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Genetics and Biochemistry Branch

Studying how cells repair damaged DNA, how chromosomes pair during meiosis, and how bacteria secrete proteins.
About the Branch

Branch Sections and Chiefs

Genetics and Biochemistry Section

Rafael Daniel Camerini-Otero, M.D., Ph.D., Section Chief

The Genetics and Biochemistry Section studies the biochemistry, molecular, and cell biology of meiotic (homologous) recombination in mice and humans. Our focus is on understanding the biology of genetic recombination and to devise new strategies to manipulate complex genomes in vitro and, in the future, in vivo. Specific projects include biophysical and structural studies of proteins, protein domains and DNA-protein complexes involved, gene rearrangements in eukaryotes and, most recently, mouse and human meiosis and evolutionary genomics. Current interests include the study of Spo11, the protein responsible for the hundreds of developmentally programmed breaks in meiosis, what determines where these breaks are made and where crossovers are located, how homologous chromosomes find each other and how meiosis has shaped the sex chromosomes.

Genetics of Development and Disease Section

Richard L. Proia, Ph.D., Section Chief

The Genetic Disease Research Section studies sphingolipids, lipid molecules that form cell membranes and transmit signals to cells. Inherited defects in their metabolic and signaling pathways cause neurodegenerative diseases, and other disorders affecting diverse physiological systems. Our work is aimed at understanding how these lipids function normally and during diseases, and how we can manipulate their pathways for new therapeutic approaches.

Genome Dynamics Section

Peggy Hsieh, Ph.D., Section Chief

The Genome Dynamics Section focuses on a highly conserved DNA repair pathway, DNA mismatch repair. Mismatch repair targets base pair mismatches that arise through DNA replication errors, homologous recombination, and DNA damage. Inactivation of mismatch repair results in a large increase in the rate of spontaneous mutation and is associated with both sporadic and hereditary cancers. The Hsieh group utilizes biochemical, structural, and cell biological approaches to study mechanistic questions concerning mismatch excision repair and the cellular response to DNA damage.

Human Disease Section

Priyanka Narayan, Ph.D., Stadtman Tenure-Track Investigator, Acting Section Chief

The Human Disease Section examines the cellular impacts of genetic and environmental risk factors for neurodegenerative diseases. Our lab works on multiple questions including: (1) How do disease risk factors alter cellular pathways to increase susceptibility or resilience to disease processes? (2) Can we identify genetic and chemical modulators of these cellular perturbations to prevent or reverse the detrimental effects of risk factors? We use a combination of genetics, biochemistry, molecular biology, and human iPSC-derived neuronal and glial cell types to answer these questions. We envision that our findings can accelerate the development of novel therapeutic or preventative strategies for neurodegenerative diseases.

Protein Biogenesis Section

Harris D. Bernstein, Ph.D., Section Chief

The Protein Biogenesis Section studies protein secretion in both pathogenic and non-pathogenic bacteria. We are continuing to pursue a long-term interest in understanding the mechanism of secretion by the autotransporter (“type V”) pathway, which is widely used by pathogenic Gram-negative bacteria to secrete virulence factors. We have also recently begun to study protein secretion in the Bacteroides, a genus of commensal bacteria that constitute a major component of the human gut microbiome.