Kai Ge, Ph.D.

Photo of Kai Ge
Scientific Focus Areas: Cell Biology, Chromosome Biology, Developmental Biology, Genetics and Genomics, Molecular Biology and Biochemistry

Publications

A selection of recent and significant publications can be viewed below.

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Enhancer priming by H3K4 methyltransferase MLL4 controls cell fate transition.
Wang C, Lee JE, Lai B, Macfarlan TS, Xu S, Zhuang L, Liu C, Peng W, Ge K.
Proc Natl Acad Sci U S A (2016 Oct 18) 113:11871-11876. Abstract/Full Text
Brd4 binds to active enhancers to control cell identity gene induction in adipogenesis and myogenesis.
Lee JE, Park YK, Park S, Jang Y, Waring N, Dey A, Ozato K, Lai B, Peng W, Ge K.
Nat Commun (2017 Dec 20) 8:2217. Abstract/Full Text
Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function.
Zhuang L, Jang Y, Park YK, Lee JE, Jain S, Froimchuk E, Broun A, Liu C, Gavrilova O, Ge K.
Nat Commun (2018 May 4) 9:1796. Abstract/Full Text
H3.3K4M destabilizes enhancer H3K4 methyltransferases MLL3/MLL4 and impairs adipose tissue development.
Jang Y, Broun A, Wang C, Park YK, Zhuang L, Lee JE, Froimchuk E, Liu C, Ge K.
Nucleic Acids Res (2019 Jan 25) 47:607-620. Abstract/Full Text
Transcriptional and Epigenomic Regulation of Adipogenesis.
Lee JE, Schmidt H, Lai B, Ge K.
Mol Cell Biol (2019 Jun 1) 39. Abstract/Full Text

Additional Publications

Somatic Mutations Increase Hepatic Clonal Fitness and Regeneration in Chronic Liver Disease.
Zhu M, Lu T, Jia Y, Luo X, Gopal P, Li L, Odewole M, Renteria V, Singal AG, Jang Y, Ge K, Wang SC, Sorouri M, Parekh JR, MacConmara MP, Yopp AC, Wang T, Zhu H.
Cell (2019 Apr 18) 177:608-621.e12. Abstract/Full Text
Histone methylation regulator PTIP is required to maintain normal and leukemic bone marrow niches.
Das P, Veazey KJ, Van HT, Kaushik S, Lin K, Lu Y, Ishii M, Kikuta J, Ge K, Nussenzweig A, Santos MA.
Proc Natl Acad Sci U S A (2018 Oct 23) 115:E10137-E10146. Abstract/Full Text
HOXA9 Reprograms the Enhancer Landscape to Promote Leukemogenesis.
Sun Y, Zhou B, Mao F, Xu J, Miao H, Zou Z, Phuc Khoa LT, Jang Y, Cai S, Witkin M, Koche R, Ge K, Dressler GR, Levine RL, Armstrong SA, Dou Y, Hess JL.
Cancer Cell (2018 Oct 8) 34:643-658.e5. Abstract/Full Text
Fasting-induced JMJD3 histone demethylase epigenetically activates mitochondrial fatty acid β-oxidation.
Seok S, Kim YC, Byun S, Choi S, Xiao Z, Iwamori N, Zhang Y, Wang C, Ma J, Ge K, Kemper B, Kemper JK.
J Clin Invest (2018 Jul 2) 128:3144-3159. Abstract/Full Text
In vivo CRISPR screening unveils histone demethylase UTX as an important epigenetic regulator in lung tumorigenesis.
Wu Q, Tian Y, Zhang J, Tong X, Huang H, Li S, Zhao H, Tang Y, Yuan C, Wang K, Fang Z, Gao L, Hu X, Li F, Qin Z, Yao S, Chen T, Chen H, Zhang G, Liu W, Sun Y, Chen L, Wong KK, Ge K, Chen L, Ji H.
