C, Bendelac A, Proia RL.
FASEB J (2008 Jan) 22:307-15. Abstract/Full Text
The sphingosine 1-phosphate receptor 1 causes tissue retention by inhibiting the entry of peripheral tissue T lymphocytes into afferent lymphatics.
Ledgerwood LG, Lal G, Zhang N, Garin A, Esses SJ, Ginhoux F, Merad M, Peche H, Lira SA, Ding Y, Yang Y, He X, Schuchman EH, Allende ML, Ochando JC, Bromberg JS.
Nat Immunol (2008 Jan) 9:42-53. Abstract/Full Text
Plasma cell S1P1 expression determines secondary lymphoid organ retention versus bone marrow tropism.
Kabashima K, Haynes NM, Xu Y, Nutt SL, Allende ML, Proia RL, Cyster JG.
J Exp Med (2006 Nov 27) 203:2683-90. Abstract/Full Text
Neutral ceramidase encoded by the Asah2 gene is essential for the intestinal degradation of sphingolipids.
Kono M, Dreier JL, Ellis JM, Allende ML, Kalkofen DN, Sanders KM, Bielawski J, Bielawska A, Hannun YA, Proia RL.
J Biol Chem (2006 Mar 17) 281:7324-31. Abstract/Full Text
Conditional LoxP-flanked glucosylceramide synthase allele controlling glycosphingolipid synthesis.
Yamashita T, Allende ML, Kalkofen DN, Werth N, Sandhoff K, Proia RL.
Genesis (2005 Dec) 43:175-80. Abstract/Full Text
Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720.
Allende ML, Sasaki T, Kawai H, Olivera A, Mi Y, van Echten-Deckert G, Hajdu R, Rosenbach M, Keohane CA, Mandala S, Spiegel S, Proia RL.
J Biol Chem (2004 Dec 10) 279:52487-92. Abstract/Full Text
The sphingosine-1-phosphate receptors S1P1, S1P2, and S1P3 function coordinately during embryonic angiogenesis.
Kono M, Mi Y, Liu Y, Sasaki T, Allende ML, Wu YP, Yamashita T, Proia RL.
J Biol Chem (2004 Jul 9) 279:29367-73. Abstract/Full Text
Regulation of limb development by the sphingosine 1-phosphate receptor S1p1/EDG-1 occurs via the hypoxia/VEGF axis.
Chae SS, Paik JH, Allende ML, Proia RL, Hla T.
Dev Biol (2004 Apr 15) 268:441-7. Abstract/Full Text
Expression of the sphingosine 1-phosphate receptor, S1P1, on T-cells controls thymic emigration.
Allende ML, Dreier JL, Mandala S, Proia RL.
J Biol Chem (2004 Apr 9) 279:15396-401. Abstract/Full Text
Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1.
Matloubian M, Lo CG, Cinamon G, Lesneski MJ, Xu Y, Brinkmann V, Allende ML, Proia RL, Cyster JG.
Nature (2004 Jan 22) 427:355-60. Abstract/Full Text
G-protein-coupled receptor S1P1 acts within endothelial cells to regulate vascular maturation.
Allende ML, Yamashita T, Proia RL.
Blood (2003 Nov 15) 102:3665-7. Abstract/Full Text
Lubricating cell signaling pathways with gangliosides.
Allende ML, Proia RL.
Curr Opin Struct Biol (2002 Oct) 12:587-92. Abstract/Full Text
Sphingosine-1-phosphate receptors and the development of the vascular system.
Allende ML, Proia RL.
Biochim Biophys Acta (2002 May 23) 1582:222-7. Abstract/Full Text
Mice expressing only monosialoganglioside GM3 exhibit lethal audiogenic seizures.
Kawai H, Allende ML, Wada R, Kono M, Sango K, Deng C, Miyakawa T, Crawley JN, Werth N, Bierfreund U, Sandhoff K, Proia RL.
J Biol Chem (2001 Mar 9) 276:6885-8. Abstract/Full Text
Last Reviewed August 2023