Kai Ge, Ph.D.

Photo of Kai Ge
Scientific Focus Areas: Cell Biology, Chromosome Biology, Developmental Biology, Genetics and Genomics, Molecular Biology and Biochemistry, Stem Cell Biology

Publications

A selection of recent and significant publications can be viewed below.

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Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation.
Jin Q, Yu LR, Wang L, Zhang Z, Kasper LH, Lee JE, Wang C, Brindle PK, Dent SY, Ge K.
EMBO J (2011 Jan 19) 30:249-62. Abstract/Full Text
H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation.
Lee JE, Wang C, Xu S, Cho YW, Wang L, Feng X, Baldridge A, Sartorelli V, Zhuang L, Peng W, Ge K.
Elife (2013 Dec 24) 2:e01503. Abstract/Full Text
Enhancer priming by H3K4 methyltransferase MLL4 controls cell fate transition.
Wang C, Lee JE, Lai B, Macfarlan TS, Xu S, Zhuang L, Liu C, Peng W, Ge K.
Proc Natl Acad Sci U S A (2016 Oct 18) 113:11871-11876. Abstract/Full Text
Brd4 binds to active enhancers to control cell identity gene induction in adipogenesis and myogenesis.
Lee JE, Park YK, Park S, Jang Y, Waring N, Dey A, Ozato K, Lai B, Peng W, Ge K.
Nat Commun (2017 Dec 20) 8:2217. Abstract/Full Text
Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function.
Zhuang L, Jang Y, Park YK, Lee JE, Jain S, Froimchuk E, Broun A, Liu C, Gavrilova O, Ge K.
Nat Commun (2018 May 4) 9:1796. Abstract/Full Text

Additional Publications

Fasting-induced JMJD3 histone demethylase epigenetically activates mitochondrial fatty acid β-oxidation.
Seok S, Kim YC, Byun S, Choi S, Xiao Z, Iwamori N, Zhang Y, Wang C, Ma J, Ge K, Kemper B, Kemper JK.
J Clin Invest (2018 Jul 2) 128:3144-3159. Abstract/Full Text
In vivo CRISPR screening unveils histone demethylase UTX as an important epigenetic regulator in lung tumorigenesis.
Wu Q, Tian Y, Zhang J, Tong X, Huang H, Li S, Zhao H, Tang Y, Yuan C, Wang K, Fang Z, Gao L, Hu X, Li F, Qin Z, Yao S, Chen T, Chen H, Zhang G, Liu W, Sun Y, Chen L, Wong KK, Ge K, Chen L, Ji H.
Proc Natl Acad Sci U S A (2018 Apr 24) 115:E3978-E3986. Abstract/Full Text
Histone H3 lysine 4 monomethylation modulates long-range chromatin interactions at enhancers.
Yan J, Chen SA, Local A, Liu T, Qiu Y, Dorighi KM, Preissl S, Rivera CM, Wang C, Ye Z, Ge K, Hu M, Wysocka J, Ren B.
Cell Res (2018 Feb) 28:204-220. Abstract/Full Text
T3 and Glucose Coordinately Stimulate ChREBP-Mediated Ucp1 Expression in Brown Adipocytes From Male Mice.
Katz LS, Xu S, Ge K, Scott DK, Gershengorn MC.
Endocrinology (2018 Jan 1) 159:557-569. Abstract/Full Text
Identification of H3K4me1-associated proteins at mammalian enhancers.
Local A, Huang H, Albuquerque CP, Singh N, Lee AY, Wang W, Wang C, Hsia JE, Shiau AK, Ge K, Corbett KD, Wang D, Zhou H, Ren B.
Nat Genet (2018 Jan) 50:73-82. Abstract/Full Text
UTX-guided neural crest function underlies craniofacial features of Kabuki syndrome.
Shpargel KB, Starmer J, Wang C, Ge K, Magnuson T.
Proc Natl Acad Sci U S A (2017 Oct 24) 114:E9046-E9055. Abstract/Full Text
Histone H3 lysine 4 methyltransferase KMT2D.
Froimchuk E, Jang Y, Ge K.
Gene (2017 Sep 5) 627:337-342. Abstract/Full Text
MLL4 prepares the enhancer landscape for Foxp3 induction via chromatin looping.