Proc Natl Acad Sci U S A (2018 Apr 24) 115:E3978-E3986. Abstract/Full Text
Histone H3 lysine 4 monomethylation modulates long-range chromatin interactions at enhancers.
Yan J, Chen SA, Local A, Liu T, Qiu Y, Dorighi KM, Preissl S, Rivera CM, Wang C, Ye Z, Ge K, Hu M, Wysocka J, Ren B.
Cell Res (2018 Feb) 28:204-220. Abstract/Full Text
Identification of H3K4me1-associated proteins at mammalian enhancers.
Local A, Huang H, Albuquerque CP, Singh N, Lee AY, Wang W, Wang C, Hsia JE, Shiau AK, Ge K, Corbett KD, Wang D, Zhou H, Ren B.
Nat Genet (2018 Jan) 50:73-82. Abstract/Full Text
UTX-guided neural crest function underlies craniofacial features of Kabuki syndrome.
Shpargel KB, Starmer J, Wang C, Ge K, Magnuson T.
Proc Natl Acad Sci U S A (2017 Oct 24) 114:E9046-E9055. Abstract/Full Text
MLL4 prepares the enhancer landscape for Foxp3 induction via chromatin looping.
Placek K, Hu G, Cui K, Zhang D, Ding Y, Lee JE, Jang Y, Wang C, Konkel JE, Song J, Liu C, Ge K, Chen W, Zhao K.
Nat Immunol (2017 Sep) 18:1035-1045. Abstract/Full Text
H3K4 Methyltransferase Activity Is Required for MLL4 Protein Stability.
Jang Y, Wang C, Zhuang L, Liu C, Ge K.
J Mol Biol (2017 Jun 30) 429:2046-2054. Abstract/Full Text
MLL3/MLL4 are required for CBP/p300 binding on enhancers and super-enhancer formation in brown adipogenesis.
Lai B, Lee JE, Jang Y, Wang L, Peng W, Ge K.
Nucleic Acids Res (2017 Jun 20) 45:6388-6403. Abstract/Full Text
Histone demethylases UTX and JMJD3 are required for NKT cell development in mice.
Northrup D, Yagi R, Cui K, Proctor WR, Wang C, Placek K, Pohl LR, Wang R, Ge K, Zhu J, Zhao K.
Cell Biosci (2017) 7:25. Abstract/Full Text
Distinct Roles of Transcription Factors KLF4, Krox20, and Peroxisome Proliferator-Activated Receptor γ in Adipogenesis.
Park YK, Wang L, Giampietro A, Lai B, Lee JE, Ge K.
Mol Cell Biol (2017 Jan 15) 37. Abstract/Full Text
Glucocorticoid Receptor Accelerates, but Is Dispensable for, Adipogenesis.
Park YK, Ge K.
Mol Cell Biol (2017 Jan 15) 37. Abstract/Full Text
Mammary-Stem-Cell-Based Somatic Mouse Models Reveal Breast Cancer Drivers Causing Cell Fate Dysregulation.
Zhang Z, Christin JR, Wang C, Ge K, Oktay MH, Guo W.
Cell Rep (2016 Sep 20) 16:3146-3156. Abstract/Full Text
Histone Demethylase KDM6A Controls the Mammary Luminal Lineage through Enzyme-Independent Mechanisms.
Yoo KH, Oh S, Kang K, Wang C, Robinson GW, Ge K, Hennighausen L.
Mol Cell Biol (2016 Aug 15) 36:2108-20. Abstract/Full Text
Replication fork stability confers chemoresistance in BRCA-deficient cells.
Ray Chaudhuri A, Callen E, Ding X, Gogola E, Duarte AA, Lee JE, Wong N, Lafarga V, Calvo JA, Panzarino NJ, John S, Day A, Crespo AV, Shen B, Starnes LM, de Ruiter JR, Daniel JA, Konstantinopoulos PA, Cortez D, Cantor SB, Fernandez-Capetillo O, Ge K, Jonkers J, Rottenberg S, Sharan SK, Nussenzweig A.
