Seeking to understand the biology of sphingolipids with the goal of developing therapies for the diseases of sphingolipid metabolism.
Select Publications
- CNS-targeted base editing of the major late-onset Tay-Sachs mutation alleviates disease in mice.
- Allende ML, Kono M, Lee YT, Olmsted SM, Huso V, Bakir JY, Pratto F, Li C, Byrnes C, Tuymetova G, Zhu H, Tifft CJ, Proia RL.
- J Clin Invest (2025 Aug 15) 135. Abstract/Full Text
- 1-Deoxysphingolipids require very-long-chain ceramide synthesis to induce ER stress and cytotoxicity.
- Byrnes C, Clarke BA, Zhu H, Lee YT, Majumder S, Kono M, Proia RL.
- J Biol Chem (2026 Aug) 302:113281. Abstract/Full Text
Last Reviewed August 2024