Placek K, Hu G, Cui K, Zhang D, Ding Y, Lee JE, Jang Y, Wang C, Konkel JE, Song J, Liu C, Ge K, Chen W, Zhao K.
Nat Immunol (2017 Sep) 18:1035-1045. Abstract/Full Text
H3K4 Methyltransferase Activity Is Required for MLL4 Protein Stability.
Jang Y, Wang C, Zhuang L, Liu C, Ge K.
J Mol Biol (2017 Jun 30) 429:2046-2054. Abstract/Full Text
MLL3/MLL4 are required for CBP/p300 binding on enhancers and super-enhancer formation in brown adipogenesis.
Lai B, Lee JE, Jang Y, Wang L, Peng W, Ge K.
Nucleic Acids Res (2017 Jun 20) 45:6388-6403. Abstract/Full Text
Histone demethylases UTX and JMJD3 are required for NKT cell development in mice.
Northrup D, Yagi R, Cui K, Proctor WR, Wang C, Placek K, Pohl LR, Wang R, Ge K, Zhu J, Zhao K.
Cell Biosci (2017) 7:25. Abstract/Full Text
Distinct Roles of Transcription Factors KLF4, Krox20, and Peroxisome Proliferator-Activated Receptor γ in Adipogenesis.
Park YK, Wang L, Giampietro A, Lai B, Lee JE, Ge K.
Mol Cell Biol (2017 Jan 15) 37. Abstract/Full Text
Glucocorticoid Receptor Accelerates, but Is Dispensable for, Adipogenesis.
Park YK, Ge K.
Mol Cell Biol (2017 Jan 15) 37. Abstract/Full Text
Mammary-Stem-Cell-Based Somatic Mouse Models Reveal Breast Cancer Drivers Causing Cell Fate Dysregulation.
Zhang Z, Christin JR, Wang C, Ge K, Oktay MH, Guo W.
Cell Rep (2016 Sep 20) 16:3146-3156. Abstract/Full Text
Histone Demethylase KDM6A Controls the Mammary Luminal Lineage through Enzyme-Independent Mechanisms.
Yoo KH, Oh S, Kang K, Wang C, Robinson GW, Ge K, Hennighausen L.
Mol Cell Biol (2016 Aug 15) 36:2108-20. Abstract/Full Text
Replication fork stability confers chemoresistance in BRCA-deficient cells.
Ray Chaudhuri A, Callen E, Ding X, Gogola E, Duarte AA, Lee JE, Wong N, Lafarga V, Calvo JA, Panzarino NJ, John S, Day A, Crespo AV, Shen B, Starnes LM, de Ruiter JR, Daniel JA, Konstantinopoulos PA, Cortez D, Cantor SB, Fernandez-Capetillo O, Ge K, Jonkers J, Rottenberg S, Sharan SK, Nussenzweig A.
Nature (2016 Jul 21) 535:382-7. Abstract/Full Text
UTX demethylase activity is required for satellite cell-mediated muscle regeneration.
Faralli H, Wang C, Nakka K, Benyoucef A, Sebastian S, Zhuang L, Chu A, Palii CG, Liu C, Camellato B, Brand M, Ge K, Dilworth FJ.
J Clin Invest (2016 Apr 1) 126:1555-65. Abstract/Full Text
KMT2D regulates specific programs in heart development via histone H3 lysine 4 di-methylation.
Ang SY, Uebersohn A, Spencer CI, Huang Y, Lee JE, Ge K, Bruneau BG.
Development (2016 Mar 1) 143:810-21. Abstract/Full Text
UTX inhibition as selective epigenetic therapy against TAL1-driven T-cell acute lymphoblastic leukemia.
Benyoucef A, Palii CG, Wang C, Porter CJ, Chu A, Dai F, Tremblay V, Rakopoulos P, Singh K, Huang S, Pflumio F, Hébert J, Couture JF, Perkins TJ, Ge K, Dilworth FJ, Brand M.
Genes Dev (2016 Mar 1) 30:508-21. Abstract/Full Text
A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex.
Starnes LM, Su D, Pikkupeura LM, Weinert BT, Santos MA, Mund A, Soria R, Cho YW, Pozdnyakova I, Kubec Højfeldt M, Vala A, Yang W, López-Méndez B, Lee JE, Peng W, Yuan J, Ge K, Montoya G, Nussenzweig A, Choudhary C, Daniel JA.
