Seeking to understand the biology of sphingolipids with the goal of developing therapies for the diseases of sphingolipid metabolism.
Select Publications
- Sialidase NEU3 action on GM1 ganglioside is neuroprotective in GM1 gangliosidosis.
- Allende ML, Lee YT, Byrnes C, Li C, Tuymetova G, Bakir JY, Nicoli ER, James VK, Brodbelt JS, Tifft CJ, Proia RL.
- J Lipid Res (2023 Oct 21) 64:100463. Abstract/Full Text
- SARS-CoV-2 ORF3a expression in brain disrupts the autophagy-lysosomal pathway, impairs sphingolipid homeostasis, and drives neuropathogenesis.
- Zhu H, Byrnes C, Lee YT, Tuymetova G, Duffy HBD, Bakir JY, Pettit SN, Angina J, Springer DA, Allende ML, Kono M, Proia RL.
- FASEB J (2023 May) 37:e22919. Abstract/Full Text