Nature (2016 Jul 21) 535:382-7. Abstract/Full Text
UTX demethylase activity is required for satellite cell-mediated muscle regeneration.
Faralli H, Wang C, Nakka K, Benyoucef A, Sebastian S, Zhuang L, Chu A, Palii CG, Liu C, Camellato B, Brand M, Ge K, Dilworth FJ.
J Clin Invest (2016 Apr 1) 126:1555-65. Abstract/Full Text
KMT2D regulates specific programs in heart development via histone H3 lysine 4 di-methylation.
Ang SY, Uebersohn A, Spencer CI, Huang Y, Lee JE, Ge K, Bruneau BG.
Development (2016 Mar 1) 143:810-21. Abstract/Full Text
UTX inhibition as selective epigenetic therapy against TAL1-driven T-cell acute lymphoblastic leukemia.
Benyoucef A, Palii CG, Wang C, Porter CJ, Chu A, Dai F, Tremblay V, Rakopoulos P, Singh K, Huang S, Pflumio F, Hébert J, Couture JF, Perkins TJ, Ge K, Dilworth FJ, Brand M.
Genes Dev (2016 Mar 1) 30:508-21. Abstract/Full Text
The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development.
Ortega-Molina A, Boss IW, Canela A, Pan H, Jiang Y, Zhao C, Jiang M, Hu D, Agirre X, Niesvizky I, Lee JE, Chen HT, Ennishi D, Scott DW, Mottok A, Hother C, Liu S, Cao XJ, Tam W, Shaknovich R, Garcia BA, Gascoyne RD, Ge K, Shilatifard A, Elemento O, Nussenzweig A, Melnick AM, Wendel HG.
Nat Med (2015 Oct) 21:1199-208. Abstract/Full Text
Disruption of KMT2D perturbs germinal center B cell development and promotes lymphomagenesis.
Zhang J, Dominguez-Sola D, Hussein S, Lee JE, Holmes AB, Bansal M, Vlasevska S, Mo T, Tang H, Basso K, Ge K, Dalla-Favera R, Pasqualucci L.
Nat Med (2015 Oct) 21:1190-8. Abstract/Full Text
An epigenetic switch induced by Shh signalling regulates gene activation during development and medulloblastoma growth.
Shi X, Zhang Z, Zhan X, Cao M, Satoh T, Akira S, Shpargel K, Magnuson T, Li Q, Wang R, Wang C, Ge K, Wu J.
Nat Commun (2014 Nov 5) 5:5425. Abstract/Full Text
Gcn5 and PCAF negatively regulate interferon-β production through HAT-independent inhibition of TBK1.
Jin Q, Zhuang L, Lai B, Wang C, Li W, Dolan B, Lu Y, Wang Z, Zhao K, Peng W, Dent SY, Ge K.
EMBO Rep (2014 Nov) 15:1192-201. Abstract/Full Text
DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier.
Santos MA, Faryabi RB, Ergen AV, Day AM, Malhowski A, Canela A, Onozawa M, Lee JE, Callen E, Gutierrez-Martinez P, Chen HT, Wong N, Finkel N, Deshpande A, Sharrow S, Rossi DJ, Ito K, Ge K, Aplan PD, Armstrong SA, Nussenzweig A.
Nature (2014 Oct 2) 514:107-11. Abstract/Full Text
Gcn5 and PCAF regulate PPARγ and Prdm16 expression to facilitate brown adipogenesis.
Jin Q, Wang C, Kuang X, Feng X, Sartorelli V, Ying H, Ge K, Dent SY.
Mol Cell Biol (2014 Oct 1) 34:3746-53. Abstract/Full Text
Transcriptional and epigenetic regulation of PPARγ expression during adipogenesis.
Lee JE, Ge K.
Cell Biosci (2014) 4:29. Abstract/Full Text
Spatial clustering for identification of ChIP-enriched regions (SICER) to map regions of histone methylation patterns in embryonic stem cells.
Xu S, Grullon S, Ge K, Peng W.