Genes Dev (2016 Jan 15) 30:149-63. Abstract/Full Text
The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development.
Ortega-Molina A, Boss IW, Canela A, Pan H, Jiang Y, Zhao C, Jiang M, Hu D, Agirre X, Niesvizky I, Lee JE, Chen HT, Ennishi D, Scott DW, Mottok A, Hother C, Liu S, Cao XJ, Tam W, Shaknovich R, Garcia BA, Gascoyne RD, Ge K, Shilatifard A, Elemento O, Nussenzweig A, Melnick AM, Wendel HG.
Nat Med (2015 Oct) 21:1199-208. Abstract/Full Text
Disruption of KMT2D perturbs germinal center B cell development and promotes lymphomagenesis.
Zhang J, Dominguez-Sola D, Hussein S, Lee JE, Holmes AB, Bansal M, Vlasevska S, Mo T, Tang H, Basso K, Ge K, Dalla-Favera R, Pasqualucci L.
Nat Med (2015 Oct) 21:1190-8. Abstract/Full Text
An epigenetic switch induced by Shh signalling regulates gene activation during development and medulloblastoma growth.
Shi X, Zhang Z, Zhan X, Cao M, Satoh T, Akira S, Shpargel K, Magnuson T, Li Q, Wang R, Wang C, Ge K, Wu J.
Nat Commun (2014 Nov 5) 5:5425. Abstract/Full Text
Gcn5 and PCAF negatively regulate interferon-β production through HAT-independent inhibition of TBK1.
Jin Q, Zhuang L, Lai B, Wang C, Li W, Dolan B, Lu Y, Wang Z, Zhao K, Peng W, Dent SY, Ge K.
EMBO Rep (2014 Nov) 15:1192-201. Abstract/Full Text
DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier.
Santos MA, Faryabi RB, Ergen AV, Day AM, Malhowski A, Canela A, Onozawa M, Lee JE, Callen E, Gutierrez-Martinez P, Chen HT, Wong N, Finkel N, Deshpande A, Sharrow S, Rossi DJ, Ito K, Ge K, Aplan PD, Armstrong SA, Nussenzweig A.
Nature (2014 Oct 2) 514:107-11. Abstract/Full Text
Gcn5 and PCAF regulate PPARγ and Prdm16 expression to facilitate brown adipogenesis.
Jin Q, Wang C, Kuang X, Feng X, Sartorelli V, Ying H, Ge K, Dent SY.
Mol Cell Biol (2014 Oct 1) 34:3746-53. Abstract/Full Text
Loss of function of mouse Pax-Interacting Protein 1-associated glutamate rich protein 1a (Pagr1a) leads to reduced Bmp2 expression and defects in chorion and amnion development.
Kumar A, Lualdi M, Loncarek J, Cho YW, Lee JE, Ge K, Kuehn MR.
Dev Dyn (2014 Jul) 243:937-47. Abstract/Full Text
Transcriptional and epigenetic regulation of PPARγ expression during adipogenesis.
Lee JE, Ge K.
Cell Biosci (2014) 4:29. Abstract/Full Text
Spatial clustering for identification of ChIP-enriched regions (SICER) to map regions of histone methylation patterns in embryonic stem cells.
Xu S, Grullon S, Ge K, Peng W.
Methods Mol Biol (2014) 1150:97-111. Abstract/Full Text
A multifunctional protein, EWS, is essential for early brown fat lineage determination.
Park JH, Kang HJ, Kang SI, Lee JE, Hur J, Ge K, Mueller E, Li H, Lee BC, Lee SB.
Dev Cell (2013 Aug 26) 26:393-404. Abstract/Full Text
The histone chaperone Spt6 coordinates histone H3K27 demethylation and myogenesis.
Wang AH, Zare H, Mousavi K, Wang C, Moravec CE, Sirotkin HI, Ge K, Gutierrez-Cruz G, Sartorelli V.
EMBO J (2013 Apr 17) 32:1075-86. Abstract/Full Text
H2A.Z facilitates access of active and repressive complexes to chromatin in embryonic stem cell self-renewal and differentiation.
Hu G, Cui K, Northrup D, Liu C, Wang C, Tang Q, Ge K, Levens D, Crane-Robinson C, Zhao K.
Cell Stem Cell (2013 Feb 7) 12:180-92. Abstract/Full Text
Histone H3K9 methyltransferase G9a represses PPARγ expression and adipogenesis.
Wang L, Xu S, Lee JE, Baldridge A, Grullon S, Peng W, Ge K.
EMBO J (2013 Jan 9) 32:45-59. Abstract/Full Text
The DNA damage- and transcription-associated protein paxip1 controls thymocyte development and emigration.
Callen E, Faryabi RB, Luckey M, Hao B, Daniel JA, Yang W, Sun HW, Dressler G, Peng W, Chi H, Ge K, Krangel MS, Park JH, Nussenzweig A.
Immunity (2012 Dec 14) 37:971-85. Abstract/Full Text
Global identification of MLL2-targeted loci reveals MLL2's role in diverse signaling pathways.
Guo C, Chang CC, Wortham M, Chen LH, Kernagis DN, Qin X, Cho YW, Chi JT, Grant GA, McLendon RE, Yan H, Ge K, Papadopoulos N, Bigner DD, He Y.
Proc Natl Acad Sci U S A (2012 Oct 23) 109:17603-8. Abstract/Full Text
Epigenetic regulation of adipogenesis by histone methylation.
Ge K.
Biochim Biophys Acta (2012 Jul) 1819:727-32. Abstract/Full Text
EZH2 Mediates epigenetic silencing of neuroblastoma suppressor genes CASZ1, CLU, RUNX3, and NGFR.
Wang C, Liu Z, Woo CW, Li Z, Wang L, Wei JS, Marquez VE, Bates SE, Jin Q, Khan J, Ge K, Thiele CJ.
Cancer Res (2012 Jan 1) 72:315-24. Abstract/Full Text
Affinity purification of MLL3/MLL4 histone H3K4 methyltransferase complex.
Cho YW, Hong S, Ge K.
Methods Mol Biol (2012) 809:465-72. Abstract/Full Text
PTIP promotes chromatin changes critical for immunoglobulin class switch recombination.
Daniel JA, Santos MA, Wang Z, Zang C, Schwab KR, Jankovic M, Filsuf D, Chen HT, Gazumyan A, Yamane A, Cho YW, Sun HW, Ge K, Peng W, Nussenzweig MC, Casellas R, Dressler GR, Zhao K, Nussenzweig A.
Science (2010 Aug 20) 329:917-23. Abstract/Full Text
UTX mediates demethylation of H3K27me3 at muscle-specific genes during myogenesis.
Seenundun S, Rampalli S, Liu QC, Aziz A, Palii C, Hong S, Blais A, Brand M, Ge K, Dilworth FJ.
EMBO J (2010 Apr 21) 29:1401-11. Abstract/Full Text
Histone H3K27 methyltransferase Ezh2 represses Wnt genes to facilitate adipogenesis.
Wang L, Jin Q, Lee JE, Su IH, Ge K.
Proc Natl Acad Sci U S A (2010 Apr 20) 107:7317-22. Abstract/Full Text
Adipogenesis is differentially impaired by thyroid hormone receptor mutant isoforms.
Mishra A, Zhu XG, Ge K, Cheng SY.
J Mol Endocrinol (2010 Apr) 44:247-55. Abstract/Full Text
Global analysis of H3K4 methylation defines MLL family member targets and points to a role for MLL1-mediated H3K4 methylation in the regulation of transcriptional initiation by RNA polymerase II.
Wang P, Lin C, Smith ER, Guo H, Sanderson BW, Wu M, Gogol M, Alexander T, Seidel C, Wiedemann LM, Ge K, Krumlauf R, Shilatifard A.
Mol Cell Biol (2009 Nov) 29:6074-85. Abstract/Full Text
Histone methylation regulator PTIP is required for PPARgamma and C/EBPalpha expression and adipogenesis.
Cho YW, Hong S, Jin Q, Wang L, Lee JE, Gavrilova O, Ge K.
Cell Metab (2009 Jul) 10:27-39. Abstract/Full Text
Accumulation of Pax2 transactivation domain interaction protein (PTIP) at sites of DNA breaks via RNF8-dependent pathway is required for cell survival after DNA damage.
Gong Z, Cho YW, Kim JE, Ge K, Chen J.
J Biol Chem (2009 Mar 13) 284:7284-93. Abstract/Full Text