Methods Mol Biol (2014) 1150:97-111. Abstract/Full Text
H2A.Z facilitates access of active and repressive complexes to chromatin in embryonic stem cell self-renewal and differentiation.
Hu G, Cui K, Northrup D, Liu C, Wang C, Tang Q, Ge K, Levens D, Crane-Robinson C, Zhao K.
Cell Stem Cell (2013 Feb 7) 12:180-92. Abstract/Full Text
Histone H3K9 methyltransferase G9a represses PPARγ expression and adipogenesis.
Wang L, Xu S, Lee JE, Baldridge A, Grullon S, Peng W, Ge K.
EMBO J (2013 Jan 9) 32:45-59. Abstract/Full Text
UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity.
Wang C, Lee JE, Cho YW, Xiao Y, Jin Q, Liu C, Ge K.
Proc Natl Acad Sci U S A (2012 Sep 18) 109:15324-9. Abstract/Full Text
Epigenetic regulation of adipogenesis by histone methylation.
Ge K.
Biochim Biophys Acta (2012 Jul) 1819:727-32. Abstract/Full Text
Affinity purification of MLL3/MLL4 histone H3K4 methyltransferase complex.
Cho YW, Hong S, Ge K.
Methods Mol Biol (2012) 809:465-72. Abstract/Full Text
PTIP promotes chromatin changes critical for immunoglobulin class switch recombination.
Daniel JA, Santos MA, Wang Z, Zang C, Schwab KR, Jankovic M, Filsuf D, Chen HT, Gazumyan A, Yamane A, Cho YW, Sun HW, Ge K, Peng W, Nussenzweig MC, Casellas R, Dressler GR, Zhao K, Nussenzweig A.
Science (2010 Aug 20) 329:917-23. Abstract/Full Text
Histone H3K27 methyltransferase Ezh2 represses Wnt genes to facilitate adipogenesis.
Wang L, Jin Q, Lee JE, Su IH, Ge K.
Proc Natl Acad Sci U S A (2010 Apr 20) 107:7317-22. Abstract/Full Text
Histone methylation regulator PTIP is required for PPARgamma and C/EBPalpha expression and adipogenesis.
Cho YW, Hong S, Jin Q, Wang L, Lee JE, Gavrilova O, Ge K.
Cell Metab (2009 Jul) 10:27-39. Abstract/Full Text
Alternative mechanisms by which mediator subunit MED1/TRAP220 regulates peroxisome proliferator-activated receptor gamma-stimulated adipogenesis and target gene expression.
Ge K, Cho YW, Guo H, Hong TB, Guermah M, Ito M, Yu H, Kalkum M, Roeder RG.
Mol Cell Biol (2008 Feb) 28:1081-91. Abstract/Full Text
Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases.
Hong S, Cho YW, Yu LR, Yu H, Veenstra TD, Ge K.
Proc Natl Acad Sci U S A (2007 Nov 20) 104:18439-44. Abstract/Full Text
PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.
Cho YW, Hong T, Hong S, Guo H, Yu H, Kim D, Guszczynski T, Dressler GR, Copeland TD, Kalkum M, Ge K.
J Biol Chem (2007 Jul 13) 282:20395-406. Abstract/Full Text
Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis.
Ge K, Guermah M, Yuan CX, Ito M, Wallberg AE, Spiegelman BM, Roeder RG.
Nature (2002 May 30) 417:563-7. Abstract/Full Text
Mechanism for elimination of a tumor suppressor: aberrant splicing of a brain-specific exon causes loss of function of Bin1 in melanoma.
Ge K, DuHadaway J, Du W, Herlyn M, Rodeck U, Prendergast GC.
Proc Natl Acad Sci U S A (1999 Aug 17) 96:9689-94. Abstract/Full Text
Transduction of cytosine deaminase gene makes rat glioma cells highly sensitive to 5-fluorocytosine.
Ge K, Xu L, Zheng Z, Xu D, Sun L, Liu X.
Int J Cancer (1997 May 16) 71:675-9. Abstract/Full Text